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438218-14-5,MFCD02253706
Catalog No.:AA00DCP9

438218-14-5 | 7-(Difluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$524.00   $367.00
- +
5g
95%
in stock  
$2,096.00   $1,467.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DCP9
Chemical Name:
7-(Difluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
438218-14-5
Molecular Formula:
C9H7F2N3O2
Molecular Weight:
227.1676
MDL Number:
MFCD02253706
SMILES:
Cc1cc(C(F)F)n2c(n1)c(cn2)C(=O)O
Properties
Computed Properties
 
Complexity:
290  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
0.9  

Downstream Synthesis Route

[1]Locationinpatent:experimentalpartPatnaik,Samarjit;Zheng,Wei;Choi,JaeH.;Motabar,Omid;Southall,Noel;Westbroek,Wendy;Lea,WendyA.;Velayati,Arash;Goldin,Ehud;Sidransky,Ellen;Leister,William;Marugan,JuanJ.[JournalofMedicinalChemistry,2012,vol.55,#12,p.5734-5748]

[1]Locationinpatent:experimentalpartPatnaik,Samarjit;Zheng,Wei;Choi,JaeH.;Motabar,Omid;Southall,Noel;Westbroek,Wendy;Lea,WendyA.;Velayati,Arash;Goldin,Ehud;Sidransky,Ellen;Leister,William;Marugan,JuanJ.[JournalofMedicinalChemistry,2012,vol.55,#12,p.5734-5748]

[1]Patnaik,Samarjit;Zheng,Wei;Choi,JaeH.;Motabar,Omid;Southall,Noel;Westbroek,Wendy;Lea,WendyA.;Velayati,Arash;Goldin,Ehud;Sidransky,Ellen;Leister,William;Marugan,JuanJ.[JournalofMedicinalChemistry,2012,vol.55,#12,p.5734-5748]

trans-4-amino-1-hydroxyadamantanehydrochloride 
  438218-14-5   
7-(difluoromethyl)-N-(5-hydroxy-2-adamantyl)-5-methyl-pyrazolo1,5-apyrimidine-3-carboxamide 

[1]Robb,GraemeR.;Boyd,Scott;Davies,ChristopherD.;Dossetter,AlexanderG.;Goldberg,FrederickW.;Kemmitt,PaulD.;Scott,JamesS.;Swales,JohnG.[MedChemComm,2015,vol.6,#5,p.926-934]

438218-14-5   
8-amino-2-(2-chloro-4-fluorophenyl)-2-azaspiro4.5decan-1-one 
 
N-(cis)-2-(2-chloro-4-fluorophenyl)-1-oxo-2-azaspiro4.5dec-8-yl-7-(difluoromethyl)-5-methylpyrazolo1,5-apyrimidine-3-carboxamide 

[1]CurrentPatentAssignee:BAYERAG-WO2016/177658,2016,A1Locationinpatent:Page/Pagecolumn591;592

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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SDS
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Tags:438218-14-5 Molecular Formula|438218-14-5 MDL|438218-14-5 SMILES|438218-14-5 7-(Difluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid