Title: Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice.
Journal: Molecular vision 20150101
Title: Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs.
Journal: The Journal of surgical research 20121101
Title: Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.
Journal: Hypertension (Dallas, Tex. : 1979) 20121101
Title: Fasudil ameliorates disease progression in experimental autoimmune encephalomyelitis, acting possibly through antiinflammatory effect.
Journal: CNS neuroscience & therapeutics 20121101
Title: RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism.
Journal: Toxicology and industrial health 20121001
Title: Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.
Journal: Cellular and molecular neurobiology 20121001
Title: Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma.
Journal: The Journal of pharmacology and experimental therapeutics 20121001
Title: A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator.
Journal: Neuroscience 20120918
Title: Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats.
Journal: European journal of pharmacology 20120915
Title: Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome.
Journal: American journal of physiology. Endocrinology and metabolism 20120915
Title: Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120901
Title: Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.
Journal: European journal of pharmacology 20120815
Title: Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats.
Journal: European journal of applied physiology 20120801
Title: Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension.
Journal: Recent patents on cardiovascular drug discovery 20120801
Title: [Effect of Fasudil on the phenotype conversion of LPS-stimulated BV-2 microglia].
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120801
Title: Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy.
Journal: Biochemical and biophysical research communications 20120727
Title: ROCK1 feedback regulation of the upstream small GTPase RhoA.
Journal: Cellular signalling 20120701
Title: Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon.
Journal: Arthritis care & research 20120601
Title: Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601
Title: Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1.
Journal: Toxicology letters 20120601
Title: The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells.
Journal: Cancer chemotherapy and pharmacology 20120601
Title: Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.
Journal: The American journal of pathology 20120601
Title: Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway.
Journal: Stem cells and development 20120501
Title: Fasudil inhibits lung carcinoma-conditioned endothelial cell viability and migration.
Journal: Oncology reports 20120501
Title: Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.
Journal: Lupus 20120501
Title: Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.
Journal: Atherosclerosis 20120501
Title: The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120401
Title: Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses.
Journal: Journal of cellular physiology 20120301
Title: [Progress in pharmacotherapy of pulmonary arterial hypertension in children].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120301
Title: Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage.
Journal: European journal of clinical pharmacology 20120201
Title: Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
Journal: Stroke 20120201
Title: Effects of fasudil in patients with high-altitude pulmonary hypertension.
Journal: The European respiratory journal 20120201
Title: Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride.
Journal: Neuroscience 20120103
Title: Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event.
Journal: Neuroradiology 20120101
Title: Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver.
Journal: Journal of hepatology 20120101
Title: Cardioprotective effect of a combination of Rho-kinase inhibitor and p38 MAPK inhibitor on cardiovascular remodeling and oxidative stress in Dahl rats.
Journal: Journal of atherosclerosis and thrombosis 20120101
Title: [Fasudil improves erectile function of hypertensive rats].
Journal: Zhonghua nan ke xue = National journal of andrology 20120101
Title: Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells.
Journal: Cancer biology & therapy 20120101
Title: Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.
Journal: BMC medicine 20120101
Title: High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.
Journal: Cardiovascular diabetology 20120101
Title: Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta.
Journal: Swiss medical weekly 20120101
Title: ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion.
Journal: Cardiovascular diabetology 20120101
Title: Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.
Journal: International journal of molecular sciences 20120101
Title: Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways.
Journal: PloS one 20120101
Title: Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions.
Journal: Molecular and cellular biochemistry 20111201
Title: Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus.
Journal: American journal of physiology. Lung cellular and molecular physiology 20111201
Title: Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.
Journal: The Journal of clinical endocrinology and metabolism 20111201
Title: Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice.
Journal: The Journal of surgical research 20111201
Title: Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20111201
Title: Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage.
Journal: Genetics and molecular research : GMR 20111129
Title: Preventive effects of fasudil on adriamycin-induced cardiomyopathy: possible involvement of inhibition of RhoA/ROCK pathway.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101
Title: Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.
Journal: American journal of physiology. Lung cellular and molecular physiology 20111101
Title: Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase.
Journal: Plastic and reconstructive surgery 20111101
Title: [Mechanism of diabetes-induced microvascular damage and therapeutic potential of ROCK inhibition].
Journal: Nippon Ganka Gakkai zasshi 20111101
Title: [Fasudil(Rho-kinase inhibitor)].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20111101
Title: The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.
Journal: Journal of neuroimmunology 20111028
Title: Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats.
Journal: Journal of neurosurgery 20111001
Title: Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats.
Journal: Clinical and experimental pharmacology & physiology 20111001
Title: Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20111001
Title: Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip¹ via the ERK signal pathway.
Journal: Chinese medical journal 20111001
Title: Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901
Title: The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures.
Journal: International journal of molecular medicine 20110901
Title: [Rho-kinase inhibitors].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110901
Title: Rho kinase as a therapeutic target in cardiovascular disease.
Journal: Future cardiology 20110901
Title: Subdose of fasudil suppresses myocardial fibrosis in aldosterone-salt-treated uninephrectomized rats.
Journal: Die Pharmazie 20110901
Title: Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.
Journal: Biochemical and biophysical research communications 20110812
Title: Agonist-induced periodic vasomotion in rat isolated pulmonary artery.
Journal: Fundamental & clinical pharmacology 20110801
Title: Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.
Journal: The Journal of thoracic and cardiovascular surgery 20110801
Title: Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats.
Journal: International journal of molecular medicine 20110801
Title: Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20110801
Title: Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis.
Journal: Journal of the neurological sciences 20110715
Title: Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.
Journal: American journal of physiology. Cell physiology 20110701
Title: Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways.
Journal: Journal of cellular biochemistry 20110701
Title: Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury.
Journal: The Journal of pharmacology and experimental therapeutics 20110701
Title: Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.
Journal: The Journal of pharmacology and experimental therapeutics 20110701
Title: Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.
Journal: Mycopathologia 20110701
Title: [The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium].
Journal: Zhonghua nei ke za zhi 20110701
Title: Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549.
Journal: Medical oncology (Northwood, London, England) 20110601
Title: The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes.
Journal: British journal of pharmacology 20110601
Title: Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity.
Journal: Cellular & molecular biology letters 20110601
Title: Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts.
Journal: Clinical and experimental pharmacology & physiology 20110601
Title: [Anti-hepatofibrosis effect of fasudil hydrochloride on Schistosoma japonicum-infected mice].
Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20110601
Title: ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase.
Journal: Microvascular research 20110501
Title: Involvement of Rho-kinase in collar-induced vasoconstriction and vascular hypersensitivity to serotonin in rat carotid.
Journal: International journal of cardiology 20110414
Title: Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20110401
Title: Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway.
Journal: Cellular and molecular neurobiology 20110301
Title: Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110215
Title: Chronic treatment with an oral rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats.
Journal: The journal of sexual medicine 20110201
Title: Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.
Journal: Kidney international 20110201
Title: Fasudil protects cultured N1E-115 cells against lysophosphatidic acid-induced neurite retraction through inhibition of Rho-kinase.
Journal: Brain research bulletin 20110201
Title: HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.
Journal: Cancer science 20110201
Title: Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.
Journal: Science signaling 20110125
Title: Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits.
Journal: Investigative ophthalmology & visual science 20110105
Title: Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion.
Journal: Life sciences 20110103
Title: Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil.
Journal: Pediatric pulmonology 20110101
Title: Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.
Journal: Toxicology and applied pharmacology 20110101
Title: Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.
Journal: Atherosclerosis 20110101
Title: Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.
Journal: Urologia internationalis 20110101
Title: Rho kinase inhibition in diabetic nephropathy.
Journal: Current opinion in nephrology and hypertension 20110101
Title: Aberrant ROCK activation promotes the development of type I diabetes in NOD mice.
Journal: Cellular immunology 20110101
Title: Advances in treatment of cerebral vasospasm: an update.
Journal: Acta neurochirurgica. Supplement 20110101
Title: Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo.
Journal: Acta neurochirurgica. Supplement 20110101
Title: Intra-arterial Administration of Fasudil Hydrochloride for Vasospasm Following Subarachnoid Haemorrhage: Experience of 90 Cases.
Journal: Acta neurochirurgica. Supplement 20110101
Title: Continuous intravertebral artery injection of fasudil hydrochloride in the treatment of cerebral vasospasm.
Journal: Neurology India 20110101
Title: Continuous intravertebral injection of fasudil hydrochloride in the treatment of cerebral vasospasm.
Journal: Neurology India 20110101
Title: Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats.
Journal: International journal of molecular sciences 20110101
Title: Potassium-induced intermittent vasomotion in rat isolated pulmonary artery.
Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101
Title: Vasodilatation produced by fasudil mesylate in vivo and in vitro.
Journal: Vascular pharmacology 20110101
Title: Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.
Journal: Renal failure 20110101
Title: Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
Journal: PloS one 20110101
Title: Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats.
Journal: Renal failure 20110101
Title: Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine.
Journal: Neurologia medico-chirurgica 20110101
Title: Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
Journal: American journal of physiology. Heart and circulatory physiology 20101201
Title: Urotensin II alters vascular reactivity in animals subjected to volume overload.
Journal: Peptides 20101101
Title: Identification of small molecules enhancing autophagic function from drug network analysis.
Journal: Autophagy 20101101
Title: [Molecular mechanisms of preretinal membrane contraction in proliferative vitreoretinal diseases and ROCK as a therapeutic target].
Journal: Nippon Ganka Gakkai zasshi 20101101
Title: [Effect of notch signaling on differentiation of rat marrow mesenchymal stem cells into neurons induced by fasudil hydrochloride].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20101101
Title: Characterization of Fasudil in preclinical models of pain.
Journal: The journal of pain : official journal of the American Pain Society 20101001
Title: Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil.
Journal: The European respiratory journal 20101001
Title: Effect of tongxinluo on vasoconstriction induced by the chronic injury of the adventitia in the rat carotid artery.
Journal: Journal of ethnopharmacology 20100915
Title: Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.
Journal: The Journal of pharmacology and experimental therapeutics 20100901
Title: Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100901
Title: Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.
Journal: Journal of neurochemistry 20100901
Title: Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro.
Journal: Canadian journal of physiology and pharmacology 20100901
Title: NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice.
Journal: American journal of physiology. Heart and circulatory physiology 20100801
Title: Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.
Journal: Brain research 20100716
Title: Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20100701
Title: Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20100605
Title: Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury.
Journal: Neuropathology : official journal of the Japanese Society of Neuropathology 20100601
Title: Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor.
Journal: Journal of neuroscience research 20100601
Title: Modulation of cerebral malaria by fasudil and other immune-modifying compounds.
Journal: Experimental parasitology 20100601
Title: Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo.
Journal: Cancer biology & therapy 20100601
Title: Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management.
Journal: Current opinion in critical care 20100401
Title: Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.
Journal: Bone 20100401
Title: Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats.
Journal: British journal of pharmacology 20100401
Title: Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20100401
Title: Increased RhoA/ROK mRNA expression and function in diabetic vein grafts compared with nondiabetic vein grafts and diabetic arterial grafts.
Journal: The Thoracic and cardiovascular surgeon 20100401
Title: Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.
Journal: Stem cell reviews 20100301
Title: Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension.
Journal: Heart and vessels 20100301
Title: Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice.
Journal: Regulatory peptides 20100225
Title: Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: experimental study in rats using vascular corrosion casts.
Journal: Neuroscience letters 20100205
Title: Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.
Journal: Pediatric research 20100201
Title: Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice.
Journal: Molecular and cellular neurosciences 20100201
Title: The influence of fasudil on the epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells from diabetic rats.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100201
Title: Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits.
Journal: Journal of vascular surgery 20100201
Title: Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage.
Journal: Brain research bulletin 20100115
Title: The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100101
Title: Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis.
Journal: Arthritis and rheumatism 20100101
Title: Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.
Journal: Neurologia medico-chirurgica 20100101
Title: Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression.
Journal: Endocrine journal 20100101
Title: HA1077 enhances the cytokeratin expression of mesenchymal stem cells.
Journal: Journal of burn care & research : official publication of the American Burn Association 20100101
Title: The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.
Journal: Experimental diabetes research 20100101
Title: Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.
Journal: Journal of Alzheimer's disease : JAD 20100101
Title: Modification of the detrimental effect of TNF-α on human endothelial progenitor cells by fasudil and Y27632.
Journal: Journal of biochemical and molecular toxicology 20100101
Title: Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.
Journal: PloS one 20100101
Title: Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria.
Journal: PloS one 20100101
Title: Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients.
Journal: Atherosclerosis 20091201
Title: Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium.
Journal: International journal of urology : official journal of the Japanese Urological Association 20091201
Title: Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20091201
Title: Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat.
Journal: Canadian journal of physiology and pharmacology 20091201
Title: A Rho-kinase inhibitor, fasudil, attenuates progressive glomerulosclerosis induced by daunorubicin in rats.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20091201
Title: Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Journal: Neurochemistry international 20091101
Title: Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF.
Journal: Brain, behavior, and immunity 20091101
Title: Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice.
Journal: Atherosclerosis 20091101
Title: Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.
Journal: Prostaglandins & other lipid mediators 20091101
Title: Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling.
Journal: American journal of physiology. Heart and circulatory physiology 20091101
Title: Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation.
Journal: Brain research 20091027
Title: Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.
Journal: Journal of viral hepatitis 20091001
Title: Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm.
Journal: Cardiovascular & hematological agents in medicinal chemistry 20091001
Title: [Experimental study on rho-kinase inhibitor by intravenous injection inhibiting intimal hyperplasia in vein grafts].
Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20090901
Title: [Fasudil promotes migration and vasculogenesis of endothelial cells differentiated from rat bone marrow mesenchymal stem cells in vitro].
Journal: Sheng li xue bao : [Acta physiologica Sinica] 20090825
Title: Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.
Journal: Canadian journal of physiology and pharmacology 20090801
Title: Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Journal: International journal of molecular medicine 20090701
Title: Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.
Journal: The Journal of pharmacology and experimental therapeutics 20090501
Title: Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.
Journal: American journal of physiology. Renal physiology 20090501
Title: Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.
Journal: American journal of physiology. Heart and circulatory physiology 20090501
Title: Vascular dysfunction in septic shock--any ROCKing news?
Journal: Critical care medicine 20090501
Title: Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease.
Journal: Pediatric cardiology 20090401
Title: Rho GTPases in hepatocellular carcinoma.
Journal: Biochimica et biophysica acta 20090401
Title: Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats.
Journal: Cellular and molecular neurobiology 20090301
Title: Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.
Journal: Clinica chimica acta; international journal of clinical chemistry 20090301
Title: Increased leukocyte ROCK activity in patients after acute ischemic stroke.
Journal: Brain research 20090227
Title: Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20090201
Title: Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.
Journal: Brain : a journal of neurology 20090201
Title: Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.
Journal: Archives of pharmacal research 20090201
Title: Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20090201
Title: Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Journal: Biochemical pharmacology 20090115
Title: Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons.
Journal: European journal of pharmacology 20090114
Title: Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
Journal: Diabetes 20090101
Title: Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.
Journal: American journal of physiology. Endocrinology and metabolism 20090101
Title: Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway.
Journal: Pharmacology 20090101
Title: In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat.
Journal: Neonatology 20090101
Title: The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading.
Journal: Current eye research 20090101
Title: Signaling through Rho GTPase pathway as viable drug target.
Journal: Current medicinal chemistry 20090101
Title: Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway.
Journal: Surgery today 20090101
Title: Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats.
Journal: Cardiovascular diabetology 20090101
Title: RhoA/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA.
Journal: Journal of cardiac surgery 20090101
Title: Rho kinase (ROCK) inhibitors and their application to inflammatory disorders.
Journal: Current topics in medicinal chemistry 20090101
Title: A Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation.
Journal: The Journal of thoracic and cardiovascular surgery 20081201
Title: A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation.
Journal: Journal of computer-aided molecular design 20081101
Title: Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.
Journal: American journal of physiology. Lung cellular and molecular physiology 20081101
Title: Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.
Journal: Arthritis and rheumatism 20081101
Title: Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.
Journal: European journal of pharmacology 20081010
Title: Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
Journal: The Journal of pharmacology and experimental therapeutics 20081001
Title: Fasudil inhibits the myogenic response in the fetal pulmonary circulation.
Journal: American journal of physiology. Heart and circulatory physiology 20081001
Title: [Role of coil embolization and arterial injection in elderly subarachnoid hemorrhage patients: preliminary report].
Journal: No shinkei geka. Neurological surgery 20081001
Title: Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Journal: Molecular and cellular endocrinology 20080910
Title: G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.
Journal: Cardiovascular research 20080901
Title: Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
Journal: British journal of pharmacology 20080901
Title: Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats.
Journal: Journal of hypertension 20080901
Title: Chronic stable angina pectoris.
Journal: Disease-a-month : DM 20080901
Title: Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.
Journal: Cardiovascular drugs and therapy 20080801
Title: Activated RHOA and peripheral axon regeneration.
Journal: Experimental neurology 20080801
Title: Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy.
Journal: The British journal of surgery 20080801
Title: Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.
Journal: Anesthesia and analgesia 20080601
Title: Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.
Journal: Molecular cancer therapeutics 20080601
Title: Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.
Journal: Neurologia medico-chirurgica 20080601
Title: Rho-kinase inhibitor and nicotinamide adenine dinucleotide phosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20080601
Title: Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.
Journal: American journal of physiology. Lung cellular and molecular physiology 20080401
Title: Central role of rho kinase in lipopolysaccharide-induced platelet capture on venous endothelium.
Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20080401
Title: Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia.
Journal: The Journal of infectious diseases 20080401
Title: Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.
Journal: Brain research 20080327
Title: Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.
Journal: Diabetes 20080301
Title: Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.
Journal: Hepatology (Baltimore, Md.) 20080301
Title: Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20080301
Title: Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration.
Journal: The American journal of pathology 20080301
Title: Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina.
Journal: Coronary artery disease 20080301
Title: Rho kinase inhibition: a new approach for treating diabetic nephropathy?
Journal: Diabetes 20080301
Title: Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats.
Journal: Journal of cardiovascular pharmacology 20080301
Title: Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.
Journal: Brain research 20080208
Title: [Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].
Journal: No shinkei geka. Neurological surgery 20080201
Title: Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.
Journal: Journal of cardiovascular pharmacology 20080201
Title: Increased static pressure promotes migration of vascular smooth muscle cells: involvement of the Rho-kinase pathway.
Journal: Journal of cardiovascular pharmacology 20080101
Title: Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor.
Journal: Japanese journal of ophthalmology 20080101
Title: In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis.
Journal: Methods in enzymology 20080101
Title: Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20080101
Title: Rho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats.
Journal: American journal of physiology. Lung cellular and molecular physiology 20071101
Title: Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.
Journal: Journal of neurochemistry 20071001
Title: Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20071001
Title: Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.
Journal: Hypertension (Dallas, Tex. : 1979) 20071001
Title: [Advances in the study of Rho kinase and its inhibitors].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071001
Title: [Exercise-induced vasospastic angina].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20070928
Title: Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats.
Journal: Life sciences 20070922
Title: Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.
Journal: British journal of pharmacology 20070901
Title: Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis.
Journal: Spine 20070901
Title: Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase.
Journal: European journal of pharmacology 20070827
Title: Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.
Journal: Journal of neuroscience research 20070815
Title: Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
Journal: Biochemical pharmacology 20070815
Title: The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.
Journal: Leukemia 20070801
Title: A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage.
Journal: Surgical neurology 20070801
Title: Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.
Journal: Nature reviews. Drug discovery 20070801
Title: Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats.
Journal: Journal of cardiovascular pharmacology 20070801
Title: Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.
Journal: Journal of cardiovascular pharmacology 20070801
Title: [Effects of fasudil on neuropathic pain-like state in mice].
Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070801
Title: The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats.
Journal: European journal of pharmacology 20070730
Title: Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide.
Journal: American journal of physiology. Heart and circulatory physiology 20070701
Title: Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.
Journal: Brain research 20070618
Title: Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.
Journal: American journal of physiology. Heart and circulatory physiology 20070601
Title: The RISK of ROCK.
Journal: American journal of physiology. Heart and circulatory physiology 20070601
Title: Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601
Title: Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats.
Journal: Journal of hypertension 20070501
Title: Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.
Journal: Molecular cancer therapeutics 20070501
Title: Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.
Journal: Circulation 20070403
Title: Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.
Journal: American journal of physiology. Heart and circulatory physiology 20070401
Title: Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors.
Journal: The Tohoku journal of experimental medicine 20070401
Title: Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070401
Title: Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.
Journal: Circulation research 20070330
Title: RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.
Journal: The Journal of biological chemistry 20070316
Title: Progress of the study of rho-kinase and future perspective of the inhibitor.
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070301
Title: A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats.
Journal: The Journal of endocrinology 20070301
Title: Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.
Journal: Journal of cardiovascular pharmacology 20070301
Title: Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.
Journal: Journal of the American College of Cardiology 20070213
Title: The Rho-associated kinase inhibitor fasudil hydrochloride enhances neural regeneration after axotomy in the peripheral nervous system.
Journal: Plastic and reconstructive surgery 20070201
Title: Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.
Journal: Journal of cardiovascular pharmacology 20070201
Title: Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
Journal: Brain research 20070112
Title: Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats.
Journal: Chinese medical journal 20070105
Title: Design and synthesis of Rho kinase inhibitors (II).
Journal: Bioorganic & medicinal chemistry 20070101
Title: Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats.
Journal: Pharmacological research 20070101
Title: Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor.
Journal: Diabetes 20070101
Title: Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract.
Journal: Journal of clinical pharmacology 20070101
Title: Fasudil: a potential addition to the anti-arthritis weaponry.
Journal: Medical hypotheses 20070101
Title: Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation.
Journal: The Journal of veterinary medical science 20070101
Title: RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.
Journal: Neurourology and urodynamics 20070101
Title: Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina.
Journal: Japanese journal of ophthalmology 20070101
Title: Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.
Journal: Circulation research 20061208
Title: Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway.
Journal: Cardiovascular research 20061201
Title: Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.
Journal: Journal of cardiovascular pharmacology 20061201
Title: [Effects of intervention with Rho kinase inhibitor fasudil on rats with hypoxic pulmonary hypertension].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20061201
Title: Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.
Journal: American journal of physiology. Lung cellular and molecular physiology 20061101
Title: The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.
Journal: Journal of neuroimmunology 20061101
Title: Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model.
Journal: The journal of sexual medicine 20061101
Title: [Fasudil inhibits HSC adhesion, migration and proliferation via Rho/ROCK pathway].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20061101
Title: ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling.
Journal: Circulation research 20061013
Title: Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury.
Journal: Journal of the peripheral nervous system : JPNS 20060901
Title: [Role of the Rho/Rho-kinase pathway in the development of hypertensive glomerulosclerosis: renoprotective effect of Rho-kinase inhibitor in hypertensive glomerulosclerosis and its molecular mechanism].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060901
Title: The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models.
Journal: Molecular cancer therapeutics 20060901
Title: Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.
Journal: Neurologia medico-chirurgica 20060901
Title: Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060901
Title: Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats.
Journal: Experimental neurology 20060801
Title: Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury.
Journal: Journal of the American Society of Nephrology : JASN 20060801
Title: In vivo X-ray angiography in the mouse brain using synchrotron radiation.
Journal: Stroke 20060701
Title: Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20060601
Title: Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits.
Journal: Journal of vascular surgery 20060601
Title: [Mechanism of signal transduction of differentiation of mesenchymal stem cells into cytokeratin-expressing epidermoid cells].
Journal: Zhonghua yi xue za zhi 20060516
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.
Journal: Journal of leukocyte biology 20060501
Title: Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.
Journal: Autonomic & autacoid pharmacology 20060401
Title: Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20060401
Title: Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20060301
Title: Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.
Journal: Biological & pharmaceutical bulletin 20060301
Title: Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.
Journal: Structure (London, England : 1993) 20060301
Title: Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.
Journal: American journal of physiology. Lung cellular and molecular physiology 20060201
Title: Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20060201
Title: Involvement of Rho-kinase in experimental vascular endothelial dysfunction.
Journal: Molecular and cellular biochemistry 20060201
Title: The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
Journal: The Journal of biological chemistry 20060106
Title: Rho-kinase as a molecular target for insulin resistance and hypertension.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
Title: Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury.
Journal: Journal of pharmacological sciences 20060101
Title: Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis.
Journal: Journal of pharmacological sciences 20060101
Title: Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.
Journal: Protein and peptide letters 20060101
Title: Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats.
Journal: Pharmacology 20060101
Title: Effect of fasudil on macrovascular disorder-induced endothelial dysfunction.
Journal: Canadian journal of physiology and pharmacology 20060101
Title: Development of specific Rho-kinase inhibitors and their clinical application.
Journal: Biochimica et biophysica acta 20051230
Title: Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats.
Journal: European journal of pharmacology 20051219
Title: Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.
Journal: British journal of pharmacology 20051201
Title: Smoking, endothelial function, and Rho-kinase in humans.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20051201
Title: Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial.
Journal: Journal of the neurological sciences 20051115
Title: Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial.
Journal: Journal of the American College of Cardiology 20051115
Title: Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.
Journal: American journal of physiology. Heart and circulatory physiology 20051101
Title: Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.
Journal: British journal of pharmacology 20051101
Title: Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
Journal: Stroke 20051001
Title: [Cerebral circulation dynamics following fasudil intravenous infusion: a CT perfusion study].
Journal: No to shinkei = Brain and nerve 20050901
Title: Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20050801
Title: Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20050701
Title: Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage.
Journal: American journal of physiology. Heart and circulatory physiology 20050601
Title: Fasudil prevents KATP channel-induced improvement in postischemic functional recovery.
Journal: American journal of physiology. Heart and circulatory physiology 20050601
Title: Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.
Journal: Circulation 20050531
Title: Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.
Journal: Circulation 20050503
Title: Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.
Journal: European journal of pharmacology 20050411
Title: Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice.
Journal: European journal of pharmacology 20050411
Title: Role of Rho-kinase and p27 in angiotensin II-induced vascular injury.
Journal: Hypertension (Dallas, Tex. : 1979) 20050401
Title: Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.
Journal: American journal of respiratory and critical care medicine 20050301
Title: Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension.
Journal: Heart (British Cardiac Society) 20050301
Title: Small guanine nucleotide-binding protein Rho and myocardial function.
Journal: Acta pharmacologica Sinica 20050301
Title: Rho-kinase and myosin II activities are required for cell type and environment specific migration.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20050201
Title: [Intra-arterial administration of fasudil hydrochloride: duration of action].
Journal: No shinkei geka. Neurological surgery 20050201
Title: [The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil].
Journal: Zhonghua xin xue guan bing za zhi 20050101
Title: Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041101
Title: Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Journal: British journal of pharmacology 20041001
Title: [Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report].
Journal: Journal of cardiology 20041001
Title: Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP.
Journal: European journal of pharmacology 20040913
Title: Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats.
Journal: Journal of hypertension 20040901
Title: Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.
Journal: Journal of cardiovascular pharmacology 20040901
Title: Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
Journal: Brain research 20040820
Title: [Development of drug delivery system for intrathecal administration and its therapeutic effect on cerebral vasospasm and ischemia].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801
Title: Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.
Journal: Circulation 20040511
Title: Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401
Title: Rho kinase inhibition initiates apoptosis in human airway epithelial cells.
Journal: American journal of respiratory cell and molecular biology 20040301
Title: Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability.
Journal: American journal of physiology. Heart and circulatory physiology 20040301
Title: [Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040301
Title: Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Journal: Circulation research 20040220
Title: [Rho-kinase inhibitor].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040201
Title: Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.
Journal: Circulation research 20040109
Title: Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040101
Title: Differential effects of Rho-kinase inhibition on artery wall mass and remodeling.
Journal: Journal of vascular surgery 20040101
Title: The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis.
Journal: Drug news & perspectives 20040101
Title: Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery.
Journal: Cell biochemistry and biophysics 20040101
Title: Rho kinase inhibitors block activation of pancreatic stellate cells.
Journal: British journal of pharmacology 20031201
Title: Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats.
Journal: Kidney international 20031201
Title: Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Journal: Structure (London, England : 1993) 20031201
Title: Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.
Journal: British journal of pharmacology 20031001
Title: Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1.
Journal: The Journal of biological chemistry 20030822
Title: Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.
Journal: European journal of pharmacology 20030711
Title: Astrocyte stellation induced by Rho kinase inhibitors in culture.
Journal: Brain research. Developmental brain research 20030612
Title: Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.
Journal: Kidney international 20030601
Title: P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030601
Title: Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans.
Journal: Hypertension (Dallas, Tex. : 1979) 20030501
Title: Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.
Journal: Circulation research 20030418
Title: Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
Journal: Biochemical and biophysical research communications 20030411
Title: Synthesis and pharmacological study of Rho-kinase inhibitors: pharmacomodulations on the lead compound Fasudil.
Journal: Journal of enzyme inhibition and medicinal chemistry 20030401
Title: Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.
Journal: The Journal of physiology 20030315
Title: Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae.
Journal: The Journal of physiology 20030201
Title: A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.
Journal: Brain research 20030103
Title: Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm.
Journal: Journal of the American College of Cardiology 20030101
Title: Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular tone.
Journal: Journal of vascular research 20030101
Title: RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Journal: British journal of pharmacology 20021201
Title: [Basic and clinical studies on coronary vasospasm].
Journal: Masui. The Japanese journal of anesthesiology 20021201
Title: Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction.
Journal: European journal of pharmacology 20021129
Title: Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats.
Journal: Life sciences 20021122
Title: Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study.
Journal: Journal of cardiovascular pharmacology 20021101
Title: The mechanism of excitation-contraction coupling in phenylephrine-stimulated human saphenous vein.
Journal: American journal of physiology. Heart and circulatory physiology 20021001
Title: Nitric oxide-induced motility in aortic smooth muscle cells: role of protein tyrosine phosphatase SHP-2 and GTP-binding protein Rho.
Journal: Circulation research 20020906
Title: Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway.
Journal: Prostaglandins & other lipid mediators 20020901
Title: [Involvement of Rho-kinase in hypertensive vascular disease--a novel therapeutic target in hypertension].
Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20020801
Title: Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes.
Journal: Biochimica et biophysica acta 20020612
Title: Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.
Journal: The Biochemical journal 20020601
Title: Enhanced contractile mechanisms in vasospasm: is endothelial dysfunction the whole story?
Journal: Circulation 20020402
Title: Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.
Journal: Circulation 20020402
Title: Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles.
Journal: Life sciences 20020322
Title: Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
Journal: Journal of cardiovascular pharmacology 20020301
Title: Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.
Journal: International journal of pharmaceutics 20020131
Title: The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway.
Journal: Pharmacology & therapeutics 20020101
Title: Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.
Journal: British journal of pharmacology 20011201
Title: Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.
Journal: Hypertension (Dallas, Tex. : 1979) 20011201
Title: Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCbetaI, PKCbetaII and PKCzeta in human neutrophils.
Journal: Mediators of inflammation 20011201
Title: Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats.
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20011101
Title: Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats.
Journal: European journal of pharmacology 20010907
Title: Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.
Journal: British journal of pharmacology 20010901
Title: Antiischemic properties of fasudil in experimental models of vasospastic angina.
Journal: Japanese journal of pharmacology 20010901
Title: Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.
Journal: Life sciences 20010810
Title: Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20010801
Title: Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.
Journal: Journal of cellular physiology 20010701
Title: Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.
Journal: Cardiovascular research 20010701
Title: Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010701
Title: Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).
Journal: Experimental cell research 20010610
Title: Efficacy of intrathecal liposomal fasudil for experimental cerebral vasospasm after subarachnoid hemorrhage.
Journal: Neurosurgery 20010401
Title: Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.
Journal: FEBS letters 20010330
Title: Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia.
Journal: Neurologia medico-chirurgica 20010301
Title: Rho-associated kinase phosphorylates MARCKS in human neuronal cells.
Journal: Biochemical and biophysical research communications 20010126
Title: Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.
Journal: Journal of muscle research and cell motility 20010101
Title: Effect of Fasudil HCl, a protein kinase inhibitor, on cerebral vasospasm.
Journal: Acta neurochirurgica. Supplement 20010101
Title: Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.
Journal: Acta neurochirurgica. Supplement 20010101
Title: A novel drug delivery system as prophylaxis for cerebral vasospasm.
Journal: Acta neurochirurgica. Supplement 20010101
Title: Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Journal: The Biochemical journal 20001001
Title: Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride.
Journal: AIDS research and human retroviruses 19980301
Title: Pretreatment of transient focal cerebral ischemia in rats with the calcium antagonist AT877.
Journal: Stroke 19940601
Title: [Treatment of cerebral vasospasm by a protein kinase inhibitor AT 877].
Journal: No to shinkei = Brain and nerve 19930901
Title: Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.
Journal: British journal of pharmacology 19891201
