[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2007/191293,2007,A1Locationinpatent:Page/Pagecolumn53
[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2007/191293,2007,A1Locationinpatent:Page/Pagecolumn53
[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2010/132110,2010,A1Locationinpatent:Page/Pagecolumn37-38
[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2022/112951,2022,A1Locationinpatent:Paragraph0118;0119
1160295-21-5
[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2010/132110,2010,A1Locationinpatent:Page/Pagecolumn38-39
[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2022/112951,2022,A1Locationinpatent:Paragraph0120;0121
Title: Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Journal: eLife 20180101
Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
Journal: The Journal of biological chemistry 20150529
Title: The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20140315
Title: NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway.
Journal: Journal of molecular biology 20120803
Title: Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program.
Journal: Pediatric blood & cancer 20120801
Title: The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth.
Journal: Cancer research 20120701
Title: Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy.
Journal: Molecular oncology 20120601
Title: A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.
Journal: Cell reports 20120419
Title: Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.
Journal: Cancer cell 20120320
Title: The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions.
Journal: Cell cycle (Georgetown, Tex.) 20120315
Title: Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.
Journal: Molecular & cellular proteomics : MCP 20120301
Title: Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents.
Journal: Molecular cancer research : MCR 20120301
Title: Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.
Journal: Cancer research 20120101
Title: The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.
Journal: PloS one 20120101
Title: The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells.
Journal: Molecular cancer therapeutics 20111201
Title: Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924.
Journal: Molecular & cellular proteomics : MCP 20111101
Title: Multimodal imaging with (18)F-FDG PET and Cerenkov luminescence imaging after MLN4924 treatment in a human lymphoma xenograft model.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20111101
Title: Global identification of modular cullin-RING ligase substrates.
Journal: Cell 20111014
Title: MLN4924 is an efficient inhibitor of NEDD8 conjugation in plants.
Journal: Plant physiology 20110601
Title: Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression.
Journal: Neoplasia (New York, N.Y.) 20110601
Title: Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme.
Journal: The Journal of organic chemistry 20110506
Title: The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation.
Journal: Molecular & cellular proteomics : MCP 20110501
Title: Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover.
Journal: Cancer research 20110415
Title: A natural product-like inhibitor of NEDD8-activating enzyme.
Journal: Chemical communications (Cambridge, England) 20110307
Title: Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid.
Journal: PloS one 20110101
Title: NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells.
Journal: Cancer research 20101215
Title: Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Journal: Cell 20101210
Title: MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma.
Journal: Blood 20100902
Title: Biochemical and cellular effects of inhibiting Nedd8 conjugation.
Journal: Biochemical and biophysical research communications 20100730
Title: Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia.
Journal: Blood 20100506
Title: SUMO, Ubiquitin, UBL Proteins: Implications For Human Diseases - Fifth International Conference.
Journal: IDrugs : the investigational drugs journal 20100401
Title: Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Journal: Molecular cell 20100115
Title: Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090615
Title: An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Journal: Nature 20090409
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