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27912-14-7,MFCD03425587
Catalog No.:AA00BC75

27912-14-7 | Levobunolol hydrochloride

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50mg
≥98%
in stock  
$123.00   $86.00
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100mg
≥98%
in stock  
$230.00   $161.00
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250mg
≥98%
in stock  
$480.00   $336.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BC75
Chemical Name:
Levobunolol hydrochloride
CAS Number:
27912-14-7
Molecular Formula:
C17H26ClNO3
Molecular Weight:
327.8462
MDL Number:
MFCD03425587
SMILES:
O[C@H](COc1cccc2c1CCCC2=O)CNC(C)(C)C.Cl
Properties
Computed Properties
 
Complexity:
350  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  

Literature

Title: Effects of anti-glaucoma drugs on resistive index of the medial long posterior ciliary artery using color Doppler imaging in Beagle dogs.

Journal: Journal of veterinary science 20110301

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20100101

Title: Comparison of effects of topical levobunolol to a combination of timolol-dorzolamide on intraocular pressure and pulse rate of healthy dogs.

Journal: Veterinary research communications 20090901

Title: Poly (epsilon-caprolactone) microparticles containing Levobunolol HCl prepared by a multiple emulsion (W/O/W) solvent evaporation technique: effects of some formulation parameters on microparticle characteristics.

Journal: Journal of microencapsulation 20090201

Title: An in vivo confocal microscopy and impression cytology analysis of preserved and unpreserved levobunolol-induced conjunctival changes.

Journal: European journal of ophthalmology 20080101

Title: Vasodilatory mechanism of levobunolol on vascular smooth muscle cells.

Journal: Experimental eye research 20070601

Title: Cellular cytotoxicity of antiglaucoma drugs in cultured corneal endothelial cells.

Journal: The Kaohsiung journal of medical sciences 20070301

Title: Allergic contact dermatitis due to levobunolol with cross-sensitivity to befunolol.

Journal: Contact dermatitis 20070101

Title: Membrane electrodes for determination of some beta-blocker drugs.

Journal: Journal of AOAC International 20070101

Title: Contact dermatitis to levobunolol eyedrops superimposed on IgE-mediated rhinoconjunctivitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061201

Title: Drops and falls.

Journal: Age and ageing 20061101

Title: Allergic contact dermatitis due to levobunolol in an ophthalmic preparation.

Journal: The Journal of dermatology 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Beta-blocker eye drops.

Journal: Nursing times 20060501

Title: Effects of antiglaucoma drugs on calcium mobility in cultured corneal endothelial cells.

Journal: The Kaohsiung journal of medical sciences 20060201

Title: The effect of once-daily levobunolol on intraocular pressure in normal-tension glaucoma.

Journal: Japanese journal of ophthalmology 20050101

Title: Reversal of disc cupping after intraocular pressure reduction in topographic image series.

Journal: Journal of glaucoma 20041001

Title: Deposits in artificial corneas: risk factors and prevention.

Journal: Clinical & experimental ophthalmology 20040401

Title: Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040401

Title: Thyroid eye disease and glaucoma.

Journal: Journal of glaucoma 20031201

Title: Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.

Journal: Cornea 20031101

Title: The effect of topical glaucoma medications evaluated by perimetry.

Journal: The British journal of ophthalmology 20030601

Title: Noninvasive assessment of aqueous humor turnover in the mouse eye.

Journal: Investigative ophthalmology & visual science 20030201

Title: A comparison of the efficacy and tolerability of 0.5% timolol maleate ophthalmic gel-forming solution QD and 0.5% levobunolol hydrochloride BID in patients with ocular hypertension or open-angle glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020401

Title: Allergic reactions to brimonidine in patients treated for glaucoma.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20020201

Title: False-negative patch test with levobunolol.

Journal: Contact dermatitis 20010401

Title: The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study.

Journal: European journal of ophthalmology 20010101

Title: Cardiovascular considerations in using topical, oral, and intravenous drugs for the treatment of glaucoma and ocular hypertension: focus on beta-adrenergic blockade.

Journal: Heart disease (Hagerstown, Md.) 20010101

Title: [Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers].

Journal: Nippon Ganka Gakkai zasshi 19990701

Title: Short-term effects of topical levobunolol on the human retinal circulation.

Journal: Eye (London, England) 19970101

Title: Syncope, bradycardia, and atrioventricular block associated with topical ophthalmic levobunolol.

Journal: American heart journal 19940301

Title: A comparison of the ocular hypotensive efficacy and systemic safety of 0.5% levobunolol and 2% carteolol.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 19940101

Title: A comparison of the ocular tolerability of a single dose of timolol and levobunolol in healthy normotensive volunteers.

Journal: Annals of ophthalmology 19930401

Title: Ocular levobunolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

Journal: Drugs 19871201

Title: Comparison of ophthalmic beta-blocking agents.

Journal: Clinical pharmacy 19870601

Title: Levobunolol for the long-term treatment of glaucoma.

Journal: General pharmacology 19860101

Title: l-Bunolol and propranolol: oral and intravenous beta-adrenoceptor blocking activity in rats compared to dogs and humans.

Journal: Journal of pharmaceutical sciences 19780101

Title: Mohammadi M, et al. Injectable drug depot engineered to release multiple ophthalmic therapeutic agents with precise time profiles for postoperative treatment following ocular surgery. Acta Biomater. 2018 Jun;73:90-102.

Title: Kumar, N, et al. Extended levobunolol release from Eudragit nanoparticle-laden contact lenses for glaucoma therapy. Futur J Pharm Sci 6, 109 (2020).

Title: Zhang M, et al. Superior oblique myokymia treated with levobunolol. J AAPOS. 2018 Feb;22(1):67-69.e2.

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