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103476-89-7,MFCD00198027
Catalog No.:AA00ILGI

103476-89-7 | Leupeptin hemisulfate

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1mg
97%
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10mg
≥90%
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25mg
≥90%
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$162.00   $113.00
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50mg
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100mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ILGI
Chemical Name:
Leupeptin hemisulfate
CAS Number:
103476-89-7
Molecular Formula:
C20H38N6O4
Molecular Weight:
426.5535
MDL Number:
MFCD00198027
SMILES:
O=CC(NC(=O)C(NC(=O)C(NC(=O)C)CC(C)C)CC(C)C)CCCN=C(N)N
Properties
Computed Properties
 
Complexity:
683  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
65  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
12  
Rotatable Bond Count:
28  

Literature

Title: Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis.

Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20141201

Title: Human salivary cystatin SA exhibits antimicrobial effect against Aggregatibacter actinomycetemcomitans.

Journal: Journal of periodontal research 20121001

Title: Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120815

Title: Porphyromonas gingivalis promotes monocyte migration by activating MMP-9.

Journal: Journal of periodontal research 20120401

Title: Preliminary study on the effect of caspase-6 and calpain inhibitors on postmortem proteolysis of myofibrillar proteins in chicken breast muscle.

Journal: Meat science 20120301

Title: Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling.

Journal: European journal of cell biology 20120201

Title: Longistatin is an unconventional serine protease and induces protective immunity against tick infestation.

Journal: Molecular and biochemical parasitology 20120101

Title: Altered T-cell responses by the periodontal pathogen Porphyromonas gingivalis.

Journal: PloS one 20120101

Title: Peroxisome degradation in mammals.

Journal: IUBMB life 20111101

Title: Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.

Journal: Autophagy 20110901

Title: Intracochlear perfusion of leupeptin and z-VAD-FMK: influence of antiapoptotic agents on gunshot-induced hearing loss.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20110701

Title: Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation.

Journal: Journal of molecular and cellular cardiology 20110701

Title: Characterization of macroautophagic flux in vivo using a leupeptin-based assay.

Journal: Autophagy 20110601

Title: Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells.

Journal: Cell 20110527

Title: Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion.

Journal: Virology 20110510

Title: A cysteine proteinase in the penetration glands of the cercariae of Cotylurus cornutus (Trematoda, Strigeidae).

Journal: Parasitology research 20110301

Title: Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.

Journal: Oncogene 20110217

Title: Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell line.

Journal: Cytokine 20110201

Title: Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.

Journal: Biochemical and biophysical research communications 20110107

Title: Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia.

Journal: The Journal of surgical research 20101101

Title: Leupeptin-based inhibitors do not improve the mdx phenotype.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20101101

Title: Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.

Journal: The FEBS journal 20101101

Title: Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit.

Journal: Antioxidants & redox signaling 20101001

Title: Human B-type natriuretic peptide is not degraded by meprin A.

Journal: Biochemical pharmacology 20101001

Title: Collagenolytic activity in sonic extracts of Tannerella forsythia.

Journal: Archives of oral biology 20100801

Title: Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction.

Journal: Nature cell biology 20100301

Title: Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste.

Journal: Journal of the science of food and agriculture 20100201

Title: CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization.

Journal: The Journal of biological chemistry 20091204

Title: Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20091013

Title: HIV-1 integrase-hydrolyzing antibodies from sera of HIV-infected patients.

Journal: Biochimie 20090901

Title: 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells.

Journal: Toxicology 20090616

Title: G.B. Quan et al., Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides, Cryobiology 56 (1) (2008) 53-61.

Journal: Cryobiology 20090401

Title: The comparison of parathyroid hormone degradation effect by various protease inhibitors in blood specimen.

Journal: The Korean journal of laboratory medicine 20090401

Title: Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.

Journal: Journal of medicinal chemistry 20090212

Title: Calpain-1 is required for hydrogen peroxide-induced myotube atrophy.

Journal: American journal of physiology. Cell physiology 20090201

Title: Role of oxidative stress in ischemia-reperfusion-induced alterations in myofibrillar ATPase activities and gene expression in the heart.

Journal: Canadian journal of physiology and pharmacology 20090201

Title: The 2,2',4,4',5,5'-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090101

Title: Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment.

Journal: Experimental parasitology 20081201

Title: Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABA(B) receptors in cortical neurons.

Journal: Molecular and cellular neurosciences 20081201

Title: Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20081001

Title: Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease.

Journal: The American journal of pathology 20080901

Title: Calpain inhibition protects spinal motoneurons from the excitotoxic effects of AMPA in vivo.

Journal: Neurochemical research 20080801

Title: The periodontal pathogen Porphyromonas gingivalis sensitises human blood platelets to epinephrine.

Journal: Platelets 20080801

Title: TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.

Journal: Traffic (Copenhagen, Denmark) 20080701

Title: Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20080701

Title: Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.

Journal: Biochemical and biophysical research communications 20080530

Title: Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons.

Journal: Neuroscience 20080502

Title: Target peptide sequence within infectious human immunodeficiency virus type 1 does not ensure envelope-specific T-helper cell reactivation: influences of cysteine protease and gamma interferon-induced thiol reductase activities.

Journal: Clinical and vaccine immunology : CVI 20080401

Title: Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.

Journal: Biochemical and biophysical research communications 20080314

Title: Endosomal proteases influence the repertoire of MAGE-A3 epitopes recognized in vivo by CD4+ T cells.

Journal: Cancer research 20080301

Title: Inhibition of high glucose-induced erythrocyte phosphatidylserine exposure by leupeptin and disaccharides.

Journal: Cryobiology 20080201

Title: Cloning, site-directed mutagenesis and expression of cathepsin L-like cysteine protease from Uronema marinum (Ciliophora: Scuticociliatida).

Journal: Molecular and biochemical parasitology 20071201

Title: Structural basis of the zinc inhibition of human tissue kallikrein 5.

Journal: Journal of molecular biology 20071102

Title: Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.

Journal: Experimental parasitology 20071001

Title: A novel 51-kDa fragment of the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase formed in the stroma of chloroplasts in dark-induced senescing wheat leaves.

Journal: Physiologia plantarum 20070901

Title: Endothelial gap junctions are down-regulated by arsenic trioxide.

Journal: European journal of pharmacology 20070813

Title: Peptide degradation is a critical determinant for cell-penetrating peptide uptake.

Journal: Biochimica et biophysica acta 20070701

Title: Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.

Journal: Journal of neurochemistry 20070601

Title: Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070301

Title: Synchronization of cell death in a dinoflagellate population is mediated by an excreted thiol protease.

Journal: Environmental microbiology 20070201

Title: Isolation and characterization of a novel acid proteinase, tropiase, from Candida tropicalis IFO 0589.

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20070101

Title: Perturbed interactions of mutant proteolipid protein/DM20 with cholesterol and lipid rafts in oligodendroglia: implications for dysmyelination in spastic paraplegia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20061108

Title: Remodeling of connexin 43 in the diabetic rat heart.

Journal: Molecular and cellular biochemistry 20061001

Title: Release of iron from ferritin requires lysosomal activity.

Journal: American journal of physiology. Cell physiology 20060901

Title: Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase.

Journal: Bioscience, biotechnology, and biochemistry 20060901

Title: Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.

Journal: Journal of cell science 20060701

Title: Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity.

Journal: The Tohoku journal of experimental medicine 20060601

Title: Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease.

Journal: Chemistry & biology 20060601

Title: Calpain inhibitors delay injury-induced apoptosis in adult mouse spinal cord motor neurons.

Journal: Neuroreport 20060529

Title: X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-->beta-tryptase transition.

Journal: Journal of molecular biology 20060317

Title: Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060315

Title: Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060201

Title: Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice.

Journal: European journal of pharmacology 20060113

Title: Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion.

Journal: International journal for parasitology 20060101

Title: High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.

Journal: Analytical chemistry 20051215

Title: Plasmodium berghei: effect of protease inhibitors during gametogenesis and early zygote development.

Journal: Experimental parasitology 20051201

Title: Tryptase increases proliferative activity of human conjunctival fibroblasts through protease-activated receptor-2.

