Name: Name:Morinidazole
Brand: AABLOCKS
SKU: AA00GU1P
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00GU1P

Chemical Name: Morinidazole

CAS Number: 92478-27-8

Molecular Formula: C11H18N4O4

Molecular Weight: 270.2850

MDL Number: MFCD28386297

SMILES: OC(Cn1c(C)ncc1[N+](=O)[O-])CN1CCOCC1

Properties

Complexity: 306

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 19

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 4

Undefined Atom Stereocenter Count: 1

Undefined Bond Stereocenter Count: 0

XLogP3: -0.3

Downstream Synthesis Route

110-91-8

16773-42-5

92478-27-8

[1]CurrentPatentAssignee:NUOWOSIDAPHARMACEUTICAL;NOVOSTARPHARMACEUTICALS-CN110776492,2020,ALocationinpatent:Paragraph0139-0141;0147-0151

Literature fold

Title: Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy chinese subjects.

Journal: Antimicrobial agents and chemotherapy20141001

Title: Simultaneous determination of morinidazole, its N-oxide, sulfate, and diastereoisomeric N(+)-glucuronides in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20121101

Title: Simultaneous quantification of metronidazole, tinidazole, ornidazole and morinidazole in human saliva.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20120615

Title: Metabolism and pharmacokinetics of morinidazole in humans: identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase 1A9.

Journal: Drug metabolism and disposition: the biological fate of chemicals20120301

Title: [Enantioselective determinination of R-warfarin/S-warfarin in human plasma using liquid chromatography-tandem mass spectrometry and its application in a drug-drug interaction study].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20120101

Title: Investigation of the effects of 24 bio-matrices on the LC-MS/MS analysis of morinidazole.

Journal: Talanta20100115

Title: Zhong K, et al. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearanceof the conjugated metabolites. Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61.

Title: Kong F, et al. Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins. Drug Metab Dispos. 2017 Jun;45(6):593-603.

Title: Lu Aifeng, et al. Application of α-(morpholine-1-yl)methyl-2-methyl-nitroimidazole-1-ethanol as anti-trichomonal agent and amebacide: China, CN1981764[P 2007-06-20.

92478-27-8 | Morinidazole