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18444-66-1,MFCD00135936
Catalog No.:AA00I1E4

18444-66-1 | Cucurbitacin E

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1mg
≥98%
in stock  
$59.00   $41.00
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5mg
≥98%
in stock  
$232.00   $162.00
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10mg
≥98%
in stock  
$432.00   $302.00
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20mg
in stock  
$658.00   $460.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I1E4
Chemical Name:
Cucurbitacin E
CAS Number:
18444-66-1
Molecular Formula:
C32H44O8
Molecular Weight:
556.6870
MDL Number:
MFCD00135936
SMILES:
CC(=O)OC(/C=C/C(=O)[C@@]([C@H]1[C@H](O)C[C@@]2([C@]1(C)CC(=O)[C@@]1([C@H]2CC=C2[C@H]1C=C(O)C(=O)C2(C)C)C)C)(O)C)(C)C
Properties
Computed Properties
 
Complexity:
1270  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.2  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2010,vol.20,p.2994-2997

Literature

Title: Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway.

Journal: Toxicology letters 20160906

Title: Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells.

Journal: Chemico-biological interactions 20160625

Title: The cucurbitacins E, D and I: investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver.

Journal: Toxicology letters 20130204

Title: The natural product cucurbitacin E inhibits depolymerization of actin filaments.

Journal: ACS chemical biology 20120921

Title: In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma.

Journal: Environmental toxicology and pharmacology 20120301

Title: The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells.

Journal: Anti-cancer drugs 20100401

Title: Stability of cucurbitacin E in human plasma: chemical hydrolysis and role of plasma esterases.

Journal: Biopharmaceutics & drug disposition 20091001

Title: Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands.

Journal: Journal of photochemistry and photobiology. B, Biology 20090603

Title: Screening of biochemical modulator by tumor cell permeability of doxorubicin.

Journal: International journal of pharmaceutics 20080416

Title: Cucurbitacin glucosides: antioxidant and free-radical scavenging activities.

Journal: Biochemical and biophysical research communications 20071207

Title: Effect of cucurbitacins on bilirubin-albumin binding in human plasma.

Journal: Life sciences 20070116

Title: An analysis of cytotoxic botanical formulations used in the traditional medicine of ancient Persia as abortifacients.

Journal: Journal of natural products 20040801

Title: Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis.

Journal: Chemical & pharmaceutical bulletin 20040301

Title: Stabilization of cucurbitacin E-glycoside, a feeding stimulant for diabroticite beetles, extracted from bitter Hawkesbury watermelon.

Journal: Journal of insect science (Online) 20020101

Title: Effect of a phloxine B-cucurbitacin bait on diabroticite beetles (Coleoptera: Chrysomelidae).

Journal: Journal of economic entomology 20010801

Title: Hsu YC, et al. Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E. Cell Death Dis. 2014 Apr 24;5:e1198.

Title: Murtaza M, et al. Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway. PLoS One. 2017 Jun 9;12(6):e0178910.

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