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18378-89-7,MFCD00135618
Catalog No.:AA00I1CR

18378-89-7 | Plicamycin

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1mg
≥98%
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5mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I1CR
Chemical Name:
Plicamycin
CAS Number:
18378-89-7
Molecular Formula:
C52H76O24
Molecular Weight:
1085.1454
MDL Number:
MFCD00135618
SMILES:
CO[C@@H]([C@@H]1Cc2cc3cc(OC4OC(C)C(C(C4)OC4CC(O)C(C(O4)C)O)O)c(c(c3c(c2C(=O)[C@H]1OC1OC(C)C(C(C1)OC1OC(C)C(C(C1)OC1OC(C)C(C(C1)(C)O)O)O)O)O)O)C)C(=O)[C@H]([C@H](O)C)O C52H76O24
Properties
Computed Properties
 
Complexity:
1940  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
25  
Heavy Atom Count:
76  
Hydrogen Bond Acceptor Count:
24  
Hydrogen Bond Donor Count:
11  
Rotatable Bond Count:
15  
XLogP3:
0.6  

Literature

Title: Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation.

Journal: Toxicology and applied pharmacology 20171101

Title: Resveratrol Represses Pokemon Expression in Human Glioma Cells.

Journal: Molecular neurobiology 20160301

Title: Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160301

Title: Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes.

Journal: Toxicology and applied pharmacology 20151201

Title: Cytotoxic effects of mithramycin DIG-MSK can depend on the rise of autophagy.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151001

Title: Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.

Journal: Toxicology and applied pharmacology 20141001

Title: The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.

Journal: Chemico-biological interactions 20140805

Title: Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis.

Journal: Oncogene 20140522

Title: Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter.

Journal: Gene 20140215

Title: Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult.

Journal: PloS one 20140101

Title: Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia.

Journal: The Journal of biological chemistry 20130816

Title: Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130801

Title: Sp sites contribute to basal and inducible expression of the human TNIP1 (TNFα-inducible protein 3-interacting protein 1) promoter.

Journal: The Biochemical journal 20130615

Title: Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway.

Journal: Marine drugs 20130401

Title: Estrogen receptor α (ESR1) over-expression mediated apoptosis in Hep3B cells by binding with SP1 proteins.

Journal: Journal of molecular endocrinology 20130101

Title: Arf induction by Tgfβ is influenced by Sp1 and C/ebpβ in opposing directions.

Journal: PloS one 20130101

Title: Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells.

Journal: PloS one 20130101

Title: Aureolic acids from a marine-derived Streptomyces sp. WBF16.

Journal: Microbiological research 20121220

Title: Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.

Journal: Biochemical pharmacology 20121101

Title: Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.

Journal: Angewandte Chemie (International ed. in English) 20121015

Title: Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function.

Journal: Arthritis and rheumatism 20121001

Title: Regulation of double-stranded RNA dependent protein kinase expression and attenuation of protein synthesis induced by bacterial toll-like receptors agonists in the absence of interferon.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20121001

Title: Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells.

Journal: Molecular and cellular endocrinology 20120925

Title: MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells.

Journal: Journal of cellular physiology 20120901

Title: Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells.

Journal: Cancer research 20120815

Title: Cigarette smoke induces MUC5AC protein expression through the activation of Sp1.

Journal: The Journal of biological chemistry 20120810

Title: A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.

Journal: Annals of hematology 20120801

Title: Cooling-increased phospho-β-arrestin-1 and β-arrestin-1 expression levels in 3T3-L1 adipocytes.

Journal: Cryobiology 20120801

Title: Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.

Journal: The FEBS journal 20120801

Title: Induction of 6-sulfated glycans with cell adhesion activity via T-bet and GATA-3 in human helper T cells.

Journal: Biochimica et biophysica acta 20120701

Title: Treatment of acute hypercalcemia.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120701

Title: A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.

Journal: Journal of medicinal chemistry 20120628

Title: Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells.

Journal: FEBS letters 20120612

Title: Promoter cloning and characterization of the human programmed cell death protein 4 (pdcd4) gene: evidence for ZBP-89 and Sp-binding motifs as essential Pdcd4 regulators.

Journal: Bioscience reports 20120601

Title: Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7.

Journal: Journal of biochemistry 20120601

Title: Parathyroid carcinoma with lung metastasis in a thirteen-year-old girl.

Journal: Journal of the Korean Surgical Society 20120601

Title: Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1.

Journal: Journal of medical virology 20120501

Title: Association of aureolic acid antibiotic, chromomycin A3 with Cu2+ and its negative effect upon DNA binding property of the antibiotic.

Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20120401

Title: Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP/Sp1 pathway.

Journal: Endocrinology 20120401

Title: CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1.

Journal: Epigenetics 20120401

Title: Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK.

Journal: Oncotarget 20120401

Title: Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation.

Journal: Artificial DNA, PNA & XNA 20120401

Title: Sp1king out cancer (....and fibrosis?).

Journal: Journal of cell communication and signaling 20120301

Title: Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes.

Journal: Biological psychiatry 20120301

Title: Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2.

Journal: The Journal of biological chemistry 20120203

Title: Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells.

Journal: Biochimica et biophysica acta 20120201

Title: Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells.

Journal: Biochimica et biophysica acta 20120201

Title: c-Jun induction is independent of early growth response factor during cerebellar granule neuron apoptosis.

Journal: Neuroreport 20120125

Title: Expression and regulation of CCL15 by human airway smooth muscle cells.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20120101

Title: Protective action of mithramycin against neurodegeneration and impairment of synaptic plasticity in the hippocampal CA1 area after transient global ischemia.

Journal: Neurochemistry international 20120101

Title: Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia.

Journal: International journal of nanomedicine 20120101

Title: Transcription of promoter from the human APRIL gene regulated by Sp1 and NF-kB.

Journal: Neoplasma 20120101

Title: Humoral hypercalcemic crisis in a pregnant woman with uterine leiomyoma.

Journal: Journal of emergencies, trauma, and shock 20120101

Title: Cytogenetic characterization and genome size of the medicinal plant Catharanthus roseus (L.) G. Don.

Journal: AoB PLANTS 20120101

Title: Conformational changes in DNA upon ligand binding monitored by circular dichroism.

Journal: International journal of molecular sciences 20120101

Title: The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes.

Journal: Arthritis research & therapy 20120101

Title: Full-Length Enrich c-DNA Libraries-Clear Cell-Renal Cell Carcinoma.

Journal: Journal of oncology 20120101

Title: Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer.

Journal: PloS one 20120101

Title: Regulation of hepatic paraoxonase-1 expression.

Journal: Journal of lipids 20120101

Title: Prevention of chronic experimental colitis induced by dextran sulphate sodium (DSS) in mice treated with FR91.

Journal: Journal of biomedicine & biotechnology 20120101

Title: The RIP140 gene is a transcriptional target of E2F1.

Journal: PloS one 20120101

Title: The first European interdisciplinary ewing sarcoma research summit.

Journal: Frontiers in oncology 20120101

Title: Expression of specificity protein transcription factors in pancreatic cancer and their association in prognosis and therapy.

Journal: Current medicinal chemistry 20120101

Title: Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma.

Journal: Journal of biomedical science 20120101

Title: C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells.

Journal: European journal of pharmacology 20111215

Title: Modulation of the biological activity of microRNA-210 with peptide nucleic acids (PNAs).

Journal: ChemMedChem 20111209

Title: Cancer chemoprevention by targeting the epigenome.

Journal: Current drug targets 20111201

Title: Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose.

Journal: Chembiochem : a European journal of chemical biology 20111125

Title: Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells.

Journal: Free radical biology & medicine 20111115

Title: Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress.

Journal: Cell death & disease 20111101

Title: Secondary gliosarcoma after the treatment of primary glioblastoma multiforme.

Journal: North American journal of medical sciences 20111101

Title: Topical mithramycin-A modulates submucosal collagen deposition after esophageal burn injury in rats.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20110901

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription.

Journal: American journal of respiratory cell and molecular biology 20110801

Title: Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29.

Journal: Journal of cellular biochemistry 20110801

Title: Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.

Journal: Cancer research 20110801

Title: Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells.

Journal: The Journal of biological chemistry 20110729

Title: Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells--the involvement of SP-1 and HIFs transcription factors.

Journal: Toxicology letters 20110728

Title: Inhibition of myeloid cell leukemia-1 by tolfenamic acid induces apoptosis in mucoepidermoid carcinoma.

Journal: Oral diseases 20110701

Title: Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase.

Journal: Free radical biology & medicine 20110701

Title: Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

Journal: Journal of the National Cancer Institute 20110622

Title: Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death.

Journal: The Journal of biological chemistry 20110603

Title: Accessible chromatin structure permits factors Sp1 and Sp3 to regulate human TGFBI gene expression.

Journal: Biochemical and biophysical research communications 20110603

Title: The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110504

Title: Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20110501

Title: Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression.

Journal: FEBS letters 20110406

Title: A critical role of Sp1 transcription factor in regulating the human Ki-67 gene expression.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20110401

Title: Identification and characterization of human PCDH10 gene promoter.

Journal: Gene 20110401

Title: Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1.

Journal: Cancer science 20110401

Title: Mithramycin reduces expression of fibro-proliferative mRNAs in human gingival fibroblasts.

Journal: Cell proliferation 20110401

Title: Combined treatment of pancreatic cancer with mithramycin a and tolfenamic Acid promotes sp1 degradation and synergistic antitumor activity--letter.

Journal: Cancer research 20110401

Title: Egr-1 transactivates Bim gene expression to promote neuronal apoptosis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110330

Title: Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway.

Journal: The Journal of biological chemistry 20110318

Title: Natural glycoconjugates with antitumor activity.

Journal: Natural product reports 20110301

Title: Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1.

Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20110301

Title: Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines.

Journal: Biochimica et biophysica acta 20110301

Title: The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.

Journal: Microbial biotechnology 20110301

Title: Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma.

Journal: Journal of neuro-oncology 20110201

Title: Platotex: an innovative and fully automated device for cell growth scale-up of agar-supported solid-state fermentation.

Journal: Journal of industrial microbiology & biotechnology 20110201

Title: Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression.

Journal: Differentiation; research in biological diversity 20110201

Title: Identification of a novel cell type-specific intronic enhancer of macrophage migration inhibitory factor (MIF) and its regulation by mithramycin.

Journal: Clinical and experimental immunology 20110201

Title: Cysteinyl-leukotrienes induce vascular endothelial growth factor production in human monocytes and bronchial smooth muscle cells.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20110201

Title: Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide.

Journal: The Journal of biological chemistry 20110114

Title: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells.

Journal: The Journal of biological chemistry 20110114

Title: SAFB1 interacts with and suppresses the transcriptional activity of p53.

Journal: FEBS letters 20110103

Title: Mithramycin A suppresses expression of the human melanoma-associated gene ABCB8.

Journal: Molecular genetics and genomics : MGG 20110101

Title: Therapeutic targeting the loss of the birt-hogg-dube suppressor gene.

Journal: Molecular cancer therapeutics 20110101

Title: Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta.

Journal: Arthritis research & therapy 20110101

Title: Kalrn promoter usage and isoform expression respond to chronic cocaine exposure.

Journal: BMC neuroscience 20110101

Title: HDAC inhibition decreases the expression of EGFR in colorectal cancer cells.

Journal: PloS one 20110101

Title: Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective.

Journal: Vascular cell 20110101

Title: Neuroprotective effect of mithramycin against endoplasmic reticulum stress-induced neurotoxicity in organotypic hippocampal slice cultures.

Journal: Neuropharmacology 20110101

Title: NFATc1 regulation of TRAIL expression in human intestinal cells.

Journal: PloS one 20110101

Title: Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons.

Journal: Molecular pain 20110101

Title: Induction and flow cytometry identification of tetraploids from seed-derived explants through colchicine treatments in Catharanthus roseus (L.) G. Don.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors.

Journal: PloS one 20110101

Title: Karyotypic conservatism in samples of Characidium cf. zebra (Teleostei, Characiformes, Crenuchidae): Physical mapping of ribosomal genes and natural triploidy.

Journal: Genetics and molecular biology 20110101

Title: Comparative genomics and transcriptomics of Propionibacterium acnes.

Journal: PloS one 20110101

Title: Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model.

Journal: ASN neuro 20110101

Title: A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.

Journal: PloS one 20110101

Title: Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.

Journal: BMC cancer 20110101

Title: Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.

Journal: PloS one 20110101

Title: In Silico discovery of transcription factors as potential diagnostic biomarkers of ovarian cancer.

Journal: BMC systems biology 20110101

Title: D-β-hydroxybutyrate is protective in mouse models of Huntington's disease.

Journal: PloS one 20110101

Title: Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving 'metronomic' zoledronic acid.

Journal: BMC cancer 20110101

Title: Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia.

Journal: OncoTargets and therapy 20110101

Title: VEGFR2 translocates to the nucleus to regulate its own transcription.

Journal: PloS one 20110101

Title: Huntington's Disease and Striatal Signaling.

Journal: Frontiers in neuroanatomy 20110101

Title: Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells.

Journal: BMC cancer 20110101

Title: Effect of DNA groove binder distamycin A upon chromatin structure.

Journal: PloS one 20110101

Title: Identification of Binding Mode of a Platinum (II) Complex, PtCl(2)(DIP), and Calf Thymus DNA.

Journal: Bioinorganic chemistry and applications 20110101

Title: Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.

Journal: International journal of nanomedicine 20110101

Title: Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.

Journal: Sarcoma 20110101

Title: The nuclear events guiding successful nerve regeneration.

Journal: Frontiers in molecular neuroscience 20110101

Title: Transcription factor Sp1 is involved in expressional regulation of coxsackie and adenovirus receptor in cancer cells.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.

Journal: PloS one 20110101

Title: Enhanced expression of tissue inhibitor of metalloproteinases-4 gene in human osteoarthritic synovial membranes and its differential regulation by cytokines in chondrocytes.

Journal: The open rheumatology journal 20110101

Title: DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis.

Journal: Biochemistry 20101214

Title: MDM2-related responses in 3T3-L1 adipocytes exposed to cooling and subsequent rewarming.

Journal: Cryobiology 20101201

Title: Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1.

Journal: Biochemical and biophysical research communications 20101119

Title: Structural and functional characterization of the mouse tescalcin promoter.

Journal: Gene 20100915

Title: A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.

Journal: Cancer cell 20100914

Title: Sp1 plays an important role in regulating the transcription of ZNF313.

Journal: Cell biology international 20100901

Title: Sp1 upregulates the four and half lim 2 (FHL2) expression in gastrointestinal cancers through transcription regulation.

Journal: Molecular carcinogenesis 20100901

Title: Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.

Journal: Gynecologic oncology 20100801

Title: Overexpression of antioxidant enzymes upregulates aryl hydrocarbon receptor expression via increased Sp1 DNA-binding activity.

Journal: Free radical biology & medicine 20100801

Title: Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells.

Journal: Biochemical pharmacology 20100701

Title: Estrogen regulated expression of the p21 Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells.

Journal: Journal of cellular physiology 20100701

Title: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer.

Journal: The FEBS journal 20100701

Title: Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells.

Journal: Cancer letters 20100601

Title: Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers.

Journal: Cancer science 20100601

Title: Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.

Journal: Cancer biology & therapy 20100601

Title: Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer.

Journal: Cancer science 20100601

Title: The neurological safety of epidural pamidronate in rats.

Journal: The Korean journal of pain 20100601

Title: Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells.

Journal: The Journal of biological chemistry 20100528

Title: Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships.

Journal: Biochemical pharmacology 20100515

Title: E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor.

Journal: Breast cancer research and treatment 20100501

Title: Upregulation of parathyroid VDR expression by extracellular calcium is mediated by ERK1/2-MAPK signaling pathway.

Journal: American journal of physiology. Renal physiology 20100501

Title: Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin.

Journal: Cancer science 20100501

Title: Associations of MDM2 SNP309, transcriptional activity, mRNA expression, and survival in stage I non-small-cell lung cancer patients with wild-type p53 tumors.

Journal: Annals of surgical oncology 20100401

Title: Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells.

Journal: Cancer letters 20100227

Title: Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity.

Journal: Journal of neuro-oncology 20100201

Title: Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity.

Journal: Cancer research 20100201

Title: Pharmacological impairment of s-nitrosoglutathione or thioredoxin reductases augments protein S-Nitrosation in human hepatocarcinoma cells.

Journal: Anticancer research 20100201

Title: Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells.

Journal: International journal of cancer 20100115

Title: Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression.

Journal: Chemico-biological interactions 20100105

Title: Profiling and comparing transcription factors activated in non-metastatic and metastatic nasopharyngeal carcinoma cells.

Journal: Journal of cellular biochemistry 20100101

Title: PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.

Journal: Endocrine journal 20100101

Title: Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma).

Journal: PloS one 20100101

Title: RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells.

Journal: Breast cancer research : BCR 20100101

Title: Induction of phospho-Thr-172 AMPK in 3T3-L1 adipocytes exposed to cold or treated with anisomycin, mithramycin A, and ionic compounds.

Journal: Cryo letters 20100101

Title: Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse.

Journal: BMC genomics 20100101

Title: PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cells.

Journal: Biology of the cell 20100101

Title: Transcriptional activation of REST by Sp1 in Huntington's disease models.

Journal: PloS one 20100101

Title: [Lung carcinoma with paraneoplastic hyponatremia and hypercalcemia].

Journal: Medicinski pregled 20100101

Title: Mithramycin protects against dopaminergic neurotoxicity in the mouse brain after administration of methamphetamine.

Journal: Brain research 20091208

Title: Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway.

Journal: The Journal of biological chemistry 20091127

Title: Identification and characterization of the human xylosyltransferase I gene promoter region.

Journal: The Journal of biological chemistry 20091106

Title: Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation.

Journal: Cancer 20091101

Title: Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation.

Journal: Journal of neurochemistry 20091101

Title: Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20091015

Title: Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs.

Journal: International journal of hematology 20091001

Title: Response of the ABCG2 promoter in T47D cells and BeWo cells to sex hormone treatment.

Journal: Molecular biology reports 20090901

Title: Mutated ras induced PLD1 gene expression through increased Sp1 transcription factor.

Journal: Nagoya journal of medical science 20090901

Title: Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression.

Journal: BMB reports 20090831

Title: Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy.

Journal: Current genomics 20090801

Title: Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells.

Journal: Biochemical and biophysical research communications 20090703

Title: Effects of polyamines on the DNA-reactive properties of dimeric mithramycin complexed with cobalt(II): implications for anticancer therapy.

Journal: Biochemistry 20090609

Title: Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway .

Journal: Biochemistry 20090602

Title: Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia.

Journal: Evidence-based complementary and alternative medicine : eCAM 20090601

Title: Antitumor compounds from marine actinomycetes.

Journal: Marine drugs 20090601

Title: ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells.

Journal: Molecular biology reports 20090501

Title: Spermatogenesis-related ring finger gene ZNF230 promoter: identification and functional analysis.

Journal: Molecular biology reports 20090501

Title: Cancer-induced hypercalcemia.

Journal: Anticancer research 20090501

Title: The penetrative abilities of liposomal mithramycin in explanted keloids.

Journal: Clinical and experimental dermatology 20090401

Title: Single and double emulsion manufacturing techniques of an amphiphilic drug in PLGA nanoparticles: formulations of mithramycin and bioactivity.

Journal: Journal of pharmaceutical sciences 20090401

Title: Structural and functional analysis of the bovine Mx1 promoter.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20090401

Title: Oxidative stress promotes transcriptional up-regulation of Fyn in BCR-ABL1-expressing cells.

Journal: The Journal of biological chemistry 20090313

Title: Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090301

Title: Endothelin-1 stimulates interleukin-6 secretion from 3T3-L1 adipocytes.

Journal: Biochimica et biophysica acta 20090301

Title: Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells.

Journal: Breast cancer research and treatment 20090201

Title: Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells.

Journal: Atherosclerosis 20090201

Title: Mechanism of inhibition of tumor angiogenesis by beta-hydroxyisovalerylshikonin.

Journal: Cancer science 20090201

Title: Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter.

Journal: American journal of respiratory cell and molecular biology 20090101

Title: TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors.

Journal: Journal of translational medicine 20090101

Title: High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research.

Journal: Genome biology 20090101

Title: Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals.

Journal: BMC molecular biology 20090101

Title: Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.

Journal: Biochimica et biophysica acta 20090101

Title: Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibition.

Journal: PloS one 20090101

Title: Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity.

Journal: BMC pharmacology 20090101

Title: Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.

Journal: PloS one 20090101

Title: Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia.

Journal: Journal of experimental & clinical cancer research : CR 20090101

Title: Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.

Journal: PloS one 20090101

Title: Drug-induced hematologic syndromes.

Journal: Advances in hematology 20090101

Title: Overexpression of Prdx6 and resistance to peroxide-induced death in Hepa1-6 cells: Prdx suppression increases apoptosis.

Journal: Redox report : communications in free radical research 20090101

Title: Ocular surface tumors.

Journal: Oman journal of ophthalmology 20090101

Title: Pharmacologic and nonpharmacologic options for the management of HIV infection during pregnancy.

Journal: HIV/AIDS (Auckland, N.Z.) 20090101

Title: Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation.

Journal: Journal of cellular biochemistry 20081215

Title: Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter.

Journal: American journal of physiology. Renal physiology 20081201

Title: High glucose induces transactivation of the human paraoxonase 1 gene in hepatocytes.

Journal: Metabolism: clinical and experimental 20081201

Title: Involvement of epigenetic mechanisms in the regulation of secreted phospholipase A2 expressions in Jurkat leukemia cells.

Journal: Neoplasia (New York, N.Y.) 20081101

Title: Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2.

Journal: British journal of cancer 20081021

Title: Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone.

Journal: Organic letters 20081016

Title: p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours.

Journal: British journal of cancer 20081007

Title: DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function.

Journal: Oncogene 20080925

Title: Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.

Journal: Chembiochem : a European journal of chemical biology 20080922

Title: Epigenetic silencing of cell adhesion molecule 1 in different cancer progenitor cells of transgenic c-Myc and c-Raf mouse lung tumors.

Journal: Cancer research 20080915

Title: NFkappaB mediates IL-1beta-induced down-regulation of TbetaRII through the modulation of Sp3 expression.

Journal: Journal of cellular and molecular medicine 20080901

Title: E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domain.

Journal: Archives of biochemistry and biophysics 20080901

Title: Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells.

Journal: Molecular cancer therapeutics 20080901

Title: Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells.

Journal: Cellular signalling 20080801

Title: The effects of local DNA sequence on the interaction of ligands with their preferred binding sites.

Journal: Biochimie 20080701

Title: Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.

Journal: Journal of neurochemistry 20080701

Title: Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models.

Journal: International journal of oncology 20080701

Title: Peroxisome proliferator-activated receptor gamma inhibits follicular and anaplastic thyroid carcinoma cells growth by upregulating p21Cip1/WAF1 gene in a Sp1-dependent manner.

