503468-95-9,MFCD11983069
Catalog No.:AA00D7Y9

503468-95-9 | Nu 7441

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$13.00   $9.00
- +
5mg
98+%
in stock  
$29.00   $20.00
- +
50mg
95%
in stock  
$208.00   $145.00
- +
100mg
95%
in stock  
$300.00   $210.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00D7Y9
Chemical Name:
Nu 7441
CAS Number:
503468-95-9
Molecular Formula:
C25H19NO3S
Molecular Weight:
413.4883
MDL Number:
MFCD11983069
SMILES:
O=c1cc(oc2c1cccc2c1cccc2c1sc1c2cccc1)N1CCOCC1
Properties
Properties
 
BP:
646.9°C at 760 mmHg  
Form:
Solid  
MP:
>194ºC (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
690  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5.5  

Literature

Title: A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.

Journal: Genes & development 20150915

Title: 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

Journal: Journal of medicinal chemistry 20130822

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.

Journal: Organic & biomolecular chemistry 20120907

Title: Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

Journal: Bioorganic & medicinal chemistry letters 20120901

Title: Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.

Journal: Cancer chemotherapy and pharmacology 20120101

Title: Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.

Journal: Organic & biomolecular chemistry 20110907

Title: DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.

Journal: Molecular pharmacology 20110801

Title: DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.

Journal: Bioorganic & medicinal chemistry letters 20110201

Title: Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia.

Journal: British journal of haematology 20110101

Title: Targeting the DNA double strand break repair machinery in prostate cancer.

Journal: PloS one 20110101

Title: Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100615

Title: Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation.

Journal: International journal of radiation oncology, biology, physics 20091201

Title: 8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).

Journal: Bioorganic & medicinal chemistry letters 20080901

Title: DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080615

Title: Judicious application of allyl protecting groups for the synthesis of 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl triflate, a key precursor of DNA-dependent protein kinase inhibitors.

Journal: Organic letters 20061221

Title: Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

Journal: Cancer research 20060515

Title: Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.

Journal: Biochemical pharmacology 20051219

Title: Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

Journal: Journal of medicinal chemistry 20051201

Title: Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.

Journal: Bioorganic & medicinal chemistry letters 20041220

Title: The DNA-dependent protein kinase.

Journal: Genes & development 19990415

Title: Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 19970701

Title: Differential implications of the oncogene-tumor suppressor gene complex in the geneses of 19 human neoplasias. Evidence in support of the steroid carcinogenesis hypothesis.

Journal: Anticancer research 19970101

Title: Justin J J Leahy, et al. Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7.

Title: Yang C, et al. NU7441 Enhances the Radiosensitivity of Liver Cancer Cells. Cell Physiol Biochem. 2016;38(5):1897-905

Title: Hardcastle IR, et al. Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46

Title: Ember SW, et al. The acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. ACS Chem Biol. 2014 Feb 25.

Title: Robert F, et al. Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 2015 Aug 27;7:93

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Tags:503468-95-9 Molecular Formula|503468-95-9 MDL|503468-95-9 SMILES|503468-95-9 Nu 7441
Catalog No.: AA00D7Y9
503468-95-9,MFCD11983069
503468-95-9 | Nu 7441
Pack Size: 1mg
Purity: 98+%
in stock
$13.00 $9.00
Pack Size: 5mg
Purity: 98+%
in stock
$29.00 $20.00
Pack Size: 50mg
Purity: 95%
in stock
$208.00 $145.00
Pack Size: 100mg
Purity: 95%
in stock
$300.00 $210.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00D7Y9
Chemical Name: Nu 7441
CAS Number: 503468-95-9
Molecular Formula: C25H19NO3S
Molecular Weight: 413.4883
MDL Number: MFCD11983069
SMILES: O=c1cc(oc2c1cccc2c1cccc2c1sc1c2cccc1)N1CCOCC1
Properties
BP: 646.9°C at 760 mmHg  
Form: Solid  
MP: >194ºC (dec.)  
Storage: Keep in dry area;-20 ℃;  
Complexity: 690  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5.5  
Literature fold

Title: A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.

Journal: Genes & development20150915

Title: 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

Journal: Journal of medicinal chemistry20130822

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.

Journal: Organic & biomolecular chemistry20120907

Title: Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

Journal: Bioorganic & medicinal chemistry letters20120901

Title: Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.

Journal: Cancer chemotherapy and pharmacology20120101

Title: Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.

Journal: Organic & biomolecular chemistry20110907

Title: DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.

Journal: Molecular pharmacology20110801

Title: DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.

Journal: Bioorganic & medicinal chemistry letters20110201

Title: Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia.

Journal: British journal of haematology20110101

Title: Targeting the DNA double strand break repair machinery in prostate cancer.

Journal: PloS one20110101

Title: Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors.

Journal: Bioorganic & medicinal chemistry letters20100615

Title: Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation.

Journal: International journal of radiation oncology, biology, physics20091201

Title: 8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).

Journal: Bioorganic & medicinal chemistry letters20080901

Title: DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20080615

Title: Judicious application of allyl protecting groups for the synthesis of 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl triflate, a key precursor of DNA-dependent protein kinase inhibitors.

Journal: Organic letters20061221

Title: Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

Journal: Cancer research20060515

Title: Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.

Journal: Biochemical pharmacology20051219

Title: Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

Journal: Journal of medicinal chemistry20051201

Title: Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.

Journal: Bioorganic & medicinal chemistry letters20041220

Title: The DNA-dependent protein kinase.

Journal: Genes & development19990415

Title: Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research19970701

Title: Differential implications of the oncogene-tumor suppressor gene complex in the geneses of 19 human neoplasias. Evidence in support of the steroid carcinogenesis hypothesis.

Journal: Anticancer research19970101

Title: Justin J J Leahy, et al. Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7.

Title: Yang C, et al. NU7441 Enhances the Radiosensitivity of Liver Cancer Cells. Cell Physiol Biochem. 2016;38(5):1897-905

Title: Hardcastle IR, et al. Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46

Title: Ember SW, et al. The acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. ACS Chem Biol. 2014 Feb 25.

Title: Robert F, et al. Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 2015 Aug 27;7:93

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