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73069-27-9,MFCD23105643
Catalog No.:AA00FEHH

73069-27-9 | 2-Butenoic acid, 2-methyl-,(9S,10S)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester, (2Z)-

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25mg
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$69.00   $48.00
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50mg
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$128.00   $89.00
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100mg
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00FEHH
Chemical Name:
2-Butenoic acid, 2-methyl-,(9S,10S)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester, (2Z)-
CAS Number:
73069-27-9
Molecular Formula:
C21H22O7
Molecular Weight:
386.3952
MDL Number:
MFCD23105643
SMILES:
C/C=C(\C(=O)O[C@H]1[C@@H](OC(=O)C)c2c(OC1(C)C)ccc1c2oc(=O)cc1)/C
Properties
Computed Properties
 
Complexity:
720  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Rotatable Bond Count:
5  
XLogP3:
3.1  

Literature

Title: Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry.

Journal: Archives of pharmacal research 20110801

Title: Praeruptorin A inhibits lipopolysaccharide-induced inflammatory response in murine macrophages through inhibition of NF-κB pathway activation.

Journal: Phytotherapy research : PTR 20110401

Title: Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110101

Title: CAR-mediated up-regulation of CYP3A4 expression in LS174T cells by Chinese herbal compounds.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Chemopreventive effects of Peucedanum praeruptorum DUNN and its major constituents on SGC7901 gastric cancer cells.

Journal: Molecules (Basel, Switzerland) 20101109

Title: Liquid chromatography tandem mass spectrometry pharmacokinetic study of DL-praeruptorin A in rat plasma.

Journal: Biomedical chromatography : BMC 20101101

Title: (+/-)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis.

Journal: Chemico-biological interactions 20100730

Title: [Extraction of praeruptorin A from Radix Peucedani by supercritical fluid extraction-CO2].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20081201

Title: (+/-)-3'-O, 4'-O-dicynnamoyl-cis-khellactone, a derivative of (+/-)-praeruptorin A, reverses P-glycoprotein mediated multidrug resistance in cancer cells.

Journal: Bioorganic & medicinal chemistry 20061101

Title: Effects of dl-praeruptorin A on nucleus factor-kappaB and tumor necrosis factor-alpha expression in ischemia-reperfusion hearts.

Journal: Acta pharmacologica Sinica 20040101

Title: [Semi-synthesis of derivatives with C-3' and C-4' trans-configuration from (+)-praeruptorin A].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030501

Title: Effect of dl-praeruptorin A on ATP sensitive potassium channels in human cortical neurons.

Journal: Acta pharmacologica Sinica 20010901

Title: Isolation of praeruptorins A and B from Peucedanum praeruptorum Dunn. and their general pharmacological evaluation in comparison with extracts of the drug.

Journal: Farmaco (Societa chimica italiana : 1989) 20010101

Title: Zhou X, et al. Effects of praeruptorin A and praeruptorin C, a racemate isolated from Peucedanum praeruptorum, on MRP2 through the CAR pathway. Planta Med. 2013 Nov;79(17):1641-7.

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Tags:73069-27-9 Molecular Formula|73069-27-9 MDL|73069-27-9 SMILES|73069-27-9 2-Butenoic acid, 2-methyl-,(9S,10S)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester, (2Z)-