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1228675-25-9,MFCD28054177
Catalog No.:AA00HH26

1228675-25-9 | 4-Benzyl 1-tert-butyl 2-oxopiperazine-1,4-dicarboxylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$14.00   $10.00
- +
1g
95%
in stock  
$41.00   $29.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00HH26
Chemical Name:
4-Benzyl 1-tert-butyl 2-oxopiperazine-1,4-dicarboxylate
CAS Number:
1228675-25-9
Molecular Formula:
C17H22N2O5
Molecular Weight:
334.3670
MDL Number:
MFCD28054177
SMILES:
O=C(N1CCN(C(=O)C1)C(=O)OC(C)(C)C)OCc1ccccc1
Properties
Computed Properties
 
Complexity:
480  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
2.1  

Downstream Synthesis Route

[1]Locationinpatent:experimentalpartTaylor,RivkaR.R.;Twin,HeatherC.;Wen,WendyW.;Mallot,RebeccaJ.;Lough,AlanJ.;Gray-Owen,ScottD.;Batey,RobertA.[Tetrahedron,2010,vol.66,#18,p.3370-3377]

[2]Argüello‐Velasco,RubénOswaldo;Sánchez‐Muñoz,GreciaKatherine;Viveros‐Ceballos,JoséLuis;Ordóñez,Mario;Kafarski,Pawel[JournalofHeterocyclicChemistry,2019,vol.56,#7,p.2068-2073]

[1]JournalofHeterocyclicChemistry,2019

[2]Tetrahedron,2010,vol.66,p.3370-3377

[3]Patent:WO2012/27261,2012,A1.Locationinpatent:Page/Pagecolumn535-537

[4]Patent:WO2013/123444,2013,A1.Locationinpatent:Page/Pagecolumn72;73

[5]JournalofMedicinalChemistry,2014,vol.57,p.325-338

[6]Patent:WO2014/35872,2014,A1.Locationinpatent:Page/Pagecolumn79-80

[7]JournalofMedicinalChemistry,2014,vol.57,p.3094-3116

[8]Nature,2013,vol.504,p.437-440

[1]CurrentPatentAssignee:AMGENINC-WO2012/27261,2012,A1

[2]CurrentPatentAssignee:AMGENINC-WO2013/123444,2013,A1

[3]St.Jean,DavidJ.;Ashton,KateS.;Bartberger,MichaelD.;Chen,Jie;Chmait,Samer;Cupples,Rod;Galbreath,Elizabeth;Helmering,Joan;Hong,Fang-Tsao;Jordan,StevenR.;Liu,Longbin;Kunz,RoxanneK.;Michelsen,Klaus;Nishimura,Nobuko;Pennington,LewisD.;Poon,SteveF.;Reid,Darren;Sivits,Glenn;Stec,MarkianM.;Tadesse,Seifu;Tamayo,Nuria;Van,Gwyneth;Yang,KevinC.;Zhang,Jiandong;Norman,MarkH.;Fotsch,Christopher;Lloyd,DavidJ.;Hale,Clarence[JournalofMedicinalChemistry,2014,vol.57,#2,p.325-338]

[4]CurrentPatentAssignee:AMGENINC-WO2014/35872,2014,A1

[5]Nishimura,Nobuko;Norman,MarkH.;Liu,Longbin;Yang,KevinC.;Ashton,KateS.;Bartberger,MichaelD.;Chmait,Samer;Chen,Jie;Cupples,Rod;Fotsch,Christopher;Helmering,Joan;Jordan,StevenR.;Kunz,RoxanneK.;Pennington,LewisD.;Poon,SteveF.;Siegmund,Aaron;Sivits,Glenn;Lloyd,DavidJ.;Hale,Clarence;St.Jean,DavidJ.[JournalofMedicinalChemistry,2014,vol.57,#7,p.3094-3116]

[6]Lloyd,DavidJ.;StJean,DavidJ.;Kurzeja,RobertJ.M.;Wahl,RobertC.;Michelsen,Klaus;Cupples,Rod;Chen,Michelle;Wu,John;Sivits,Glenn;Helmering,Joan;Komorowski,Renee;Ashton,KateS.;Pennington,LewisD.;Fotsch,Christopher;Vazir,Mukta;Chen,Kui;Chmait,Samer;Zhang,Jiandong;Liu,Longbin;Norman,MarkH.;Andrews,KristinL.;Bartberger,MichaelD.;Van,Gwyneth;Galbreath,ElizabethJ.;Vonderfecht,StevenL.;Wang,Minghan;Jordan,StevenR.;Veniant,MurielleM.;Hale,Clarence[Nature,2013,vol.504,#7480,p.437-440]

[7]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-CN113620944,2021,A

1228675-25-9   
1-propynylmagnesiumbromide 
  1361224-49-8 

[1]St.Jean,DavidJ.;Ashton,KateS.;Bartberger,MichaelD.;Chen,Jie;Chmait,Samer;Cupples,Rod;Galbreath,Elizabeth;Helmering,Joan;Hong,Fang-Tsao;Jordan,StevenR.;Liu,Longbin;Kunz,RoxanneK.;Michelsen,Klaus;Nishimura,Nobuko;Pennington,LewisD.;Poon,SteveF.;Reid,Darren;Sivits,Glenn;Stec,MarkianM.;Tadesse,Seifu;Tamayo,Nuria;Van,Gwyneth;Yang,KevinC.;Zhang,Jiandong;Norman,MarkH.;Fotsch,Christopher;Lloyd,DavidJ.;Hale,Clarence[JournalofMedicinalChemistry,2014,vol.57,#2,p.325-338]

[2]Lloyd,DavidJ.;StJean,DavidJ.;Kurzeja,RobertJ.M.;Wahl,RobertC.;Michelsen,Klaus;Cupples,Rod;Chen,Michelle;Wu,John;Sivits,Glenn;Helmering,Joan;Komorowski,Renee;Ashton,KateS.;Pennington,LewisD.;Fotsch,Christopher;Vazir,Mukta;Chen,Kui;Chmait,Samer;Zhang,Jiandong;Liu,Longbin;Norman,MarkH.;Andrews,KristinL.;Bartberger,MichaelD.;Van,Gwyneth;Galbreath,ElizabethJ.;Vonderfecht,StevenL.;Wang,Minghan;Jordan,StevenR.;Veniant,MurielleM.;Hale,Clarence[Nature,2013,vol.504,#7480,p.437-440]

[3]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-CN113620944,2021,ALocationinpatent:Paragraph0315;0321-0322

[4]CurrentPatentAssignee:AMGENINC-WO2012/27261,2012,A1Locationinpatent:Page/Pagecolumn536;537

[5]CurrentPatentAssignee:AMGENINC-WO2013/123444,2013,A1Locationinpatent:Page/Pagecolumn73

[6]CurrentPatentAssignee:AMGENINC-WO2014/35872,2014,A1Locationinpatent:Page/Pagecolumn80

[7]Nishimura,Nobuko;Norman,MarkH.;Liu,Longbin;Yang,KevinC.;Ashton,KateS.;Bartberger,MichaelD.;Chmait,Samer;Chen,Jie;Cupples,Rod;Fotsch,Christopher;Helmering,Joan;Jordan,StevenR.;Kunz,RoxanneK.;Pennington,LewisD.;Poon,SteveF.;Siegmund,Aaron;Sivits,Glenn;Lloyd,DavidJ.;Hale,Clarence;St.Jean,DavidJ.[JournalofMedicinalChemistry,2014,vol.57,#7,p.3094-3116]

[1]CurrentPatentAssignee:AMGENINC-WO2012/27261,2012,A1

[2]CurrentPatentAssignee:AMGENINC-WO2013/123444,2013,A1

[3]St.Jean,DavidJ.;Ashton,KateS.;Bartberger,MichaelD.;Chen,Jie;Chmait,Samer;Cupples,Rod;Galbreath,Elizabeth;Helmering,Joan;Hong,Fang-Tsao;Jordan,StevenR.;Liu,Longbin;Kunz,RoxanneK.;Michelsen,Klaus;Nishimura,Nobuko;Pennington,LewisD.;Poon,SteveF.;Reid,Darren;Sivits,Glenn;Stec,MarkianM.;Tadesse,Seifu;Tamayo,Nuria;Van,Gwyneth;Yang,KevinC.;Zhang,Jiandong;Norman,MarkH.;Fotsch,Christopher;Lloyd,DavidJ.;Hale,Clarence[JournalofMedicinalChemistry,2014,vol.57,#2,p.325-338]

[4]CurrentPatentAssignee:AMGENINC-WO2014/35872,2014,A1

[5]Nishimura,Nobuko;Norman,MarkH.;Liu,Longbin;Yang,KevinC.;Ashton,KateS.;Bartberger,MichaelD.;Chmait,Samer;Chen,Jie;Cupples,Rod;Fotsch,Christopher;Helmering,Joan;Jordan,StevenR.;Kunz,RoxanneK.;Pennington,LewisD.;Poon,SteveF.;Siegmund,Aaron;Sivits,Glenn;Lloyd,DavidJ.;Hale,Clarence;St.Jean,DavidJ.[JournalofMedicinalChemistry,2014,vol.57,#7,p.3094-3116]

[6]Lloyd,DavidJ.;StJean,DavidJ.;Kurzeja,RobertJ.M.;Wahl,RobertC.;Michelsen,Klaus;Cupples,Rod;Chen,Michelle;Wu,John;Sivits,Glenn;Helmering,Joan;Komorowski,Renee;Ashton,KateS.;Pennington,LewisD.;Fotsch,Christopher;Vazir,Mukta;Chen,Kui;Chmait,Samer;Zhang,Jiandong;Liu,Longbin;Norman,MarkH.;Andrews,KristinL.;Bartberger,MichaelD.;Van,Gwyneth;Galbreath,ElizabethJ.;Vonderfecht,StevenL.;Wang,Minghan;Jordan,StevenR.;Veniant,MurielleM.;Hale,Clarence[Nature,2013,vol.504,#7480,p.437-440]

[7]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-CN113620944,2021,A

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Tags:1228675-25-9 Molecular Formula|1228675-25-9 MDL|1228675-25-9 SMILES|1228675-25-9 4-Benzyl 1-tert-butyl 2-oxopiperazine-1,4-dicarboxylate