Title: Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat.
Journal: Pharmacological research 20121001
Title: HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits.
Journal: Neurobiology of aging 20120801
Title: Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy.
Journal: Biochemical and biophysical research communications 20120727
Title: Hydroxyfasudil ameliorates bladder dysfunction in male spontaneously hypertensive rats.
Journal: Urology 20120501
Title: Long-term treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: possible involvement of Rho-kinase pathway.
Journal: European heart journal 20120301
Title: Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation.
Journal: Anesthesiology 20120201
Title: Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats.
Journal: Neurochemistry international 20120201
Title: Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage.
Journal: Journal of pharmacological sciences 20120101
Title: High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.
Journal: Cardiovascular diabetology 20120101
Title: Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137.
Journal: PloS one 20120101
Title: Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19.
Journal: Molecular vision 20120101
Title: On the role of RhoA/ROCK signaling in contact guidance of bone-forming cells on anisotropic Ti6Al4V surfaces.
Journal: Acta biomaterialia 20110401
Title: Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Journal: American journal of physiology. Heart and circulatory physiology 20110401
Title: Fasudil protects cultured N1E-115 cells against lysophosphatidic acid-induced neurite retraction through inhibition of Rho-kinase.
Journal: Brain research bulletin 20110201
Title: Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110101
Title: Dynamic changes in neurexins' alternative splicing: role of Rho-associated protein kinases and relevance to memory formation.
Journal: PloS one 20110101
Title: Secrets of aging: What does a normally aging brain look like?
Journal: F1000 biology reports 20110101
Title: Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.
Journal: PloS one 20110101
Title: ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration.
Journal: Frontiers in molecular neuroscience 20110101
Title: Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway.
Journal: The Journal of biological chemistry 20101126
Title: Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20100605
Title: Effects of sex and estrogen on chicken ductus arteriosus reactivity.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100501
Title: Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.
Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20100301
Title: Abstracts of the 16th Annual Society on NeuroImmune Pharmacology (SNIP) Conference. April 13-17, 2010. Manhattan Beach, California, USA.
Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20100301
Title: Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
Journal: Journal of medicinal chemistry 20100128
Title: Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage.
Journal: Brain research bulletin 20100115
Title: Recent development of cyclic amide (pyridone/lactam) moiety containing heterocycles as protein kinase inhibitors.
Journal: Current medicinal chemistry 20100101
Title: Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.
Journal: PloS one 20100101
Title: The role of RhoA/Rho kinase pathway in endothelial dysfunction.
Journal: Journal of cardiovascular disease research 20100101
Title: Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in pigs in vivo.
Journal: Journal of the American College of Cardiology 20091208
Title: Maturation of O2 sensing and signaling in the chicken ductus arteriosus.
Journal: American journal of physiology. Lung cellular and molecular physiology 20091001
Title: Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model.
Journal: International journal of urology : official journal of the Japanese Urological Association 20091001
Title: Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20090901
Title: Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Journal: Journal of biochemistry 20090601
Title: Remote periconditioning reduces myocardial no-reflow by the activation of K ATP channel via inhibition of Rho-kinase.
Journal: International journal of cardiology 20090403
Title: A role for Rho-kinase in Ca-independent contractions induced by phorbol-12,13-dibutyrate.
Journal: Clinical and experimental pharmacology & physiology 20090301
Title: Morphological and functional alterations of the ductus arteriosus in a chicken model of hypoxia-induced fetal growth retardation.
Journal: Pediatric research 20090301
Title: Peripheral delivery of a ROCK inhibitor improves learning and working memory.
Journal: Behavioral neuroscience 20090201
Title: RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension.
Journal: Vascular health and risk management 20090101
Title: Dopamine D2 receptor stimulation potentiates PolyQ-Huntingtin-induced mouse striatal neuron dysfunctions via Rho/ROCK-II activation.
Journal: PloS one 20090101
Title: Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes.
Journal: Biophysical journal 20081001
Title: Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins.
Journal: Diabetes 20081001
Title: Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes.
Journal: Arthritis and rheumatism 20080901
Title: Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase.
Journal: Cellular and molecular neurobiology 20080801
Title: Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study.
Journal: Neurologia medico-chirurgica 20080601
Title: The therapeutic effects of Rho-ROCK inhibitors on CNS disorders.
Journal: Therapeutics and clinical risk management 20080601
Title: Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model.
Journal: Brain research 20080208
Title: Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model.
Journal: Virchows Archiv : an international journal of pathology 20071101
Title: The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation.
Journal: Vascular health and risk management 20071001
Title: Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.
Journal: Brain research 20070618
Title: [Regulatory effects of RhoGTPase on transition of liver sinusoidal capillarization: experiment with mice of schistosomal hepatic fibrosis].
Journal: Zhonghua yi xue za zhi 20070612
Title: Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070501
Title: Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.
Journal: Journal of cardiovascular pharmacology 20070201
Title: Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
Journal: Brain research 20070112
Title: Different migration of vascular smooth muscle cells from human coronary artery bypass vessels. Role of Rho/ROCK pathway.
Journal: Journal of vascular research 20070101
Title: Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo: a possible link between stress and coronary vasospasm.
Journal: Circulation research 20060929
Title: 8-Isoprostane-induced endothelin-1 production by infant rat pulmonary artery smooth muscle cells is mediated by Rho-kinase.
Journal: Free radical biology & medicine 20060915
Title: Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits.
Journal: Journal of vascular surgery 20060601
Title: Determination of the enantiomeric excess of an M3 antagonist drug substance by chemometric analysis of the IR spectra of different guest-host complexes.
Journal: Chirality 20060515
Title: Critical role of the Rho-kinase pathway in TGF-beta2-dependent collagen gel contraction by retinal pigment epithelial cells.
Journal: Experimental eye research 20060501
Title: The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
Journal: The Journal of biological chemistry 20060106
Title: Rho-kinase as a molecular target for insulin resistance and hypertension.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
Title: Cardioprotective effect of hydroxyfasudil as a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microvessels in vivo.
Journal: Clinical hemorheology and microcirculation 20060101
Title: Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway.
Journal: Cardiovascular research 20051201
Title: Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial.
Journal: Journal of the neurological sciences 20051115
Title: Inhibition of rho-kinase by hydroxyfasudil prevents vasopressin-induced myocardial ischemia in Donryu rats by attenuating coronary vasoconstriction.
Journal: Pharmacology 20051101
Title: Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
Journal: Stroke 20051001
Title: Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells.
Journal: Circulation 20050621
Title: Age-related differences in vasoconstrictor responses to isoprostanes in piglet pulmonary and mesenteric vascular smooth muscle.
Journal: Pediatric research 20050601
Title: Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo.
Journal: Journal of the American College of Cardiology 20050215
Title: Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension.
Journal: Journal of cardiovascular pharmacology 20050201
Title: Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats.
Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20050101
Title: Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss.
Journal: BMC ear, nose, and throat disorders 20050101
Title: Chronologic changes of fasudil hydrochloride and hydroxyfasudil in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage.
Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20050101
Title: The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes.
Journal: Investigative ophthalmology & visual science 20041101
Title: Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20041001
Title: Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C.
Journal: Circulation 20040706
Title: Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.
Journal: Circulation 20040511
Title: Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040501
Title: Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Journal: Circulation research 20040220
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Journal: Nihon rinsho. Japanese journal of clinical medicine 20040201
Title: Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.
Journal: Circulation research 20040109
Title: Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20031201
Title: Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system.
Journal: Circulation research 20031017
Title: Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae.
Journal: The Journal of physiology 20030201
Title: Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction.
Journal: European journal of pharmacology 20021129
Title: Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study.
Journal: Journal of cardiovascular pharmacology 20021101
Title: [Involvement of Rho-kinase in hypertensive vascular disease--a novel therapeutic target in hypertension].
Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20020801
Title: Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase.
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Title: Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
Journal: Journal of cardiovascular pharmacology 20020301
Title: Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20020201
Title: Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.
Journal: British journal of pharmacology 20011201
Title: Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts.
Journal: Biochemical and biophysical research communications 20010921
Title: Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats.
Journal: European journal of pharmacology 20010907
Title: Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.
Journal: Cardiovascular research 20010701
Title: Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase.
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