Title: Kinetic characterization of bile salt transport by human NTCP (SLC10A1).
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201
Title: Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes.
Journal: Basic & clinical pharmacology & toxicology 20160201
Title: Ursodeoxycholyl lysophosphatidylethanolamide inhibits cholestasis- and hypoxia-induced apoptosis by upregulating antiapoptosis proteins.
Journal: Experimental biology and medicine (Maywood, N.J.) 20150201
Title: 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.
Journal: Molecular metabolism 20140801
Title: Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential.
Journal: Biochemical and biophysical research communications 20120810
Title: Glycochenodeoxycholate induces rat alveolar epithelial type II cell death and inhibits surfactant secretion in vitro.
Journal: Free radical biology & medicine 20120701
Title: Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP and increase in H2AX phosphorylation after exposure to γ-rays.
Journal: Biomedical research (Tokyo, Japan) 20120601
Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Journal: Journal of medicinal chemistry 20120524
Title: Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120501
Title: Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry.
Journal: Molecular bioSystems 20120401
Title: Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy.
Journal: Biochemistry 20120306
Title: In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions.
Journal: Pharmaceutical research 20120201
Title: The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation.
Journal: Frontiers in pharmacology 20120101
Title: Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes.
Journal: PloS one 20120101
Title: Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis.
Journal: PloS one 20120101
Title: Structural requirements for cooperativity in ileal bile acid-binding proteins.
Journal: The Journal of biological chemistry 20111111
Title: Complexation of tauro- and glyco-conjugated bile salts with α-cyclodextrin and hydroxypropyl-α-cyclodextrin studied by affinity capillary electrophoresis and molecular modelling.
Journal: Journal of separation science 20111101
Title: iNOS/NO signaling regulates apoptosis induced by glycochenodeoxycholate in hepatocytes.
Journal: Cellular signalling 20111001
Title: Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids.
Journal: Journal of hepato-biliary-pancreatic sciences 20110901
Title: C/EBPα and C/EBPβ binding proteins modulate hepatocyte apoptosis through iNOS signaling pathway.
Journal: Biochimica et biophysica acta 20110801
Title: cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20110801
Title: Nitric oxide mimics transcriptional and post-translational regulation during α-tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes.
Journal: Journal of hepatology 20110701
Title: Mitochondrial genome depletion dysregulates bile acid- and paracetamol-induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells.
Journal: British journal of pharmacology 20110401
Title: Plasma metabolomic profile in nonalcoholic fatty liver disease.
Journal: Metabolism: clinical and experimental 20110301
Title: Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20110201
Title: Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells.
Journal: Gut 20110101
Title: The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin.
Journal: Clinical endocrinology 20110101
Title: Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells.
Journal: Molecular cancer 20110101
Title: Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure.
Journal: PloS one 20110101
Title: Survivin signaling is regulated through nuclear factor-kappa B pathway during glycochenodeoxycholate-induced hepatocyte apoptosis.
Journal: Biochimica et biophysica acta 20101201
Title: Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells.
Journal: Journal of hepatology 20101101
Title: Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20101101
Title: Inhibition of interferon-α-induced signaling by hyperosmolarity and hydrophobic bile acids.
Journal: Biological chemistry 20101001
Title: Protective effects of glycoursodeoxycholic acid in Barrett's esophagus cells.
Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20100201
Title: Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid-induced apoptosis.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20100201
Title: Interpreting metabolomic profiles using unbiased pathway models.
Journal: PLoS computational biology 20100201
Title: Learning from the pregnane X receptor: how to fight one aggressor with two strategies.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20100201
Title: Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes.
Journal: Toxicology and applied pharmacology 20100115
Title: Glycochenodeoxycholate-induced apoptosis is not reduced by augmenter of liver regeneration in the human hepatoma cell line HuH-7.
Journal: Digestion 20100101
Title: HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology.
Journal: Molecular systems biology 20100101
Title: Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants.
Journal: PloS one 20100101
Title: Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes.
Journal: Chemical research in toxicology 20091201
Title: Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090901
Title: Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis.
Journal: The Journal of biological chemistry 20090814
Title: Current concepts of mechanisms in drug-induced hepatotoxicity.
Journal: Current medicinal chemistry 20090801
Title: Thermodynamics and structure of inclusion compounds of tauro- and glyco-conjugated bile salts and beta-cyclodextrin.
Journal: Physical chemistry chemical physics : PCCP 20090707
Title: Absence of glycochenodeoxycholic acid (GCDCA) in human bile is an indication of cholestasis: a 1H MRS study.
Journal: NMR in biomedicine 20090601
Title: The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes.
Journal: Molecular and cellular biochemistry 20090501
Title: cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20090401
Title: Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent.
Journal: The Journal of biological chemistry 20090130
Title: Determination of intralumenal individual bile acids by HPLC with charged aerosol detection.
Journal: Journal of lipid research 20081201
Title: Resistance of young rat hepatic mitochondria to bile acid-induced permeability transition: potential role of alpha-tocopherol.
Journal: Pediatric research 20081101
Title: The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis.
Journal: Journal of hepatology 20081101
Title: Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury.
Journal: Laboratory investigation; a journal of technical methods and pathology 20080901
Title: Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig.
Journal: Gut 20080801
Title: Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes.
Journal: Journal of hepatology 20080801
Title: Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis.
Journal: Biochemical and biophysical research communications 20080704
Title: Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand.
Journal: Journal of gastroenterology and hepatology 20080701
Title: Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
Journal: Journal of medicinal chemistry 20080327
Title: CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20080201
Title: Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis.
Journal: Clinical and experimental gastroenterology 20080101
Title: Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 cells.
Journal: Toxicology 20071130
Title: PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071001
Title: Complexation of tauro- and glyco-conjugated bile salts with three neutral beta-CDs studied by ACE.
Journal: Electrophoresis 20071001
Title: Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis.
Journal: Hepatology (Baltimore, Md.) 20070801
Title: Is vitamin E beneficial in chronic liver disease?
Journal: Hepatology (Baltimore, Md.) 20070801
Title: Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070701
Title: Structural basis for bile salt inhibition of pancreatic phospholipase A2.
Journal: Journal of molecular biology 20070601
Title: Kinetic mechanism of ligand binding in human ileal bile acid binding protein as determined by stopped-flow fluorescence analysis.
Journal: Biochemistry 20070508
Title: Taurodeoxycholate modulates apical Cl-/OH- exchange activity in Caco2 cells.
Journal: Digestive diseases and sciences 20070501
Title: Glycochenodeoxycholate (GCDC) inhibits cytokine induced iNOS expression in rat hepatocytes.
Journal: The Journal of surgical research 20070301
Title: Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Title: Bile acid salt binding with colesevelam HCl is not affected by suspension in common beverages.
Journal: Journal of pharmaceutical sciences 20061201
Title: Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver.
Journal: Hepatology (Baltimore, Md.) 20061101
Title: Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes.
Journal: Toxicology letters 20061010
Title: [Bile salts induce differentiation in cultured human normal esophageal mucosal epithelial cells].
Journal: Zhonghua yi xue za zhi 20060912
Title: Maternal ethanol consumption during pregnancy enhances bile acid-induced oxidative stress and apoptosis in fetal rat liver.
Journal: Toxicology 20060815
Title: Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum.
Journal: The Journal of pharmacy and pharmacology 20060801
Title: Honokiol reduces oxidative stress, c-jun-NH2-terminal kinase phosphorylation and protects against glycochenodeoxycholic acid-induced apoptosis in primary cultured rat hepatocytes.
Journal: Planta medica 20060601
Title: Single-step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy.
Journal: Lipids 20060601
Title: Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers.
Journal: Gut 20060501
Title: Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20060401
Title: High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B.
Journal: Journal of proteome research 20060301
Title: The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis.
Journal: Biochemical and biophysical research communications 20060217
Title: Determinants of cooperativity and site selectivity in human ileal bile acid binding protein.
Journal: Biochemistry 20060124
Title: Effect of tamoxifen and raloxifene on the conjugation of bile acids with taurine and glycine in ovariectomized rats.
Journal: Pharmacological reports : PR 20060101
Title: Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholangiocytes via oxidative DNA damage.
Journal: Free radical biology & medicine 20051201
Title: Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.
Journal: Hepatology (Baltimore, Md.) 20051201
Title: Bile salts inhibit growth and induce apoptosis of culture human normal esophageal mucosal epithelial cells.
Journal: World journal of gastroenterology 20051107
Title: The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes.
Journal: Toxicology 20051015
Title: Bile salts inhibit growth and induce apoptosis of human esophageal cancer cell line.
Journal: World journal of gastroenterology 20050907
Title: Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids.
Journal: Journal of pediatric gastroenterology and nutrition 20050801
Title: Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20050701
Title: Reversibility of caspase activation and its role during glycochenodeoxycholate-induced hepatocyte apoptosis.
Journal: The Journal of biological chemistry 20050624
Title: Increased susceptibility of fat-laden Zucker-rat hepatocytes to bile acid-induced oncotic necrosis: an in vitro model of steatocholestasis.
Journal: The Journal of laboratory and clinical medicine 20050501
Title: Inhibition of hepatocyte growth factor production in human fibroblasts by ursodeoxycholic acid.
Journal: Biological & pharmaceutical bulletin 20050401
Title: A nuclear receptor ligand down-regulates cytosolic phospholipase A2 expression to reduce bile acid-induced cyclooxygenase 2 activity in cholangiocytes: implications of anticarcinogenic action of farnesoid X receptor agonists.
Journal: Digestive diseases and sciences 20050301
Title: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20050101
Title: Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs.
Journal: Carcinogenesis 20050101
Title: Roles of protein kinase C and fructose in hepatic injury caused by obstructive jaundice.
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Title: Bifidobacterium animalis strain DN-173 010 hydrolyses bile salts in the gastrointestinal tract of pigs.
Journal: Scandinavian journal of gastroenterology 20041201
Title: Bile salt exposure causes phosphatidyl-inositol-3-kinase-mediated proliferation in a Barrett's adenocarcinoma cell line.
Journal: Surgery 20040801
Title: Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways.
Journal: Hepatology (Baltimore, Md.) 20040601
Title: Beta-carotene prevents bile acid-induced cytotoxicity in the rat hepatocyte: Evidence for an antioxidant and anti-apoptotic role of beta-carotene in vitro.
Journal: Pediatric research 20040501
Title: Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes.
Journal: Digestive diseases and sciences 20031201
Title: Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20031101
Title: Roles of reactive oxygen species, NF-kappaB, and peroxiredoxins in glycochenodeoxycholic acid-induced rat hepatocytes death.
Journal: Pharmacology 20030901
Title: Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation.
Journal: Gastroenterology 20030901
Title: Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation.
Journal: Journal of hepatology 20030801
Title: Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).
Journal: Bioorganic & medicinal chemistry letters 20030602
Title: Gallium-67 activated charcoal: a new method for preparation of radioactive capsules for colonic transit study.
Journal: European journal of nuclear medicine and molecular imaging 20030601
Title: Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis.
Journal: The Journal of biological chemistry 20030103
Title: Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes.
Journal: Clinical science (London, England : 1979) 20021101
Title: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors.
Journal: Gastroenterology 20021101
Title: Prevention of bile acid-induced apoptosis by betaine in rat liver.
Journal: Hepatology (Baltimore, Md.) 20021001
Title: Solubilization of drugs by physiological mixtures of bile salts.
Journal: Pharmaceutical research 20020801
Title: Nitric oxide ameliorates hydrophobic bile acid-induced apoptosis in isolated rat hepatocytes by non-mitochondrial pathways.
Journal: The Journal of biological chemistry 20020712
Title: High metabolic function of primary human and porcine hepatocytes in a polyurethane foam/spheroid culture system in plasma from patients with fulminant hepatic failure.
Journal: Cell transplantation 20020101
Title: [Release of cytochrome C with the interaction of bilirubin, amyloid beta-peptide and glycochenodeoxycholate from isolated mitochondria].
Journal: Acta medica portuguesa 20020101
Title: The bcl-2 mRNA expression in GCDC-induced obstructive jaundice in rats and its implication in hepatocellular apoptosis.
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Title: Spontaneous nitric oxide in hepatocyte monolayers and inhibition of compound-induced apoptosis.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20011201
Title: Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury.
Journal: The Journal of pharmacology and experimental therapeutics 20011201
Title: Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids.
Journal: Gastroenterology 20011201
Title: The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis.
Journal: The Journal of biological chemistry 20011019
Title: The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes.
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Title: Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes.
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Title: Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes.
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Title: Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition.
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Title: Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line.
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