Home Amines 937174-76-0
937174-76-0,MFCD14105605
Catalog No.:AA00GRSB

937174-76-0 | 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

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1mg
98+%
in stock  
$39.00   $28.00
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5mg
98+%
in stock  
$99.00   $69.00
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25mg
99% (HPLC)
in stock  
$473.00   $331.00
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50mg
99% (HPLC)
in stock  
$761.00   $533.00
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100mg
99% (HPLC)
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$1,270.00   $889.00
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500mg
99% (HPLC)
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$3,958.00   $2,771.00
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1000mg
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in stock  
$6,295.00   $4,407.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GRSB
Chemical Name:
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
CAS Number:
937174-76-0
Molecular Formula:
C21H27N7O3
Molecular Weight:
425.4842
MDL Number:
MFCD14105605
SMILES:
CCn1c(nc2c1c(OC[C@@H]1CCCNC1)cnc2C#CC(O)(C)C)c1nonc1N
Properties
Properties
 
BP:
683.8 °C at 760 mmHg  
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
680  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
0.3  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells.

Journal: Molecular cancer therapeutics 20120701

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.

Journal: The Journal of biological chemistry 20111028

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells.

Journal: The Prostate 20101101

Title: Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.

Journal: Biological psychiatry 20100815

Title: Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693.

Journal: BMC genomics 20100101

Title: Personalized therapies in the cancer 'omics' era.

Journal: Molecular cancer 20100101

Title: Aminofurazans as potent inhibitors of AKT kinase.

Journal: Bioorganic & medicinal chemistry letters 20090301

Title: Mechanism and management of AKT inhibitor-induced hyperglycemia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090101

Title: Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.

Journal: Journal of medicinal chemistry 20080925

Title: Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.

Journal: Cancer research 20080401

Title: Rhodes N, et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res, 2008, 68(7), 2366-2374.

Title: Levy DS, et al. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood, 2009, 113(8), 1723-1729.

Title: Altomare DA, et al. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res, 2010, 16(2), 486-496.

Title: Konno H, et al. Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep. 2018 Apr 24;23(4):1112-1123.

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Tags:937174-76-0 Molecular Formula|937174-76-0 MDL|937174-76-0 SMILES|937174-76-0 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol