Home Fluorides 91296-86-5
91296-86-5,MFCD03840489
Catalog No.:AA00GRG7

91296-86-5 | Difluoxacin Hydrochloride

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5g
98+%
in stock  
$23.00   $16.00
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25g
98+%
in stock  
$81.00   $57.00
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100g
98+%
in stock  
$260.00   $182.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GRG7
Chemical Name:
Difluoxacin Hydrochloride
CAS Number:
91296-86-5
Molecular Formula:
C21H20ClF2N3O3
Molecular Weight:
435.8516
MDL Number:
MFCD03840489
SMILES:
CN1CCN(CC1)c1cc2c(cc1F)c(=O)c(cn2c1ccc(cc1)F)C(=O)O.Cl
NSC Number:
759646
Properties
Computed Properties
 
Complexity:
672  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Downstream Synthesis Route
109-01-3   
C20H13BF3NO7 
  91296-86-5 

[1]CurrentPatentAssignee:SHENYANGPHARMACEUTICALUNIVERSITY-CN113527288,2021,A

C25H24BF2N3O7 
  91296-86-5 

[1]CurrentPatentAssignee:SHENYANGPHARMACEUTICALUNIVERSITY-CN113527288,2021,ALocationinpatent:Paragraph0089-0091;0179

Literature

Title: Development of a dispersive liquid-liquid microextraction method for the determination of fluoroquinolones in chicken liver by high performance liquid chromatography.

Journal: Analytica chimica acta 20120612

Title: Mutant prevention concentration and phenotypic and molecular basis of fluoroquinolone resistance in clinical isolates and in vitro-selected mutants of Escherichia coli from dogs.

Journal: Veterinary microbiology 20120127

Title: Short term effects of copper, sulfadiazine and difloxacin on the anaerobic digestion of pig manure at low organic loading rates.

Journal: Waste management (New York, N.Y.) 20120101

Title: Persistence of the fluoroquinolone antibiotic difloxacin in soil and lacking effects on nitrogen turnover.

Journal: Journal of environmental quality 20120101

Title: Determination of water content by capillary gas chromatography coupled with thermal conductivity detection.

Journal: Pharmeuropa bio & scientific notes 20111101

Title: Pharmacokinetic and milk penetration of a difloxacin long-acting poloxamer gel formulation with carboxy-methylcellulose in lactating goats.

Journal: Veterinary journal (London, England : 1997) 20110401

Title: Effects of cytochrome P450 1A substrate (difloxacin) on enzyme gene expression and pharmacokinetics in crucian carp (hybridized Prussian carp).

Journal: Environmental toxicology and pharmacology 20110301

Title: Plasma disposition and tissue depletion of difloxacin and its metabolite sarafloxacin in the food producing animals, chickens for fattening.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110201

Title: Effects of fish CYP inducers on difloxacin N-demethylation in kidney cell of Chinese idle (Ctenopharyngodon idellus).

Journal: Fish physiology and biochemistry 20100901

Title: Pharmacokinetics and milk penetration of difloxacin after a long-acting formulation for subcutaneous administration to lactating goats.

Journal: Journal of dairy science 20100701

Title: Behaviour of (14)C-sulfadiazine and (14)C-difloxacin during manure storage.

Journal: The Science of the total environment 20100301

Title: Simultaneous determination of quinolones for veterinary use by high-performance liquid chromatography with electrochemical detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

Title: In vitro residual anti-bacterial activity of difloxacin, sarafloxacin and their photoproducts after photolysis in water.

Journal: Environmental pollution (Barking, Essex : 1987) 20091001

Title: Photolysis of difloxacin and sarafloxacin in aqueous systems.

Journal: Chemosphere 20091001

Title: Quantification of danofloxacin and difloxacin in chicken tissues in the presence of sarafloxacin as interference.

Journal: Journal of agricultural and food chemistry 20090909

Title: Metabolism and excretion kinetics of 14C-labeled and non-labeled difloxacin in pigs after oral administration, and antimicrobial activity of manure containing difloxacin and its metabolites.

Journal: Environmental research 20090401

Title: Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria?

Journal: Rapid communications in mass spectrometry : RCM 20090401

Title: Pharmacokinetics and intramuscular bioavailability of difloxacin in dromedary camels (Camelus dromedarius).

Journal: Veterinary journal (London, England : 1997) 20090201

Title: In vitro susceptibilities to fluoroquinolones in current and archived Mycoplasma gallisepticum and Mycoplasma synoviae isolates from meat-type turkeys.

