65189-71-1,MFCD00076710
Catalog No.:AA00E9L7

65189-71-1 | KEMPTIDE

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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00E9L7
Chemical Name:
KEMPTIDE
CAS Number:
65189-71-1
Molecular Formula:
C24H46N10O6
Molecular Weight:
570.6854
MDL Number:
MFCD00076710
SMILES:
OCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CCC(C)C)CCCN=C(N)N)CCCN=C(N)N)C)C=O
Properties
Properties
 
Form:
Solid  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
1320  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
54  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
13  
Isotope Atom Count:
0  
Rotatable Bond Count:
26  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-5.7  

Literature

Title: A gene-delivery system specific for hepatoma cells and an intracellular kinase signal based on human liver-specific bionanocapsules and signal-responsive artificial polymer.

Journal: International journal of pharmaceutics 20100830

Title: Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons.

Journal: Neuroscience 20100811

Title: Global consequences of activation loop phosphorylation on protein kinase A.

Journal: The Journal of biological chemistry 20100205

Title: Leishmania major: effect of protein kinase A and phosphodiesterase activity on infectivity and proliferation of promastigotes.

Journal: Experimental parasitology 20090901

Title: Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling.

Journal: Bioorganic & medicinal chemistry 20090901

Title: Tandem mass spectrometry investigation of ADP-ribosylated kemptide.

Journal: Journal of the American Society for Mass Spectrometry 20090301

Title: Simple device for multiplexed electrophoretic separations using gradient elution moving boundary electrophoresis with channel current detection.

Journal: Analytical chemistry 20081215

Title: A real-time bioluminescent HTS method for measuring protein kinase activity influenced neither by ATP concentration nor by luciferase inhibition.

Journal: Assay and drug development technologies 20080801

Title: A microPLC-based approach for determining kinase-substrate specificity.

Journal: Assay and drug development technologies 20070801

Title: Microarray-based kinase inhibition assay by gold nanoparticle probes.

Journal: Analytical chemistry 20070115

Title: Glucose-dependent activation of protein kinase A activity in Saccharomyces cerevisiae and phosphorylation of its TPK1 catalytic subunit.

Journal: Cellular signalling 20060701

Title: Inhibition of cyclic AMP dependent protein kinase by vanadyl sulfate.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20060401

Title: Fluorometric TLC assay for evaluation of protein kinase inhibitors.

Journal: Analytical biochemistry 20050501

Title: Substrate enhances the sensitivity of type I protein kinase a to cAMP.

Journal: The Journal of biological chemistry 20050408

Title: Signal transduction abnormalities in melancholic depression.

Journal: The international journal of neuropsychopharmacology 20050301

Title: Regulation of serum response factor-dependent gene expression by proteasome inhibitors.

Journal: Molecular pharmacology 20050301

Title: Kinetic analysis of inhibition of cAMP-dependent protein kinase catalytic subunit by the peptide-nucleoside conjugate AdcAhxArg6.

Journal: Bioorganic chemistry 20041201

Title: Preparing protein microarrays by soft-landing of mass-selected ions.

Journal: Science (New York, N.Y.) 20030905

Title: Quantitative analysis of protein phosphorylation status and protein kinase activity on microarrays using a novel fluorescent phosphorylation sensor dye.

Journal: Proteomics 20030701

Title: Activation of protein kinase A induces neuronal differentiation of HiB5 hippocampal progenitor cells.

Journal: Brain research. Molecular brain research 20021230

Title: In vivo and in vitro phosphorylation of two isoforms of yeast pyruvate kinase by protein kinase A.

Journal: The Journal of biological chemistry 20020823

Title: Molecular characterization of a coccidian parasite cGMP dependent protein kinase.

Journal: Molecular and biochemical parasitology 20020409

Title: Signal transduction in Entamoeba histolytica induced by interaction with fibronectin: presence and activation of phosphokinase A and its possible relation to invasiveness.

Journal: Archives of medical research 20020101

Title: Evaluation of in vivo activation of protein kinase A under non-dissociable conditions through the overexpression of wild-type and mutant regulatory subunits in Saccharomyces cerevisiae.

Journal: Microbiology (Reading, England) 20010501

Title: Possible roles of protein kinase A in cell motility and excystation of the early diverging eukaryote Giardia lamblia.

Journal: The Journal of biological chemistry 20010330

Title: Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin.

Journal: The Journal of biological chemistry 20000512

Title: Ethanol-induced translocation of cAMP-dependent protein kinase to the nucleus. Mechanism and functional consequences.

Journal: The Journal of biological chemistry 19990917

Title: Divergent functional roles for p90rsk kinase domains.

Journal: The Journal of biological chemistry 19950811

Title: (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor.

Journal: European journal of pharmacology 19941014

Title: Use of synthetic peptide libraries and phosphopeptide-selective mass spectrometry to probe protein kinase substrate specificity.

Journal: The Journal of biological chemistry 19940311

Title: Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor.

Journal: The Journal of biological chemistry 19940121

Title: The C gamma subunit is a unique isozyme of the cAMP-dependent protein kinase.

Journal: The Journal of biological chemistry 19921215

Title: Purification and characterization of a cytosolic insulin-stimulated serine kinase from rat liver.

Journal: The Journal of biological chemistry 19920515

Title: Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit.

Journal: The Journal of biological chemistry 19920305

Title: Acidic pentapeptide phosphorylated in vitro by calf thymus protein kinase NII binds to DNA in the presence of Mg2+ cations.

Journal: FEBS letters 19911007

Title: Subunit interactions control protein phosphatase 2A. Effects of limited proteolysis, N-ethylmaleimide, and heparin on the interaction of the B subunit.

Journal: The Journal of biological chemistry 19910715

Title: Principal neurofilament-associated protein kinase in squid axoplasm is related to casein kinase I.

Journal: The Journal of biological chemistry 19910315

Title: Multiple arginine residues contribute to the increased efficacy of peptide substrates for the cAMP-dependent protein kinase.

Journal: Biochemical and biophysical research communications 19891130

Title: Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode.

Journal: The Journal of biological chemistry 19890825

Title: Substrate phosphorylation can inhibit proteolysis by trypsin-like enzymes.

Journal: Archives of biochemistry and biophysics 19890801

Title: Probing the peptide binding site of the cAMP-dependent protein kinase by using a peptide-based photoaffinity label.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19880801

Title: Purification and characterization of C1, the catalytic subunit of Saccharomyces cerevisiae cAMP-dependent protein kinase encoded by TPK1.

Journal: The Journal of biological chemistry 19880705

Title: Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.

Journal: The Journal of biological chemistry 19880205

Title: Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-inhibited protein kinase in brain.

Journal: The Journal of biological chemistry 19880105

Title: Role of enzyme-peptide substrate backbone hydrogen bonding in determining protein kinase substrate specificities.

Journal: Biochemistry 19870714

Title: Conformation of Leu-Arg-Arg-Ala-Ser-Leu-Gly bound in the active site of adenosine cyclic 3',5'-phosphate dependent protein kinase.

Journal: Biochemistry 19870714

Title: Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies.

Journal: Biochemistry 19870630

Title: The use of N-methylated peptides and depsipeptides to probe the binding of heptapeptide substrates to cAMP-dependent protein kinase.

Journal: The Journal of biological chemistry 19851215

Title: Drosophila cAMP-dependent protein kinase.

Journal: The Journal of biological chemistry 19841110

Title: NMR studies of the mechanism of cyclic AMP-dependent protein kinase.

Journal: Federation proceedings 19840801

Title: Protein phosphorylation of plasma membranes from bovine epididymal spermatozoa.

Journal: Biology of reproduction 19840801

Title: Mechanistic studies of cAMP-dependent protein kinase action.

Journal: CRC critical reviews in biochemistry 19840101

Title: Adenosine cyclic 3',5'-monophosphate dependent protein kinase: interaction of the catalytic subunit and holoenzyme with lin-benzoadenine nucleotides.

Journal: Biochemistry 19830510

Title: Standardization of the assay for the catalytic subunit of cyclic AMP-dependent protein kinase using a synthetic peptide substrate.

