Home Pyridines 845714-00-3
845714-00-3,MFCD11870790
Catalog No.:AA0038BU

845714-00-3 | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one

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10mg
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$244.00   $171.00
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50mg
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$716.00   $501.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0038BU
Chemical Name:
1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one
CAS Number:
845714-00-3
Molecular Formula:
C12H11N3O
Molecular Weight:
213.2352
MDL Number:
MFCD11870790
SMILES:
O=C1NCCc2c1cc([nH]2)c1ccncc1
Properties
Computed Properties
 
Complexity:
275  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
0.6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-WO2005/13986,2005,A1Locationinpatent:Page/Pagecolumn32

[1]JournalofMedicinalChemistry,2007,vol.50,p.2647-2654

[1]Patent:US2007/142414,2007,A1.Locationinpatent:Page/Pagecolumn19

Literature

Title: Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

Journal: Journal of medicinal chemistry 20101028

Title: Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

Journal: Journal of medicinal chemistry 20100923

Title: First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.

Journal: Journal of medicinal chemistry 20090122

Title: A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

Journal: Nature chemical biology 20080601

Title: Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.

Journal: Journal of medicinal chemistry 20080214

Title: Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

Journal: Journal of medicinal chemistry 20070531

Title: Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300.

Title: Li W, et al. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets. 2015;15(3):196-204.

Title: Erbayraktar Z, et al. Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness. Cancer Cell Int. 2016 Nov 18;16:88.

Title: Montagnoli A, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65.

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SDS
Tags:845714-00-3 Molecular Formula|845714-00-3 MDL|845714-00-3 SMILES|845714-00-3 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one