Home Other Building Blocks 78186-34-2
78186-34-2,MFCD00872137
Catalog No.:AA00G2CQ

78186-34-2 | Bisantrene

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95+%
in stock  
$26.00   $18.00
- +
10mg
95+%
in stock  
$87.00   $61.00
- +
25mg
95%
in stock  
$137.00   $96.00
- +
50mg
95+%
in stock  
$252.00   $177.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G2CQ
Chemical Name:
Bisantrene
CAS Number:
78186-34-2
Molecular Formula:
C22H22N8
Molecular Weight:
398.4637
MDL Number:
MFCD00872137
SMILES:
C1CN=C(N1)N/N=C/c1c2ccccc2c(c2c1cccc2)/C=N/NC1=NCCN1
Properties
Computed Properties
 
Complexity:
630  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
1.9  

Downstream Synthesis Route

[1]Murdock,K.C.;Lee,VingJ.;Citarella,RonaldV.;Durr,FrederickE.;Nicolau,Gabriela;Kohlbrenner,Michael[JournalofMedicinalChemistry,1993,vol.36,#15,p.2098-2101]

[1]Murdock,K.C.;Lee,VingJ.;Citarella,RonaldV.;Durr,FrederickE.;Nicolau,Gabriela;Kohlbrenner,Michael[JournalofMedicinalChemistry,1993,vol.36,#15,p.2098-2101]

2524-64-3    78186-34-2   
<9,10-anthracenediylbis<methylidynehydrazo(4,5-dihydro-1H-imidazole-2,1-diyl)>>bis<phosphonicacid>tetraphenylester 

[1]Murdock,K.C.;Lee,VingJ.;Citarella,RonaldV.;Durr,FrederickE.;Nicolau,Gabriela;Kohlbrenner,Michael[JournalofMedicinalChemistry,1993,vol.36,#15,p.2098-2101]

[1]Murdock,K.C.;Lee,VingJ.;Citarella,RonaldV.;Durr,FrederickE.;Nicolau,Gabriela;Kohlbrenner,Michael[JournalofMedicinalChemistry,1993,vol.36,#15,p.2098-2101]

[1]Murdock;Child;Lin;Warren;Fabio;Lee;Izzo;LangJr.;Angier;Citarella;Wallace;Durr[JournalofMedicinalChemistry,1982,vol.25,#5,p.505-518]

Literature

Title: In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

Journal: Bioorganic & medicinal chemistry letters 20101215

Title: Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer.

Journal: Biochemical pharmacology 20100615

Title: meso-Substituted bisanthenes as soluble and stable near-infrared dyes.

Journal: The Journal of organic chemistry 20100205

Title: Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Journal: Chemical research in toxicology 20080401

Title: Anti-tumour effects of HL-37, a novel anthracene derivative, in-vivo and in-vitro.

Journal: The Journal of pharmacy and pharmacology 20080201

Title: In silico identification and biochemical characterization of novel inhibitors of NQO1.

Journal: Bioorganic & medicinal chemistry letters 20061215

Title: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein.

Journal: Cancer research 20030315

Title: A randomized trial of doxorubicin, mitoxantrone and bisantrene in advanced breast cancer (a South West Oncology Group Study).

Journal: Investigational new drugs 19850101

Title: Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45.

Title: Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43(3):1402-4.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 78186-34-2
Tags:78186-34-2 Molecular Formula|78186-34-2 MDL|78186-34-2 SMILES|78186-34-2 Bisantrene