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53772-83-1,MFCD00867744
Catalog No.:AA00DF4T

53772-83-1 | Zuclopenthixol

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10mg
98%
in stock  
$79.00   $55.00
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100mg
≥98%
in stock  
$89.00   $62.00
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250mg
≥98%
in stock  
$203.00   $142.00
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500mg
≥98%
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$386.00   $270.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DF4T
Chemical Name:
Zuclopenthixol
CAS Number:
53772-83-1
Molecular Formula:
C22H25ClN2OS
Molecular Weight:
400.9647
MDL Number:
MFCD00867744
SMILES:
OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(Cl)cc2
Properties
Computed Properties
 
Complexity:
509  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
4.3  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Paradoxical severe agitation induced by add-on high-doses quetiapine in schizo-affective disorder.

Journal: Psychiatry research 20140515

Title: Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate.

Journal: European archives of psychiatry and clinical neuroscience 20140301

Title: Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of analytical toxicology 20120901

Title: Network-assisted investigation of antipsychotic drugs and their targets.

Journal: Chemistry & biodiversity 20120501

Title: Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses.

Journal: The Cochrane database of systematic reviews 20120101

Title: RE: PBS delisting.

Journal: The Australian and New Zealand journal of psychiatry 20111201

Title: A 41 year old man with an itchy rash.

Journal: BMJ (Clinical research ed.) 20111117

Title: Effects of zuclopenthixol on aggressive disruptive behavior in adults with mental retardation--a 2-year follow-up on a withdrawal study.

Journal: Pharmacopsychiatry 20111101

Title: The pharmacoepidemiology of antipsychotics for adults with schizophrenia in Canada, 2005 to 2009.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20111001

Title: Zuclopenthixol acetate treatment in children with bipolar disorder and severe aggression.

Journal: Journal of clinical psychopharmacology 20110601

Title: PBS delisting.

Journal: The Australian and New Zealand journal of psychiatry 20110601

Title: Neuroleptic malignant syndrome in adolescents: four probable cases in the Western Cape.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20110525

Title: Stereotyped paroxysmal psychiatric symptoms during oculogyric crisis or 'cognitive dystonia': a case report.

Journal: Current drug safety 20110201

Title: An unusual presentation of cortical venous thrombosis and its association with typical antipsychotics.

Journal: BMJ case reports 20110101

Title: How to dose a psychotropic drug: beyond therapeutic drug monitoring to genotyping the patient.

Journal: Acta psychiatrica Scandinavica 20101201

Title: Characterisation of zuclopenthixol metabolism by in vitro and therapeutic drug monitoring studies.

Journal: Acta psychiatrica Scandinavica 20101201

Title: Prescription persistence and safety of antipsychotic medication: a national registry-based 3-year follow-up.

Journal: European journal of clinical pharmacology 20100901

Title: Severe laryngeal dystonia in a patient receiving zuclopenthixol 'Acuphase' and fluoxetine.

Journal: Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists 20100401

Title: Antipsychotic side-effect - potential risk of patients rejecting their treatments.

Journal: Psychiatria Danubina 20100301

Title: An unusual case of neuroleptic malignant syndrome.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20100101

Title: Metabolic syndrome with different antipsychotics: a multicentre cross-sectional study.

Journal: Psychopharmacology bulletin 20100101

Title: Remission of schizophrenia psychosis and strong reduction of obsessive-compulsive disorder after adding clozapine to aripiprazole.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20091113

Title: Zuclopenthixol dihydrochloride for schizophrenia.

Journal: Schizophrenia bulletin 20090901

Title: [Mental handicap].

Journal: Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie 20090701

Title: Stability of medication in early psychosis: a comparison between second-generation and low-dose first-generation antipsychotics.

Journal: Early intervention in psychiatry 20090201

Title: Zuclopenthixol-induced neuroleptic malignant syndrome presenting as fever of unknown origin, hyperglycaemia and acute myocardial infarction in a 60-year-old man.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

Title: Intramuscular olanzapine versus short-acting typical intramuscular antipsychotics: comparison of real-life effectiveness in the treatment of agitation.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

Title: Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

Title: A double-blind placebo-controlled discontinuation study of zuclopenthixol for the treatment of aggressive disruptive behaviours in adults with mental retardation - secondary parameter analyses.

Journal: Pharmacopsychiatry 20081101

Title: The potential role of zuclopenthixol acetate in the management of refractory hyperactive delirium at the end of life.

Journal: Journal of pain and symptom management 20080401

Title: Antipsychotic polypharmacy in the emergency treatment of highly aggressive schizophrenic prisoners - a retrospective study.

Journal: International journal of prisoner health 20080101

Title: Associations between venous thromboembolism and antipsychotics. A study of the WHO database of adverse drug reactions.

Journal: Drug safety 20080101

Title: Long-acting neuroleptics used in wildlife management do not impair thermoregulation or physical activity in goats (Capra hircus).

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070601

Title: Zuclopenthixol in adults with intellectual disabilities and aggressive behaviours: discontinuation study.

Journal: The British journal of psychiatry : the journal of mental science 20070501

Title: Basal ganglia volumes in drug-naive first-episode schizophrenia patients before and after short-term treatment with either a typical or an atypical antipsychotic drug.

Journal: Psychiatry research 20070415

Title: Refractory schizophrenia treated with clozapine combined with zuclopenthixol.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070413

Title: Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl.

Journal: Clinical toxicology (Philadelphia, Pa.) 20070101

Title: Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine.

Journal: The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20070101

Title: Quetiapine-induced leucopenia and thrombocytopenia.

Journal: Psychosomatics 20070101

Title: Manic episode precipitated by withdrawal of hormone replacement therapy in severe hypothyroidism.

Journal: Journal of psychiatric practice 20061101

Title: Differential early onset of therapeutic response with risperidone vs conventional antipsychotics in patients with chronic schizophrenia.

Journal: International clinical psychopharmacology 20060901

Title: Long-acting injectable risperidone compared with zuclopenthixol in the treatment of schizophrenia with substance abuse comorbidity.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20060701

Title: [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].

Journal: No to shinkei = Brain and nerve 20060601

Title: The rational use of medications in acute psychotic presentations -- the case for less is more.

Journal: Journal of psychiatry & neuroscience : JPN 20060501

Title: Randomised clinical trial comparing oral versus depot formulations of zuclopenthixol in patients with schizophrenia and previous violence.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20060101

Title: Antipsychotic medication and length of stay at a psychiatric maximum-security unit in Norway (1987-2000).

Journal: Nordic journal of psychiatry 20060101

Title: Recurrent heat-related illnesses during antipsychotic treatment.

Journal: The Annals of pharmacotherapy 20051101

Title: Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects.

Journal: International clinical psychopharmacology 20051101

Title: Zuclopenthixol dihydrochloride for schizophrenia.

Journal: The Cochrane database of systematic reviews 20051019

Title: Long term results of unilateral posteroventral pallidotomy for antipsychotic drug induced tardive dyskinesia.

Journal: Journal of neurology, neurosurgery, and psychiatry 20050701

Title: Oral risperidone with lorazepam versus oral zuclopenthixol with lorazepam in the treatment of acute psychosis in emergency psychiatry: a prospective, comparative, open-label study.

Journal: Journal of psychopharmacology (Oxford, England) 20050101

Title: Left-sided chest pain as an unusual presentation of extrapyramidal symptoms.

Journal: General hospital psychiatry 20050101

Title: The impact of neuroleptic medication on seizure threshold and duration in electroconvulsive therapy.

Journal: Ideggyogyaszati szemle 20041120

Title: Chronic antidopaminergic medication might affect amygdala structure in patients with schizophrenia.

Journal: Pharmacopsychiatry 20040901

Title: Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats.

Journal: Human & experimental toxicology 20040801

Title: Long-acting injectable risperidone: safety and efficacy in stable patients switched from conventional depot antipsychotics.

Journal: International clinical psychopharmacology 20040701

Title: Effects of low-dose risperidone and low-dose zuclopenthixol on cognitive functions in first-episode drug-naive schizophrenic patients.

Journal: CNS spectrums 20040501

Title: Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses.

Journal: The Cochrane database of systematic reviews 20040101

Title: Facialis palsy attributable to depot antipsychotic therapy.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20031101

Title: Neuroleptic malignant syndrome: a case that may shed new light into the etiology and treatment.

Journal: The Australian and New Zealand journal of psychiatry 20030801

Title: Liquid chromatographic analysis of the cis(Z)- and trans(E)-isomers of clopenthixol in human plasma using a novel solid phase extraction procedure.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030725

Title: Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms.

Journal: Pharmacology, biochemistry, and behavior 20030701

Title: Local-global processing in early-onset schizophrenia: evidence for an impairment in shifting the spatial scale of attention.

Journal: Brain and cognition 20030201

Title: Zuclopenthixol-acetate treatment in catatonic patients: the implication of iron metabolism.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20030201

Title: [Psychotropic drugs used in a psychiatric hospital (pharmaco-epidemiologic aspects)].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: Comparative study of the effectiveness of zuclopenthixol acetate and haloperidol in acutely disturbed psychotic patients.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20021201

Title: Effects of antipsychotics on prepulse inhibition of the startle response in drug-naïve schizophrenic patients.

Journal: Biological psychiatry 20021101

Title: Treatment of acute mania with topiramate in hospitalized patients.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20021001

Title: Classical and atypical neuroleptics, and bone mineral density, in patients with schizophrenia.

Journal: The International journal of neuroscience 20020701

Title: Priapism associated with zuclopenthixol.

Journal: The Annals of pharmacotherapy 20020601

Title: Rapid tranquillisation: time for a reappraisal of options for parenteral therapy.

Journal: The British journal of psychiatry : the journal of mental science 20020601

Title: Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype.