Journal: Endocrine-related cancer 20080601

Title: The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation.

Journal: Bioscience reports 20080601

Title: Studies of sequence-specific DNA binding, DNA cleavage, and topoisomerase I inhibition by the dimeric chromomycin A3 complexed with Fe(II).

Journal: Biochemistry 20080520

Title: SP1-regulated p27/Kip1 gene expression is involved in terbinafine-induced human A431 cancer cell differentiation: an in vitro and in vivo study.

Journal: Biochemical pharmacology 20080501

Title: SP1 regulates a human SNAP-25 gene expression.

Journal: Journal of neurochemistry 20080401

Title: Multiple functions of generic drugs: future perspectives of aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs.

Journal: Mini reviews in medicinal chemistry 20080401

Title: Self-association of the anionic form of the DNA-binding anticancer drug mithramycin.

Journal: The journal of physical chemistry. B 20080313

Title: Histone deacetylase inhibitors upregulate p57Kip2 level by enhancing its expression through Sp1 transcription factor.

Journal: Carcinogenesis 20080301

Title: Regulation of RON tyrosine kinase-mediated invasion of breast cancer cells.

Journal: The Journal of biological chemistry 20080227

Title: Cloning and characterization of the promoter of Hugl-2, the human homologue of Drosophila lethal giant larvae (lgl) polarity gene.

Journal: Biochemical and biophysical research communications 20080222

Title: Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.

Journal: Blood 20080215

Title: Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity.

Journal: Journal of natural products 20080201

Title: Lipopolysaccharide induces hypoxia-inducible factor-1 alpha mRNA expression and activation via NADPH oxidase and Sp1-dependent pathway in BV2 murine microglial cells.

Journal: Neuroscience letters 20080131

Title: Expression and regulation of CCR1 by airway smooth muscle cells in asthma.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20080115

Title: Sp1-mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20080101

Title: Medical treatment of malignancy-associated hypercalcemia.

Journal: Current medicinal chemistry 20080101

Title: DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription.

Journal: BMC molecular biology 20080101

Title: Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1.

Journal: JPEN. Journal of parenteral and enteral nutrition 20080101

Title: Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells.

Journal: Journal of experimental & clinical cancer research : CR 20080101

Title: M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo.

Journal: PloS one 20080101

Title: Synergistic induction of CX3CL1 by TNF alpha and IFN gamma in osteoblasts from rheumatoid arthritis: involvement of NF-kappa B and STAT-1 signaling pathways.

Journal: Journal of inflammation research 20080101

Title: Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer.

Journal: Cancer 20071215

Title: Control of core 2 beta1,6 N-acetylglucosaminyltransferase-I transcription by Sp1 in lymphocytes and epithelial cells.

Journal: Glycoconjugate journal 20071201

Title: REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation.

Journal: Journal of neurochemistry 20071201

Title: Evolutionary cytogenetics of the Hoplias lacerdae, Miranda Ribeiro, 1908 group. A particular pathway concerning the other Erythrinidae fish.

Journal: Brazilian journal of biology = Revista brasleira de biologia 20071201

Title: PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20071101

Title: K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress.

Journal: American journal of physiology. Heart and circulatory physiology 20071101

Title: Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1.

Journal: American journal of physiology. Renal physiology 20071101

Title: Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells.

Journal: Anti-cancer drugs 20071101

Title: Mithramycin inhibits etoposide resistance in glucose-deprived HT-29 human colon carcinoma cells.

Journal: Journal of microbiology and biotechnology 20071101

Title: Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids.

Journal: Biochemistry 20071016

Title: Characterization of the SOCS3 promoter response to prostaglandin E2 in T47D cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20071001

Title: Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells.

Journal: American journal of physiology. Renal physiology 20070901

Title: TNF-alpha induces MUC1 gene transcription in lung epithelial cells: its signaling pathway and biological implication.

Journal: American journal of physiology. Lung cellular and molecular physiology 20070901

Title: Transcriptional control of human T-BET expression: the role of Sp1.

Journal: European journal of immunology 20070901

Title: Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis.

Journal: Microbiology (Reading, England) 20070901

Title: Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK.

Journal: Journal of cell communication and signaling 20070901

Title: Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.

Journal: Cellular signalling 20070701

Title: Glucose enhances protein tyrosine phosphatase 1B gene transcription in hepatocytes.

Journal: Molecular and cellular endocrinology 20070615

Title: Modulation of nucleosome dynamics in Huntington's disease.

Journal: Human molecular genetics 20070515

Title: Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A.

Journal: Cancer research 20070515

Title: Identification and characterization of a novel antisense RNA transcribed from the opposite strand of the human blood group ABO gene.

Journal: Transfusion 20070501

Title: Sp1 and Sp3 regulate basal transcription of the survivin gene.

Journal: Biochemical and biophysical research communications 20070427

Title: Structure of the human 5-HT7 receptor gene and characterization of its promoter region.

Journal: Gene 20070415

Title: PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.

Journal: Biochemical and biophysical research communications 20070316

Title: Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation.

Journal: International journal of oncology 20070201

Title: Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells.

Journal: The Journal of biological chemistry 20070126

Title: Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells.

Journal: Biochemical pharmacology 20070101

Title: Association of antitumor antibiotics, mithramycin and chromomycin, with Zn(II).

Journal: Journal of inorganic biochemistry 20070101

Title: Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate.

Journal: The American journal of pathology 20070101

Title: Sp1 is essential for p16 expression in human diploid fibroblasts during senescence.

Journal: PloS one 20070101

Title: Rad9 modulates the P21WAF1 pathway by direct association with p53.

Journal: BMC molecular biology 20070101

Title: Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans.

Journal: PloS one 20070101

Title: Sp1 expression is disrupted in schizophrenia; a possible mechanism for the abnormal expression of mitochondrial complex I genes, NDUFV1 and NDUFV2.

