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7753-60-8,MFCD00921393
Catalog No.:AA00G49A

7753-60-8 | ANECORTAVE ACETATE F0E2980.997MG/MG(AI)

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25mg
≥98%
in stock  
$113.00   $79.00
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50mg
98%
in stock  
$122.00   $85.00
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100mg
≥98%
in stock  
$203.00   $142.00
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250mg
98%
in stock  
$281.00   $197.00
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1g
98%
in stock  
$674.00   $472.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G49A
Chemical Name:
ANECORTAVE ACETATE F0E2980.997MG/MG(AI)
CAS Number:
7753-60-8
Molecular Formula:
C23H30O5
Molecular Weight:
386.4813
MDL Number:
MFCD00921393
SMILES:
CC(=O)OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)CC=C1[C@H]2CCC2=CC(=O)CC[C@]12C
Properties
Computed Properties
 
Complexity:
808  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2.1  

Literature

Title: VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid.

Journal: Bioorganic & medicinal chemistry 20130415

Title: A novel in vitro three-dimensional retinoblastoma model for evaluating chemotherapeutic drugs.

Journal: Molecular vision 20120101

Title: Retinoblastoma treatment: impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LH(BETA)T(AG) retinal tumors.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20120101

Title: Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase.

Journal: Disease models & mechanisms 20110901

Title: Novel retinoblastoma treatment avoids chemotherapy: the effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LH(BETA)T(AG) retinoblastoma tumors.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20110101

Title: Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LH(BETA)T(AG) retinal tumors.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20110101

Title: Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits.

Journal: Molecular vision 20110101

Title: Retinoblastoma: Recent trends A mini review based on published literature.

Journal: Oman journal of ophthalmology 20110101

Title: Gelatinase expression in retinoblastoma: modulation of LH(BETA)T(AG) retinal tumor development by anecortave acetate.

Journal: Investigative ophthalmology & visual science 20100601

Title: Time-lapse imaging of retinal angiogenesis reveals decreased development and progression of neovascular sprouting by anecortave desacetate.

Journal: Investigative ophthalmology & visual science 20100501

Title: In vitro transport and partitioning of AL-4940, active metabolite of angiostatic agent anecortave acetate, in ocular tissues of the posterior segment.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100401

Title: Suppression of corticosteroid-induced ocular hypertension in sheep by anecortave.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20100301

Title: Suppression and reduction of corticosteroid-induced ocular hypertension by anecortave in sheep.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20100301

Title: Increased hypoxia following vessel targeting in a murine model of retinoblastoma.

Journal: Investigative ophthalmology & visual science 20091201

Title: Reduction of intraocular pressure with anecortave acetate in eyes with ocular steroid injection-related glaucoma.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20090201

Title: Anterior juxtascleral delivery of anecortave acetate in eyes with primary open-angle glaucoma: a pilot investigation.

Journal: American journal of ophthalmology 20090101

Title: [Is there a drug therapy for age-related macular degeneration?--current status and new therapeutic approaches].

Journal: Klinische Monatsblatter fur Augenheilkunde 20080601

Title: [Screening of anti-tumor parts from the seeds of Livistona chinensis and its anti-angiogenesis effect].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080501

Title: Anecortave acetate for fibrotic lesions with presence of residual peripheral activity in age-related macular degeneration.

Journal: Annals of ophthalmology (Skokie, Ill.) 20080101

Title: Triamcinolone acetonide and anecortave acetate do not stimulate uveal melanoma cell growth.

Journal: Molecular vision 20080101

Title: Mechanism of retinoblastoma tumor cell death after focal chemotherapy, radiation, and vascular targeting therapy in a mouse model.

Journal: Investigative ophthalmology & visual science 20071201

Title: An update of treatment options for neovascular age-related macular degeneration.

Journal: Hong Kong medical journal = Xianggang yi xue za zhi 20071201

Title: Diagnostic and therapeutic challenges.

Journal: Retina (Philadelphia, Pa.) 20071001

Title: [Position of the Retinological Society, the German Ophthalmological Society and the Professional Association of Ophthalmologists in Germany on the current therapeutic possibilities for neovascular age-related macular degeneration].

Journal: Klinische Monatsblatter fur Augenheilkunde 20070701

Title: Retinoblastoma tumor vessel maturation impacts efficacy of vessel targeting in the LH(BETA)T(AG) mouse model.

Journal: Investigative ophthalmology & visual science 20070601

Title: First clinical experience with anecortave acetate (Retaane).

Journal: Klinische Monatsblatter fur Augenheilkunde 20070401

Title: Anecortave may help choroidal neovascularization regression in serpiginous choroiditis.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070201

Title: Progressive visual loss in subfoveal exudation in age-related macular degeneration: a meta-analysis using Lineweaver-Burke plots.

Journal: American journal of ophthalmology 20070101

Title: Mechanism of action of the angiostatic cortisene anecortave acetate.

Journal: Survey of ophthalmology 20070101

Title: Preclinical efficacy of anecortave acetate.

Journal: Survey of ophthalmology 20070101

Title: Pharmacokinetics and metabolism of anecortave acetate in animals and humans.

Journal: Survey of ophthalmology 20070101

Title: Posterior juxtascleral depot administration of anecortave acetate.

Journal: Survey of ophthalmology 20070101

Title: Clinical safety profile of posterior juxtascleral depot administration of anecortave acetate 15 mg suspension as primary therapy or adjunctive therapy with photodynamic therapy for treatment of wet age-related macular degeneration.

Journal: Survey of ophthalmology 20070101

Title: Anecortave acetate for the treatment of exudative age-related macular degeneration--a review of clinical outcomes.

Journal: Survey of ophthalmology 20070101

Title: The Digital Angiography Reading Center (DARC) role in the anecortave acetate clinical trials.

Journal: Survey of ophthalmology 20070101

Title: [Age-related macular degeneration (AMD): etiopathogenesis and therapeutic strategies].

Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20070101

Title: Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema.

Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20070101

Title: Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular age-related macular degeneration.

Journal: The Cochrane database of systematic reviews 20070101

Title: Treatment of choroidal neovascularization in AMD.

Journal: Ophthalmology 20061201

Title: Evolving European guidance on the medical management of neovascular age related macular degeneration.

Journal: The British journal of ophthalmology 20060901

Title: Anecortave acetate treatment for retinal angiomatous proliferation: a pilot study.

Journal: Retina (Philadelphia, Pa.) 20060901

Title: Anecortave acetate for the treatment of idiopathic perifoveal telangiectasia: a pilot study.

Journal: Retina (Philadelphia, Pa.) 20060901

Title: Anecortave acetate in the treatment of age-related macular degeneration.

Journal: Clinical interventions in aging 20060901

Title: Macular degeneration. Advances in treatment.

Journal: Mayo Clinic health letter (English ed.) 20060701

Title: Treatment of nonexudative (dry) age-related macular degeneration.

Journal: Current opinion in ophthalmology 20060601

Title: Anecortave acetate as single and adjuvant therapy in the treatment of retinal tumors of LH(BETA)T(AG) mice.

Journal: Investigative ophthalmology & visual science 20060401

Title: [Comments on current therapeutic possibilities for neovascular age-related macula degeneration].

Journal: Klinische Monatsblatter fur Augenheilkunde 20060401

Title: Anecortave acetate (15 milligrams) versus photodynamic therapy for treatment of subfoveal neovascularization in age-related macular degeneration.

Journal: Ophthalmology 20060101

Title: The state of being noninferior.

Journal: Ophthalmology 20060101

Title: A preliminary benefit-risk assessment of verteporfin in age-related macular degeneration.

Journal: Drug safety 20060101

Title: Drug pricing for a novel treatment for wet macular degeneration: using incremental cost-effectiveness ratios to ensure societal value.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20050601

Title: Anecortave (Alcon Laboratories).

Journal: IDrugs : the investigational drugs journal 20050401

Title: Safety of posterior juxtascleral depot administration of the angiostatic cortisene anecortave acetate for treatment of subfoveal choroidal neovascularization in patients with age-related macular degeneration.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20050101

Title: Anecortave acetate for the treatment of subfoveal choroidal neovascularization secondary to age-related macular degeneration.

Journal: European journal of ophthalmology 20050101

Title: Ocular neovascularisation and excessive vascular permeability.

Journal: Expert opinion on biological therapy 20040901

Title: Anecortave acetate as monotherapy for treatment of subfoveal neovascularization in age-related macular degeneration: twelve-month clinical outcomes.

Journal: Ophthalmology 20031201

Title: [Alternative therapies for choroidal neovessels resulting from age-related macular degeneration].

Journal: Journal francais d'ophtalmologie 20031001

Title: Anecortave acetate as monotherapy for the treatment of subfoveal lesions in patients with exudative age-related macular degeneration (AMD): interim (month 6) analysis of clinical safety and efficacy.

Journal: Retina (Philadelphia, Pa.) 20030201

Title: The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity.

Journal: Investigative ophthalmology & visual science 20010101

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