Home Amines 64862-96-0
64862-96-0,MFCD00723741
Catalog No.:AA00EINF

64862-96-0 | 1,4-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione

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1mg
≥90%
in stock  
$63.00   $44.00
- +
5mg
98% by HPLC
in stock  
$224.00   $157.00
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10mg
98% by HPLC
in stock  
$335.00   $234.00
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25mg
98% by HPLC
in stock  
$637.00   $446.00
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50mg
98% by HPLC
in stock  
$1,040.00   $728.00
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100mg
98% by HPLC
in stock  
$1,752.00   $1,227.00
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500mg
98% by HPLC
in stock  
$5,515.00   $3,861.00
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1000mg
98% by HPLC
in stock  
$8,787.00   $6,151.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EINF
Chemical Name:
1,4-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione
CAS Number:
64862-96-0
Molecular Formula:
C22H28N4O4
Molecular Weight:
412.4821
MDL Number:
MFCD00723741
SMILES:
OCCNCCNc1ccc(c2c1C(=O)c1c(C2=O)cccc1)NCCNCCO
NSC Number:
196473
Properties
Properties
 
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
513  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
12  
XLogP3:
1.7  

Downstream Synthesis Route

[1]Locationinpatent:experimentalpartGianoncelli,Alessandra;Basili,Serena;Scalabrin,Matteo;Sosic,Alice;Moro,Stefano;Zagotto,Giuseppe;Palumbo,Manlio;Gresh,Nohad;Gatto,Barbara[ChemMedChem,2010,vol.5,#7,p.1080-1091]

[2]Krapcho,A.Paul;Getahun,Zelleka;Avery,KennethL.;Vargas,KevinJ.;Hacker,MilesP.;etal.[JournalofMedicinalChemistry,1991,vol.34,#8,p.2373-2380]

[3]Artigas,Gerard;Lpez-Senn,Paula;Gonzlez,Carlos;Escaja,Nria;Marchn,Vicente[OrganicandBiomolecularChemistry,2015,vol.13,#2,p.452-464]

[4]Artigas,Gerard;Marchán,Vicente[JournalofOrganicChemistry,2015,vol.80,#4,p.2155-2164]

[1]Patent:US2015/7851,2015,A1.Locationinpatent:Paragraph0156;0157;0158

Literature

Title: Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells.

Journal: Anti-cancer drugs 20120401

Title: Rational design, synthesis, and DNA binding properties of novel sequence-selective peptidyl congeners of ametantrone.

Journal: ChemMedChem 20100705

Title: Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones.

Journal: Bioorganic & medicinal chemistry 20090301

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Effects of peroxidase substrates on the Amplex red/peroxidase assay: antioxidant properties of anthracyclines.

Journal: Analytical biochemistry 20050715

Title: Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies.

Journal: European journal of medicinal chemistry 20050401

Title: Metabolite fingerprinting in transgenic Nicotiana tabacum altered by the Escherichia coli glutamate dehydrogenase gene.

Journal: Journal of biomedicine & biotechnology 20050101

Title: Comparison of cardiotoxicity of two anthracenediones and doxorubicin in rats.

Journal: Toxicology letters 19820501

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SDS
Tags:64862-96-0 Molecular Formula|64862-96-0 MDL|64862-96-0 SMILES|64862-96-0 1,4-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione