Home Other Building Blocks 70553-76-3
70553-76-3,MFCD00221740
Catalog No.:AA00FBD6

70553-76-3 | daurisoline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$133.00   $93.00
- +
10mg
≥98%
in stock  
$238.00   $166.00
- +
25mg
98% by HPLC
in stock  
$500.00   $350.00
- +
50mg
98% by HPLC
in stock  
$808.00   $565.00
- +
100mg
98% by HPLC
in stock  
$1,350.00   $945.00
- +
500mg
98% by HPLC
in stock  
$4,218.00   $2,952.00
- +
1000mg
98% by HPLC
in stock  
$6,710.00   $4,697.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBD6
Chemical Name:
daurisoline
CAS Number:
70553-76-3
Molecular Formula:
C37H42N2O6
Molecular Weight:
610.7392
MDL Number:
MFCD00221740
SMILES:
COc1cc2c(cc1OC)CCN([C@@H]2Cc1ccc(cc1)Oc1cc(ccc1O)C[C@H]1N(C)CCc2c1cc(O)c(c2)OC)C
Properties
Computed Properties
 
Complexity:
917  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
6.4  

Literature

Title: Effect of daurisoline on HERG channel electrophysiological function and protein expression.

Journal: Journal of natural products 20120928

Title: Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current.

Journal: The American journal of Chinese medicine 20100101

Title: [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051001

Title: [Protective effects of phenolic alkaloids from Menispermum dauricum on inflammatory injury following focal cerebral ischemia-reperfusion in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801

Title: [Determination of daurisoline in rabbit plasma and study on its pharmacokinetics].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20031201

Title: Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs.

Journal: Acta pharmacologica Sinica 20031001

Title: Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier.

Journal: Acta pharmacologica Sinica 20020501

Title: Liu Q, et al. Effect of daurisoline on HERG channel electrophysiological function and protein expression. J Nat Prod. 2012 Sep 28;75(9):1539-45.

Title: Wu MY, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells tocamptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8(44):77673-77684.

Title: Shi SJ, et al. Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs. Acta Pharmacol Sin. 2003 Oct;24(10):1011-5.

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Tags:70553-76-3 Molecular Formula|70553-76-3 MDL|70553-76-3 SMILES|70553-76-3 daurisoline