Journal: Analytical biochemistry 19830101

Title: Magnetic resonance measurements of intersubstrate distances at the active site of protein kinase using substitution-inert cobalt(III) and chromium(III) complexes of adenosine 5'-(beta, gamma-methylenetriphosphate).

Journal: Biochemistry 19800722

Title: Phosphorylation of acyl and dansyl derivatives of the peptide Leu-Arg-Arg-Ala-Ser-Leu-Gly by the cAMP-dependent protein kinase.

Journal: The Journal of biological chemistry 19800410

Title: Regulatory subunit of the type I cAMP-dependent protein kinase as an inhibitor and substrate of the cGMP-dependent protein kinase.

Journal: The Journal of biological chemistry 19800210

Title: Phosphorylation of synthetic peptide analogs of rabbit cardiac troponin inhibitory subunit by the cyclic AMP-dependent protein kinase.

Journal: The Journal of biological chemistry 19790425

Title: Inhibition of cyclic AMP-dependent protein kinase by analogues of a synthetic peptide substrate.

Journal: The Journal of biological chemistry 19781225

Title: In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19780101

Title: Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19771001

Title: Endogenous protein kinase inhibitors. Purification, characterization, and distribution in different tissues.

Journal: The Journal of biological chemistry 19770610

Title: Kübler D, et al. Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode. J Biol Chem. 1989 Aug 25;264(24):14549-55.

Title: Duncan FE, et al. Transducin-like enhancer of split-6 (TLE6) is a substrate of protein kinase A activity during mouse oocyte maturation. Biol Reprod. 2014 Mar 20;90(3):63.

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SDS
Tags:65189-71-1 Molecular Formula|65189-71-1 MDL|65189-71-1 SMILES|65189-71-1 KEMPTIDE
Catalog No.: AA00E9L7
65189-71-1,MFCD00076710
65189-71-1 | KEMPTIDE
Pack Size: 1mg
Purity: ≥95%
in stock
$63.00 $44.00
Pack Size: 5mg
Purity: ≥95%
in stock
$200.00 $140.00
Pack Size: 10mg
Purity: ≥95%
in stock
$368.00 $257.00
Pack Size: 25mg
Purity: ≥95%
in stock
$838.00 $586.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00E9L7
Chemical Name: KEMPTIDE
CAS Number: 65189-71-1
Molecular Formula: C24H46N10O6
Molecular Weight: 570.6854
MDL Number: MFCD00076710
SMILES: OCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CCC(C)C)CCCN=C(N)N)CCCN=C(N)N)C)C=O
Properties
Form: Solid  
Storage: 2-8℃;  
Complexity: 1320  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 6  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 54  
Hydrogen Bond Acceptor Count: 12  
Hydrogen Bond Donor Count: 13  
Isotope Atom Count: 0  
Rotatable Bond Count: 26  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -5.7  
Literature fold

Title: A gene-delivery system specific for hepatoma cells and an intracellular kinase signal based on human liver-specific bionanocapsules and signal-responsive artificial polymer.

Journal: International journal of pharmaceutics20100830

Title: Acute Ca(2+)-dependent desensitization of 5-HT(1A) receptors is mediated by activation of protein kinase A (PKA) in rat serotonergic neurons.

Journal: Neuroscience20100811

Title: Global consequences of activation loop phosphorylation on protein kinase A.

Journal: The Journal of biological chemistry20100205

Title: Leishmania major: effect of protein kinase A and phosphodiesterase activity on infectivity and proliferation of promastigotes.

Journal: Experimental parasitology20090901

Title: Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling.

Journal: Bioorganic & medicinal chemistry20090901

Title: Tandem mass spectrometry investigation of ADP-ribosylated kemptide.

Journal: Journal of the American Society for Mass Spectrometry20090301

Title: Simple device for multiplexed electrophoretic separations using gradient elution moving boundary electrophoresis with channel current detection.

Journal: Analytical chemistry20081215

Title: A real-time bioluminescent HTS method for measuring protein kinase activity influenced neither by ATP concentration nor by luciferase inhibition.

Journal: Assay and drug development technologies20080801

Title: A microPLC-based approach for determining kinase-substrate specificity.

Journal: Assay and drug development technologies20070801

Title: Microarray-based kinase inhibition assay by gold nanoparticle probes.

Journal: Analytical chemistry20070115

Title: Glucose-dependent activation of protein kinase A activity in Saccharomyces cerevisiae and phosphorylation of its TPK1 catalytic subunit.

Journal: Cellular signalling20060701

Title: Inhibition of cyclic AMP dependent protein kinase by vanadyl sulfate.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry20060401

Title: Fluorometric TLC assay for evaluation of protein kinase inhibitors.

Journal: Analytical biochemistry20050501

Title: Substrate enhances the sensitivity of type I protein kinase a to cAMP.

Journal: The Journal of biological chemistry20050408

Title: Signal transduction abnormalities in melancholic depression.

Journal: The international journal of neuropsychopharmacology20050301

Title: Regulation of serum response factor-dependent gene expression by proteasome inhibitors.

Journal: Molecular pharmacology20050301

Title: Kinetic analysis of inhibition of cAMP-dependent protein kinase catalytic subunit by the peptide-nucleoside conjugate AdcAhxArg6.

Journal: Bioorganic chemistry20041201

Title: Preparing protein microarrays by soft-landing of mass-selected ions.

Journal: Science (New York, N.Y.)20030905

Title: Quantitative analysis of protein phosphorylation status and protein kinase activity on microarrays using a novel fluorescent phosphorylation sensor dye.

Journal: Proteomics20030701

Title: Activation of protein kinase A induces neuronal differentiation of HiB5 hippocampal progenitor cells.

Journal: Brain research. Molecular brain research20021230

Title: In vivo and in vitro phosphorylation of two isoforms of yeast pyruvate kinase by protein kinase A.

Journal: The Journal of biological chemistry20020823

Title: Molecular characterization of a coccidian parasite cGMP dependent protein kinase.

Journal: Molecular and biochemical parasitology20020409

Title: Signal transduction in Entamoeba histolytica induced by interaction with fibronectin: presence and activation of phosphokinase A and its possible relation to invasiveness.

Journal: Archives of medical research20020101

Title: Evaluation of in vivo activation of protein kinase A under non-dissociable conditions through the overexpression of wild-type and mutant regulatory subunits in Saccharomyces cerevisiae.

Journal: Microbiology (Reading, England)20010501

Title: Possible roles of protein kinase A in cell motility and excystation of the early diverging eukaryote Giardia lamblia.

Journal: The Journal of biological chemistry20010330

Title: Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin.

Journal: The Journal of biological chemistry20000512

Title: Ethanol-induced translocation of cAMP-dependent protein kinase to the nucleus. Mechanism and functional consequences.

Journal: The Journal of biological chemistry19990917

Title: Divergent functional roles for p90rsk kinase domains.

Journal: The Journal of biological chemistry19950811

Title: (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor.

Journal: European journal of pharmacology19941014

Title: Use of synthetic peptide libraries and phosphopeptide-selective mass spectrometry to probe protein kinase substrate specificity.

Journal: The Journal of biological chemistry19940311

Title: Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor.

Journal: The Journal of biological chemistry19940121

Title: The C gamma subunit is a unique isozyme of the cAMP-dependent protein kinase.

Journal: The Journal of biological chemistry19921215

Title: Purification and characterization of a cytosolic insulin-stimulated serine kinase from rat liver.

Journal: The Journal of biological chemistry19920515

Title: Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit.

Journal: The Journal of biological chemistry19920305

Title: Acidic pentapeptide phosphorylated in vitro by calf thymus protein kinase NII binds to DNA in the presence of Mg2+ cations.

Journal: FEBS letters19911007

Title: Subunit interactions control protein phosphatase 2A. Effects of limited proteolysis, N-ethylmaleimide, and heparin on the interaction of the B subunit.

Journal: The Journal of biological chemistry19910715

Title: Principal neurofilament-associated protein kinase in squid axoplasm is related to casein kinase I.

