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200959-48-4,MFCD02262126
Catalog No.:AA00BCPI

200959-48-4 | AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2

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1mg
> 95%
3 weeks  
$509.00   $357.00
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5mg
> 95%
3 weeks  
$845.00   $592.00
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10mg
> 95%
3 weeks  
$1,124.00   $787.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BCPI
Chemical Name:
AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2
CAS Number:
200959-48-4
Molecular Formula:
C44H70N14O9
Molecular Weight:
939.1150
MDL Number:
MFCD02262126
SMILES:
NCCCC[C@@H](C(=O)N)NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CCCNC(=N)N)Cc1ccc(cc1)O)Cc1ccc(cc1)O)CCCNC(=N)N
Properties
Computed Properties
 
Complexity:
1640  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
67  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
14  
Rotatable Bond Count:
30  
XLogP3:
-1.6  

Literature

Title: Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor.

Journal: Bioorganic & medicinal chemistry 20111215

Title: In vitro studies of the activity of newly sinthesized nociceptin / orphanin FQ receptor ligand analogues.

Journal: Protein and peptide letters 20100501

Title: Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist.

Journal: Bioorganic & medicinal chemistry 20080301

Title: Opioid receptor-like 1 (ORL1) receptor binding and the biological properties of Ac-Arg-Tyr-Tyr-Arg-Ile-Arg-NH2 and its analogs.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20071001

Title: Receptor binding properties and antinociceptive effects of chimeric peptides consisting of a micro-opioid receptor agonist and an ORL1 receptor antagonist.

Journal: Biological & pharmaceutical bulletin 20070701

Title: Inhibition of striatal and retinal dopamine release via nociceptin/orphanin FQ receptors.

Journal: British journal of pharmacology 20021201

Title: Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle.

Journal: British journal of pharmacology 20000901

Title: H Berger, et al. Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br J Pharmacol. 1999 Feb;126(3):555-8.

Title: H Berger, et al. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties.Peptides. 2000 Jul;21(7):1131-9.

Title: C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.

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SDS
Tags:200959-48-4 Molecular Formula|200959-48-4 MDL|200959-48-4 SMILES|200959-48-4 AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2