Journal: Investigative ophthalmology & visual science 20051201

Title: Enzymatic measurement of tryptase-like protease release from isolated perfused guinea pig heart during ischemia-reperfusion.

Journal: Biological & pharmaceutical bulletin 20051101

Title: Leupeptin-sensitive proteases involved in cell survival after X-ray irradiation in human RSa cells.

Journal: Cell biology international 20050801

Title: Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.

Journal: The Journal of biological chemistry 20050513

Title: B-domain deleted factor VIII is aggregated and degraded through proteasomal and lysosomal pathways.

Journal: Thrombosis and haemostasis 20050501

Title: Alpha-synuclein-positive structures induced in leupeptin-infused rats.

Journal: Brain research 20050408

Title: Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway.

Journal: Biochemical and biophysical research communications 20050401

Title: Schistosoma mansoni: functional proteasomes are required for development in the vertebrate host.

Journal: Experimental parasitology 20050401

Title: The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease.

Journal: Biochemistry 20050308

Title: Induction of cell death in rat small intestine by ischemia reperfusion: differential roles of Fas/Fas ligand and Bcl-2/Bax systems depending upon cell types.

Journal: Histochemistry and cell biology 20050301

Title: Transient expression of polymeric immunoglobulin receptor in human adenocarcinoma cell line HT-29.

Journal: Journal of oral science 20050301

Title: Testing the 'garbage' accumulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy.

Journal: Biogerontology 20050101

Title: Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site.

Journal: Journal of molecular biology 20041105

Title: [Effect of tryptase inhibitors on histamine release from human colon mast cells].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20041101

Title: Transferrin-oligomers as potential carriers in anticancer drug delivery.

Journal: Pharmaceutical research 20041101

Title: Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis.

Journal: The Journal of veterinary medical science 20041001

Title: Substrate-dependent modulation of the mechanism of factor XIa inhibition.

Journal: Biochemistry 20040921

Title: Myosin Va is proteolysed in rat cerebellar granule neurons after excitotoxic injury.

Journal: Neuroscience letters 20040909

Title: The function of a trypsin-like enzyme in the saliva of Euplectrus separatae larvae.

Journal: Journal of insect physiology 20040901

Title: Multiple cleavage sites for polymeric immunoglobulin receptor.

Journal: Immunology 20040801

Title: The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart.

Journal: Journal of molecular and cellular cardiology 20040701

Title: Loss of lipopolysaccharide receptor CD14 from the surface of human macrophage-like cells mediated by Porphyromonas gingivalis outer membrane vesicles.

Journal: Microbial pathogenesis 20040601

Title: Regulation of muscle Cav1.1 channels by long-term depolarization involves proteolysis of the alpha1s subunit.

Journal: The Journal of membrane biology 20040601

Title: A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin.

Journal: The Biochemical journal 20040501

Title: Partial and delayed release of troponin-I compared with the release of lactate dehydrogenase from necrotic cardiomyocytes.

Journal: Pflugers Archiv : European journal of physiology 20040501

Title: Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20040401

Title: Calpain inhibitors improve myocardial dysfunction and inflammation induced by endotoxin in rats.

Journal: Shock (Augusta, Ga.) 20040401

Title: Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria.

Journal: Biochemistry 20040217

Title: Interaction of Porphyromonas gingivalis with low-density lipoproteins: implications for a role for periodontitis in atherosclerosis.

Journal: Journal of periodontal research 20040201

Title: The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma.

Journal: Clinica chimica acta; international journal of clinical chemistry 20040201

Title: [Effects of protease inhibitors on intestinal absorption of insulin].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040201

Title: Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.

Journal: The Journal of biological chemistry 20040130

Title: Protease inhibitor leupeptin attenuates myocardial stunning in rat heart.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20040101

Title: Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization.

Journal: Experimental cell research 20040101

Title: Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration.

Journal: Neuroscience 20040101

Title: Monocytes stimulated with group B streptococci or interferons release tumour necrosis factor-related apoptosis-inducing ligand.

Journal: Scandinavian journal of immunology 20040101

Title: Entamoeba histolytica: correlation of assessment methods to measure erythrocyte digestion, and effect of cysteine proteinases inhibitors in HM-1:IMSS and HK-9:NIH strains.

Journal: Experimental parasitology 20040101

Title: A cysteine-activated protease isolated from Todarodes pacificus squid degrades collagen below its denaturation temperature.

Journal: Connective tissue research 20040101

Title: Characterization of a new p94-like calpain form in human lymphocytes.

Journal: The Biochemical journal 20031101

Title: Modulation of enzymatic activity of human mast cell tryptase and chymase by protease inhibitors.

Journal: Acta pharmacologica Sinica 20030901

Title: Increase in epidermal growth factor receptor protein induced in osteoblastic cells after exposure to flow of culture media.

Journal: American journal of physiology. Cell physiology 20030801

Title: Calpain-2 as a target for limiting prostate cancer invasion.

Journal: Cancer research 20030801

Title: Endostatin induces autophagic cell death in EAhy926 human endothelial cells.

Journal: Histology and histopathology 20030701

Title: Differential DNA synthesis in response to activation of protease-activated receptors on cultured guinea-pig tracheal smooth muscle cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030701

Title: Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions.

Journal: The international journal of biochemistry & cell biology 20030501

Title: A nonintrinsic regional basis for increased infrarenal aortic MMP-9 expression and activity.

Journal: Journal of vascular surgery 20030501

Title: Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity.

Journal: Acta oto-laryngologica 20030501

Title: Calpain-mediated AQP2 proteolysis in inner medullary collecting duct.

Journal: Biochemical and biophysical research communications 20030328

Title: Impact of cysteine proteinase inhibition in midgut fluid and oral secretion on fecundity and pollen consumption of western corn rootworm (Diabrotica virgifera virgifera).

Journal: Archives of insect biochemistry and physiology 20030301

Title: Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187.

Journal: Journal of helminthology 20030301

Title: Intracellular expression of CD69 in endometrial and peripheral T cells represents a useful marker in women with recurrent miscarriage: modulation after allogeneic leukocyte immunotherapy.

Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 20030301

Title: Expression, purification, and inhibition of in vitro proteolysis of human AMPD2 (isoform L) recombinant enzymes.

Journal: Protein expression and purification 20030201

Title: Neuroprotection of vestibular sensory cells from gentamicin ototoxicity obtained using nitric oxide synthase inhibitors, reactive oxygen species scavengers, brain-derived neurotrophic factors and calpain inhibitors.

Journal: Acta oto-laryngologica 20030101

Title: 4-(2-aminooxyethoxy)-2-(ethylureido)quinoline-oligonucleotide conjugates: synthesis, binding interactions, and derivatization with peptides.

Journal: Bioconjugate chemistry 20030101

Title: The calpain-calpastatin system and the calcium paradox in the isolated perfused pigeon heart.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101

Title: Calpain and caspase-3 inhibitors reduce infarct size and post-ischemic apoptosis in rat heart without modifying contractile recovery.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20030101

Title: Sustained-release delivery of leupeptin in the chinchilla: hearing results.

Journal: The international tinnitus journal 20030101

Title: Matrix metalloprotease 2-mediated activation of Ca(2+)-ATPase by superoxide radical (O2*-) in plasma membrane of bovine pulmonary vascular smooth muscle.

Journal: Indian journal of biochemistry & biophysics 20021201

Title: Natural killer-like cells in the sheep: functional characterization and regulation by pregnancy-associated proteins.

Journal: Experimental biology and medicine (Maywood, N.J.) 20021001

Title: Involvement of proteases in the action of IFN-gamma on WISH cells.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020801

Title: Complexity of agonist- and cyclic AMP-mediated downregulation of the human beta 1-adrenergic receptor: role of internalization, degradation, and mRNA destabilization.

Journal: Biochemistry 20020625

Title: Stage-specific antimalarial activity of cysteine protease inhibitors.

Journal: Biological chemistry 20020501

Title: Opening of ligand-gated cation channel families by calpain inhibitors.

Journal: FEBS letters 20020424

Title: Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin.

Journal: Regulatory peptides 20020415

Title: Aggregation of human platelets by gingipain-R from Porphyromonas gingivalis cells and membrane vesicles.

Journal: Platelets 20020201

Title: Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity.

Journal: Hearing research 20020201

Title: Calpain inhibitors: a treatment for Alzheimer's disease.

Journal: Journal of molecular neuroscience : MN 20020101

Title: Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D.

Journal: Biological chemistry 20020101

Title: In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020101

Title: Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes.

Journal: Biochimica et biophysica acta 20011219

Title: Human muscle protein degradation in vitro by eosinophil cationic protein (ECP).

Journal: Muscle & nerve 20011201

Title: Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria.

Journal: Cell death and differentiation 20011201

Title: Electrostatic recognition between enzyme and inhibitor: interaction between papain and leupeptin.

Journal: Archives of biochemistry and biophysics 20011015

Title: Studies on the aminopeptidase activities of Porphyromonas gingivalis.

Journal: Oral microbiology and immunology 20010801

Title: Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.

Journal: Biochemical and biophysical research communications 20010720

Title: Heat-induced proteasomic degradation of HSF1 in serum-starved human fibroblasts aging in vitro.

Journal: Experimental cell research 20010715

Title: Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010501

Title: Biogenesis of lysosomes in marshall cells and in cells of the male reproductive system.

Journal: Molecular reproduction and development 20010501

Title: Immune-complex assays for tyrosine protein kinases.

Journal: Current protocols in immunology 20010501

Title: Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.

Journal: BioTechniques 20010401

Title: Association between bcl-x(L) and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells.

Journal: Toxicology 20010307

Title: NO donors inhibit Leishmania infantum cysteine proteinase activity.

Journal: Biochimica et biophysica acta 20010209

Title: Leupeptin-induced appearance of partial fragment of betaine homocysteine methyltransferase during autophagic maturation in rat hepatocytes.

Journal: Journal of biochemistry 20010201

Title: Salivary histatin 5 is a potent competitive inhibitor of the cysteine proteinase clostripain.

Journal: FEBS letters 20010126

Title: Role of calcium-dependent protease(s) in globulization of isolated rat lens cortical fiber cells.

Journal: Investigative ophthalmology & visual science 20010101

Title: Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).

Journal: Free radical biology & medicine 20010101

Title: Suppression of gingival inflammation induced by Porphyromonas gingivalis in rats by leupeptin.

Journal: Japanese journal of pharmacology 20010101

Title: Kinetic and structural properties of two isoforms of trypsin isolated from the viscera of Japanese anchovy, Engraulis japonicus.

Journal: Journal of protein chemistry 20010101

Title: Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water.

Journal: BMC structural biology 20010101

Title: Coaggregation of Porphyromonas gingivalis and Prevotella intermedia.

Journal: Microbiology and immunology 20010101

Title: Characterization of an important enzymatic component in collagenase that is essential for the effective digestion of the human and porcine pancreas.

Journal: Cell transplantation 20010101

Title: Il-1-related cytokine responses of nonimmune skin cells subjected to CEES exposure with and without potential vesicant antagonists.

Journal: In vitro & molecular toxicology 20000101

Title: Activation of Xenopus eggs by proteases: possible involvement of a sperm protease in fertilization.

Journal: Developmental biology 19990401

Title: Efficacy of serine protease inhibitors against Cryptosporidium parvum infection in a bovine fallopian tube epithelial cell culture system.

Journal: The Journal of parasitology 19960801

Title: Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells.

Journal: The Biochemical journal 19941001

Title: Protease activities in carp retina.

Journal: Neurochemistry international 19921201

Title: Significant effects of Z-Gln-Val-Val-OME, common sequences of thiol proteinase inhibitors on thiol proteinases.

Journal: Biochemical and biophysical research communications 19870313

Title: Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle.

Journal: FEBS letters 19850909

Title: Inhibition of the growth of human coronavirus 229E by leupeptin.

Journal: The Journal of general virology 19850201

Title: Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42.

Title: Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.

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Tags:103476-89-7 Molecular Formula|103476-89-7 MDL|103476-89-7 SMILES|103476-89-7 Leupeptin hemisulfate