Journal: Psychopharmacology 20020601

Title: Use of azaperone and zuclopenthixol acetate to facilitate translocation of white-tailed deer (Odocoileus virginianus).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020601

Title: [Clopixol: new possibilities in therapy of mental disorders (a review of clinical studies)].

Journal: Voenno-meditsinskii zhurnal 20020301

Title: Separation of cis- and trans-isomers of thioxanthene and dibenz[b,e]oxepin derivatives on calixarene- and resorcinarene-bonded high-performance liquid chromatography stationary phases.

Journal: Journal of chromatography. A 20020301

Title: HPLC-ESI-MS/MS determination of zuclopenthixol in a fatal intoxication during psychiatric therapy.

Journal: Forensic science international 20011201

Title: [Chronic colonic pseudo-obstruction secondary to neuroleptics].

Journal: Gastroenterologia y hepatologia 20011201

Title: Comparison of analgesic techniques for antler removal in wapiti.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20011201

Title: Flow-injection chemiluminometric determination of some thioxanthene derivatives in pharmaceutical formulations and biological fluids using the [Ru(dipy)3(2+)]-Ce(IV) system.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20011101

Title: Neuroleptic malignant syndrome during zuclopenthixol therapy in X-linked cerebral adrenoleukodystrophy.

Journal: Journal of inherited metabolic disease 20011001

Title: Evaluation of long-term sedation in cheetah (Acinonyx jubatus) with perphenazine enanthate and zuclopenthixol acetate.

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010901

Title: Dimensionality, responsiveness and standardization of the Bech-Rafaelsen Mania Scale in the ultra-short therapy with antipsychotics in patients with severe manic episodes.

Journal: Acta psychiatrica Scandinavica 20010701

Title: Antipsychotic-induced extrapyramidal syndromes. Risperidone compared with low- and high-potency conventional antipsychotic drugs.

Journal: European journal of clinical pharmacology 20010701

Title: Clozapine and weight gain.

Journal: The American journal of psychiatry 20010501

Title: Therapeutic drug monitoring of haloperidol, perphenazine, and zuclopenthixol in serum by a fully automated sequential solid phase extraction followed by high-performance liquid chromatography.

Journal: Therapeutic drug monitoring 20010401

Title: Treating acquired haemophilia: an ethical conundrum.

Journal: Age and ageing 20010101

Title: Concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol in a lethal case involving zuclopenthixol, diazepam, and cyamemazine.

Journal: Journal of analytical toxicology 20010101

Title: Zuclopenthixol treatment of behavioral disturbances in mentally retarded children and adolescents: an open-label study.

Journal: Journal of child and adolescent psychopharmacology 20010101

Title: Zuclopenthixol acetate in the treatment of acute schizophrenia and similar serious mental illnesses.

Journal: The Cochrane database of systematic reviews 20010101

Title: Effects of butaclamol, clopenthixol, mepromazine and cannabinol stereoisomers on apoptosis induction.

Journal: Anticancer research 20010101

Title: Psychosis and pregnancy: five cases of severely ill women.

Journal: Nordic journal of psychiatry 20010101

Title: Effect of some psychotropic drugs and a barbiturate on mycoplasmas.

Journal: International journal of antimicrobial agents 20000401

Title: Central D2 receptor occupancy and effects of zuclopenthixol acetate in humans.

Journal: International clinical psychopharmacology 19951101

Title: [acute dystonias in combined abuse of cocaine and neuroleptics].

Journal: Nederlands tijdschrift voor geneeskunde 19941126

Title: [Drug-induced asterixis].

Journal: Deutsche medizinische Wochenschrift (1946) 19940422

Title: Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 19911201

Title: Reversible lithium neurotoxicity at normal serum level may refer to intracranial pathology.

Journal: Journal of neurology, neurosurgery, and psychiatry 19890501

Title: Zuclopenthixol and haloperidol/levomepromazine in the treatment of elderly patients with symptoms of aggressiveness and agitation: a double-blind, multi-centre study.

Journal: Pharmatherapeutica 19890101

Title: Zuclopenthixol and perphenazine in patients with acute psychotic states. A double-blind multicentre study.

Journal: Pharmacopsychiatry 19870701

Title: Prolonged oculogyric crisis on addition of nifedipine to neuroleptic medication regime.

Journal: The British journal of psychiatry : the journal of mental science 19870101

Title: The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria.

Journal: Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology 19861201

Title: Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions.

Journal: European journal of pharmacology 19840713

Title: [The extrapyramidal symptoms in the combination of lithium long-term lithium therapy with nortriptyline. A case report on the formation of a pathogenesis hypothesis].

Journal: Der Nervenarzt 19760101

Title: The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy.

Journal: The Psychiatric quarterly 19670101

Title: Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):11-5.

Title: Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23(9):439-45.

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Tags:53772-83-1 Molecular Formula|53772-83-1 MDL|53772-83-1 SMILES|53772-83-1 Zuclopenthixol