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53467-23-5,MFCD01311882
Catalog No.:AA00DDEQ

53467-23-5 | (3S)-3-Hydroxy Quinidine

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1mg
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$513.00   $359.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00DDEQ
Chemical Name:
(3S)-3-Hydroxy Quinidine
CAS Number:
53467-23-5
Molecular Formula:
C20H24N2O3
Molecular Weight:
340.4162
MDL Number:
MFCD01311882
SMILES:
C=C[C@@]1(O)CN2CC[C@H]1C[C@@H]2[C@H](c1ccnc2c1cc(OC)cc2)O
Properties
Properties
 
Form:
Solid  
MP:
195-197°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
501  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
1.8  

Literature

Title: Genetic epidemiology of induced CYP3A4 activity.

Journal: Pharmacogenetics and genomics 20111001

Title: Rapid quantification of quinine and its major metabolite (3S)-3-hydroxyquinine in diluted urine by UPLC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20110601

Title: Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans.

Journal: Therapeutic drug monitoring 20100601

Title: Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration.

Journal: British journal of clinical pharmacology 20100301

Title: Simultaneous liquid chromatographic analysis of ritonavir, quinine and 3-hydroxyquinine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090201

Title: A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4.

Journal: Epilepsia 20070301

Title: Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.

Journal: European journal of clinical pharmacology 20070201

Title: Pharmacokinetics of quinine and its metabolites in pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria.

Journal: Journal of clinical pharmacy and therapeutics 20070201

Title: Quinine distribution in pregnant mice with Plasmodium berghei malaria.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060701

Title: The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide.

Journal: British journal of clinical pharmacology 20060101

Title: Ketoconazole increases plasma concentrations of antimalarial mefloquine in healthy human volunteers.

Journal: Journal of clinical pharmacy and therapeutics 20050601

Title: Confirmation of the structure of (3S)-3-hydroxyquinine: synthesis and X-ray crystal structure of its 9-aceto analogue.

Journal: Journal of natural products 20050601

Title: Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide.

Journal: European journal of clinical pharmacology 20040401

Title: High-performance liquid chromatographic method for the determination of quinine and 3-hydroxyquinine in blood samples dried on filter paper.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030925

Title: Metabolism and elimination of quinine in healthy volunteers.

Journal: European journal of clinical pharmacology 20030901

Title: Identification of epitopes on cytochrome P450 3A4/5 recognized by monoclonal antibodies.

Journal: Archives of biochemistry and biophysics 20030615

Title: Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.

Journal: European journal of clinical pharmacology 20030501

Title: Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201

Title: Quinine pharmacokinetics in chronic haemodialysis patients.

Journal: British journal of clinical pharmacology 20021201

Title: Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

Journal: British journal of clinical pharmacology 20021201

Title: Characterization of quinidine 3-hydroxylation as a probe for the CYP 3A enzyme using a novel capillary electrophoresis technique.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020901

Title: Effects of cigarette smoking on quinine pharmacokinetics in malaria.

Journal: European journal of clinical pharmacology 20020801

Title: Determination of (3S)-3-hydroxy quinidine for metabolism screening experiments using direct injection capillary electrophoresis and laser-induced fluorescence detection.

Journal: Biomedical chromatography : BMC 20020201

Title: Simultaneous determination of quinine and four metabolites in plasma and urine by high-performance liquid chromatography.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010415

Title: Evidence supporting 3(S)-3-hydroxyquinidine-associated cardiotoxicity.

Journal: Therapeutic drug monitoring 19850101

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