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1160295-21-5,MFCD17215670
Catalog No.:AA008TFJ

1160295-21-5 | MLN4924 hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
1 week  
$146.00   $102.00
- +
5mg
99%
1 week  
$241.00   $169.00
- +
10mg
99%
1 week  
$336.00   $235.00
- +
50mg
99%
1 week  
$908.00   $635.00
- +
100mg
99%
1 week  
$1,574.00   $1,102.00
- +
200mg
99%
1 week  
$2,717.00   $1,902.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TFJ
Chemical Name:
MLN4924 hydrochloride
CAS Number:
1160295-21-5
Molecular Formula:
C21H26ClN5O4S
Molecular Weight:
479.9802
MDL Number:
MFCD17215670
SMILES:
O[C@H]1C[C@@H](C[C@H]1COS(=O)(=O)N)n1ccc2c1ncnc2N[C@H]1CCc2c1cccc2.Cl
Properties
Computed Properties
 
Complexity:
734  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Downstream Synthesis Route
((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo2,3-dpyrimidin-7-yl)-2-hydroxycyclopentyl)-methylsulfamate 
  1160295-21-5 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2010/132110,2010,A1Locationinpatent:Page/Pagecolumn38-39

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2022/112951,2022,A1Locationinpatent:Paragraph0120;0121

C20H20O5 
  1160295-21-5 

[1]CurrentPatentAssignee:CHENGDUBRIGHBIOTECH-CN106854208,2017,A

[1]CurrentPatentAssignee:CHENGDUBRIGHBIOTECH-CN106854208,2017,A

C26H22ClN3O4 
  1160295-21-5 

[1]CurrentPatentAssignee:CHENGDUBRIGHBIOTECH-CN106854208,2017,A

Literature

Title: Soucy TA, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009 Apr 9;458(7239):732-6.

Title: J. Claire Godbersen, e tal. The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells.

Title: Lan H, et al. Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells. Sci Rep. 2016 Apr 11;6:24218.

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SDS
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Tags:1160295-21-5 Molecular Formula|1160295-21-5 MDL|1160295-21-5 SMILES|1160295-21-5 MLN4924 hydrochloride
Catalog No.: AA008TFJ
1160295-21-5,MFCD17215670
1160295-21-5 | MLN4924 hydrochloride
Pack Size： 1mg
Purity： 99%
1 week
$146.00 $102.00
Pack Size： 5mg
Purity： 99%
1 week
$241.00 $169.00
Pack Size： 10mg
Purity： 99%
1 week
$336.00 $235.00
Pack Size： 50mg
Purity： 99%
1 week
$908.00 $635.00
Pack Size： 100mg
Purity： 99%
1 week
$1,574.00 $1,102.00
Pack Size： 200mg
Purity： 99%
1 week
$2,717.00 $1,902.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA008TFJ
Chemical Name: MLN4924 hydrochloride
CAS Number: 1160295-21-5
Molecular Formula: C21H26ClN5O4S
Molecular Weight: 479.9802
MDL Number: MFCD17215670
SMILES: O[C@H]1C[C@@H](C[C@H]1COS(=O)(=O)N)n1ccc2c1ncnc2N[C@H]1CCc2c1cccc2.Cl
Properties
Complexity: 734  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 4  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 32  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Downstream Synthesis Route
((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo2,3-dpyrimidin-7-yl)-2-hydroxycyclopentyl)-methylsulfamate 
  1160295-21-5 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2010/132110,2010,A1Locationinpatent:Page/Pagecolumn38-39

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2022/112951,2022,A1Locationinpatent:Paragraph0120;0121

C20H20O5 
  1160295-21-5 

[1]CurrentPatentAssignee:CHENGDUBRIGHBIOTECH-CN106854208,2017,A

3680-69-1    1160295-21-5 

[1]CurrentPatentAssignee:CHENGDUBRIGHBIOTECH-CN106854208,2017,A

C26H22ClN3O4 
  1160295-21-5 

[1]CurrentPatentAssignee:CHENGDUBRIGHBIOTECH-CN106854208,2017,A

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