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96020-91-6,MFCD00242734
Catalog No.:AA005VXI

96020-91-6 | Eflornithine hydrochloride hydrate

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1mg
98%
in stock  
$6.00   $4.00
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50mg
98%
in stock  
$8.00   $6.00
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100mg
98%
in stock  
$15.00   $11.00
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1g
98%
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$65.00   $46.00
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5g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005VXI
Chemical Name:
Eflornithine hydrochloride hydrate
CAS Number:
96020-91-6
Molecular Formula:
C6H15ClF2N2O3
Molecular Weight:
236.6447
MDL Number:
MFCD00242734
SMILES:
NCCCC(C(=O)O)(C(F)F)N.O.Cl
Properties
Properties
 
Form:
Solid  
MP:
>210°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
166  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20150415

Title: Cells derived from normal or cancer breast tissue exhibit different growth properties when deprived of arginine.

Journal: Medical oncology (Northwood, London, England) 20121201

Title: HuR-mediated posttranscriptional regulation of p21 is involved in the effect of Glycyrrhiza uralensis licorice aqueous extract on polyamine-depleted intestinal crypt cells proliferation.

Journal: The Journal of nutritional biochemistry 20121001

Title: Topical eflornithine hydrochloride improves the effectiveness of standard laser hair removal for treating pseudofolliculitis barbae: a randomized, double-blinded, placebo-controlled trial.

Journal: Journal of the American Academy of Dermatology 20121001

Title: Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas.

Journal: Cancer causes & control : CCC 20121001

Title: Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis.

Journal: American journal of physiology. Cell physiology 20120701

Title: The investigation and management of hirsutism.

Journal: The journal of family planning and reproductive health care 20120701

Title: Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis.

Journal: Parasitology 20120601

Title: Combination chemoprevention: future direction of colorectal cancer prevention.

Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20120501

Title: Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

Journal: PLoS neglected tropical diseases 20120501

Title: The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine.

Journal: British journal of pharmacology 20120401

Title: Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts.

Journal: Biochimica et biophysica acta 20120401

Title: Ribonuclease activity of p53 in cytoplasm in response to various stress signals.

Journal: Cell cycle (Georgetown, Tex.) 20120401

Title: Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.

Journal: The Biochemical journal 20120315

Title: High-throughput decoding of antitrypanosomal drug efficacy and resistance.

Journal: Nature 20120125

Title: Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats.

Journal: Pharmacology, biochemistry, and behavior 20120101

Title: Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20120101

Title: The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries.

Journal: PloS one 20120101

Title: [Analysis of oncogenic signaling pathway induced by a myeloproliferative neoplasm-associated Janus kinase 2 (JAK2) V617F mutant].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101

Title: Vulnerability of the retinal microvasculature to hypoxia: role of polyamine-regulated K(ATP) channels.

Journal: Investigative ophthalmology & visual science 20111201

Title: In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.

Journal: Phytochemistry 20111101

Title: Nonmelanoma skin cancer chemoprevention.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20111101

Title: [Congenital human African trypanosomiasis: an observation at the University Hospital of Brazzaville (Congo)].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20111001

Title: Drug resistance in human African trypanosomiasis.

Journal: Future microbiology 20110901

Title: Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design.

Journal: Journal of medicinal chemistry 20110811

Title: Role of peripheral polyamines in the development of inflammatory pain.

Journal: Biochemical pharmacology 20110801

Title: Target repurposing for neglected diseases.

Journal: Future medicinal chemistry 20110801

Title: DFMO: targeted risk reduction therapy for colorectal neoplasia.

Journal: Best practice & research. Clinical gastroenterology 20110801

Title: Reversal of difluoromethylornithine effects by the administration of putrescine in rats.

Journal: JPMA. The Journal of the Pakistan Medical Association 20110801

Title: The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.

Journal: Journal of medicinal chemistry 20110714

Title: Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.

Journal: Cancer prevention research (Philadelphia, Pa.) 20110701

Title: Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20110701

Title: Biomarkers in exploring the frontiers of diagnosis, prognosis, and therapy of Barrett's esophagus.

Journal: Cancer prevention research (Philadelphia, Pa.) 20110601

Title: Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia.

Journal: Cancer prevention research (Philadelphia, Pa.) 20110601

Title: Studies on cell migration model in intestinal epithelial restitution for pharmacological research.

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

Title: A pro-survival effect of polyamine depletion on norepinephrine-mediated apoptosis in cardiac cells: role of signaling enzymes.

Journal: Amino acids 20110401

Title: Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice.

Journal: Molecular and biochemical parasitology 20110401

Title: [Nifurtimox, a bright future for treatment of Chagas disease].

Journal: Medecine tropicale : revue du Corps de sante colonial 20110401

Title: Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.

Journal: Molecular and biochemical parasitology 20110301

Title: New agents for prevention of ultraviolet-induced nonmelanoma skin cancer.

Journal: Seminars in cutaneous medicine and surgery 20110301

Title: Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.

Journal: Molecular and biochemical parasitology 20110101

Title: Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.

Journal: PloS one 20110101

Title: Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma.

Journal: Arzneimittel-Forschung 20110101

Title: Repeated agmatine treatment attenuates nicotine sensitization in mice: modulation by alpha2-adrenoceptors.

Journal: Behavioural brain research 20101201

Title: Potential new drugs for human African trypanosomiasis: some progress at last.

Journal: Current opinion in infectious diseases 20101201

Title: Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.

Journal: Carcinogenesis 20101101

Title: Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.

Journal: Anti-cancer drugs 20101101

Title: [Pseudofolliculitis barbae].

Journal: Actas dermo-sifiliograficas 20101101

Title: A molecular mechanism for eflornithine resistance in African trypanosomes.

Journal: PLoS pathogens 20101101

Title: Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients.

Journal: Journal of the National Cancer Institute 20101006

Title: Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells.

Journal: Experimental cell research 20101001

Title: Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.

Journal: Gastroenterology 20101001

Title: Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma.

Journal: Gastroenterology 20100901

Title: Polyamines and hair: a couple in search of perfection.

Journal: Experimental dermatology 20100901

Title: Smoothened antagonists for hair inhibition.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: Chemotherapy for second-stage Human African trypanosomiasis.

Journal: The Cochrane database of systematic reviews 20100804

Title: Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100801

Title: Best practice options for hair removal in patients with unwanted facial hair using combination therapy with laser: guidelines drawn up by an expert working group.

Journal: Dermatology (Basel, Switzerland) 20100801

Title: Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats.

Journal: European journal of pharmacology 20100710

Title: Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-L-cysteine and liquid chromatography with UV detection.

Journal: Biomedical chromatography : BMC 20100701

Title: Comprehensive clinical management of hirsutism.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100701

Title: Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

Journal: Journal of cellular and molecular medicine 20100601

Title: Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer.

Journal: Anticancer research 20100601

Title: NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness.

Journal: PLoS neglected tropical diseases 20100501

Title: The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation.

Journal: The Journal of biological chemistry 20100423

Title: Late-stage human African trypanosomiasis in a Sudanese refugee.

Journal: The Medical journal of Australia 20100405

Title: Hirsutism: Diagnosis and management.

Journal: Gender medicine 20100401

Title: Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture.

Journal: Experimental dermatology 20100301

Title: Difluoromethylornithine inhibits hypertrophic, pro-fibrotic and pro-apoptotic actions of aldosterone in cardiac cells.

Journal: Amino acids 20100201

Title: Computed tomographic features of oral squamous cell carcinoma in cats: 18 cases (2002-2008).

Journal: Journal of the American Veterinary Medical Association 20100201

Title: [Human African trypanosomiasis: description of two pediatric cases in Yaoundé, Cameroon].

Journal: Medecine tropicale : revue du Corps de sante colonial 20100201

Title: Human African trypanosomiasis.

Journal: Lancet (London, England) 20100109

Title: Killer coma: the evolving story of sleeping sickness treatment.

Journal: Lancet (London, England) 20100109

Title: Fever of unknown origin in an infant with an unexpected blood film report: a case report.

Journal: Rural and remote health 20100101

Title: A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.

Journal: Cancer prevention research (Philadelphia, Pa.) 20100101

Title: A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.

Journal: PLoS neglected tropical diseases 20100101

Title: Effects of oral administration of synthesized delta-amides of eflornithine in the rat.

Journal: Arzneimittel-Forschung 20100101

Title: Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue.

Journal: World journal of urology 20091201

Title: S-Nitrosylation of secreted recombinant human glypican-1.

Journal: Glycoconjugate journal 20091201

Title: Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome.

Journal: American journal of physiology. Cell physiology 20091201

Title: Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry.

Journal: Analytical and quantitative cytology and histology 20091201

Title: Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway.

Journal: Organic & biomolecular chemistry 20091121

Title: Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention.

Journal: Essays in biochemistry 20091104

Title: Identification of proteins whose synthesis is preferentially enhanced by polyamines at the level of translation in mammalian cells.

Journal: The international journal of biochemistry & cell biology 20091101

Title: Inner ear protection and regeneration: a 'historical' perspective.

Journal: Current opinion in otolaryngology & head and neck surgery 20091001

Title: Role of polyamines and cAMP-dependent mechanisms on 5alpha-dihydrotestosterone-elicited functional effects in isolated right atria of rat.

Journal: Journal of cardiovascular pharmacology 20091001

Title: Nutrition and colon cancer prevention.

Journal: Current opinion in clinical nutrition and metabolic care 20090901

Title: Hirsutism.

Journal: BMJ (Clinical research ed.) 20090828

Title: Recent advances in the development of polyamine analogues as antitumor agents.

Journal: Journal of medicinal chemistry 20090813

Title: The change of antizyme inhibitor expression and its possible role during mammalian cell cycle.

Journal: Experimental cell research 20090801

Title: Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats.

Journal: Neuroscience 20090707

Title: Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.

Journal: Lancet (London, England) 20090704

Title: NECT trial: more than a small victory over sleeping sickness.

Journal: Lancet (London, England) 20090704

Title: Green tea extract: a novel addition to the antihirsutism armamentarium?

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20090701

Title: Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.

Journal: The Journal of pharmacology and experimental therapeutics 20090601

Title: Magnetic resonance imaging findings in human African trypanosomiasis: a four-year follow-up study in a patient and review of the literature.

Journal: The American journal of tropical medicine and hygiene 20090601

Title: Functional K(ATP) channels in the rat retinal microvasculature: topographical distribution, redox regulation, spermine modulation and diabetic alteration.

Journal: The Journal of physiology 20090515

Title: Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor.

Journal: Journal of medicinal chemistry 20090409

Title: Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function.

Journal: American journal of physiology. Cell physiology 20090401

Title: Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome.

Journal: Oncology reports 20090401

Title: Off-label use of approved drugs.

Journal: Nature reviews. Clinical oncology 20090401

Title: Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.

Journal: Bioorganic & medicinal chemistry 20090315

Title: Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20090301

Title: Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats.

Journal: Pharmacology, biochemistry, and behavior 20090301

Title: Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas.

Journal: Cancer prevention research (Philadelphia, Pa.) 20090301

Title: Effect ofalpha-difluormethylornithine on Anastrepha fraterculus (Diptera, Tephritidae) ovary size.

Journal: Brazilian journal of biology = Revista brasleira de biologia 20090201

Title: Reducing the risk of recurrent colon polyps.

Journal: Clinical advances in hematology & oncology : H&O 20090201

Title: Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.

Journal: Cancer research 20090115

Title: Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.

Journal: The Journal of biological chemistry 20090109

Title: Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.

Journal: Cancer letters 20090108

Title: Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol.

Journal: Journal of plant physiology 20090101

Title: The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries.

Journal: British journal of pharmacology 20090101

Title: [Agents for the treatment of African sleeping sickness. Those developed in the last century].

Journal: Pharmazie in unserer Zeit 20090101

Title: [Molecular functions of polyamines in neoplastic growth and their role in control of the NF-kappaB transcription factor in experimental tumors cells].

Journal: Likars'ka sprava 20090101

Title: Effect of difluoromethylornithine on thyroid function in rats.

Journal: Journal of Ayub Medical College, Abbottabad : JAMC 20090101

Title: Spermine-induced morphogenesis and effect of partial immersion system on the shoot cultures of banana.

Journal: Applied biochemistry and biotechnology 20081201

Title: Polycystic ovary syndrome (PCOS) trilogy: a translational and clinical review.

Journal: Clinical endocrinology 20081201

Title: ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.

Journal: Cancer research 20081201

Title: Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.

Journal: Cancer research 20081201

Title: Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.

Journal: Cancer prevention research (Philadelphia, Pa.) 20081201

Title: Putrescine modulation of acute activation of the beta-adrenergic system in the left atrium of rat.

Journal: European journal of pharmacology 20081119

Title: Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase.

Journal: Cancer research 20081115

Title: Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells.

Journal: Breast cancer research and treatment 20081101

Title: The blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain.

Journal: Journal of neurochemistry 20081101

Title: Chemoprevention of bladder cancer.

Journal: BJU international 20081101

Title: Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt.

Journal: American journal of physiology. Renal physiology 20081001

Title: Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.

Journal: Endocrinology 20081001

Title: Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice.

Journal: Carcinogenesis 20080801

Title: Role of putrescine on androgen-elicited positive inotropism in the left atrium of rats.

Journal: Journal of cardiovascular pharmacology 20080801

Title: Effect of the polyamine analogue N1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes.

Journal: Journal of cellular physiology 20080701

Title: Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target.

Journal: Molecular and biochemical parasitology 20080701

Title: Drugs to prevent colon cancer show promise, but hurdles remain for chemoprevention.

Journal: Journal of the National Cancer Institute 20080604

Title: High-frequency ultrasonic atomization for drug delivery to rodent animal models - optimal particle size for lung inhalation of difluoromethyl ornithine.

Journal: Experimental lung research 20080601

Title: Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial.

Journal: Cancer prevention research (Philadelphia, Pa.) 20080601

Title: Clinical prevention of recurrence of colorectal adenomas by the combination of difluoromethylornithine and sulindac: an important milestone.

Journal: Cancer prevention research (Philadelphia, Pa.) 20080601

Title: Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period.

Journal: Endocrinology 20080501

Title: Making a difference: 30 years of TDR.

Journal: Nature reviews. Microbiology 20080501

Title: Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation.

Journal: International journal of oncology 20080401

Title: African sleeping sickness.

Journal: BMJ (Clinical research ed.) 20080329

Title: Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study.

Journal: BMJ (Clinical research ed.) 20080329

Title: Synergistic antitumor effects of anthracenylmethyl homospermidine and alpha-difluoromethylornithine on promyelocytic leukemia HL60 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080301

Title: Hirsutism.

Journal: International journal of clinical practice 20080301

Title: Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes.

Journal: Journal of cellular biochemistry 20080301

Title: Polyamine metabolism during sclerotial development of Sclerotinia sclerotiorum.

Journal: Mycological research 20080301

Title: Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips.

Journal: Acta biologica Hungarica 20080301

Title: Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and alpha-keto acid homeostasis?

Journal: Amino acids 20080201

Title: Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion.

Journal: Biological chemistry 20080201

Title: The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080201

Title: Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola.

Journal: Tropical medicine & international health : TM & IH 20080201

Title: Idiopathic hirsutism: excessive bodily and facial hair in women.

Journal: British journal of nursing (Mark Allen Publishing) 20080201

Title: Validation of spermidine synthase as a drug target in African trypanosomes.

Journal: The Biochemical journal 20080115

Title: Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.

Journal: Breast cancer research and treatment 20080101

Title: Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.

Journal: Breast cancer research and treatment 20080101

Title: Chemoprevention with special reference to inherited colorectal cancer.

Journal: Familial cancer 20080101

Title: A 4-month, open-label study evaluating the efficacy of eflornithine 11.5% cream in the treatment of unwanted facial hair in women using TrichoScan.

Journal: European journal of dermatology : EJD 20080101

Title: Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme.

Journal: PLoS neglected tropical diseases 20080101

Title: Hypothesis: the potential utility of topical eflornithine against cutaneous leishmaniasis.

Journal: Indian journal of dermatology, venereology and leprology 20080101

Title: Combination chemoprevention of intestinal carcinogenesis in a murine model of familial adenomatous polyposis.

Journal: Nutrition and cancer 20080101

Title: EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.

Journal: Cellular signalling 20071201

Title: Trypanosoma cruzi as a model system to study the expression of exogenous genes coding for polyamine biosynthetic enzymes. Induction of DFMO resistance in transgenic parasites.

Journal: Biochimica et biophysica acta 20071201

Title: Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201

Title: Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201

Title: Sleeping hearts: the role of the heart in sleeping sickness (human African trypanosomiasis).

Journal: Tropical medicine & international health : TM & IH 20071201

Title: Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.

Journal: The Journal of biological chemistry 20071130

Title: Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy.

Journal: International journal of cancer 20071115

Title: Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.

Journal: International journal of oncology 20071101

Title: Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series.

Journal: PLoS neglected tropical diseases 20071101

Title: Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.

Journal: The Journal of biological chemistry 20070914

Title: Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and alpha-keto acid homeostasis or immunocompetence.

Journal: Amino acids 20070901

Title: Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.

Journal: Breast cancer research and treatment 20070901

Title: Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070901

Title: The effect of eflornithine 13.9% cream on the bother and discomfort due to hirsutism.

Journal: International journal of dermatology 20070901

Title: Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention.

Journal: Amino acids 20070801

Title: Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide.

Journal: Amino acids 20070801

Title: Polyamines and mRNA stability in regulation of intestinal mucosal growth.

Journal: Amino acids 20070801

Title: Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential.

Journal: Amino acids 20070801

Title: Kidney growth, hypertrophy and the unifying mechanism of diabetic complications.

Journal: Amino acids 20070801

Title: Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.

Journal: American journal of physiology. Cell physiology 20070801

Title: Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells.

Journal: Amino acids 20070801

Title: Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.

Journal: Amino acids 20070801

Title: Does eflornithine help women face hirsutism?

Journal: Drug and therapeutics bulletin 20070801

Title: A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women.

Journal: Journal of the American Academy of Dermatology 20070701

Title: p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion.

Journal: American journal of physiology. Cell physiology 20070701

Title: Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination.

Journal: International journal of oncology 20070701

Title: Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion.

Journal: The Biochemical journal 20070501

Title: Difluoromethylornithine decreases long-lasting protein oxidation induced by neonatal ethanol exposure in the hippocampus of adolescent rats.

Journal: Alcoholism, clinical and experimental research 20070501

Title: Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts.

Journal: International journal of molecular medicine 20070501

Title: Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels.

Journal: American journal of physiology. Endocrinology and metabolism 20070401

Title: Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models.

Journal: Biochemical Society transactions 20070401

Title: Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent.

Journal: Biochemical Society transactions 20070401

Title: Astroglia growth retardation and increased microglia proliferation by lithium and ornithine decarboxylase inhibitor in rat cerebellar cultures: Cytotoxicity by combined lithium and polyamine inhibition.

Journal: Journal of neuroscience research 20070215

Title: Determination of eflornithine enantiomers in plasma, by solid-phase extraction and liquid chromatography with evaporative light-scattering detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

Title: HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.

Journal: Molecular cancer therapeutics 20070201

Title: Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair.

Journal: International journal of dermatology 20070101

Title: [Characteristics of polyamine biosynthesis regulation and tumor growth rate in hormone-dependant grafted breast tumors of mice and rats].

Journal: Likars'ka sprava 20070101

Title: Eflornithine.

Journal: Indian journal of dermatology, venereology and leprology 20070101

Title: Modulation of cell proliferation and polyamine metabolism in rat liver cell cultures by the iron chelator O-trensox.

Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20061201

Title: Polyamines, PI(4,5)P2, and actin polymerization.

Journal: Journal of cellular physiology 20061101

Title: Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors.

Journal: Molecular cancer therapeutics 20061101

Title: Eflornithine cream combined with laser therapy in the management of unwanted facial hair growth in women: a randomized trial.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20061001

Title: Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo.

Journal: Bulletin of the World Health Organization 20061001

Title: Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo.

Journal: Bulletin of the World Health Organization 20061001

Title: The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase.

Journal: Biochemical pharmacology 20060928

Title: New dimensions in Hirsutism.

Journal: Lasers in medical science 20060901

Title: Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene.

Journal: Life sciences 20060822

Title: Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3.

Journal: The Biochemical journal 20060801

Title: Randomized prospective phase III trial of difluoromethylornithine vs placebo in preventing recurrence of completely resected low risk superficial bladder cancer.

Journal: The Journal of urology 20060801

Title: Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs.

Journal: The Journal of biological chemistry 20060714

Title: Nitric oxide and polyamine pathway-dependent modulation of neutrophil free amino- and alpha-keto acid profiles or host defense capability.

Journal: Amino acids 20060701

Title: In vivo enhancement of herpes simplex virus thymidine kinase/ganciclovir cancer gene therapy with polyamine biosynthesis inhibition.

Journal: International journal of cancer 20060601

Title: Treatment of hirsutism and acne in hyperandrogenism.

Journal: Best practice & research. Clinical endocrinology & metabolism 20060601

Title: Excess salt and pepper hair treated with a combination of laser hair removal and topical eflornithine HCl.

Journal: Journal of drugs in dermatology : JDD 20060601

Title: Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma.

Journal: International journal of cancer 20060501

Title: The rise and fall of sleeping sickness.

Journal: Lancet (London, England) 20060429

Title: Examples of tropical disease control in the humanitarian medical programmes of MSF and Merlin.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20060401

Title: alpha-Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo-prevention.

Journal: International journal of dermatology 20060401

Title: Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.

Journal: The Journal of parasitology 20060401

Title: Role of polyamines derived from arginine in differentiation and proliferation of human blood cells.

Journal: Biological & pharmaceutical bulletin 20060201

Title: Understanding the causes and management of hirsutism.

Journal: Nursing times 20060201

Title: Effect of polyamine homologation on the transport and biological properties of heterocyclic amidines.

Journal: Journal of medicinal chemistry 20060112

Title: Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha.

Journal: Journal of cellular physiology 20060101

Title: Induction of apoptotic cell death by putrescine.

Journal: The international journal of biochemistry & cell biology 20060101

Title: Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.

Journal: Oncology 20060101

Title: STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.

Journal: The Biochemical journal 20051201

Title: Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.

Journal: Cancer research 20051201

Title: Treatments for unwanted facial hair.

Journal: Skin therapy letter 20051201

Title: [Effect of alpha-difluoromethylornithine and polyhexamethyleneguanidine (PMG), polyamine biosynthesis inhibitors on leucosis L1210 growth kinetics and life expectancy of animals with cancer].

Journal: Likars'ka sprava 20051201

Title: Adherence assessment using medication weight in a phase IIb clinical trial of difluoromethylornithine for the chemoprevention of skin cancer.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051101

Title: A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene.

Journal: Annals of the New York Academy of Sciences 20051101

Title: [Effect of alpha-difluoromethylornithine on the expression of ODC mRNA in the cortex and hippocampus in rats after cerebral ischemia reperfusion].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20051001

Title: Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells.

Journal: The Journal of biological chemistry 20050902

Title: Polyamine depletion inhibits irradiation-induced apoptosis in intestinal epithelia.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050901

Title: Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050901

Title: Karyometry in the early detection and chemoprevention of intraepithelial lesions.

Journal: European journal of cancer (Oxford, England : 1990) 20050901

Title: Suppression and regression of choroidal neovascularization by polyamine analogues.

Journal: Investigative ophthalmology & visual science 20050901

Title: Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells.

Journal: Stem cells (Dayton, Ohio) 20050801

Title: Guidance for the management of hirsutism.

Journal: Current medical research and opinion 20050801

Title: Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity.

Journal: Apoptosis : an international journal on programmed cell death 20050801

Title: Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes.

Journal: Differentiation; research in biological diversity 20050701

Title: Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050601

Title: Polyamines protect against radiation-induced oxidative stress.

Journal: Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 20050601

Title: B23 is a downstream target of polyamine-modulated CK2.

Journal: Molecular and cellular biochemistry 20050601

Title: Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors.

Journal: World journal of gastroenterology 20050528

Title: Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons.

Journal: Journal of neurophysiology 20050501

Title: Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats.

Journal: Journal of hypertension 20050501

Title: Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells.

Journal: Kidney international 20050501

Title: Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.

Journal: Cancer cell 20050501

Title: Effect of difluoromethylornithine on reperfusion injury after temporary middle cerebral artery occlusion.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050501

Title: Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity.

Journal: The Journal of biological chemistry 20050415

Title: Molecular mechanisms of polyamine analogs in cancer cells.

Journal: Anti-cancer drugs 20050301

Title: Depletion of polyamines and increase of transforming growth factor-beta1, c-myc, collagen-type I, matrix metalloproteinase-1, and metalloproteinase-2 mRNA in primary human gingival fibroblasts.

Journal: Journal of periodontology 20050301

Title: Independent roles of eIF5A and polyamines in cell proliferation.

Journal: The Biochemical journal 20050201

Title: Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization.

Journal: Endocrinology 20050201

Title: Colorectal cancer prevention: is an ounce of prevention worth a pound of cure?

Journal: Seminars in oncology 20050201

Title: Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis.

Journal: Cancer research 20050115

Title: Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050101

Title: Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.

Journal: Clinical & experimental metastasis 20050101

Title: Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment.

Journal: Breast cancer research : BCR 20050101

Title: Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.

Journal: Clinical & experimental metastasis 20050101

Title: [Key aspects of excessive hair in 2005].

Journal: Annales de dermatologie et de venereologie 20050101

Title: [Eflornithine: evidence of efficacy].

Journal: Annales de dermatologie et de venereologie 20050101

Title: [Vaniqa in daily practice].

Journal: Annales de dermatologie et de venereologie 20050101

Title: [Vaniqa and laser depilation in practice].

Journal: Annales de dermatologie et de venereologie 20050101

Title: Polycystic ovary syndrome (PCOS) in the adolescent patient: recommendations for practice.

Journal: Pediatric nursing 20050101

Title: Lung distribution of the chemopreventive agent difluoromethylornithine (DFMO) following oral and inhalation delivery.

Journal: Experimental lung research 20041201

Title: The role of polyamines in human cancer: prospects for drug combination therapies.

Journal: Hawaii medical journal 20041201

Title: Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20041101

Title: Polyamines regulate eukaryotic initiation factor 4E-binding protein 1 gene transcription.

Journal: Biochemical and biophysical research communications 20041008

Title: Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors.

Journal: Carcinogenesis 20041001

Title: Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts.

Journal: Amino acids 20041001

Title: Polyamines and cancer: old molecules, new understanding.

Journal: Nature reviews. Cancer 20041001

Title: Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells.

Journal: Experimental oncology 20040901

Title: Protective role of arginase in a mouse model of colitis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040801

Title: Polyamine depletion switches the form of 2-deoxy-D-ribose-induced cell death from apoptosis to necrosis in HL-60 cells.

Journal: The international journal of biochemistry & cell biology 20040701

Title: A novel role for polyamines in adult neurogenesis in rodent brain.

Journal: The European journal of neuroscience 20040701

Title: Irreversible ototoxicity associated with difluoromethylornithine.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040701

Title: Inhibitors of polyamine metabolism: review article.

Journal: Amino acids 20040701

Title: Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.

Journal: The Journal of biological chemistry 20040625

Title: The pharmacokinetics of eflornithine (alpha-difluoromethylornithine) in patients with late-stage T.b. gambiense sleeping sickness.

Journal: European journal of clinical pharmacology 20040601

Title: Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.

Journal: European journal of cancer (Oxford, England : 1990) 20040601

Title: Difluoromethylornithine-induced reversible hearing loss across a wide frequency range.

Journal: The Laryngoscope 20040601

Title: Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion.

Journal: The Journal of biological chemistry 20040521

Title: Activation of the Akt/nuclear factor-kappaB signaling axis in developing lung neoplasia.

Journal: Chest 20040501

Title: [Clinical reasoning and decision making in practice. A depressive foreign woman with symptoms of malaise].

Journal: Nederlands tijdschrift voor geneeskunde 20040417

Title: The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells.

Journal: Molecular carcinogenesis 20040401

Title: Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil.

Journal: Cancer research 20040401

Title: Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice.

Journal: The Journal of clinical investigation 20040315

Title: The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas.

Journal: American journal of obstetrics and gynecology 20040301

Title: Possible cases of sexual and congenital transmission of sleeping sickness.

Journal: Lancet (London, England) 20040117

Title: Review article: chemoprevention of colorectal cancer.

Journal: Alimentary pharmacology & therapeutics 20040101

Title: Retaking sleeping sickness control in Angola.

Journal: Tropical medicine & international health : TM & IH 20040101

Title: Developmental treatment with difluoromethylornithine has few effects on behavior or body weight in Sprague-Dawley rats.

Journal: Neurotoxicology and teratology 20040101

Title: Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention.

Journal: Environmental and molecular mutagenesis 20040101

Title: Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.

Journal: Clinical & experimental metastasis 20040101

Title: Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201

Title: Hexachlorobenzene-induced early changes in ornithine decarboxylase and protein tyrosine kinase activities, polyamines and c-Myc, c-Fos and c-Jun proto-oncogenes in rat liver.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031201

Title: [Apoptotic induction of human lung carcinoma A549 cells by DFMO through Fas/FasL pathway].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20031201

Title: A perspective of polyamine metabolism.

Journal: The Biochemical journal 20031115

Title: Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031101

Title: Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031101

Title: Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation.

Journal: Experimental cell research 20031101

Title: Alpha-difluoromethylornithine, ornithine decarboxylase inhibitor, antagonizes H2O2-induced cytotoxicity in HL-60 leukemia cells: regulation of iron-dependent lysosomal damage.

Journal: Cell biology and toxicology 20031101

Title: Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine.

Journal: The Biochemical journal 20031015

Title: Modulation by alpha-difluoromethyl-ornithine and aminoguanidine of pain threshold, morphine analgesia and tolerance.

Journal: European journal of pharmacology 20031008

Title: RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031001

Title: Antimalarial effect of agmatine on Plasmodium berghei K173 strain.

Journal: Acta pharmacologica Sinica 20030901

Title: Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood.

Journal: Brain research 20030815

Title: Lytic infection of pseudorabies virus in the presence of spermine, spermidine, or DFMO.

Journal: Virus research 20030801

Title: The opposing effects of endothelin-1 and C-type natriuretic peptide on apoptosis of neonatal rat cardiac myocytes.

Journal: European journal of pharmacology 20030801

Title: Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis.

Journal: Cancer research 20030715

Title: In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry.

Journal: Cancer research 20030701

Title: Pseudofolliculitis barbae: review and update on new treatment modalities.

Journal: Military medicine 20030701

Title: Barrett's esophagus: chemoprevention.

Journal: Gastrointestinal endoscopy clinics of North America 20030701

Title: Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.

Journal: Cancer research 20030615

Title: Polyamines in cultured rabbit corneal cells.

Journal: Investigative ophthalmology & visual science 20030601

Title: Current chemotherapy of human African trypanosomiasis.

Journal: Parasitology research 20030601

Title: Eflornithine for the treatment of human African trypanosomiasis.

Journal: Parasitology research 20030601

Title: High-performance liquid chromatographic method for determination of 2-difluoromethyl-DL-ornithine in plasma and cerebrospinal fluid.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525

Title: Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity.

Journal: Oncogene 20030501

Title: The evaluation and management of hirsutism.

Journal: Obstetrics and gynecology 20030501

Title: Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.

Journal: Carcinogenesis 20030501

Title: The requirement for polyamines for intestinal epithelial cell migration is mediated through Rac1.

Journal: The Journal of biological chemistry 20030411

Title: Polyamine biosynthesis inhibition enhances HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity in tumor cells.

Journal: International journal of cancer 20030410

Title: Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030301

Title: Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate.

Journal: Gut 20030201

Title: Contribution of spermidine to stimulation by hepatocyte growth factor in repair after damage of rabbit gastric mucosal cells in primary culture.

Journal: Biochimica et biophysica acta 20030120

Title: Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.

Journal: BMC cancer 20030101

Title: Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries.

Journal: Plant physiology 20030101

Title: Comparison of varicella-zoster virus ORF47 protein kinase and casein kinase II and their substrates.

Journal: Journal of medical virology 20030101

Title: Suramin selectively inhibits carcinoma cell growth that is dependent on extracellular polyamines.

Journal: Anticancer research 20030101

Title: Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice.

Journal: Clinical & experimental metastasis 20030101

Title: [Eflornithine in the treatment of African trypanosomiasis].

Journal: Medecine tropicale : revue du Corps de sante colonial 20030101

Title: [The return of sleeping sickness in an epidemic form: international action for drugs].

Journal: Nederlands tijdschrift voor geneeskunde 20021228

Title: Polyamine metabolism as chemotherapeutic target in protozoan parasites.

Journal: Mini reviews in medicinal chemistry 20021201

Title: Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.

Journal: Carcinogenesis 20021201

Title: Removal of unwanted facial hair.

Journal: American family physician 20021115

Title: Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine.

Journal: Journal of medicinal chemistry 20021107

Title: A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021001

Title: Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion.

Journal: FEBS letters 20020911

Title: Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migration.

Journal: American journal of physiology. Cell physiology 20020901

Title: Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents.

Journal: Carcinogenesis 20020901

Title: Effect of polyamine depletion on cone photoreceptors of the developing rabbit retina.

Journal: Investigative ophthalmology & visual science 20020901

Title: Resurrecting the resurrection drug.

Journal: Nature medicine 20020901

Title: Combination of eflornithine and melarsoprol for melarsoprol-resistant Gambian trypanosomiasis.

Journal: Tropical medicine & international health : TM & IH 20020901

Title: Polyamine-mediated post-transcriptional regulation of COX-2.

Journal: Biochimie 20020801

Title: [Effect of alpha-difluoromethylornithine on growth characteristics and expression of ALT-04ag gene of human lung carcinoma cells].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020801

Title: Stress-induced dynamic changes in mouse brain polyamines. Role in behavioral reactivity.

Journal: Brain research 20020705

Title: Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205.

Journal: Molecular endocrinology (Baltimore, Md.) 20020701

Title: RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion.

Journal: Gastroenterology 20020701

Title: Treatment of human African trypanosomiasis--present situation and needs for research and development.

Journal: The Lancet. Infectious diseases 20020701

Title: Polyamine uptake is necessary for a normal biochemical maturation of astrocytes in culture.

Journal: Neuroreport 20020612

Title: Polyamine depletion prevents camptothecin-induced apoptosis by inhibiting the release of cytochrome c.

Journal: American journal of physiology. Cell physiology 20020601

Title: Involvement of polyamines in root development at low temperature in the subantarctic cruciferous species Pringlea antiscorbutica.

Journal: Journal of experimental botany 20020601

Title: Are polyamines involved in olfaction? An EAG and biochemical study in Periplaneta americana antennae.

Journal: Chemical senses 20020601

Title: Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.

Journal: Oncogene 20020516

Title: Effects of difluoromethylornithine on growth inhibition and apoptosis in human cervical epithelial and cancerous cell lines.

Journal: Gynecologic oncology 20020501

Title: Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020501

Title: The preovulatory rise of ovarian ornithine decarboxylase is required for progesterone secretion by the corpus luteum.

Journal: Biochemical and biophysical research communications 20020426

Title: Quantitation of polyamines in hypothalamus and pituitary of female and male developing rats.

Journal: Neuroscience letters 20020419

Title: Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding.

Journal: American journal of physiology. Cell physiology 20020401

Title: Effects of polyamines on the release of gonadotropin-releasing hormone and gonadotropins in developing female rats.

Journal: Experimental biology and medicine (Maywood, N.J.) 20020401

Title: Polyamine-dependent migration of retinal pigment epithelial cells.

Journal: Investigative ophthalmology & visual science 20020401

Title: Plating densities, alpha-difluoromethylornithine effects and time dependence on the proliferation of IEC-6 cells.

Journal: Chinese medical journal 20020401

Title: Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines.

Journal: Clinical science (London, England : 1979) 20020301

Title: Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice.

Journal: Cancer research 20020301

Title: Inhibition of placental ornithine decarboxylase by DL-alpha-difluoro-methyl ornithine causes fetal growth restriction in rat.

Journal: Life sciences 20020208

Title: Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition.

Journal: Biochimica et biophysica acta 20020130

Title: [Chemoprevention of colorectal cancer].

Journal: Presse medicale (Paris, France : 1983) 20020126

Title: Activities of arginase I and II are limiting for endothelial cell proliferation.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020101

Title: Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020101

Title: Chemoprevention of colorectal cancer.

Journal: The American journal of gastroenterology 20020101

Title: The ornithine decarboxylase inhibitor, difluoromethylornithine, inhibits casein kinase II activity, c-Myc expression and normal human keratinocyte proliferation.

Journal: Archives of dermatological research 20020101

Title: Glucocorticoids and polyamine inhibitors synergize to kill human leukemic CEM cells.

Journal: Neoplasia (New York, N.Y.) 20020101

Title: Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells.

Journal: Clinical & experimental metastasis 20020101

Title: Winterbottom's sign and hypertrophic cardiomyopathy.

Journal: Scandinavian journal of infectious diseases 20020101

Title: Chemoprevention of prostate carcinogenesis by DFMO and/or finasteride treatment in male Wistar rats.

Journal: Tumori 20020101

Title: Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells.

Journal: The Journal of biological chemistry 20011207

Title: Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20011201

Title: Eflornithine.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011201

Title: Chemopreventive agents inhibit aberrant proliferation of the aneuploid phenotype in a colon epithelial cell line established from Apc 1638N [+/-] mouse.

Journal: Annals of the New York Academy of Sciences 20011201

Title: Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.

Journal: Annals of the New York Academy of Sciences 20011201

Title: The future of colon cancer prevention.

Journal: Annals of the New York Academy of Sciences 20011201

Title: The effect of polyamine biosynthesis inhibition on growth and differentiation of the phytopathogenic fungus Sclerotinia sclerotiorum.

Journal: Antonie van Leeuwenhoek 20011201

Title: No alterations in the performance of two interval timing operant tasks after alpha-difluoromethylornithine (DFMO)-induced cerebellar stunting.

Journal: Behavioural brain research 20011129

Title: Spermidine is essential for normal proliferation of trypanosomatid protozoa.

Journal: FEBS letters 20011123

Title: The eflornithine story.

Journal: Journal of the American Academy of Dermatology 20011101

Title: Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.

Journal: Cancer research 20011101

Title: Availability and affordability of treatment for Human African Trypanosomiasis.

Journal: Tropical medicine & international health : TM & IH 20011101

Title: Cell culture analysis of the regulatory frameshift event required for the expression of mammalian antizymes.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20011101

Title: [Current treatment of hypertrichosis].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20011101

Title: The effect of DFMO induced uptake of [3H] putrescine on human glioma cells.

Journal: Journal of neuro-oncology 20011101

Title: Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors.

Journal: Journal of medicinal chemistry 20011025

Title: 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice.

Journal: Cancer research 20011015

Title: Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation.

Journal: American journal of physiology. Cell physiology 20010901

Title: Percutaneous absorption and pharmacokinetics of eflornithine HCl 13.9% cream in women with unwanted facial hair.

Journal: Journal of clinical pharmacology 20010901

Title: Cytoskeletal organization and cell motility correlates with metastatic potential and state of differentiation in prostate cancer.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20010901

Title: Measurement of chemopreventive efficacy in skin biopsies.

Journal: Analytical and quantitative cytology and histology 20010801

Title: [Effect of inhibition of polyamine biosynthesis on the growth and telomerase activity of human laryngeal carcinoma cells Hep-2].

Journal: Zhonghua er bi yan hou ke za zhi 20010801

Title: Polyamines regulate gap junction communication in connexin 43-expressing cells.

Journal: The Biochemical journal 20010715

Title: Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010701

Title: Changes in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin-independent rooting model.

Journal: Tree physiology 20010701

Title: Thank God for rich women with mustaches.

Journal: Medicine and health, Rhode Island 20010701

Title: Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture.

Journal: Breast cancer research and treatment 20010701

Title: A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia.

Journal: Archives of internal medicine 20010625

Title: Increases in ornithine decarboxylase activity in the positive inotropism induced by androgens in isolated left atrium of the rat.

Journal: European journal of pharmacology 20010622

Title: A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line.

Journal: Biochemical pharmacology 20010601

Title: Phase I chemoprevention study of difluoromethylornithine in subjects with organ transplants.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010601

Title: NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010501

Title: Transporters in African trypanosomes: role in drug action and resistance.

Journal: International journal for parasitology 20010501

Title: Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501

Title: Effects of difluoromethylornithine chemoprevention on audiometry thresholds and otoacoustic emissions.

Journal: Archives of otolaryngology--head & neck surgery 20010501

Title: Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.

Journal: Tropical medicine & international health : TM & IH 20010501

Title: Delayed, reversible hearing loss caused by difluoromethylornithine (DFMO).

Journal: The Laryngoscope 20010501

Title: Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi.

Journal: Biochemical and biophysical research communications 20010420

Title: Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration.

Journal: American journal of physiology. Cell physiology 20010401

Title: Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.

Journal: The Biochemical journal 20010401

Title: Prostate cancer prevention strategies using antiproliferative or differentiating agents.

Journal: Urology 20010401

Title: Vaniqa--eflornithine 13.9% cream.

Journal: Skin therapy letter 20010401

Title: Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity.

Journal: Journal of neuroscience research 20010301

Title: Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010301

Title: Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20010301

Title: Involvement of K(ATP) channels in diethylstilbestrol-induced relaxation in rat aorta.

Journal: European journal of pharmacology 20010209

Title: Polyamines, NO and cGMP mediate stimulation of DNA synthesis by tumor necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes.

Journal: Cardiovascular research 20010201

Title: [Eflornithine for hair removal. Topical application for hirsutism].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20010201

Title: p53 independent G(1) arrest induced by DL-alpha-difluoromethylornithine.

Journal: Biochemical and biophysical research communications 20010126

Title: Hypertrophy and hyperfunction of the diabetic kidney.

Journal: The Journal of clinical investigation 20010115

Title: Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.

Journal: The Journal of clinical investigation 20010115

Title: Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts.

Journal: The Journal of biological chemistry 20010112

Title: Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells.

Journal: Journal of the National Cancer Institute 20010103

Title: Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial.

Journal: Journal of the National Cancer Institute 20010103

Title: Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice.

Journal: Carcinogenesis 20010101

Title: Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme.

Journal: International journal of radiation oncology, biology, physics 20010101

Title: Development of difluoromethyl-ornithine and Bowman-Birk inhibitor as chemopreventive agents by assessment of relevant biomarker modulation: some lessons learned.

Journal: IARC scientific publications 20010101

Title: Human dermal safety studies with eflornithine HCl 13.9% cream (Vaniqa), a novel treatment for excessive facial hair.

Journal: Current medical research and opinion 20010101

Title: Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation.

Journal: Anticancer research 20010101

Title: Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi.

Journal: The Journal of eukaryotic microbiology 20010101

Title: Induction of gastric ornithine decarboxylase in early weaning rats.

Journal: Digestion 20010101

Title: Hirsutism: diagnosis and management.

Journal: The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20010101

Title: Effect of tumour size on the in vivo growth inhibition of human colon carcinoma cells (HT-29) by colon mitosis inhibitor.

Journal: In vivo (Athens, Greece) 20010101

Title: Topical eflornithine.

Journal: American journal of clinical dermatology 20010101

Title: Characterization of spermine uptake by Ehrlich tumour cells in culture.

Journal: Amino acids 20010101

Title: Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice.

Journal: Experimental lung research 20001201

Title: Attenuation of isoproterenol-mediated myocardial injury in rat by an inhibitor of polyamine synthesis.

Journal: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20000101

Title: Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart.

Journal: Life sciences 19990101

Title: Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells.

Journal: Biochemical pharmacology 19980415

Title: Rapid induction of apoptosis by deregulated uptake of polyamine analogues.

Journal: The Biochemical journal 19971115

Title: Inhibition by 1alpha,25-dihydroxyvitamin D3 of activin A-induced differentiation of murine erythroleukemic F5-5 cells.

Journal: Archives of biochemistry and biophysics 19970715

Title: Catecholamines are required for androgen-induced ODC expression but not for hypertrophy of mouse kidney.

Journal: Biochimica et biophysica acta 19970527

Title: Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine.

Journal: Antimicrobial agents and chemotherapy 19960401

Title: Polyamine depletion and growth inhibition of Cryptococcus neoformans by alpha-difluoromethylornithine and cyclohexylamine.

Journal: Mycopathologia 19901001

Title: Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia.

Journal: Antimicrobial agents and chemotherapy 19900901

Title: Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.

Journal: Antimicrobial agents and chemotherapy 19880801

Title: Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.

Journal: Antimicrobial agents and chemotherapy 19880601

Title: Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness.

Journal: Lancet (London, England) 19871219

Title: Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine.

Journal: Journal of neuroscience research 19850101

Title: Factors which may be significant regarding regulation of the clofibrate-dependent induction of hepatic peroxisomal beta-oxidation and hepatomegaly.

Journal: Biochemical pharmacology 19840401

Title: Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19840201

Title: Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.

Journal: Journal of molecular and cellular cardiology 19820801

Title: Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.

Title: Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202.

Title: Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501.

Title: Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.

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Tags:96020-91-6 Molecular Formula|96020-91-6 MDL|96020-91-6 SMILES|96020-91-6 Eflornithine hydrochloride hydrate