[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-EP2199291,2010,A1Locationinpatent:Page/Pagecolumn4
[1]CurrentPatentAssignee:DECHRAPHARMACEUTICALSPLC-US2011/152283,2011,A1
[1]CurrentPatentAssignee:DECHRAPHARMACEUTICALSPLC-US2011/152283,2011,A1
[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2011/124638,2011,A1Locationinpatent:Page/Pagecolumn22-23
[2]CurrentPatentAssignee:CHINAAGRICULTURALUNIVERSITY-CN111518081,2020,ALocationinpatent:Paragraph0015;0070;0076
[3]CurrentPatentAssignee:QINGDAOAGRICULTURALUNIVERSITY-CN106518850,2017,ALocationinpatent:Paragraph0024;0025;0031;0037;0043;0049
[4]CurrentPatentAssignee:DECHRAPHARMACEUTICALSPLC-US2011/152283,2011,A1Locationinpatent:Page/Pagecolumn4-5
Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: A review of the pharmacology and clinical uses of pimobendan.
Journal: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) 20120801
Title: Effect of oral administration of pimobendan in cats with heart failure.
Journal: Journal of the American Veterinary Medical Association 20120701
Title: Effect of pimobendan on the clinical outcome and survival of cats with non-taurine responsive dilated cardiomyopathy.
Journal: Journal of feline medicine and surgery 20120401
Title: Clinical signs of cardiovascular effects secondary to suspected pimobendan toxicosis in five dogs.
Journal: Journal of the American Animal Hospital Association 20120101
Title: Compounded pimobendan for canine chronic degenerative mitral valve disease and pulmonary hypertension.
Journal: International journal of pharmaceutical compounding 20120101
Title: Use of pimobendan in 170 cats (2006-2010).
Journal: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20111201
Title: Effects of furosemide and the combination of furosemide and the labeled dosage of pimobendan on the circulating renin-angiotensin-aldosterone system in clinically normal dogs.
Journal: American journal of veterinary research 20111201
Title: Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases.
Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20111101
Title: Congenital cardiac anomalies in an English bulldog.
Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20111101
Title: [Calcium mobilizers and calcium sensitizers].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20111101
Title: Lack of efficacy of low-dose spironolactone as adjunct treatment to conventional congestive heart failure treatment in dogs.
Journal: Journal of veterinary pharmacology and therapeutics 20110801
Title: Conserved expression and functions of PDE4 in rodent and human heart.
Journal: Basic research in cardiology 20110301
Title: Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical mitral valve disease.
Journal: The Veterinary record 20110226
Title: Congenital Pelger-Huët anomaly in a Danish/Swedish Farmdog: case report.
Journal: Acta veterinaria Scandinavica 20110101
Title: The challenge to verify ceramide's role of apoptosis induction in human cardiomyocytes--a pilot study.
Journal: Journal of cardiothoracic surgery 20110101
Title: A locus on chromosome 5 is associated with dilated cardiomyopathy in Doberman Pinschers.
Journal: PloS one 20110101
Title: Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract.
Journal: Research in pharmaceutical sciences 20110101
Title: The effect of pimobendan on left atrial pressure in dogs with mitral valve regurgitation.
Journal: Journal of veterinary internal medicine 20110101
Title: Can the vector space model be used to identify biological entity activities?
Journal: BMC genomics 20110101
Title: Canine dilated cardiomyopathy: a retrospective study of prognostic findings in 367 clinical cases.
Journal: The Journal of small animal practice 20100801
Title: Current use of pimobendan in canine patients with heart disease.
Journal: The Veterinary clinics of North America. Small animal practice 20100701
Title: Canine degenerative myxomatous mitral valve disease: natural history, clinical presentation and therapy.
Journal: The Veterinary clinics of North America. Small animal practice 20100701
Title: Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivatives.
Journal: Bioorganic & medicinal chemistry 20100601
Title: ECG of the month. Arrhythmogenic right ventricular cardiomyopathy in a Boxer.
Journal: Journal of the American Veterinary Medical Association 20100501
Title: Patients' self-assessed functional status in heart failure by New York Heart Association class: a prognostic predictor of hospitalizations, quality of life and death.
Journal: Journal of cardiac failure 20100201
Title: Human cardiac tissue in a microperfusion chamber simulating extracorporeal circulation--ischemia and apoptosis studies.
Journal: Journal of cardiothoracic surgery 20100101
Title: Synthesis of new 4,5-3(2H)pyridazinone derivatives and their cardiotonic, hypotensive, and platelet aggregation inhibition activities.
Journal: Archives of pharmacal research 20100101
Title: Sarcomere control mechanisms and the dynamics of the cardiac cycle.
Journal: Journal of biomedicine & biotechnology 20100101
Title: Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond.
Journal: Heart failure reviews 20091201
Title: A randomized, double-blind, placebo-controlled study to determine the effects of valsartan on exercise time in patients with symptomatic heart failure with preserved ejection fraction.
Journal: European journal of heart failure 20091001
Title: Readability estimates for commonly used health-related quality of life surveys.
Journal: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20090901
Title: Transient tricuspid valve regurgitation following surgical treatment of cor triatriatum dexter in a dog.
Journal: The Journal of small animal practice 20090501
Title: Chronic cor pulmonale secondary to pulmonary atherosclerosis in an African Grey parrot.
Journal: Journal of the American Veterinary Medical Association 20090415
Title: Effect of pimobendan on echocardiographic values in dogs with asymptomatic mitral valve disease.
Journal: Journal of veterinary internal medicine 20090101
Title: Assessment of the pharmacological effects of inotropic drugs on left ventricular pressure and contractility: an evaluation of the QA interval as an indirect indicator of cardiac inotropism.
Journal: Journal of pharmacological and toxicological methods 20090101
Title: Acute effect of pimobendan and furosemide on the circulating renin-angiotensin-aldosterone system in healthy dogs.
Journal: Journal of veterinary internal medicine 20090101
Title: Cardiac sarcoidosis culminating in severe biventricular failure.
Journal: Case reports in medicine 20090101
Title: Evaluation of pimobendan and N-terminal probrain natriuretic peptide in the treatment of pulmonary hypertension secondary to degenerative mitral valve disease in dogs.
Journal: Journal of veterinary internal medicine 20090101
Title: Cardiac Ca2+ signaling and Ca2+ sensitizers.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20081201
Title: Canine heart disease: progress and promise.
Journal: The Journal of small animal practice 20081101
Title: Treatment of congestive heart failure in dogs.
Journal: The Veterinary record 20081025
Title: Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex.
Journal: Biochemistry 20080715
Title: Effect of short-term treatment with meloxicam and pimobendan on the renal function in healthy beagle dogs.
Journal: Journal of veterinary pharmacology and therapeutics 20080401
Title: Validity, reliability, and responsiveness of the Kansas City Cardiomyopathy Questionnaire in anemic heart failure patients.
Journal: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20080301
Title: Alterations in vasomotor control of coronary resistance vessels in remodelled myocardium of swine with a recent myocardial infarction.
Journal: Medical & biological engineering & computing 20080101
Title: Concerns about 'Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative mitral valve disease: a prospective, controlled, blinded and randomized study'.
Journal: Journal of veterinary internal medicine 20080101
Title: Concerns about 'Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative mitral valve disease'.
Journal: Journal of veterinary internal medicine 20080101
Title: Effect of pimobendan on case fatality rate in Doberman Pinschers with congestive heart failure caused by dilated cardiomyopathy.
Journal: Journal of veterinary internal medicine 20080101
Title: The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
Journal: PloS one 20080101
Title: Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study.
Journal: Journal of veterinary internal medicine 20080101
Title: A QUEST begins.
Journal: Journal of veterinary internal medicine 20080101
Title: Anaesthesia for the geriatric dog and cat.
Journal: Irish veterinary journal 20080101
Title: Beta-blockers use in patients with chronic obstructive pulmonary disease and concomitant cardiovascular conditions.
Journal: International journal of chronic obstructive pulmonary disease 20071201
Title: Treatment options in myocarditis: what we know from experimental data and how it translates to clinical trials.
Journal: Herz 20070901
Title: A pilot study to assess the feasibility of a submaximal exercise test to measure individual response to cardiac medication in dogs with acquired heart failure.
Journal: Veterinary research communications 20070801
Title: [Combined therapy with weight loss and amiodarone improved cardiac function in a patient with idiopathic dilated cardiomyopathy complicated with severe obesity: a case report].
Journal: Journal of cardiology 20070801
Title: Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation.
Journal: Circulation research 20070720
Title: Translational medicine with a capital T, troponin T, that is.
