Title: Cells derived from normal or cancer breast tissue exhibit different growth properties when deprived of arginine.
Journal: Medical oncology (Northwood, London, England) 20121201
Title: HuR-mediated posttranscriptional regulation of p21 is involved in the effect of Glycyrrhiza uralensis licorice aqueous extract on polyamine-depleted intestinal crypt cells proliferation.
Journal: The Journal of nutritional biochemistry 20121001
Title: Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis.
Journal: American journal of physiology. Cell physiology 20120701
Title: Inhibition of ornithine decarboxylase alters the roscovitine-induced mitochondrial-mediated apoptosis in MCF-7 breast cancer cells.
Journal: Molecular medicine reports 20120501
Title: Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.
Journal: PLoS neglected tropical diseases 20120501
Title: Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis.
Journal: PLoS genetics 20120301
Title: Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells.
Journal: Amino acids 20120201
Title: Biochemical, mutational and in silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica.
Journal: PLoS neglected tropical diseases 20120201
Title: The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries.
Journal: PloS one 20120101
Title: Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion.
Journal: Cancer cell international 20120101
Title: [Analysis of oncogenic signaling pathway induced by a myeloproliferative neoplasm-associated Janus kinase 2 (JAK2) V617F mutant].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101
Title: A prolonged and exaggerated wound response with elevated ODC activity mimics early tumor development.
Journal: Carcinogenesis 20110901
Title: The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.
Journal: Journal of medicinal chemistry 20110714
Title: Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation.
Journal: American journal of physiology. Endocrinology and metabolism 20110701
Title: Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20110701
Title: SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
Journal: PLoS neglected tropical diseases 20110601
Title: Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma?
Journal: European journal of clinical pharmacology 20110501
Title: Studies on cell migration model in intestinal epithelial restitution for pharmacological research.
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501
Title: A pro-survival effect of polyamine depletion on norepinephrine-mediated apoptosis in cardiac cells: role of signaling enzymes.
Journal: Amino acids 20110401
Title: Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice.
Journal: Molecular and biochemical parasitology 20110401
Title: Polyamines are implicated in the emergence of the embryo from obligate diapause.
Journal: Endocrinology 20110401
Title: Elevated epidermal ornithine decarboxylase activity suppresses contact hypersensitivity.
Journal: The Journal of investigative dermatology 20110101
Title: Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.
Journal: PloS one 20110101
Title: Clinical trials update: Tertiary prevention of colorectal cancer.
Journal: Journal of carcinogenesis 20110101
Title: Oral carcinogenesis and oral cancer chemoprevention: a review.
Journal: Pathology research international 20110101
Title: Perspective: Chemoprevention of colorectal neoplasia: Translating scientific promise into clinical practice.
Journal: Journal of carcinogenesis 20110101
Title: Trypanosome prereplication machinery: a potential new target for an old problem.
Journal: Enzyme research 20110101
Title: Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma.
Journal: Arzneimittel-Forschung 20110101
Title: Pathobiology and chemoprevention of bladder cancer.
Journal: Journal of oncology 20110101
Title: The mechanisms by which polyamines accelerate tumor spread.
Journal: Journal of experimental & clinical cancer research : CR 20110101
Title: Cellular diamine levels in cancer chemoprevention: modulation by ibuprofen and membrane plasmalogens.
Journal: Lipids in health and disease 20110101
Title: Use of antimony in the treatment of leishmaniasis: current status and future directions.
Journal: Molecular biology international 20110101
Title: Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model.
Journal: PloS one 20110101
Title: MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP).
Journal: BMC medical imaging 20110101
Title: Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial.
Journal: Journal of the National Cancer Institute 20101215
Title: Synthesis and bioevaluation of aryl-guanidino polyamine conjugates targeting the polyamine transporter.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.
Journal: Gastroenterology 20101101
Title: Use of transgenic mice as models for prostate cancer chemoprevention.
Journal: Current molecular medicine 20101101
Title: A molecular mechanism for eflornithine resistance in African trypanosomes.
Journal: PLoS pathogens 20101101
Title: Polyamine biosynthesis in Phytomonas: biochemical characterisation of a very unstable ornithine decarboxylase.
Journal: International journal for parasitology 20101001
Title: Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells.
Journal: Experimental cell research 20101001
Title: The early history of polyamine research.
Journal: Plant physiology and biochemistry : PPB 20100701
Title: Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.
Journal: Journal of cellular and molecular medicine 20100601
Title: Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer.
Journal: Anticancer research 20100601
Title: Nonsurgical innovations in the treatment of nonmelanoma skin cancer.
Journal: The Journal of clinical and aesthetic dermatology 20100601
Title: Suppression of exogenous gene expression by spermidine/spermine N1-acetyltransferase 1 (SSAT1) cotransfection.
Journal: The Journal of biological chemistry 20100514
Title: The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation.
Journal: The Journal of biological chemistry 20100423
Title: A simplified method for quantifying cell migration/wound healing in 96-well plates.
Journal: Journal of biomolecular screening 20100401
Title: Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity.
Journal: Amino acids 20100201
Title: Difluoromethylornithine inhibits hypertrophic, pro-fibrotic and pro-apoptotic actions of aldosterone in cardiac cells.
Journal: Amino acids 20100201
Title: Novel convenient synthesis of biologically active esters of hydroxylamine.
Journal: Amino acids 20100201
Title: Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum.
Journal: Amino acids 20100201
Title: Overexpression of ornithine decarboxylase increases myogenic potential of H9c2 rat myoblasts.
Journal: Amino acids 20100201
Title: A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.
Journal: Cancer prevention research (Philadelphia, Pa.) 20100101
Title: Downregulation of the ornithine decarboxylase/polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the NO/cGMP-dependent protein kinase type-I pathway.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.
Journal: BMC systems biology 20100101
Title: Polyamines are present in mast cell secretory granules and are important for granule homeostasis.
Journal: PloS one 20100101
Title: Role of β-adrenoceptors, cAMP phosphodiesterase and external Ca2+ on polyamine-induced relaxation in isolated bovine tracheal strips.
Journal: Pharmacological reports : PR 20100101
Title: Conversion of protocorm-like bodies of Dendrobium huoshanense to shoots: the role of polyamines in relation to the ratio of total cytokinins and indole-3-acetic acid.
Journal: Journal of plant physiology 20091215
Title: S-Nitrosylation of secreted recombinant human glypican-1.
Journal: Glycoconjugate journal 20091201
Title: Involvement of the ornithine decarboxylase/polyamine system in precondition-induced cardioprotection through an interaction with PKC in rat hearts.
Journal: Molecular and cellular biochemistry 20091201
Title: Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome.
Journal: American journal of physiology. Cell physiology 20091201
Title: Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway.
Journal: Organic & biomolecular chemistry 20091121
Title: Identification of proteins whose synthesis is preferentially enhanced by polyamines at the level of translation in mammalian cells.
Journal: The international journal of biochemistry & cell biology 20091101
Title: Role of polyamines and cAMP-dependent mechanisms on 5alpha-dihydrotestosterone-elicited functional effects in isolated right atria of rat.
Journal: Journal of cardiovascular pharmacology 20091001
Title: Polyamines affect histamine synthesis during early stages of IL-3-induced bone marrow cell differentiation.
Journal: Journal of cellular biochemistry 20090901
Title: RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.
Journal: Eukaryotic cell 20090501
Title: Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells.
Journal: Cellular signalling 20090401
Title: New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
Journal: Journal of medicinal chemistry 20090312
Title: Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats.
Journal: Pharmacology, biochemistry, and behavior 20090301
Title: Effect ofalpha-difluormethylornithine on Anastrepha fraterculus (Diptera, Tephritidae) ovary size.
Journal: Brazilian journal of biology = Revista brasleira de biologia 20090201
Title: Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.
Journal: Cancer research 20090115
Title: Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.
Journal: The Journal of biological chemistry 20090109
Title: Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.
Journal: Cancer letters 20090108
Title: Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol.
Journal: Journal of plant physiology 20090101
Title: The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries.
Journal: British journal of pharmacology 20090101
Title: Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum.
Journal: PloS one 20090101
Title: Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice.
Journal: BMC gastroenterology 20090101
Title: Chemotherapy of human african trypanosomiasis.
Journal: Interdisciplinary perspectives on infectious diseases 20090101
Title: Modulatory role of endogenous androgens on airway smooth muscle tone in isolated guinea-pig and bovine trachea; involvement of beta2-adrenoceptors, the polyamine system and external calcium.
Journal: European journal of pharmacology 20081228
Title: ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.
Journal: Cancer research 20081201
Title: Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.
Journal: Cancer research 20081201
Title: Putrescine modulation of acute activation of the beta-adrenergic system in the left atrium of rat.
Journal: European journal of pharmacology 20081119
Title: Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase.
Journal: Cancer research 20081115
Title: Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells.
Journal: Breast cancer research and treatment 20081101
Title: The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain.
Journal: Journal of neurochemistry 20081101
Title: Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel.
Journal: British journal of cancer 20081007
Title: Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.
Journal: Endocrinology 20081001
Title: Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes.
Journal: PLoS pathogens 20081001
Title: Role of putrescine on androgen-elicited positive inotropism in the left atrium of rats.
Journal: Journal of cardiovascular pharmacology 20080801
Title: The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice.
Journal: PLoS pathogens 20080801
Title: Synthesis and cytotoxic activities of usnic acid derivatives.
Journal: Bioorganic & medicinal chemistry 20080715
Title: Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB.
Journal: Leukemia research 20080701
Title: Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period.
Journal: Endocrinology 20080501
Title: Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Journal: Cancer research 20080401
Title: Synergistic antitumor effects of anthracenylmethyl homospermidine and alpha-difluoromethylornithine on promyelocytic leukemia HL60 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080301
Title: Polyamine metabolism during sclerotial development of Sclerotinia sclerotiorum.
Journal: Mycological research 20080301
Title: Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips.
Journal: Acta biologica Hungarica 20080301
Title: Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion.
Journal: Biological chemistry 20080201
Title: Occurrence of agmatine pathway for putrescine synthesis in Selenomonas ruminatium.
Journal: Bioscience, biotechnology, and biochemistry 20080201
Title: Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
Journal: Breast cancer research and treatment 20080101
Title: Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Journal: Breast cancer research and treatment 20080101
Title: Polyamine depletion induces G1 and S phase arrest in human retinoblastoma Y79 cells.
Journal: Cancer cell international 20080101
Title: Comparison of mouse mammary gland imaging techniques and applications: reflectance confocal microscopy, GFP imaging, and ultrasound.
Journal: BMC cancer 20080101
Title: Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme.
Journal: PLoS neglected tropical diseases 20080101
Title: Evidence for impulsivity in the Spontaneously Hypertensive Rat drawn from complementary response-withholding tasks.
Journal: Behavioral and brain functions : BBF 20080101
Title: The role of polyamines in protein-dependent hypoxic tolerance of Drosophila.
Journal: BMC physiology 20080101
Title: EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
Journal: Cellular signalling 20071201
Title: Trypanosoma cruzi as a model system to study the expression of exogenous genes coding for polyamine biosynthetic enzymes. Induction of DFMO resistance in transgenic parasites.
Journal: Biochimica et biophysica acta 20071201
Title: Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
Journal: Carcinogenesis 20071101
Title: Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
Journal: International journal of oncology 20071101
Title: Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Journal: Breast cancer research and treatment 20070901
Title: Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20070901
Title: Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.
Journal: American journal of physiology. Cell physiology 20070801
Title: Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells.
Journal: Amino acids 20070801
Title: Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Journal: Amino acids 20070801
Title: A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
Journal: The Biochemical journal 20070715
Title: p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion.
Journal: American journal of physiology. Cell physiology 20070701
Title: Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels.
Journal: American journal of physiology. Endocrinology and metabolism 20070401
Title: Astroglia growth retardation and increased microglia proliferation by lithium and ornithine decarboxylase inhibitor in rat cerebellar cultures: Cytotoxicity by combined lithium and polyamine inhibition.
Journal: Journal of neuroscience research 20070215
Title: HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.
Journal: Molecular cancer therapeutics 20070201
Title: Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20070101
Title: Polyamines and the intestinal tract.
Journal: Critical reviews in clinical laboratory sciences 20070101
Title: Impact of phase II trials with progression-free survival as end-points on survival-based phase III studies in patients with anaplastic gliomas.
Journal: BMC cancer 20070101
Title: Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox.
Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20061201
Title: Androgens differentially potentiate mouse intestinal smooth muscle by nongenomic activation of polyamine synthesis and Rho kinase activation.
Journal: Endocrinology 20061201
Title: Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda.
Journal: PLoS clinical trials 20061201
Title: Polyamines, PI(4,5)P2, and actin polymerization.
Journal: Journal of cellular physiology 20061101
Title: Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors.
Journal: Molecular cancer therapeutics 20061101
Title: Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide.
Journal: Nitric oxide : biology and chemistry 20060901
Title: Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region.
Journal: The Biochemical journal 20060901
Title: Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20060901
Title: Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs.
Journal: The Journal of biological chemistry 20060714
Title: Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia.
Journal: Journal of molecular and cellular cardiology 20060601
Title: The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia.
Journal: Peptides 20060401
Title: alpha-Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo-prevention.
Journal: International journal of dermatology 20060401
Title: Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2.
Journal: Apoptosis : an international journal on programmed cell death 20060301
Title: Role of polyamines derived from arginine in differentiation and proliferation of human blood cells.
Journal: Biological & pharmaceutical bulletin 20060201
Title: Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha.
Journal: Journal of cellular physiology 20060101
Title: Induction of apoptotic cell death by putrescine.
Journal: The international journal of biochemistry & cell biology 20060101
Title: Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.
Journal: Oncology 20060101
Title: Changes in skeletal muscle gene expression following clenbuterol administration.
Journal: BMC genomics 20060101
Title: Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
Journal: Cancer research 20051201
Title: [Effect of alpha-difluoromethylornithine and polyhexamethyleneguanidine (PMG), polyamine biosynthesis inhibitors on leucosis L1210 growth kinetics and life expectancy of animals with cancer].
Journal: Likars'ka sprava 20051201
Title: [Effect of alpha-difluoromethylornithine on the expression of ODC mRNA in the cortex and hippocampus in rats after cerebral ischemia reperfusion].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20051001
Title: Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells.
Journal: The Journal of biological chemistry 20050902
Title: Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha.
Journal: Journal of cellular physiology 20050901
Title: Polyamine depletion inhibits irradiation-induced apoptosis in intestinal epithelia.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20050901
Title: Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells.
Journal: American journal of physiology. Cell physiology 20050901
Title: Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells.
Journal: Stem cells (Dayton, Ohio) 20050801
Title: Regulation of apoptosis signal-regulating kinase 1 (ASK1) by polyamine levels via protein phosphatase 5.
Journal: The Journal of biological chemistry 20050708
Title: Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes.
Journal: Differentiation; research in biological diversity 20050701
Title: Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20050601
Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.
Journal: Chemical research in toxicology 20050601
Title: B23 is a downstream target of polyamine-modulated CK2.
Journal: Molecular and cellular biochemistry 20050601
Title: Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats.
Journal: Journal of hypertension 20050501
Title: Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells.
Journal: Kidney international 20050501
Title: Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion.
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050501
Title: Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity.
Journal: The Journal of biological chemistry 20050415
Title: Expression of arginine decarboxylase and ornithine decarboxylase genes in apple cells and stressed shoots.
Journal: Journal of experimental botany 20050401
Title: Molecular mechanisms of polyamine analogs in cancer cells.
Journal: Anti-cancer drugs 20050301
Title: Depletion of polyamines and increase of transforming growth factor-beta1, c-myc, collagen-type I, matrix metalloproteinase-1, and metalloproteinase-2 mRNA in primary human gingival fibroblasts.
Journal: Journal of periodontology 20050301
Title: Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.
Journal: The Journal of biological chemistry 20050204
Title: Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization.
Journal: Endocrinology 20050201
Title: Polyamine transport in parasites: a potential target for new antiparasitic drug development.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050201
Title: Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis.
Journal: Cancer research 20050115
Title: Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation.
Journal: American journal of physiology. Cell physiology 20050101
Title: Polyamines modulate carcinogen-induced mutagenesis in vivo.
Journal: Environmental and molecular mutagenesis 20050101
Title: Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells.
Journal: BMC cancer 20050101
Title: Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
Journal: Clinical & experimental metastasis 20050101
Title: Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment.
Journal: Breast cancer research : BCR 20050101
Title: Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Journal: Clinical & experimental metastasis 20050101
Title: Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo.
Journal: International journal of oncology 20041201
Title: Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine.
Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20041101
Title: Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors.
Journal: Carcinogenesis 20041001
Title: Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts.
Journal: Amino acids 20041001
Title: Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases.
Journal: The Journal of biological chemistry 20040820
Title: Protective role of arginase in a mouse model of colitis.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040801
Title: Inhibitors of polyamine metabolism: review article.
Journal: Amino acids 20040701
Title: Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
Journal: The Journal of biological chemistry 20040625
Title: Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion.
Journal: The Journal of biological chemistry 20040521
Title: NF-kappaB-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion.
Journal: American journal of physiology. Cell physiology 20040501
Title: The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells.
Journal: Molecular carcinogenesis 20040401
Title: Synthesis of a novel nitroimidazole-spermidine derivative as a tumor-targeted hypoxia-selective cytotoxin.
Journal: Bioorganic & medicinal chemistry letters 20040322
Title: Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice.
Journal: The Journal of clinical investigation 20040315
Title: Prevention of TNF-alpha-induced apoptosis in polyamine-depleted IEC-6 cells is mediated through the activation of ERK1/2.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20040301
Title: The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas.
Journal: American journal of obstetrics and gynecology 20040301
Title: A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells.
Journal: Toxicology and applied pharmacology 20040215
Title: Ornithine and arginine decarboxylase activities and effect of some polyamine biosynthesis inhibitors on Gigaspora rosea germinating spores.
Journal: FEMS microbiology letters 20040115
Title: Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
Journal: Clinical & experimental metastasis 20040101
Title: Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201
Title: Ornithine decarboxylase activity in in vivo and in vitro models of cerebral ischemia.
Journal: Neurochemical research 20031201
Title: Defining the molecular requirements for the selective delivery of polyamine conjugates into cells containing active polyamine transporters.
Journal: Journal of medicinal chemistry 20031120
Title: Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines.
Journal: American journal of physiology. Cell physiology 20031101
Title: Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20031101
Title: Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20031101
Title: Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation.
Journal: Experimental cell research 20031101
Title: Alpha-difluoromethylornithine, ornithine decarboxylase inhibitor, antagonizes H2O2-induced cytotoxicity in HL-60 leukemia cells: regulation of iron-dependent lysosomal damage.
Journal: Cell biology and toxicology 20031101
Title: Modulation by alpha-difluoromethyl-ornithine and aminoguanidine of pain threshold, morphine analgesia and tolerance.
Journal: European journal of pharmacology 20031008
Title: Antimalarial effect of agmatine on Plasmodium berghei K173 strain.