Journal: PloS one 20070101

Title: LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms.

Journal: Respiratory research 20070101

Title: Responses of hyperthermophilic crenarchaea to UV irradiation.

Journal: Genome biology 20070101

Title: Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes.

Journal: Gene regulation and systems biology 20070101

Title: Regulation of the prepronociceptin gene and its effect on neuronal differentiation.

Journal: Gene 20061215

Title: ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20061212

Title: Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1.

Journal: The Journal of endocrinology 20061201

Title: Sp1 elements regulate transcriptional activity within the murine Toll-like receptor 4 promoter.

Journal: Surgical infections 20061201

Title: The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.

Journal: Applied microbiology and biotechnology 20061101

Title: Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites.

Journal: Molecular cancer therapeutics 20061101

Title: Involvement of Sp1 in lipopolysaccharide-induced expression of HDC mRNA in RAW 264 cells.

Journal: Biochemical and biophysical research communications 20061020

Title: SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium.

Journal: Biology of reproduction 20061001

Title: Sp1 mediates repression of the resistin gene by PPARgamma agonists in 3T3-L1 adipocytes.

Journal: Biochemical and biophysical research communications 20060915

Title: Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOII.

Journal: Angewandte Chemie (International ed. in English) 20060825

Title: Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1.

Journal: Free radical biology & medicine 20060715

Title: GC-selective DNA-binding antibiotic, mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis.

Journal: Oncogene 20060713

Title: Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.

Journal: The Journal of biological chemistry 20060616

Title: Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060501

Title: Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites.

Journal: Biochemical and biophysical research communications 20060421

Title: Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells.

Journal: American journal of respiratory cell and molecular biology 20060401

Title: Tandem Sp1/Sp3 sites together with an Ets-1 site cooperate to mediate alpha11 integrin chain expression in mesenchymal cells.

Journal: Matrix biology : journal of the International Society for Matrix Biology 20060301

Title: Expression of myelin basic protein in two oligodendroglial cell lines is modulated by apotransferrin through different transcription factors.

Journal: Journal of neuroscience research 20060301

Title: Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.

Journal: Molecular cancer research : MCR 20060301

Title: Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds.

Journal: Biochemical pharmacology 20060214

Title: 7,12-Dimethylbenzanthracene-dependent transcriptional regulation of adenomatous polyposis coli (APC) gene expression in normal breast epithelial cells is mediated by GC-box binding protein Sp3.

Journal: Carcinogenesis 20060201

Title: Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060201

Title: Peroxisome proliferator-activated receptor-gamma transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1.

Journal: Endocrinology 20060201

Title: Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress.

Journal: The Journal of biological chemistry 20060120

Title: Mithramycin A activates Fas death pathway in leukemic cell lines.

Journal: Apoptosis : an international journal on programmed cell death 20060101

Title: The induction of CCN2 by TGFbeta1 involves Ets-1.

Journal: Arthritis research & therapy 20060101

Title: Normocalcemic parathyroid carcinoma: an unusual clinical presentation.

Journal: World journal of surgical oncology 20060101

Title: Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.

Journal: Nucleic acids research 20060101

Title: Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery.

Journal: Molecular cancer 20060101

Title: Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.

Journal: BMC neuroscience 20060101

Title: GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site.

Journal: Biochimica et biophysica acta 20051230

Title: Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus.

Journal: Journal of the American Chemical Society 20051221

Title: Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycin.

Journal: Annals of the rheumatic diseases 20051201

Title: Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway.

Journal: Cellular signalling 20051201

Title: DNA structural similarity in the 2:1 complexes of the antitumor drugs trabectedin (Yondelis) and chromomycin A3 with an oligonucleotide sequence containing two adjacent TGG binding sites on opposing strands.

Journal: Molecular pharmacology 20051201

Title: Prostaglandin E2 enhances neurotrophin-4 production via EP3 receptor in human keratinocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20051101

Title: Crystallization and X-ray diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the mithramycin biosynthetic pathway in Streptomyces argillaceus.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20051101

Title: COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites.

Journal: International journal of cancer 20050910

Title: Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050901

Title: Alpha-tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli.

Journal: Biochemical and biophysical research communications 20050826

Title: Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors.

Journal: Biochemical and biophysical research communications 20050812

Title: Neutrophil elastase stimulates MUC1 gene expression through increased Sp1 binding to the MUC1 promoter.

Journal: American journal of physiology. Lung cellular and molecular physiology 20050801

Title: Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cells.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050801

Title: Regulation of human resistin gene expression in cell systems: an important role of stimulatory protein 1 interaction with a common promoter polymorphic site.

Journal: Diabetologia 20050601

Title: Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript.

Journal: Journal of biochemistry 20050601

Title: Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells.

Journal: FEBS letters 20050523

Title: Molecular dynamics study on the interaction of a mithramycin dimer with a decanucleotide duplex.

Journal: The journal of physical chemistry. B 20050519

Title: Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis.

Journal: British journal of cancer 20050509

Title: TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor.

Journal: Journal of cellular physiology 20050501

Title: Characterization of the basal promoter element of the human type 5 17beta-hydroxysteroid dehydrogenase gene.

Journal: Biochimica et biophysica acta 20050501

Title: Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.

Journal: Chembiochem : a European journal of chemical biology 20050401

Title: Expression of the human melanocortin-4 receptor gene is controlled by several members of the Sp transcription factor family.

Journal: Journal of molecular endocrinology 20050401

Title: Sp1 and Sp3 transcription factors upregulate the proximal promoter of the human prostate-specific antigen gene in prostate cancer cells.

Journal: Archives of biochemistry and biophysics 20050315

Title: Binding of (MTR)2Zn2+ complex to chromatin: a comparison with (MTR)2Mg2+ complex.

Journal: Journal of inorganic biochemistry 20050301

Title: Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene.

Journal: Metabolism: clinical and experimental 20050201

Title: Ets1 is an effector of protein kinase Calpha in cancer cells.

Journal: Oncogene 20050120

Title: Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins.

Journal: The Biochemical journal 20050115

Title: Calculation of binding length of base-specific DNA dyes by comparison of sequence and flow cytometric data. Application to Oryza sativa and Arabidopsis thaliana.

Journal: Journal of theoretical biology 20050107

Title: Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells.

Journal: American journal of physiology. Renal physiology 20050101

Title: Effect of complex formation between Zn2+ ions and the anticancer drug mithramycin upon enzymatic activity of zinc(II)-dependent alcohol dehydrogenase.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050101

Title: Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes.

Journal: Arthritis research & therapy 20050101

Title: Bioactive C-glycosides from bacterial secondary metabolism.

Journal: Current topics in medicinal chemistry 20050101

Title: Inhibition of p53-mediated transcriptional responses by mithramycin A.

Journal: Oncogene 20041209

Title: Sp1 is involved in the transcriptional activation of lysozyme in epithelial cells.

Journal: Biochemical and biophysical research communications 20041126

Title: Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041117

Title: Transforming growth factor beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors.

Journal: Journal of cellular biochemistry 20041015

Title: Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.

Journal: Journal of cellular biochemistry 20041015

Title: Roles of Sp1 and protein kinase C in regulation of human serum paraoxonase 1 (PON1) gene transcription in HepG2 cells.

Journal: Atherosclerosis 20041001

Title: Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1.

Journal: The Journal of biological chemistry 20040917

Title: Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus.

Journal: Molecular microbiology 20040801

Title: Rapamycin-mediated induction of gamma-globin mRNA accumulation in human erythroid cells.

Journal: British journal of haematology 20040801

Title: Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells.

Journal: American journal of physiology. Endocrinology and metabolism 20040701

Title: Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.

Journal: Molecular endocrinology (Baltimore, Md.) 20040701

Title: Systematic review of bisphosphonates for hypercalcaemia of malignancy.

Journal: Palliative medicine 20040701

Title: The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).

Journal: British journal of cancer 20040517

Title: Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.

Journal: The Biochemical journal 20040515

Title: Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression.

Journal: The American journal of pathology 20040501

Title: SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors.

Journal: Biochemical and biophysical research communications 20040423

Title: N-terminal tail domains of core histones in nucleosome block the access of anticancer drugs, mithramycin and daunomycin, to the nucleosomal DNA.

Journal: Biophysical chemistry 20040401

Title: Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene.

Journal: The Journal of biological chemistry 20040319

Title: Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1.

Journal: Oncogene 20040304

Title: MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.

Journal: The Journal of biological chemistry 20040227

Title: bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity.

Journal: The Journal of biological chemistry 20040220

Title: Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways.

Journal: Molecular pharmacology 20040201

Title: Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.

Journal: Biochemical pharmacology 20040201

Title: A systematic review of the role of bisphosphonates in metastatic disease.

Journal: Health technology assessment (Winchester, England) 20040101

Title: Aureolic acids: similar antibiotics with different biosynthetic gene clusters.

Journal: Chemistry & biology 20040101

Title: Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.

Journal: Chemistry & biology 20040101

Title: Asbestos induces tissue factor in Beas-2B human lung bronchial epithelial cells in vitro.

Journal: Lung 20040101

Title: [Metabolic emergencies in the oncology patient].

Journal: Anales del sistema sanitario de Navarra 20040101

Title: Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL.

Journal: Biochemical and biophysical research communications 20031017

Title: Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression.

Journal: American journal of respiratory cell and molecular biology 20031001

Title: Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.

Journal: Oncogene 20030904

Title: Accumulation of gamma-globin mRNA in human erythroid cells treated with angelicin.

Journal: European journal of haematology 20030901

Title: Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells.

Journal: Blood 20030815

Title: Enhanced binding of Sp1/Sp3 transcription factors mediates the hyperoxia-induced increased expression of the lung type I cell gene T1alpha.

Journal: Journal of cellular biochemistry 20030801

Title: Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target.

Journal: Biochemistry 20030715

Title: Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3.

Journal: Bioorganic & medicinal chemistry 20030703

Title: The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.

Journal: Molecular microbiology 20030601

Title: Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia.

Journal: Planta medica 20030601

Title: Stereoselective synthesis of functionalized precursors of the CDEF and CDE 2,6-dideoxy-tetra- and trisaccharide units of durhamycins A and B.

Journal: Organic letters 20030529

Title: Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2.

Journal: The Journal of biological chemistry 20030516

Title: Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.

Journal: Journal of the American Chemical Society 20030514

Title: Induction of nonmuscle myosin heavy chain II-C by butyrate in RAW 264.7 mouse macrophages.

Journal: The Journal of biological chemistry 20030425

Title: Apoptosis enzyme-linked immunosorbent assay distinguishes anticancer drugs from toxic chemicals and predicts drug synergism.

Journal: Chemico-biological interactions 20030306

Title: Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer.

Journal: Cancer research 20030301

Title: Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.

Journal: The Journal of biological chemistry 20030207

Title: Association of anticancer drug mithramycin with H1-depleted chromatin: a comparison with native chromatin.

Journal: Journal of inorganic biochemistry 20030201

Title: Essential role of an activator protein-2 (AP-2)/specificity protein 1 (Sp1) cluster in the UVB-mediated induction of the human vascular endothelial growth factor in HaCaT keratinocytes.

Journal: The Biochemical journal 20030115

Title: Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney.

Journal: American journal of physiology. Renal physiology 20030101

Title: The diagnosis and management of hypercalcaemia.

Journal: Annals of the Academy of Medicine, Singapore 20030101

Title: c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases.

Journal: Cell cycle (Georgetown, Tex.) 20030101

Title: Pervilleine F, a new tropane alkaloid aromatic ester that reverses multidrug resistance.

Journal: Anticancer research 20030101

Title: Anthracyclines.