Journal: Circulation research 20070720
Title: [Calcium sensitizer: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528
Title: [Phosphodiesterase III inhibitor--characteristics, mechanisms of action, pharmacokinetics, indications, contraindications, clinical trials, and side effects].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528
Title: [Calcium sensitizer agents in heart failure therapy].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528
Title: Effects of pimobendan for mitral valve regurgitation in dogs.
Journal: The Journal of veterinary medical science 20070401
Title: The value added by measuring myocardial contractility 'in vivo' in safety pharmacological profiling of drug candidates.
Journal: Journal of pharmacological and toxicological methods 20070101
Title: Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative mitral valve disease: a prospective, controlled, blinded, and randomized study.
Journal: Journal of veterinary internal medicine 20070101
Title: Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts: the measurements of cellular Ca2+ and nitric oxide release.
Journal: European journal of pharmacology 20061215
Title: A review of levosimendan in the treatment of heart failure.
Journal: Vascular health and risk management 20061201
Title: Acute heart failure: inotropic agents and their clinical uses.
Journal: Expert opinion on pharmacotherapy 20061101
Title: New insights in the treatment strategy for pulmonary arterial hypertension.
Journal: Cardiovascular drugs and therapy 20061001
Title: Preclinical dilated cardiomyopathy in the dobermann.
Journal: The Veterinary record 20060527
Title: [Subarachnoid hemorrhage complicated with different manifestations of transient abnormal left ventricular wall motion: two case reports].
Journal: Journal of cardiology 20060501
Title: Syncope secondary to transient atrioventricular block in a German shepherd dog with dilated cardiomyopathy and atrial fibrillation.
Journal: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20060501
Title: Pimobendan in heart failure therapy--a silver bullet?
Journal: Journal of the American Animal Hospital Association 20060101
Title: Clinical efficacy of pimobendan versus benazepril for the treatment of acquired atrioventricular valvular disease in dogs.
Journal: Journal of the American Animal Hospital Association 20060101
Title: Ca2+-sensitisers--a promising option to treat heart failure?
Journal: Cardiovascular drugs and therapy 20051201
Title: Effect of pimobendan on cardiopulmonary baroreflex control of sympathetic nerve activity in healthy young men.
Journal: Autonomic neuroscience : basic & clinical 20051030
Title: Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Journal: Bioorganic & medicinal chemistry letters 20050915
Title: Calcium sensitizer agents: a new class of inotropic agents in the treatment of decompensated heart failure.
Journal: International journal of cardiology 20050901
Title: [If the myofilaments become sensitive: Ca2+-sensitizer for the therapy of heart insufficiency].
Journal: Deutsche medizinische Wochenschrift (1946) 20050415
Title: Efficacy and safet of pimobendan in canine heart failure caused by myxomatous mitral valve disease.
Journal: The Journal of small animal practice 20050301
Title: [Cytokine antagonists and endothelin antagonists for therapy of heart failure].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20050210
Title: Selective blockade of nicotinic acetylcholine receptors by pimobendan, a drug for the treatment of heart failure: reduction of catecholamine secretion and synthesis in adrenal medullary cells.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050201
Title: Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers.
Journal: Biological & pharmaceutical bulletin 20050101
Title: Increased mitral valve regurgitation and myocardial hypertrophy in two dogs with long-term pimobendan therapy.
Journal: Cardiovascular toxicology 20050101
Title: Use of pimobendan in the management of heart failure.
Journal: The Veterinary clinics of North America. Small animal practice 20040901
Title: Successful allogeneic bone marrow transplantation for acute myelogenous leukemia after drug-induced cardiomyopathy.
Journal: The Tohoku journal of experimental medicine 20040901
Title: Do medical house officers value the health of veterans differently from the health of non-veterans?
Journal: Health and quality of life outcomes 20040101
Title: Treatment of congestive heart failure.
Journal: The Journal of small animal practice 20031101
Title: Investigation of pimobendan versus benazepril in canine myxomatous valvular disease.
Journal: The Veterinary record 20031004
Title: The role of Ca++-sensitizers for the treatment of heart failure.
Journal: Current opinion in critical care 20031001
Title: Low-dose systemic phosphodiesterase III inhibitor pimobendan combined with prostacyclin therapy in a patient with severe primary pulmonary hypertension.
Journal: Cardiovascular drugs and therapy 20030701
Title: [Roles of cytokines in the pathogenesis of heart failure].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20030501
Title: [Inotropic agents].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20030501
Title: Plasma concentration profile of orally administered pimobendan and plasma brain natriuretic peptide level in patients with severe heart failure.
