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848193-68-0,MFCD20503073
Catalog No.:AA00G3O9

848193-68-0 | (S)-6-Chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide

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Purity
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Price(USD)
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5mg
95%
in stock  
$140.00   $98.00
- +
25mg
95%
in stock  
$426.00   $298.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G3O9
Chemical Name:
(S)-6-Chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide
CAS Number:
848193-68-0
Molecular Formula:
C13H13ClN2O
Molecular Weight:
248.7081
MDL Number:
MFCD20503073
SMILES:
NC(=O)[C@H]1CCCc2c1[nH]c1c2cc(cc1)Cl
Properties
Computed Properties
 
Complexity:
323  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
2.5  

Literature

Title: Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.

Journal: Journal of medicinal chemistry 20100211

Title: Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38.

Title: Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849.

Title: Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17.

Title: Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

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SDS
Tags:848193-68-0 Molecular Formula|848193-68-0 MDL|848193-68-0 SMILES|848193-68-0 (S)-6-Chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide