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92478-27-8,MFCD28386297
Catalog No.:AA00GU1P

92478-27-8 | Morinidazole

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Purity
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Price(USD)
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1mg
98%
in stock  
$416.00   $292.00
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5mg
98%
in stock  
$809.00   $567.00
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10mg
98%
in stock  
$1,131.00   $792.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU1P
Chemical Name:
Morinidazole
CAS Number:
92478-27-8
Molecular Formula:
C11H18N4O4
Molecular Weight:
270.2850
MDL Number:
MFCD28386297
SMILES:
OC(Cn1c(C)ncc1[N+](=O)[O-])CN1CCOCC1
Properties
Computed Properties
 
Complexity:
306  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:NUOWOSIDAPHARMACEUTICAL;NOVOSTARPHARMACEUTICALS-CN110776492,2020,ALocationinpatent:Paragraph0139-0141;0147-0151

Literature

Title: Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy chinese subjects.

Journal: Antimicrobial agents and chemotherapy 20141001

Title: Simultaneous determination of morinidazole, its N-oxide, sulfate, and diastereoisomeric N(+)-glucuronides in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121101

Title: Simultaneous quantification of metronidazole, tinidazole, ornidazole and morinidazole in human saliva.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120615

Title: Metabolism and pharmacokinetics of morinidazole in humans: identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase 1A9.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120301

Title: [Enantioselective determinination of R-warfarin/S-warfarin in human plasma using liquid chromatography-tandem mass spectrometry and its application in a drug-drug interaction study].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120101

Title: Investigation of the effects of 24 bio-matrices on the LC-MS/MS analysis of morinidazole.

Journal: Talanta 20100115

Title: Zhong K, et al. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearanceof the conjugated metabolites. Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61.

Title: Kong F, et al. Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins. Drug Metab Dispos. 2017 Jun;45(6):593-603. 

Title: Lu Aifeng, et al. Application of α-(morpholine-1-yl)methyl-2-methyl-nitroimidazole-1-ethanol as anti-trichomonal agent and amebacide: China, CN1981764[P 2007-06-20.

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