Home Other Building Blocks 942425-68-5
942425-68-5,MFCD11519962
Catalog No.:AA00GU6L

942425-68-5 | PHA-767491 (hydrochloride)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%
in stock  
$23.00   $16.00
- +
10mg
98%
in stock  
$34.00   $24.00
- +
50mg
98%
in stock  
$96.00   $68.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU6L
Chemical Name:
PHA-767491 (hydrochloride)
CAS Number:
942425-68-5
Molecular Formula:
C12H12ClN3O
Molecular Weight:
249.6962
MDL Number:
MFCD11519962
SMILES:
O=C1NCCc2c1cc([nH]2)c1ccncc1.Cl
Properties
Computed Properties
 
Complexity:
275  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  

Literature

Title: Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300.

Title: Li W, et al. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets. 2015;15(3):196-204.

Title: Erbayraktar Z, et al. Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness. Cancer Cell Int. 2016 Nov 18;16:88.

Title: Montagnoli A, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65.

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SDS
Tags:942425-68-5 Molecular Formula|942425-68-5 MDL|942425-68-5 SMILES|942425-68-5 PHA-767491 (hydrochloride)