Name: Name:Ku-0060648
Brand: AABLOCKS
SKU: AA00H0FK
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00H0FK

Chemical Name: Ku-0060648

CAS Number: 881375-00-4

Molecular Formula: C33H34N4O4S

Molecular Weight: 582.7125

MDL Number: MFCD17214218

SMILES: CCN1CCN(CC1)CC(=O)Nc1ccc(c2c1c1ccccc1s2)c1cccc2c1oc(cc2=O)N1CCOCC1

Properties

Complexity: 1010

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 42

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.9

Literature fold

Title: 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

Journal: Journal of medicinal chemistry20130822

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

Journal: Bioorganic & medicinal chemistry letters20120901

Title: Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K.

Journal: Molecular cancer therapeutics20120801

Title: DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.

Journal: Bioorganic & medicinal chemistry letters20110201

Title: DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype.

Journal: Journal of medicinal chemistry20101223

Title: Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors.

Journal: Bioorganic & medicinal chemistry letters20100615

Title: The DNA-dependent protein kinase.

Journal: Genes & development19990415

Title: Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research19970701

Title: Differential implications of the oncogene-tumor suppressor gene complex in the geneses of 19 human neoplasias. Evidence in support of the steroid carcinogenesis hypothesis.

Journal: Anticancer research19970101

881375-00-4 | Ku-0060648