Home Other Building Blocks 874450-44-9
874450-44-9,MFCD17167027
Catalog No.:AA00GX8Z

874450-44-9 | SEN 12333

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
≥98%
in stock  
$160.00   $112.00
- +
50mg
≥98%
in stock  
$678.00   $474.00
- +
100mg
≥98%
in stock  
$1,193.00   $835.00
- +
250mg
≥98%
in stock  
$2,641.00   $1,849.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GX8Z
Chemical Name:
SEN 12333
CAS Number:
874450-44-9
Molecular Formula:
C20H25N3O2
Molecular Weight:
339.4314
MDL Number:
MFCD17167027
SMILES:
O=C(Nc1ccc(cc1)c1cccnc1)CCCCN1CCOCC1
Properties
Computed Properties
 
Complexity:
390  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
2  

Literature

Title: Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333.

Journal: Bioorganic & medicinal chemistry letters 20120401

Title: Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).

Journal: Journal of medicinal chemistry 20100610

Title: SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.

Journal: Bioorganic & medicinal chemistry 20090715

Title: Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

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