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356068-97-8,MFCD18252482
Catalog No.:AA007A66

356068-97-8 | N-Desethyl Sunitinib

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1mg
≥95%
in stock  
$98.00   $68.00
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5mg
≥95%
in stock  
$405.00   $283.00
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10mg
≥95%
in stock  
$606.00   $424.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007A66
Chemical Name:
N-Desethyl Sunitinib
CAS Number:
356068-97-8
Molecular Formula:
C20H23FN4O2
Molecular Weight:
370.4206
MDL Number:
MFCD18252482
SMILES:
CCNCCNC(=O)c1c(C)[nH]c(c1C)/C=C/1\C(=O)Nc2c1cc(F)cc2
Properties
Computed Properties
 
Complexity:
597  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
1.8  

Downstream Synthesis Route
110-72-5    356068-93-4   
N-DesethylSunitinib 

[1]Patent:CN110016052,2019,A.Locationinpatent:Paragraph0055;0063-0068

[1]Backos,DonaldS.;Casalvieri,KimberlyA.;Jordan,CraigT.;Matheson,ChristopherJ.;Minhajuddin,Mohammed;Reigan,Philip[EuropeanJournalofMedicinalChemistry,2020,vol.197]

Literature

Title: Quantitation of unbound sunitinib and its metabolite N-desethyl sunitinib (SU12662) in human plasma by equilibrium dialysis and liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20121101

Title: Sunitinib, a receptor tyrosine kinase inhibitor, increases blood pressure in rats without associated changes in cardiac structure and function.

Journal: Cardiovascular therapeutics 20121001

Title: Pharmacokinetics, distribution, and metabolism of [14C]sunitinib in rats, monkeys, and humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120301

Title: Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of sunitinib (SU11248) and its active metabolite, N-desethyl sunitinib (SU12662), in human plasma: application to an explorative study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110401

Title: Biomarker response on exposure to sunitinib and its primary metabolite (SU12662) in metastatic colorectal cancer patients.

Journal: International journal of clinical pharmacology and therapeutics 20110101

Title: Pharmacokinetics of sunitinib malate in subjects with hepatic impairment.

Journal: Cancer chemotherapy and pharmacology 20100901

Title: Bioanalytical method for the quantification of sunitinib and its n-desethyl metabolite SU12662 in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20100311

Title: A phase II study of sunitinib in patients with recurrent and/or metastatic non-nasopharyngeal head and neck cancer.

Journal: Cancer chemotherapy and pharmacology 20100301

Title: A routine feasible HPLC analysis for the anti-angiogenic tyrosine kinase inhibitor, sunitinib, and its main metabolite, SU12662, in plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101

Title: A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090401

Title: Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multi-targeted receptor tyrosine kinase inhibitor: results from a phase I study in healthy subjects.

Journal: Anti-cancer drugs 20060301

Title: Sun L, et al. Discovery of 5--fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor r

Title: Mendel DB, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Can

Title: O'Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. Epub 2003 Jan 16.

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SDS
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