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68377-92-4,MFCD00865895
Catalog No.:AA00F9RY

68377-92-4 | Arotinolol

Pack Size
Purity
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Price(USD)
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5mg
97%(HPLC)
in stock  
$143.00   $100.00
- +
10mg
97%(HPLC)
in stock  
$239.00   $167.00
- +
25mg
97%(HPLC)
in stock  
$488.00   $342.00
- +
100mg
98%
in stock  
$1,945.00   $1,362.00
- +
250mg
98%
in stock  
$4,302.00   $3,012.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00F9RY
Chemical Name:
Arotinolol
CAS Number:
68377-92-4
Molecular Formula:
C15H21N3O2S3
Molecular Weight:
371.5411
MDL Number:
MFCD00865895
SMILES:
OC(CSc1scc(n1)c1ccc(s1)C(=O)N)CNC(C)(C)C
NSC Number:
317940
Properties
Computed Properties
 
Complexity:
406  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.3  

Literature

Title: New perspectives for the treatment of pulmonary hypertension.

Journal: British journal of pharmacology 20110501

Title: Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling.

Journal: Trends in pharmacological sciences 20110401

Title: Treatment of Essential Tremor: Are there Issues We are Overlooking?

Journal: Frontiers in neurology 20110101

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Overview of essential tremor.

Journal: Neuropsychiatric disease and treatment 20100101

Title: Carteolol hydrochloride suppresses the generation of reactive oxygen species and rescues cell death after ultraviolet irradiation of cultured lens epithelial cells.

Journal: The open ophthalmology journal 20100101

Title: Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20091201

Title: Are adrenergic receptor blockers effective or contraindicated in pulmonary arterial hypertension?

Journal: Circulation journal : official journal of the Japanese Circulation Society 20091201

Title: Effect of arotinolol on left ventricular function in patients with idiopathic dilated cardiomyopathy.

Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20071201

Title: Carvedilol, a nonselective beta-blocker, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro.

Journal: Translational research : the journal of laboratory and clinical medicine 20070401

Title: Spectrofluorometric determination of some beta-blockers in tablets and human plasma using 9,10-dimethoxyanthracene-2-sodium sulfonate.

Journal: Die Pharmazie 20050401

Title: Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol.

Journal: Parkinsonism & related disorders 20050301

Title: Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene.

Journal: Journal of the neurological sciences 20041015

Title: Relapse of Graves' disease in a patient with pheochromocytoma.

Journal: Endocrine journal 20031201

Title: Enantioselective determination of arotinolol in human plasma by HPLC using teicoplanin chiral stationary phase.

Journal: Biomedical chromatography : BMC 20031001

Title: A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor.

Journal: Parkinsonism & related disorders 20030801

Title: Micellar electrokinetic capillary chromatography determination of +S and -R arotinolol in serum using UV detection and solid phase extraction.

Journal: Chirality 20020101

Title: Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010901

Title: Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes.

Journal: Canadian journal of physiology and pharmacology 20010701

Title: Comparison of the effects of an ACE inhibitor and alphabeta blocker on the progression of renal failure with left ventricular hypertrophy: preliminary report.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010301

Title: The alpha/beta-adrenergic receptor blocker arotinolol activates the thermogenesis of brown adipose tissue in monosodium-L-glutamate-induced obese mice.

Journal: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 19940501

Title: Effects of beta-adrenergic blockers with different ancillary properties on lipid peroxidation in hyperthyroid rat cardiac muscle.

Journal: Endocrinologia japonica 19891001

Title: Synthesis and beta-adrenergic blocking action of a new thiazolylthiopropanolamine derivative.

Journal: Journal of pharmaceutical sciences 19780901

Title: Zhou W, et al. Mechanisms of improved aortic stiffness by arotinolol in spontaneously hypertensive rats.PLoS One. 2014 Feb 12;9(2):e88722.

Title: Hiroshi TSUCHIHASHI, et al. Characteristics of 1251-lodocyanopindolol Binding to 8-Adrenergic and Serotonin-1B Receptors of Rat Brain: Selectivity of 19-Adrenergic Agents

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