Journal: Acta pharmacologica Sinica 20030901
Title: Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood.
Journal: Brain research 20030815
Title: The opposing effects of endothelin-1 and C-type natriuretic peptide on apoptosis of neonatal rat cardiac myocytes.
Journal: European journal of pharmacology 20030801
Title: Induction of hypersensitive cell death by hydrogen peroxide produced through polyamine degradation in tobacco plants.
Journal: Plant physiology 20030801
Title: Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis.
Journal: Cancer research 20030715
Title: Molecular requirements for targeting the polyamine transport system. Synthesis and biological evaluation of polyamine-anthracene conjugates.
Journal: Journal of medicinal chemistry 20030619
Title: Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Journal: Cancer research 20030615
Title: X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility.
Journal: The Journal of biological chemistry 20030613
Title: Biomarkers and their use in cervical cancer chemoprevention.
Journal: Critical reviews in oncology/hematology 20030601
Title: Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity.
Journal: Oncogene 20030501
Title: The requirement for polyamines for intestinal epithelial cell migration is mediated through Rac1.
Journal: The Journal of biological chemistry 20030411
Title: Polyamines as modifiers of genetic risk factors in human intestinal cancers.
Journal: Biochemical Society transactions 20030401
Title: Polyamine analogues as anticancer drugs.
Journal: Biochemical Society transactions 20030401
Title: Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.
Journal: BMC cancer 20030101
Title: Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries.
Journal: Plant physiology 20030101
Title: Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis.
Journal: BMC microbiology 20030101
Title: Suramin selectively inhibits carcinoma cell growth that is dependent on extracellular polyamines.
Journal: Anticancer research 20030101
Title: Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice.
Journal: Clinical & experimental metastasis 20030101
Title: Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat.
Journal: Life sciences 20021227
Title: Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.
Journal: Carcinogenesis 20021201
Title: Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line.
Journal: Cancer research 20021115
Title: Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine.
Journal: Journal of medicinal chemistry 20021107
Title: Why phase II trials in cervical chemoprevention are negative: what have we learned?
Journal: Cancer causes & control : CCC 20021101
Title: A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021001
Title: Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion.
Journal: FEBS letters 20020911
Title: Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migration.
Journal: American journal of physiology. Cell physiology 20020901
Title: Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents.
Journal: Carcinogenesis 20020901
Title: JunD stabilization results in inhibition of normal intestinal epithelial cell growth through P21 after polyamine depletion.
Journal: Gastroenterology 20020901
Title: Effect of polyamine depletion on cone photoreceptors of the developing rabbit retina.
Journal: Investigative ophthalmology & visual science 20020901
Title: Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP.
Journal: Nitric oxide : biology and chemistry 20020901
Title: Polyamine-mediated post-transcriptional regulation of COX-2.
Journal: Biochimie 20020801
Title: Entamoeba histolytica: purification and characterization of ornithine decarboxylase.
Journal: Experimental parasitology 20020801
Title: [Effect of alpha-difluoromethylornithine on growth characteristics and expression of ALT-04ag gene of human lung carcinoma cells].
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020801
Title: Stress-induced dynamic changes in mouse brain polyamines. Role in behavioral reactivity.
Journal: Brain research 20020705
Title: Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205.
Journal: Molecular endocrinology (Baltimore, Md.) 20020701
Title: RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion.
Journal: Gastroenterology 20020701
Title: Polyamine depletion prevents camptothecin-induced apoptosis by inhibiting the release of cytochrome c.
Journal: American journal of physiology. Cell physiology 20020601
Title: Are polyamines involved in olfaction? An EAG and biochemical study in Periplaneta americana antennae.
Journal: Chemical senses 20020601
Title: Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.
Journal: Oncogene 20020516
Title: Effect of non-steroidal anti-inflammatory drugs on colon carcinoma Caco-2 cell responsiveness to topoisomerase inhibitor drugs.
Journal: British journal of cancer 20020506
Title: The preovulatory rise of ovarian ornithine decarboxylase is required for progesterone secretion by the corpus luteum.
Journal: Biochemical and biophysical research communications 20020426
Title: Quantitation of polyamines in hypothalamus and pituitary of female and male developing rats.
Journal: Neuroscience letters 20020419
Title: Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats.
Journal: Experimental biology and medicine (Maywood, N.J.) 20020401
Title: Plating densities, alpha-difluoromethylornithine effects and time dependence on the proliferation of IEC-6 cells.
Journal: Chinese medical journal 20020401
Title: Inhibition of placental ornithine decarboxylase by DL-alpha-difluoro-methyl ornithine causes fetal growth restriction in rat.
Journal: Life sciences 20020208
Title: Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition.
Journal: Biochimica et biophysica acta 20020130
Title: Activities of arginase I and II are limiting for endothelial cell proliferation.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020101
Title: Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.
Journal: Cancer research 20020101
Title: Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells.
Journal: Clinical & experimental metastasis 20020101
Title: Effects of insulin-like growth factor I on growth and polyamine metabolism in various organs in rats.
Journal: Digestion 20020101
Title: Cancer therapy and prevention by green tea: role of ornithine decarboxylase.
Journal: Amino acids 20020101
Title: Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells.
Journal: The Journal of biological chemistry 20011207
Title: The effect of polyamine biosynthesis inhibition on growth and differentiation of the phytopathogenic fungus Sclerotinia sclerotiorum.
Journal: Antonie van Leeuwenhoek 20011201
Title: No alterations in the performance of two interval timing operant tasks after alpha-difluoromethylornithine (DFMO)-induced cerebellar stunting.
Journal: Behavioural brain research 20011129
Title: Spermidine is essential for normal proliferation of trypanosomatid protozoa.
Journal: FEBS letters 20011123
Title: Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.
Journal: Cancer research 20011101
Title: Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines.
Journal: Carcinogenesis 20011101
Title: The effect of DFMO induced uptake of [3H] putrescine on human glioma cells.
Journal: Journal of neuro-oncology 20011101
Title: Down-modulation of c-myc expression by phorbol ester protects CEM T leukaemia cells from starvation-induced apoptosis: role of ornithine decarboxylase and polyamines.
Journal: Cell death and differentiation 20011001
Title: Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation.
Journal: American journal of physiology. Cell physiology 20010901
Title: A definitive role of ornithine decarboxylase in photocarcinogenesis.
Journal: The American journal of pathology 20010901
Title: Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20010701
Title: Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture.
Journal: Breast cancer research and treatment 20010701
Title: Increases in ornithine decarboxylase activity in the positive inotropism induced by androgens in isolated left atrium of the rat.
Journal: European journal of pharmacology 20010622
Title: A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line.
Journal: Biochemical pharmacology 20010601
Title: Polyamines: new cues in cellular signal transduction.
Journal: News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 20010601
Title: NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20010501
Title: Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration.
Journal: American journal of physiology. Cell physiology 20010401
Title: Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.
Journal: The Biochemical journal 20010401
Title: Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010301
Title: Transforming growth factor-beta(1) stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis.
Journal: Circulation 20010227
Title: p53 independent G(1) arrest induced by DL-alpha-difluoromethylornithine.
Journal: Biochemical and biophysical research communications 20010126
Title: Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial.
Journal: Journal of the National Cancer Institute 20010103
Title: Colorectal cancer chemoprevention: biochemical targets and clinical development of promising agents.
Journal: European journal of cancer (Oxford, England : 1990) 20010101
Title: Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi.
Journal: The Journal of eukaryotic microbiology 20010101
Title: Qu N, et al. Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J. 2003 Oct 15;375(Pt 2):465-70.
Title: Jansson-Löfmark R, et al. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Antimicrob Agents Chemother. 2015 Feb;59(2):1299-307.
