Home Other Building Blocks 874101-00-5
874101-00-5,MFCD19443685
Catalog No.:AA00GU3C

874101-00-5 | Ro4987655

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$85.00   $59.00
- +
5mg
≥98%
in stock  
$253.00   $177.00
- +
10mg
≥98%
in stock  
$380.00   $266.00
- +
25mg
≥98%
in stock  
$738.00   $516.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU3C
Chemical Name:
Ro4987655
CAS Number:
874101-00-5
Molecular Formula:
C20H19F3IN3O5
Molecular Weight:
565.2816
MDL Number:
MFCD19443685
SMILES:
OCCONC(=O)c1cc(CN2OCCCC2=O)c(c(c1Nc1ccc(cc1F)I)F)F
Properties
Computed Properties
 
Complexity:
652  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
3  

Literature

Title: Phase I and pharmacokinetics/pharmacodynamics study of the MEK inhibitor RO4987655 in Japanese patients with advanced solid tumors.

Journal: Investigational new drugs 20150601

Title: Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20140815

Title: MEK and the inhibitors: from bench to bedside.

Journal: Journal of hematology & oncology 20130101

Title: Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the MEK inhibitor RO4987655 (CH4987655) in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120901

Title: Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.

Journal: Bioorganic & medicinal chemistry letters 20110315

Title: Hypertension in pregnancy: an invitational symposium.

Journal: The Journal of reproductive medicine 19751101

Title: Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. Clin Cancer Res. 2009 Dec 1;15(23):7368-74.

Title: Tegnebratt T, et al. Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F FDG-PET imaging combined with proteomic approaches. EJNMMI Res. 2014 Dec;4(1):34.

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SDS
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