Journal: Veterinary microbiology 20081015

Title: Pharmacokinetics of difloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications.

Journal: Journal of veterinary pharmacology and therapeutics 20080601

Title: Disposition kinetics and pharmacokinetics--pharmacodynamic integration of difloxacin against Staphylococcus aureus isolates from rabbits.

Journal: Research in veterinary science 20080201

Title: Efficacy of difloxacin for the control of postpartum uterine infections of ewes.

Journal: Journal of veterinary pharmacology and therapeutics 20071201

Title: Pharmacokinetics after intravenous, intramuscular and subcutaneous administration of difloxacin in sheep.

Journal: Research in veterinary science 20071001

Title: Allometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis.

Journal: Journal of veterinary pharmacology and therapeutics 20071001

Title: [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20070701

Title: Disposition kinetics of difloxacin after intravenous, intramuscular and subcutaneous administration in calves.

Journal: Veterinary research communications 20070501

Title: Simultaneous multiresidue determination of tetracyclines and fluoroquinolones in catfish muscle using high performance liquid chromatography with fluorescence detection.

Journal: Analytica chimica acta 20070314

Title: Sensitive luminescent determination of DNA using the terbium(III)-difloxacin complex.

Journal: Analytica chimica acta 20070219

Title: Pharmacokinetics and milk penetration of difloxacin after intravenous, subcutaneous and intramuscular administration to lactating goats.

Journal: Journal of veterinary pharmacology and therapeutics 20070201

Title: Determination of the inhibitory concentration 50% (IC50) of four selected drugs (chlortetracycline, doxycycline, enrofloxacin and difloxacin) that reduce in vitro the multiplication of Chlamydophila psittaci.

Journal: DTW. Deutsche tierarztliche Wochenschrift 20061101

Title: Pharmacokinetics of difloxacin after intravenous, intramuscular, and intragastric administration to horses.

Journal: American journal of veterinary research 20060601

Title: Pharmacokinetics of difloxacin and its concentration in body fluids and endometrial tissues of mares after repeated intragastric administration.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20050701

Title: Efficacy of difloxacin against respiratory infections of lambs.

Journal: Journal of veterinary pharmacology and therapeutics 20050601

Title: Disposition kinetics of difloxacin in rabbit after intravenous and intramuscular injection of Dicural.

Journal: Veterinary research communications 20050501

Title: Determination of enrofloxacin and its primary metabolite, ciprofloxacin, in pig tissues. Application to residue studies.

Journal: Biomedical chromatography : BMC 20050101

Title: Multiresidue determination of fluoroquinolones in shrimp by liquid chromatography-fluorescence-mass spectrometry.

Journal: Journal of AOAC International 20050101

Title: Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: single laboratory validation study.

Journal: Journal of AOAC International 20050101

Title: Multiresidue determination of eleven quinolones in milk by liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International 20050101

Title: Separation and determination of synthetic impurities of difloxacin by reversed-phase high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20041119

Title: Pharmacokinetics of difloxacin in goats.

Journal: DTW. Deutsche tierarztliche Wochenschrift 20020701

Title: Determination of difloxacin and sarafloxacin in chicken muscle using solid-phase extraction and capillary electrophoresis.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020215

Title: Using nonaqueous capillary electrophoresis to analyze several quinolones in pig kidney samples.

Journal: Electrophoresis 20020201

Title: Comparative serum pharmacokinetics of the fluoroquinolones enrofloxacin, difloxacin, marbofloxacin, and orbifloxacin in dogs after single oral administration.

Journal: Journal of veterinary pharmacology and therapeutics 20020201

Title: Activity and postantibiotic effect of marbofloxacin, enrofloxacin, difloxacin and ciprofloxacin against feline Bordetella bronchiseptica isolates.

Journal: Veterinary microbiology 20010703

Title: Determination of fluoroquinolones in serum using an on-line clean-up column coupled to high-performance immunoaffinity-reversed-phase liquid chromatography.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010415

Title: Reversal of multidrug resistance-associated protein-mediated drug resistance in cultured human neuroblastoma cells by the quinolone antibiotic difloxacin.

Journal: Medical and pediatric oncology 20010101

Title: Comparative antimycobacterial activities of difloxacin, temafloxacin, enoxacin, pefloxacin, reference fluoroquinolones, and a new macrolide, clarithromycin.

Journal: Antimicrobial agents and chemotherapy 19890401

Title: Abo El-Ela FI, et al. Pharmacokinetics of difloxacin in healthy and E. coli-infected broiler chickens. Br Poult Sci. 2014;55(6):830-6.

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