Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells.
Journal: Molecular cancer therapeutics 20120701
Title: Comprehensive analysis of kinase inhibitor selectivity.
Journal: Nature biotechnology 20111030
Title: IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
Journal: The Journal of biological chemistry 20111028
Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.
Journal: Chemistry & biology 20101124
Title: 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells.
Journal: The Prostate 20101101
Title: Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.
Journal: Biological psychiatry 20100815
Title: Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693.
Journal: BMC genomics 20100101
Title: Personalized therapies in the cancer 'omics' era.
Journal: Molecular cancer 20100101
Title: Aminofurazans as potent inhibitors of AKT kinase.
Journal: Bioorganic & medicinal chemistry letters 20090301
Title: Mechanism and management of AKT inhibitor-induced hyperglycemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090101
Title: Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Journal: Journal of medicinal chemistry 20080925
Title: Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.
Journal: Cancer research 20080401
Title: Rhodes N, et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res, 2008, 68(7), 2366-2374.
Title: Levy DS, et al. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood, 2009, 113(8), 1723-1729.
Title: Altomare DA, et al. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res, 2010, 16(2), 486-496.
Title: Konno H, et al. Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep. 2018 Apr 24;23(4):1112-1123.