Journal: Cancer chemotherapy and biological response modifiers 20030101

Title: Current management strategies for hypercalcemia.

Journal: Treatments in endocrinology 20030101

Title: Engaged urokinase receptors enhance tumor breast cell migration and invasion by upregulating alpha(v)beta5 vitronectin receptor cell surface expression.

Journal: International journal of cancer 20021220

Title: The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells.

Journal: Oncogene 20021205

Title: Transcriptional regulation of the rat type IIA phospholipase A2 gene by cAMP and interleukin-1beta in vascular smooth muscle cells: interplay of the CCAAT/enhancer binding protein (C/EBP), nuclear factor-kappaB and Ets transcription factors.

Journal: The Biochemical journal 20021201

Title: Functional role of Egr-1 mediating VEGF-induced tissue factor expression in the retinal capillary endothelium.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20021201

Title: Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men: regulation by estrogen.

Journal: Cardiovascular research 20021001

Title: Vascular smooth muscle alpha-actin gene transcription during myofibroblast differentiation requires Sp1/3 protein binding proximal to the MCAT enhancer.

Journal: The Journal of biological chemistry 20020927

Title: The role of Sp1 in BMP2-up-regulated Erk2 gene expression.

Journal: Biochemical and biophysical research communications 20020913

Title: Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells.

Journal: The Journal of biological chemistry 20020823

Title: Durhamycin A, a potent inhibitor of HIV Tat transactivation.

Journal: Journal of natural products 20020801

Title: Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.

Journal: Journal of the American Chemical Society 20020529

Title: Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1.

Journal: The Journal of biological chemistry 20020510

Title: Treatment of malignant hypercalcaemia.

Journal: Expert opinion on pharmacotherapy 20020501

Title: Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells.

Journal: The Journal of biological chemistry 20020405

Title: Identification and functional analysis of the rat caspase-3 gene promoter.

Journal: The Journal of biological chemistry 20020308

Title: Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.

Journal: Journal of the American Chemical Society 20020227

Title: Chemotherapeutic stress mediated by certain antitumor antibiotics induces an atypical CD69+ surface phenotype in peripheral T-lymphocytes.

Journal: International immunopharmacology 20020201

Title: Modern therapy for Paget's disease of bone: focus on bisphosphonates.

Journal: Treatments in endocrinology 20020101

Title: The transcription factors Sp1 and Sp3 are required for human angiotensin II type 1 receptor gene expression in H295-R cells.

Journal: Biochimica et biophysica acta 20011230

Title: Local delivery of mithramycin restores vascular reactivity and inhibits neointimal formation in injured arteries and vascular grafts.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20011213

Title: Conventional treatment of hypercalcemia of malignancy.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011115

Title: Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motif.

Journal: Molecular endocrinology (Baltimore, Md.) 20011001

Title: Use of isogenic human cancer cells for high-throughput screening and drug discovery.

Journal: Nature biotechnology 20011001

Title: Paget's disease of the spine and its management.

Journal: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20011001

Title: Reversion of transcriptional repression of Sp1 by 5 aza-2' deoxycytidine restores TGF-beta type II receptor expression in the pancreatic cancer cell line MIA PaCa-2.

Journal: Cancer research 20010815

Title: Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression.

Journal: The Journal of investigative dermatology 20010801

Title: Sp1 involvement in the 4beta-phorbol 12-myristate 13-acetate (TPA)-mediated increase in resistance to methotrexate in Chinese hamster ovary cells.

Journal: European journal of biochemistry 20010601

Title: Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine.

Journal: British journal of haematology 20010601

Title: Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells.

Journal: The Journal of biological chemistry 20010309

Title: Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons.

Journal: Annals of neurology 20010301

Title: Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.

Journal: Chemistry & biology 20010301

Title: The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.

Journal: Molecular & general genetics : MGG 20010201

Title: Intra- and intermolecular triplex DNA formation in the murine c-myb proto-oncogene promoter are inhibited by mithramycin.

Journal: Biological chemistry 20010201

Title: The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters.

Journal: Cancer research 20010115

Title: Interaction of antitumor drug, mithramycin, with chromatin.

Journal: Biochemical and biophysical research communications 20010112

Title: Staining and measurement of DNA in bacteria.

Journal: Methods in cell biology 20010101

Title: Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse.

Journal: BMC cell biology 20010101

Title: Differential interactions of antitumor antibiotics chromomycin A(3) and mithramycin with d(TATGCATA)(2) in presence of Mg(2+).

Journal: Biopolymers 20010101

Title: Hydroxyl radical footprinting.

Journal: Methods in molecular biology (Clifton, N.J.) 20010101

Title: Interactions of chromomycin A3 and mithramycin with the sequence d(TAGCTAGCTA)2.

Journal: Indian journal of biochemistry & biophysics 20010101

Title: Interaction of mithramycin with chromatin.

Journal: Indian journal of biochemistry & biophysics 20010101

Title: The structure of mithramycin reinvestigated.

Journal: Journal of natural products 19990101

Title: Expression of beta-galactosidase under the control of the human c-myc promoter in transgenic mice is inhibited by mithramycin.

Journal: Oncogene 19950615

Title: [Nephrotoxicity of antitumor chemotherapy].

Journal: Presse medicale (Paris, France : 1983) 19840428

Title: Neuraxonal dystrophy of the brain in patients receiving antineoplastic chemotherapy.

Journal: Acta neuropathologica 19770331

Title: Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.

Journal: Cancer 19751101

Title: MITHRAMYCIN IN THE TREATMENT OF DISSEMINATED TESTICULAR NEOPLASMS.

Journal: The New England journal of medicine 19650121

Title: Choi ES, et al. Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer. Sci Rep. 2014 Nov 24;4:7162.

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Tags:18378-89-7 Molecular Formula|18378-89-7 MDL|18378-89-7 SMILES|18378-89-7 Plicamycin