Journal: Cardiovascular drugs and therapy 20030501
Title: [Pharmacological treatment of heart failure].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20030401
Title: Effects of rolipram, pimobendan and zaprinast on ischaemia-induced dysrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
Journal: European journal of anaesthesiology 20030301
Title: Inhibition and facilitation by pimobendan, a calcium sensitizer, of catecholamine secretion from bovine adrenal chromaffin cells.
Journal: Journal of pharmacological sciences 20030301
Title: Role of nonglycosidic inotropic agents: indications, ethics, and limitations.
Journal: The Medical clinics of North America 20030301
Title: Normalization of left ventricular parameters following combined pimobendan and carvedilol treatment in a case of unclassified cardiomyopathy with longstanding refractory status.
Journal: Internal medicine (Tokyo, Japan) 20021201
Title: Disparate force-frequency effects of pimobendan and dobutamine in conscious dogs with tachycardia-induced cardiomyopathy.
Journal: Journal of cardiac failure 20021201
Title: Combined endpoints: can we use them?
Journal: Statistics in medicine 20021015
Title: Mechanisms of action of novel cardiotonic agents.
Journal: Journal of cardiovascular pharmacology 20020901
Title: Inotropic agents and immune modulation.
Journal: Cardiovascular drugs and therapy 20020501
Title: Beta-blocker therapy combined with low-dose pimobendan in patients with idiopathic dilated cardiomyopathy and chronic obstructive pulmonary disease: report on two cases.
Journal: Cardiovascular drugs and therapy 20020501
Title: Effects of pimobendan on adverse cardiac events and physical activities in patients with mild to moderate chronic heart failure: the effects of pimobendan on chronic heart failure study (EPOCH study).
Journal: Circulation journal : official journal of the Japanese Circulation Society 20020201
Title: A double-blind, randomized, placebo-controlled study of pimobendan in dogs with dilated cardiomyopathy.
Journal: Journal of veterinary internal medicine 20020101
Title: Beneficial effects of the Ca2+ sensitizer EMD 57033 in exercising pigs with infarction-induced chronic left ventricular dysfunction.
Journal: British journal of pharmacology 20011001
Title: Decrease in Ca(2+)-sensitizing effect of UD-CG 212 Cl, a metabolite of pimobendan, under acidotic condition in canine ventricular myocardium.
Journal: The Journal of pharmacology and experimental therapeutics 20010901
Title: Mechanism of action of Ca2+ sensitizers--update 2001.
Journal: Cardiovascular drugs and therapy 20010901
Title: Effects of Ca2+ sensitizers on contraction, [Ca2+]i transient and myofilament Ca2+ sensitivity in diabetic rat myocardium: potential usefulness as inotropic agents.
Journal: The Journal of pharmacology and experimental therapeutics 20010801
Title: A case of severe hypoglycemia due to pimobendan.
Journal: International journal of cardiology 20010801
Title: New pharmacological strategies for the treatment of heart failure.
Journal: Current opinion in investigational drugs (London, England : 2000) 20010701
Title: The role of inflammatory mediators in the failing heart: immunomodulation of cytokines in experimental models of heart failure.
Journal: Heart failure reviews 20010301
Title: Increase in myofibrillar Ca2+ sensitivity induced by UD-CG 212 Cl, an active metabolite of pimobendan, in canine ventricular myocardium.
Journal: Journal of cardiovascular pharmacology 20010201
Title: Effect of pimobendan in patients with chronic heart failure.
Journal: Experimental and clinical cardiology 20010101
Title: Identification of cytochrome P-450 isoform(s) responsible for the metabolism of pimobendan in human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20000101
Title: Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis.
Journal: Journal of the American College of Cardiology 19990401
Title: The novel insulinotropic mechanism of pimobendan: direct enhancement of the exocytotic process of insulin secretory granules by increased Ca2+ sensitivity in beta-cells.
Journal: Endocrinology 19980301
Title: Differential modulation of cytokine production by drugs: implications for therapy in heart failure.
Journal: Journal of molecular and cellular cardiology 19961201
Title: Kajimoto K, et al. Contribution of phosphodiesterase isozymes to the regulation of the L-type calcium current in human cardiac myocytes. Br J Pharmacol. 1997 Aug;121(8):1549-56.
Title: Iwasaki A, et al. Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. J Am Coll Cardiol. 1999 Apr;33(5):1400-7.