Journal: The Journal of biological chemistry19910315

Title: Multiple arginine residues contribute to the increased efficacy of peptide substrates for the cAMP-dependent protein kinase.

Journal: Biochemical and biophysical research communications19891130

Title: Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode.

Journal: The Journal of biological chemistry19890825

Title: Substrate phosphorylation can inhibit proteolysis by trypsin-like enzymes.

Journal: Archives of biochemistry and biophysics19890801

Title: Probing the peptide binding site of the cAMP-dependent protein kinase by using a peptide-based photoaffinity label.

Journal: Proceedings of the National Academy of Sciences of the United States of America19880801

Title: Purification and characterization of C1, the catalytic subunit of Saccharomyces cerevisiae cAMP-dependent protein kinase encoded by TPK1.

Journal: The Journal of biological chemistry19880705

Title: Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.

Journal: The Journal of biological chemistry19880205

Title: Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-inhibited protein kinase in brain.

Journal: The Journal of biological chemistry19880105

Title: Role of enzyme-peptide substrate backbone hydrogen bonding in determining protein kinase substrate specificities.

Journal: Biochemistry19870714

Title: Conformation of Leu-Arg-Arg-Ala-Ser-Leu-Gly bound in the active site of adenosine cyclic 3',5'-phosphate dependent protein kinase.

Journal: Biochemistry19870714

Title: Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies.

Journal: Biochemistry19870630

Title: The use of N-methylated peptides and depsipeptides to probe the binding of heptapeptide substrates to cAMP-dependent protein kinase.

Journal: The Journal of biological chemistry19851215

Title: Drosophila cAMP-dependent protein kinase.

Journal: The Journal of biological chemistry19841110

Title: NMR studies of the mechanism of cyclic AMP-dependent protein kinase.

Journal: Federation proceedings19840801

Title: Protein phosphorylation of plasma membranes from bovine epididymal spermatozoa.

Journal: Biology of reproduction19840801

Title: Mechanistic studies of cAMP-dependent protein kinase action.

Journal: CRC critical reviews in biochemistry19840101

Title: Adenosine cyclic 3',5'-monophosphate dependent protein kinase: interaction of the catalytic subunit and holoenzyme with lin-benzoadenine nucleotides.

Journal: Biochemistry19830510

Title: Standardization of the assay for the catalytic subunit of cyclic AMP-dependent protein kinase using a synthetic peptide substrate.

Journal: Analytical biochemistry19830101

Title: Magnetic resonance measurements of intersubstrate distances at the active site of protein kinase using substitution-inert cobalt(III) and chromium(III) complexes of adenosine 5'-(beta, gamma-methylenetriphosphate).

Journal: Biochemistry19800722

Title: Phosphorylation of acyl and dansyl derivatives of the peptide Leu-Arg-Arg-Ala-Ser-Leu-Gly by the cAMP-dependent protein kinase.

Journal: The Journal of biological chemistry19800410

Title: Regulatory subunit of the type I cAMP-dependent protein kinase as an inhibitor and substrate of the cGMP-dependent protein kinase.

Journal: The Journal of biological chemistry19800210

Title: Phosphorylation of synthetic peptide analogs of rabbit cardiac troponin inhibitory subunit by the cyclic AMP-dependent protein kinase.

Journal: The Journal of biological chemistry19790425

Title: Inhibition of cyclic AMP-dependent protein kinase by analogues of a synthetic peptide substrate.

Journal: The Journal of biological chemistry19781225

Title: In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase.

Journal: Proceedings of the National Academy of Sciences of the United States of America19780101

Title: Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase.

Journal: Proceedings of the National Academy of Sciences of the United States of America19771001

Title: Endogenous protein kinase inhibitors. Purification, characterization, and distribution in different tissues.

Journal: The Journal of biological chemistry19770610

Title: Kübler D, et al. Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode. J Biol Chem. 1989 Aug 25;264(24):14549-55.

Title: Duncan FE, et al. Transducin-like enhancer of split-6 (TLE6) is a substrate of protein kinase A activity during mouse oocyte maturation. Biol Reprod. 2014 Mar 20;90(3):63.

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