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Home Pyridines 446859-33-2
446859-33-2,MFCD09037561
Catalog No.:AA00DEDG

446859-33-2 | 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DEDG
Chemical Name:
2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE
CAS Number:
446859-33-2
Molecular Formula:
C17H13N5
Molecular Weight:
287.3186
MDL Number:
MFCD09037561
SMILES:
Cc1cccc(n1)c1n[nH]cc1c1ccc2c(n1)cccn2
Properties
Properties
 
BP:
501.911 °C at 760 mmHg  
Form:
Solid  
MP:
189 - 192°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
376  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.2  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Nephronectin expression is regulated by SMAD signaling in osteoblast-like MC3T3-E1 cells.

Journal: Biochemical and biophysical research communications 20120824

Title: A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Journal: Cell stem cell 20091106

Title: Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors.

Journal: Journal of medicinal chemistry 20040826

Title: Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506.

Title: Ichida JK, et al. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 6;5(5):491-503.

Title: Shi CJ, Lian JJ, Zhang BW, et al. TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice [published online ahead of print, 2022 Jul 6 Acta Pharmacol Sin. 2022;10.1038/s41401-022-00932-4.

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SDS
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Tags:446859-33-2 Molecular Formula|446859-33-2 MDL|446859-33-2 SMILES|446859-33-2 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE