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7755-01-3,MFCD13194757
Catalog No.:AA00G4AR

7755-01-3 | Protopanaxadiol

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5mg
≥98%
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10mg
≥98%
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$205.00   $143.00
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25mg
≥98%
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$453.00   $317.00
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50mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G4AR
Chemical Name:
Protopanaxadiol
CAS Number:
7755-01-3
Molecular Formula:
C30H52O3
Molecular Weight:
460.7321
MDL Number:
MFCD13194757
SMILES:
CC(=CCC[C@]([C@H]1CC[C@]2([C@@H]1[C@H](O)C[C@H]1[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](C2(C)C)O)C)(O)C)C
Properties
Computed Properties
 
Complexity:
783  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
7.2  

Literature

Title: 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.

Journal: Chemico-biological interactions 20180105

Title: Production of rare ginsenosides (compound Mc, compound Y and aglycon protopanaxadiol) by β-glucosidase from Dictyoglomus turgidum that hydrolyzes β-linked, but not α-linked, sugars in ginsenosides.

Journal: Biotechnology letters 20120901

Title: Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng.

Journal: Plant & cell physiology 20120901

Title: Conversion of protopanaxadiol type saponins to ginsenoside Rg3 by lemon.

Journal: Natural product communications 20120901

Title: Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120801

Title: Fungal sensitivity to and enzymatic deglycosylation of ginsenosides.

Journal: Phytochemistry 20120601

Title: A novel oral dosage formulation of the ginsenoside aglycone protopanaxadiol exhibits therapeutic activity against a hormone-insensitive model of prostate cancer.

Journal: Anti-cancer drugs 20120601

Title: Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice.

Journal: Genes & nutrition 20120401

Title: Co-transformation of Panax major ginsenosides Rb₁ and Rg₁ to minor ginsenosides C-K and F₁ by Cladosporium cladosporioides.

Journal: Journal of industrial microbiology & biotechnology 20120401

Title: Effects of protopanaxatriol-ginsenoside metabolites on rat N-methyl-d-aspartic Acid receptor-mediated ion currents.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20120401

Title: Determination of 20(S)-protopanaxadiol ocotillol type epimers in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301

Title: Kinetics of a cloned special ginsenosidase hydrolyzing 3-O-glucoside of multi-protopanaxadiol-type ginsenosides, named ginsenosidase type III.

Journal: Journal of microbiology and biotechnology 20120301

Title: Target separation of a new anti-tumor saponin and metabolic profiling of leaves of Panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20120205

Title: Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics.

Journal: Chinese medicine 20120101

Title: Antioxidant and hepatoprotective effects of the red ginseng essential oil in H(2)O(2)-treated hepG2 cells and CCl(4)-treated mice.

Journal: International journal of molecular sciences 20120101

Title: Application of Monoclonal Antibodies against Bioactive Natural Products: Eastern Blotting and Preparation of Knockout Extract.

Journal: International journal of analytical chemistry 20120101

Title: Panax ginseng modulates cytokines in bone marrow toxicity and myelopoiesis: ginsenoside Rg1 partially supports myelopoiesis.

Journal: PloS one 20120101

Title: Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics.

Journal: PloS one 20120101

Title: Korean Red Ginseng Suppresses Metastasis of Human Hepatoma SK-Hep1 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen Activator.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Cell and molecular biology underpinning the effects of PEDF on cancers in general and osteosarcoma in particular.

Journal: Journal of biomedicine & biotechnology 20120101

Title: The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives.

Journal: Molecules (Basel, Switzerland) 20111219

Title: Snailase preparation of ginsenoside M1 from protopanaxadiol-type ginsenoside and their protective effects against CCl4-induced chronic hepatotoxicity in mice.

Journal: Molecules (Basel, Switzerland) 20111206

Title: The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng.

Journal: Plant & cell physiology 20111201

Title: 20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells.

Journal: European journal of pharmacology 20111001

Title: Acylated protopanaxadiol-type ginsenosides from the root of Panax ginseng.

Journal: Chemistry & biodiversity 20111001

Title: Ginseng total saponin improves podocyte hyperpermeability induced by high glucose and advanced glycosylation endproducts.

Journal: Journal of Korean medical science 20111001

Title: Anti-cancer effects of 20(S)-protopanoxadiol on human acute lymphoblastic leukemia cell lines Reh and RS4;11.

Journal: Medical oncology (Northwood, London, England) 20110901

Title: Subchronic toxicity studies with ginsenoside compound K delivered to dogs via intravenous administration.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801

Title: (3S,12R,20S,24R)-20,24-Ep-oxy-dammarane-3,12,25-triol.

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: Cell-type-specific regulation of raft-associated Akt signaling.

Journal: Cell death & disease 20110401

Title: (3R,6R,12R,20S,24R)-20,24-Ep-oxy-dammarane-3,6,12,25-tetra-ol.

Journal: Acta crystallographica. Section E, Structure reports online 20110401

Title: Identification of 20(S)-protopanaxadiol metabolites in human liver microsomes and human hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301

Title: Preparation of knockout extract for determination of really active compound using MAb.

Journal: Current drug discovery technologies 20110301

Title: Development of new staining technology 'eastern blotting' using monoclonal antibody.

Journal: Current drug discovery technologies 20110301

Title: Production of aglycon protopanaxadiol via compound K by a thermostable β-glycosidase from Pyrococcus furiosus.

Journal: Applied microbiology and biotechnology 20110201

Title: Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells.

Journal: Planta medica 20110101

Title: Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities.

Journal: Anti-cancer drugs 20110101

Title: (3R,6R,12R,20S,24S)-3,6,12-Triacetyl-20,24-ep-oxy-dammarane-3,6,12,25-tetra-ol.

Journal: Acta crystallographica. Section E, Structure reports online 20110101

Title: Neuroprotective effects of ginsenosides Rh1 and Rg2 on neuronal cells.

Journal: Chinese medicine 20110101

Title: Effect of plant extracts on Alzheimer's disease: An insight into therapeutic avenues.

Journal: Journal of neurosciences in rural practice 20110101

Title: Ginseng (Panax quinquefolius) Reduces Cell Growth, Lipid Acquisition and Increases Adiponectin Expression in 3T3-L1 Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Synthesis and cytotoxic activities of new fatty acid esters of 20(S)-protopanaxadiol.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20110101

Title: Comparative study on saponin fractions from Panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion.

Journal: Chinese medicine 20110101

Title: American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.

Journal: BMC complementary and alternative medicine 20110101

Title: Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers.

Journal: BMC genomics 20110101

Title: Ginseng for cognition.

Journal: The Cochrane database of systematic reviews 20101208

Title: Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.

Journal: Fitoterapia 20101201

Title: 20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20101201

Title: (3R,6R,12R,20S,24S)-20,24-Ep-oxy-dammarane-3,6,12,25-tetraol dihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study.

Journal: Psychopharmacology 20101001

Title: Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats.

Journal: Diabetes 20101001

Title: Enzymatic preparation of 20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from black ginseng.

Journal: Phytochemistry 20100901

Title: Validated quantification for selective cellular uptake of ginsenosides on MCF-7 human breast cancer cells by liquid chromatography-mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20100401

Title: [Preparation and study in vitro of 20 (S)-protopanaxadiol pharmacosomes].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

Title: Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and Akt.

Journal: Archives of pharmacal research 20100101

Title: Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling.

Journal: Lipids in health and disease 20100101

Title: De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis.

Journal: BMC genomics 20100101

Title: Biotransformation of ginsenosides Rb1, Rg3 and Rh2 in rat gastrointestinal tracts.

Journal: Chinese medicine 20100101

Title: Pharmacology of ginsenosides: a literature review.

Journal: Chinese medicine 20100101

Title: Development of a UPLC-ESI-MS/MS assay for 20(S)-protopanaxadiol and pharmacokinetic application of its two formulations in rats.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101

Title: New achievements in ginseng research and its future prospects.

Journal: Chinese journal of integrative medicine 20091201

Title: Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells.

Journal: Journal of agricultural and food chemistry 20091125

Title: Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090901

Title: 20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells.

Journal: Planta medica 20090801

Title: Induction of chemoprotective phase 2 enzymes by ginseng and its components.

Journal: Planta medica 20090801

Title: Antioxidant and apoptotic effects of korean white ginseng extracted with the same ratio of protopanaxadiol and protopanaxatriol saponins in human hepatoma HepG2 cells.

Journal: Annals of the New York Academy of Sciences 20090801

Title: [Determination of content and entrapment efficiency of 20 (S)-protopanaxadiol in pharmacosomes by RP-HPLC method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501

Title: [Preparation and isolation on the rare ginsenoside derivatives with anti-cancer activity].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090501

Title: Rapid and sensitive LC-MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215

Title: Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells.

Journal: British journal of pharmacology 20090201

Title: Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng.

Journal: Phytotherapy research : PTR 20090101

Title: Biotransformation of 20(S)-protopanaxadiol by Mucor spinosus.

Journal: Phytochemistry 20090101

Title: Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells.

Journal: BMC cancer 20090101

Title: Sensitive determination of 20(S)-protopanaxadiol in rat plasma using HPLC-APCI-MS: application of pharmacokinetic study in rats.

Journal: Journal of pharmaceutical and biomedical analysis 20081215

Title: Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: critical roles of ERK2 and cAMP.

Journal: The Journal of pharmacy and pharmacology 20081101

Title: Protopanaxadiol 6-hydroxylase and its role in regulating the ginsenoside heterogeneity in Panax notoginseng cells.

Journal: Biotechnology and bioengineering 20080801

Title: Enhanced inhibitory effect of ultra-fine granules of red ginseng on LPS-induced cytokine expression in the monocyte-derived macrophage THP-1 cells.

Journal: International journal of molecular sciences 20080801

Title: Comparative analysis on microbial and rat metabolism of ginsenoside Rb1 by high-performance liquid chromatography coupled with tandem mass spectrometry.

Journal: Biomedical chromatography : BMC 20080701

Title: Pharmacokinetics of salvianolic acids after intravenous injection, with and without Panax quinquefolium protopanaxadiol saponins, in rats.

Journal: Journal of ethnopharmacology 20080522

Title: 20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080401

Title: Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.

Journal: Journal of natural products 20080301

Title: 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action.

Journal: British journal of cancer 20080226

Title: Manipulation of ginsenoside heterogeneity of Panax notoginseng cells in flask and bioreactor cultivations with addition of phenobarbital.

Journal: Bioprocess and biosystems engineering 20080201

Title: Effects of ginsenosides Re and Rg3 on intracellular redox state and cell proliferation in C6 glioma cells.

Journal: Chinese medicine 20080101

Title: Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.

Journal: PloS one 20080101

Title: Two new dammarane triterpene glycosides from the rhizomes of Panax notoginseng.

Journal: Journal of Asian natural products research 20080101

Title: Potential role of ginseng in the treatment of colorectal cancer.

Journal: The American journal of Chinese medicine 20080101

Title: 20-O-β-d-Xylopyranos-yl(1→6)-β-d-glucopyranosyl-20(S)-protopanaxadiol methanol solvate.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells.

Journal: Cell biology international 20071001

Title: Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method.

Journal: Chemical & pharmaceutical bulletin 20071001

Title: [Advances in the study of ginsenoside compound K].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070901

Title: Antiestrogenic effect of 20S-protopanaxadiol and its synergy with tamoxifen on breast cancer cells.

Journal: Cancer 20070601

Title: Eastern blotting and immunoaffinity concentration using monoclonal antibody for ginseng saponins in the field of traditional chinese medicines.

Journal: Journal of agricultural and food chemistry 20070516

Title: 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways.

Journal: Journal of natural products 20070201

Title: Purification and characterization of new special ginsenosidase hydrolyzing multi-glycisides of protopanaxadiol ginsenosides, ginsenosidase type I.

Journal: Chemical & pharmaceutical bulletin 20070201

Title: Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice.

Journal: Vaccine 20070122

Title: Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng.

Journal: FEBS letters 20061002

Title: Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD.

Journal: Journal of pharmaceutical and biomedical analysis 20060828

Title: Physicochemical characteristics and bioavailability of a novel intestinal metabolite of ginseng saponin (IH901) complexed with beta-cyclodextrin.

Journal: International journal of pharmaceutics 20060619

Title: Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by PI3-kinase cascade.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060601

Title: Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060601

Title: Ginsenoside 20(S)-protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells.

Journal: Basic & clinical pharmacology & toxicology 20060601

Title: Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain.

Journal: European journal of pharmacology 20060113

Title: Relationship between haemolytic and adjuvant activity and structure of protopanaxadiol-type saponins from the roots of Panax notoginseng.

Journal: Vaccine 20051201

Title: Anti-inflammatory activity of 20(S)-protopanaxadiol: enhanced heme oxygenase 1 expression in RAW 264.7 cells.

Journal: Planta medica 20051201

Title: Effect of ginseng saponins on a rat visceral hypersensitivity model.

Journal: Biological & pharmaceutical bulletin 20051101

Title: Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect.

Journal: Biological & pharmaceutical bulletin 20051001

Title: [Alkaline-degradation products of ginsenosides from leaves and stems of Panax quinquefolium].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051001

Title: Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms.

Journal: Biotechnology letters 20050601

Title: High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425

Title: Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis.

Journal: Cancer research 20050301

Title: A role for the carbohydrate portion of ginsenoside Rg3 in Na+ channel inhibition.

Journal: Molecules and cells 20050227

Title: Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells.

Journal: Biological & pharmaceutical bulletin 20050201

Title: Liquid chromatography/tandem mass spectrometry for pharmacokinetic studies of 20(R)-ginsenoside Rg3 in dog.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity.

Journal: Biological & pharmaceutical bulletin 20041001

Title: Selection of high ginsenoside producing ginseng hairy root lines using targeted metabolic analysis.

Journal: Phytochemistry 20041001

Title: Simultaneous determination of triterpene saponins in ginseng drugs by high-performance liquid chromatography.

Journal: Chemical & pharmaceutical bulletin 20040801

Title: Abeta(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040501

Title: Ginsenoside Rh2 reduces ischemic brain injury in rats.

Journal: Biological & pharmaceutical bulletin 20040301

Title: Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2.

Journal: Canadian journal of physiology and pharmacology 20040301

Title: Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.

Journal: Molecules and cells 20040227

Title: Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants.

Journal: Archives of pharmacal research 20040101

Title: Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells.

Journal: Journal of biochemical and molecular toxicology 20040101

Title: In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins.

Journal: Biochemical pharmacology 20031201

Title: Modulating effects of Korean ginseng saponins on ovarian function in immature rats.

Journal: Biological & pharmaceutical bulletin 20031101

Title: A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells.

Journal: International journal of oncology 20031001

Title: Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes.

Journal: Archives of pharmacal research 20031001

Title: Degradation of ginsenosides in humans after oral administration.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030801

Title: In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes.

Journal: Journal of agricultural and food chemistry 20030423

Title: Ginsenosides inhibit EGF-induced proliferation of renal proximal tubule cells via decrease of c-fos and c-jun gene expression in vitro.

Journal: Planta medica 20021101

Title: Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells.

Journal: Japanese journal of pharmacology 20021101

Title: Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line.

Journal: Archives of biochemistry and biophysics 20021001

Title: Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity.

Journal: Biological & pharmaceutical bulletin 20020601

Title: Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities.

Journal: Biological & pharmaceutical bulletin 20020101

Title: [Comparative study of cytotoxic and hemolytic effects of triterpenoids isolated from Ginseng and Sea cucumber].

Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20020101

Title: Ginsenosides protect apical transporters of cultured proximal tubule cells from dysfunctions induced by h(2)o(2).

Journal: Kidney & blood pressure research 20020101

Title: Double staining of ginsenosides by Western blotting using anti-ginsenoside Rb1 and Rg1 monoclonal antibodies.

Journal: Biological & pharmaceutical bulletin 20011001

Title: [Metabolism of ginsenoside Rb1 and panaxadiol saponins by fungi].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010801

Title: Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice.

Journal: Journal of ethnopharmacology 19990801

Title: Liu L, et al. Enzymatic preparation of 20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from black ginseng. Phytochemistry. 2010 Sep;71(13):1514-20.

Title: Bae EA, et al. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull. 2002 Jan;25(1):58-63.

Title: Hasegawa H, et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60(3):240-3.

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Tags:7755-01-3 Molecular Formula|7755-01-3 MDL|7755-01-3 SMILES|7755-01-3 Protopanaxadiol