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65996-58-9,MFCD09540493
Catalog No.:AA00FAUX

65996-58-9 | 2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
97%
in stock  
$83.00   $58.00
- +
1g
97%
in stock  
$232.00   $162.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00FAUX
Chemical Name:
2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
CAS Number:
65996-58-9
Molecular Formula:
C6H6N4O
Molecular Weight:
150.1380
MDL Number:
MFCD09540493
SMILES:
Nc1nc2cc[nH]c2c(=O)[nH]1
NSC Number:
344522
Properties
Computed Properties
 
Complexity:
225  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.8  

Literature

Title: Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model.

Journal: PloS one 20110101

Title: Antiproliferative activity of purine nucleoside phosphorylase multisubstrate analogue inhibitors containing difluoromethylene phosphonic acid against leukaemia and lymphoma cells.

Journal: Chemical biology & drug design 20100401

Title: 9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.

Journal: The FEBS journal 20100401

Title: Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs.

Journal: Bioorganic & medicinal chemistry 20100315

Title: New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.

Journal: Journal of medicinal chemistry 20090312

Title: 9-Deazaguanine derivatives: synthesis and inhibitory properties as multi-substrate analogue inhibitors of mammalian PNPs.

Journal: Nucleic acids symposium series (2004) 20080101

Title: Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.

Journal: Bioorganic & medicinal chemistry letters 20070801

Title: Synthesis and evaluation of 9-deazaguanine derivatives as multi-substrate analogue inhibitors of PNP.

Journal: Nucleic acids symposium series (2004) 20070101

Title: Fluorescence studies of calf spleen purine nucleoside phosphorylase (PNP) complexes with guanine and 9-deazaguanine.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: pH-Independent triplex formation: hairpin DNA containing isoguanine or 9-deaza-9-propynylguanine in place of protonated cytosine.

Journal: Organic & biomolecular chemistry 20061107

Title: Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate.

Journal: Nature structural biology 20031001

Title: Role of the flexible loop of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus in enzyme catalysis.

Journal: Biochemistry 20010410

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19951109

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Tags:65996-58-9 Molecular Formula|65996-58-9 MDL|65996-58-9 SMILES|65996-58-9 2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
Catalog No.: AA00FAUX
65996-58-9,MFCD09540493
65996-58-9 | 2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
Pack Size： 250mg
Purity： 97%
in stock
$83.00 $58.00
Pack Size： 1g
Purity： 97%
in stock
$232.00 $162.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00FAUX
Chemical Name: 2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
CAS Number: 65996-58-9
Molecular Formula: C6H6N4O
Molecular Weight: 150.1380
MDL Number: MFCD09540493
SMILES: Nc1nc2cc[nH]c2c(=O)[nH]1
NSC Number: 344522
Properties
Complexity: 225  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 11  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.8  
Literature fold

Title: Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model.

Journal: PloS one20110101

Title: Antiproliferative activity of purine nucleoside phosphorylase multisubstrate analogue inhibitors containing difluoromethylene phosphonic acid against leukaemia and lymphoma cells.

Journal: Chemical biology & drug design20100401

Title: 9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.

Journal: The FEBS journal20100401

Title: Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs.

Journal: Bioorganic & medicinal chemistry20100315

Title: New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.

Journal: Journal of medicinal chemistry20090312

Title: 9-Deazaguanine derivatives: synthesis and inhibitory properties as multi-substrate analogue inhibitors of mammalian PNPs.

Journal: Nucleic acids symposium series (2004)20080101

Title: Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.

Journal: Bioorganic & medicinal chemistry letters20070801

Title: Synthesis and evaluation of 9-deazaguanine derivatives as multi-substrate analogue inhibitors of PNP.

Journal: Nucleic acids symposium series (2004)20070101

Title: Fluorescence studies of calf spleen purine nucleoside phosphorylase (PNP) complexes with guanine and 9-deazaguanine.

Journal: Nucleosides, nucleotides & nucleic acids20070101

Title: pH-Independent triplex formation: hairpin DNA containing isoguanine or 9-deaza-9-propynylguanine in place of protonated cytosine.

Journal: Organic & biomolecular chemistry20061107

Title: Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate.

Journal: Nature structural biology20031001

Title: Role of the flexible loop of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus in enzyme catalysis.

Journal: Biochemistry20010410

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology19951109

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