Home Fluorides 874819-74-6
874819-74-6,MFCD25372034
Catalog No.:AA00GU4D

874819-74-6 | (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$95.00   $67.00
- +
1g
98%
in stock  
$211.00   $148.00
- +
5g
98%
in stock  
$610.00   $427.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU4D
Chemical Name:
(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate
CAS Number:
874819-74-6
Molecular Formula:
C22H28FN4O6P
Molecular Weight:
494.4531
MDL Number:
MFCD25372034
SMILES:
OP(=O)(O)O.Fc1ccc2c(c1)C(=Cc1[nH]c(c(c1C)C(=O)NCCN1CCCC1)C)C(=O)N2
Properties
Computed Properties
 
Complexity:
713  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
5  

Literature

Title: Safety evaluation of combination vinblastine and toceranib phosphate (Palladia®) in dogs: a phase I dose-finding study.

Journal: Veterinary and comparative oncology 20120901

Title: Safety evaluation of combination toceranib phosphate (Palladia®) and piroxicam in tumour-bearing dogs (excluding mast cell tumours): a phase I dose-finding study.

Journal: Veterinary and comparative oncology 20120901

Title: Primary frontal sinus squamous cell carcinoma in three dogs treated with piroxicam combined with carboplatin or toceranib.

Journal: Veterinary and comparative oncology 20120901

Title: Preliminary evidence for biologic activity of toceranib phosphate (Palladia(®)) in solid tumours.

Journal: Veterinary and comparative oncology 20120901

Title: Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy.

Journal: Veterinary and comparative oncology 20120901

Title: Multicenter prospective trial of hypofractionated radiation treatment, toceranib, and prednisone for measurable canine mast cell tumors.

Journal: Journal of veterinary internal medicine 20120101

Title: Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer.

Journal: Journal of veterinary internal medicine 20120101

Title: Preliminary evaluation of serial (18) FDG-PET/CT to assess response to toceranib phosphate therapy in canine cancer.

Journal: Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20120101

Title: Calcitriol (1,25-dihydroxycholecalciferol) enhances mast cell tumour chemotherapy and receptor tyrosine kinase inhibitor activity in vitro and has single-agent activity against spontaneously occurring canine mast cell tumours.

Journal: Veterinary and comparative oncology 20100901

Title: Distribution, metabolism, and excretion of toceranib phosphate (Palladia, SU11654), a novel tyrosine kinase inhibitor, in dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20100401

Title: Pharmacokinetic properties of toceranib phosphate (Palladia, SU11654), a novel tyrosine kinase inhibitor, in laboratory dogs and dogs with mast cell tumors.

Journal: Journal of veterinary pharmacology and therapeutics 20100401

Title: Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090601

Title: Proof of target for SU11654: inhibition of KIT phosphorylation in canine mast cell tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031115

Title: Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701

Title: Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors.

Journal: Blood 20020715

Title: London CA, et al. Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies. Clin Cancer Res. 2003 Jul;9(7):2755-68.

Title: Halsey CH, et al. Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia?) in canine mast cell tumor. BMC Vet Res. 2014 May 6;10:105.

Title: Mitchell L, et al. Clinical and immunomodulatory effects of toceranib combined with low-dose cyclophosphamide in dogs with cancer. J Vet Intern Med. 2012 Mar-Apr;26(2):355-62.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:874819-74-6 Molecular Formula|874819-74-6 MDL|874819-74-6 SMILES|874819-74-6 (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate