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668463-35-2,MFCD23136021
Catalog No.:AA00FBYZ

668463-35-2 | Rpr-260243

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Purity
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Price(USD)
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5mg
98% by HPLC
in stock  
$437.00   $306.00
- +
10mg
98% by HPLC
in stock  
$695.00   $486.00
- +
25mg
98% by HPLC
in stock  
$1,399.00   $980.00
- +
50mg
98% by HPLC
in stock  
$2,340.00   $1,638.00
- +
100mg
98% by HPLC
in stock  
$4,002.00   $2,802.00
- +
500mg
98% by HPLC
in stock  
$12,783.00   $8,948.00
- +
1000mg
98% by HPLC
in stock  
$20,417.00   $14,292.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBYZ
Chemical Name:
Rpr-260243
CAS Number:
668463-35-2
Molecular Formula:
C28H25F3N2O4
Molecular Weight:
510.5043
MDL Number:
MFCD23136021
SMILES:
COc1ccc2c(c1)c(ccn2)C(=O)CC[C@@H]1CCN(C[C@@H]1C(=O)O)CC#Cc1cc(F)cc(c1F)F
Properties
Computed Properties
 
Complexity:
876  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
2  

Literature

Title: Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.

Journal: Molecular pharmacology 20110101

Title: Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels.

Journal: British journal of pharmacology 20101001

Title: A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.

Journal: Molecular pharmacology 20080401

Title: Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity.

Journal: Molecular pharmacology 20050901

Title: Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel.

Journal: Molecular pharmacology 20050301

Title: Activators of cation channels: potential in treatment of channelopathies.

Journal: Molecular pharmacology 20050301

Title: Wu W, et al. Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243. Mol Pharmacol. 2015;87(3):401-409.

Title: Kang J, et al. Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. Mol Pharmacol. 2005;67(3):827-836.

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Tags:668463-35-2 Molecular Formula|668463-35-2 MDL|668463-35-2 SMILES|668463-35-2 Rpr-260243