Title: Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
Journal: Toxicology letters 20161215
Title: STAT3-dependent VEGF production from keratinocytes abrogates dendritic cell activation and migration by arsenic: a plausible regional mechanism of immunosuppression in arsenical cancers.
Journal: Chemico-biological interactions 20150205
Title: Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer.
Journal: Chemico-biological interactions 20140805
Title: Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140201
Title: The cucurbitacins E, D and I: investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver.
Journal: Toxicology letters 20130204
Title: Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.
Journal: The Journal of biological chemistry 20120511
Title: Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.
Journal: Autophagy 20120401
Title: In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma.
Journal: Environmental toxicology and pharmacology 20120301
Title: High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes.
Journal: Neuroscience 20120127
Title: Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells.
Journal: BMC cancer 20110101
Title: Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis.
Journal: Molecular cancer therapeutics 20101201
Title: Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells.
Journal: Molecular cancer therapeutics 20101101
Title: The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells.
Journal: Hepatology (Baltimore, Md.) 20100401
Title: The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo.
Journal: Cancer research 20100215
Title: Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics.
Journal: PloS one 20100101
Title: Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands.
Journal: Journal of photochemistry and photobiology. B, Biology 20090603
Title: Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.
Journal: Journal of molecular endocrinology 20090401
Title: Self-associating poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer for the solubilization of STAT-3 inhibitor cucurbitacin I.
Journal: Biomacromolecules 20090309
Title: Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling.
Journal: Experimental & molecular medicine 20081231
Title: Development of a STAT3 reporter prostate cancer cell line for high throughput screening of STAT3 activators and inhibitors.
Journal: Biochemical and biophysical research communications 20081212
Title: Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway.
Journal: The Journal of investigative dermatology 20081001
Title: Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin.
Journal: Cell death and differentiation 20080401
Title: Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors.
Journal: International journal of pharmaceutics 20080122
Title: Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity.
Journal: Journal of natural products 20080101
Title: STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction.
Journal: Circulation research 20071026
Title: Effect of cucurbitacins on bilirubin-albumin binding in human plasma.
Journal: Life sciences 20070116
Title: Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061201
Title: JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells.
Journal: British journal of haematology 20061001
Title: STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.
Journal: Biochemical pharmacology 20060628
Title: Development of a sensitive and specific liquid chromatography/mass spectrometry method for the quantification of cucurbitacin I (JSI-124) in rat plasma.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20060101
Title: Targeting Stat3 in cancer therapy.
Journal: Anti-cancer drugs 20050701
Title: Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
Journal: Journal of medicinal chemistry 20041230
Title: An analysis of cytotoxic botanical formulations used in the traditional medicine of ancient Persia as abortifacients.
Journal: Journal of natural products 20040801
Title: Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
Journal: Cancer research 20030315
Title: Song J, et al. Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33(4):1867-71.
Title: van Kester MS, et al. Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells. J Invest Dermatol. 2008 Jul;128(7):1691-5.
Title: Jeong MH, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS One. 2015 Aug 21;10(8):e0136236.
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