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34540-22-2,MFCD03411893
Catalog No.:AA00I6QY

34540-22-2 | Madecassoside

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5mg
95%(HPLC)
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$59.00   $42.00
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25mg
95%(HPLC)
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$118.00   $83.00
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100mg
95%(HPLC)
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$300.00   $210.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I6QY
Chemical Name:
Madecassoside
CAS Number:
34540-22-2
Molecular Formula:
C48H78O20
Molecular Weight:
975.1209
MDL Number:
MFCD03411893
SMILES:
OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC(=O)[C@@]34CC[C@H]([C@@H]([C@H]4C4=CC[C@H]5[C@@]([C@]4(CC3)C)(C)C[C@@H](O)[C@@H]3[C@]5(C)C[C@H]([C@@H]([C@@]3(C)CO)O)O)C)C)[C@@H]([C@H]([C@@H]2O)O)O)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O
Properties
Computed Properties
 
Complexity:
1860  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
28  
Heavy Atom Count:
68  
Hydrogen Bond Acceptor Count:
20  
Hydrogen Bond Donor Count:
13  
Rotatable Bond Count:
10  
XLogP3:
-1.2  

Literature

Title: Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress.

Journal: Journal of biochemical and molecular toxicology 20121001

Title: Development and validation of high-performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20120101

Title: In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110601

Title: Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase.

Journal: Plant cell reports 20100401

Title: Contact dermatitis due to Centella asiatica.

Journal: Contact dermatitis 20100101

Title: Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090601

Title: Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin.

Journal: Experimental dermatology 20081101

Title: Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins.

Journal: Journal of chromatography. A 20080606

Title: Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice.

Journal: Planta medica 20080601

Title: [Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20080501

Title: Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat.

Journal: Biological & pharmaceutical bulletin 20080301

Title: Simultaneous quantitation of three major triterpenoid glycosides in Centella asiatica extracts by high performance liquid chromatography with evaporative light scattering detection.

Journal: Biomedical chromatography : BMC 20080201

Title: [Protective effect of madecassoside against reperfusion injury after regional ischemia in rabbit heart in vivo].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070501

Title: Cytotoxic cycloartane triterpene saponins from Actaea asiatica.

Journal: Journal of natural products 20061001

Title: Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry.

Journal: Biomedical chromatography : BMC 20060201

Title: [Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20041101

Title: In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20010501

Title: Zexin Li et al. Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway. Int Immunopharmacol. 2016 Apr;33:24-32.

Title: Xia Y et al. Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. Br J Pharmacol. 2016 Apr;173(7):1219-35

Title: Su Z et al. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Sci Rep. 2015 Dec 14

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