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876310-60-0,MFCD11974995
Catalog No.:AA00GV10

876310-60-0 | 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE

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1mg
≥98%
in stock  
$133.00   $93.00
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5mg
≥98%
in stock  
$490.00   $343.00
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10mg
≥98%
in stock  
$848.00   $593.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GV10
Chemical Name:
2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
CAS Number:
876310-60-0
Molecular Formula:
C26H38N6O3
Molecular Weight:
482.6183
MDL Number:
MFCD11974995
SMILES:
NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3
Properties
Computed Properties
 
Complexity:
777  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
11  
XLogP3:
1.4  

Literature

Title: Selective mode of action of guanidine-containing non-peptides at human NPFF receptors.

Journal: Journal of medicinal chemistry 20120712

Title: RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity.

Journal: Journal of neuroendocrinology 20120501

Title: Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.

Journal: British journal of pharmacology 20120101

Title: Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice.

Journal: Endocrinology 20120101

Title: Modulation of neuropeptide FF (NPFF) receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats.

Journal: Peptides 20120101

Title: Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice.

Journal: Peptides 20110401

Title: Electrophysiological analysis of the inhibitory effects of FMRFamide-like peptides on the pacemaker activity of gonadotropin-releasing hormone neurons.

Journal: Journal of neurophysiology 20101201

Title: Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice.

Journal: Neuropeptides 20101001

Title: Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications.

Journal: Endocrinology 20100401

Title: Pharmacological characterization of the mouse NPFF2 receptor.

Journal: Peptides 20100201

Title: Prolactin-releasing peptide effects in the rat brain are mediated through the Neuropeptide FF receptor.

Journal: The European journal of neuroscience 20091001

Title: Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice.

Journal: Peptides 20080701

Title: Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist.

Journal: Regulatory peptides 20080410

Title: RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20060110

Title: [RF9, a powerful and selective antagonist of the neuropeptide FF receptors, prevents the development of the tolerance to opioids].

Journal: Medecine sciences : M/S 20060101

Title: Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71.

Title: Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15;27(4):630-643.

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Tags:876310-60-0 Molecular Formula|876310-60-0 MDL|876310-60-0 SMILES|876310-60-0 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE