Name: Name:GW 842166X
Brand: AABLOCKS
SKU: AA00FBG2
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00FBG2

Chemical Name: GW 842166X

CAS Number: 666260-75-9

Molecular Formula: C18H17Cl2F3N4O2

Molecular Weight: 449.2544

MDL Number: MFCD11045840

SMILES: Clc1cc(cc(c1)Cl)Nc1ncc(c(n1)C(F)(F)F)C(=O)NCC1CCOCC1

Properties

Storage: -20 ℃;

Complexity: 552

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 29

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 2

Rotatable Bond Count: 5

XLogP3: 4.1

Literature fold

Title: The endocannabinoid system: an overview.

Journal: Frontiers in behavioral neuroscience20120101

Title: Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists.

Journal: Journal of medicinal chemistry20111027

Title: A randomized, controlled study to investigate the analgesic efficacy of single doses of the cannabinoid receptor-2 agonist GW842166, ibuprofen or placebo in patients with acute pain following third molar tooth extraction.

Journal: The Clinical journal of pain20111001

Title: Design and evaluation of a novel fluorescent CB2 ligand as probe for receptor visualization in immune cells.

Journal: Bioorganic & medicinal chemistry letters20111001

Title: Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.

Journal: Journal of medicinal chemistry20091008

Title: Morpholine containing CB2 selective agonists.

Journal: Bioorganic & medicinal chemistry letters20090315

Title: Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.

Journal: Bioorganic & medicinal chemistry letters20090101

Title: Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action.

Journal: Bioorganic & medicinal chemistry20080201

Title: Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.

Journal: Journal of medicinal chemistry20070531

Title: Giblin GM, et al. Discovery of 2-[(2,4-dichlorophenyl)amino-N-[(tetrahydro- 2H-pyran-4-yl)methyl-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600.

666260-75-9 | GW 842166X