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Title: Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives.
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Title: Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.
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Title: Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.
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Title: Isobaric peptide termini labeling utilizing site-specific N-terminal succinylation.
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Title: Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.
Journal: Journal of medicinal chemistry20110324
Title: Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms.
Journal: The Journal of biological chemistry20110225
Title: S-trityl-L-cysteine derivative induces caspase-independent cell death in K562 human chronic myeloid leukemia cell line.
Journal: Cancer letters20101201
Title: Proteomic analysis of annexin A2 phosphorylation induced by microtubule interfering agents and kinesin spindle protein inhibitors.
Journal: Journal of proteome research20100903
Title: Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids.
Journal: Analytical and bioanalytical chemistry20100701
Title: The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5.
Journal: Biophysical journal20100602
Title: Docetaxel-resistant prostate cancer cells remain sensitive to S-trityl-L-cysteine-mediated Eg5 inhibition.
Journal: Molecular cancer therapeutics20100601
Title: Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression.
Journal: Current biology : CB20100413
Title: Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.
Journal: PLoS biology20100401
Title: Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.
Journal: Biochemical pharmacology20100315
Title: Biochemical analysis of cellular target of S-trityl-L-cysteine derivatives using affinity matrix.
Journal: Bioorganic & medicinal chemistry letters20100301
Title: Glyfoline induces mitotic catastrophe and apoptosis in cancer cells.
Journal: International journal of cancer20100215
Title: Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition.
Journal: Molecular & cellular proteomics : MCP20100201
Title: Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest.
Journal: PloS one20100101
Title: An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex.
Journal: The Biochemical journal20091214
Title: Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation.
Journal: Cell cycle (Georgetown, Tex.)20090915
Title: Isobaric peptide termini labeling for MS/MS-based quantitative proteomics.
Journal: Journal of proteome research20090901
Title: Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
Journal: PLoS biology20090501
Title: The effect of the copper(II) salt anion in the Chiral Ligand-Exchange Chromatography of amino acids.
Journal: Analytica chimica acta20090413
Title: Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest.
Journal: Journal of proteomics20090130
Title: Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.
Journal: PloS one20090101
Title: Localization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa.
Journal: BMC research notes20090101
Title: KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?
Journal: BMC cancer20090101
Title: Cysteine-based chiral selectors for the ligand-exchange separation of amino acids.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20081101
Title: Descriptive structure-separation relationship studies in chiral ligand-exchange chromatography.
Journal: Journal of separation science20080701
Title: Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.
Journal: Journal of medicinal chemistry20080313
Title: S-trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids.
Journal: Journal of separation science20080301
Title: Cysteine-S-trityl a key derivative to prepare N-methyl cysteines.
Journal: Journal of combinatorial chemistry20080101
Title: Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.
Journal: Proteomics20080101
Title: ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
Journal: Nature chemical biology20071101
Title: Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly.
Journal: Journal of molecular modeling20070901
Title: Estrogen-dependent regulation of Eg5 in breast cancer cells.
Journal: Anti-cancer drugs20070801
Title: Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells.
Journal: Journal of pharmacological sciences20070801
Title: Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.
Journal: Bioorganic & medicinal chemistry letters20070715
Title: Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
Journal: Cancer chemotherapy and pharmacology20070201
Title: Regulation and targeting of Eg5, a mitotic motor protein in blast crisis CML: overcoming imatinib resistance.
Journal: Cell cycle (Georgetown, Tex.)20061001
Title: Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.
Journal: Journal of molecular biology20060707
Title: S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.
Journal: The Journal of biological chemistry20060630
Title: Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol.
Journal: BMC chemical biology20060101
Title: Kinesin-5 motors are required for organization of spindle microtubules in Silvetia compressa zygotes.
Journal: BMC plant biology20060101
Title: Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells.
Journal: Molecular cancer therapeutics20050901
Title: Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.
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Title: In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.
Journal: Molecular cancer therapeutics20040901
Title: Enhanced antitumor activity of irofulven in combination with antimitotic agents.
Journal: Investigational new drugs20020801
Title: seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties.
Journal: Journal of medicinal chemistry20010215
