Home Amines 848942-61-0
848942-61-0,MFCD18385011
Catalog No.:AA00G3OR

848942-61-0 | 2-[4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]-N-methylacetamide

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5mg
98%
in stock  
$50.00   $35.00
- +
10mg
98%
in stock  
$74.00   $52.00
- +
25mg
98%
in stock  
$124.00   $87.00
- +
50mg
98%
in stock  
$210.00   $147.00
- +
100mg
98%
in stock  
$356.00   $249.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3OR
Chemical Name:
2-[4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]-N-methylacetamide
CAS Number:
848942-61-0
Molecular Formula:
C23H25ClFN5O3
Molecular Weight:
473.9277
MDL Number:
MFCD18385011
SMILES:
CNC(=O)CN1CCC(CC1)Oc1cc2c(ncnc2cc1OC)Nc1cccc(c1F)Cl
UNII:
3499328002
Properties
Computed Properties
 
Complexity:
641  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4  

Downstream Synthesis Route
612500-78-4    96-30-0   
Sapitinib 

[1]BioorganicandMedicinalChemistryLetters,2014,vol.24,p.4455-4459

[2]Patent:WO2005/28469,2005,A1.Locationinpatent:Page/Pagecolumn58

[3]ACSMedicinalChemistryLetters,2013,vol.4,p.742-746

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2009/286982,2009,A1Locationinpatent:Page/Pagecolumn14-15

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US2009/286982,2009,A1Locationinpatent:Page/Pagecolumn18-19

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2010/122340,2010,A2Locationinpatent:Page/Pagecolumn30-31

1196531-32-4    2106-04-9   
Sapitinib 

[1]Goundry,WilliamR.F.;Boardman,Kay;Cunningham,Oliver;Evans,Matthew;Jones,MartinF.;Millard,Kirsty;Rozada-Sanchez,Raquel;Sawyer,Yvonne;Siedlecki,Paul;Whitlock,Brian[OrganicProcessResearchandDevelopment,2017,vol.21,#3,p.336-345]

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2009/286982,2009,A1Locationinpatent:Page/Pagecolumn15-16

[3]CurrentPatentAssignee:ASTRAZENECAPLC-WO2010/122340,2010,A2Locationinpatent:Page/Pagecolumn17-18;21

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2010/122340,2010,A2Locationinpatent:Page/Pagecolumn21-24

[2]Goundry,WilliamR.F.;Boardman,Kay;Cunningham,Oliver;Evans,Matthew;Jones,MartinF.;Millard,Kirsty;Rozada-Sanchez,Raquel;Sawyer,Yvonne;Siedlecki,Paul;Whitlock,Brian[OrganicProcessResearchandDevelopment,2017,vol.21,#3,p.336-345]

Literature

Title: Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors.

Journal: ACS medicinal chemistry letters 20130808

Title: AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100215

Title: Hickinson DM, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res. 2010 Feb 15;16(4):1159-69.

Title: Mu Z, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models. J Exp Clin Cancer Res. 2014 May 30;33:47.

Title: Barlaam B, et al. Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors. ACS Med Chem Lett. 2013 May 31;4(8):742-6.

Title: Wang R, et al. Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion. Mol Cancer Res. 2018 Aug 21. pii: molcanres.0341.2018.

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SDS
Tags:848942-61-0 Molecular Formula|848942-61-0 MDL|848942-61-0 SMILES|848942-61-0 2-[4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]-N-methylacetamide