Name: Name:2,2-Difluoro-2-phenylacetic acid
Brand: AABLOCKS
SKU: AA00I729
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00I729

Chemical Name: 2,2-Difluoro-2-phenylacetic acid

CAS Number: 360-03-2

Molecular Formula: C8H6F2O2

Molecular Weight: 172.1288

MDL Number: MFCD00040968

SMILES: OC(=O)C(c1ccccc1)(F)F

Properties

BP: 258.1°C at 760 mmHg

Form: Solid

MP: 76-77°C

Storage: Keep in dry area;Room Temperature;

Complexity: 174

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 12

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 1

Rotatable Bond Count: 2

XLogP3: 2.1

Downstream Synthesis Route

360-03-2

312-24-3

[1]Jagupol'skii;Belinskaja[ZhurnalObshcheiKhimii,1958,vol.28,p.772,774;engl.Ausg.S.750,752]

[2]Desrosiers,Jean-Nicolas;Kelly,ChristopherB.;Fandrick,DanielR.;Nummy,Larry;Campbell,ScotJ.;Wei,Xudong;Sarvestani,Max;Lee,Heewon;Sienkiewicz,Alexander;Sanyal,Sanjit;Zeng,Xingzhong;Grinberg,Nelu;Ma,Shengli;Song,JinhuaJ.;Senanayake,ChrisH.[OrganicLetters,2014,vol.16,#6,p.1724-1727]

[3]CurrentPatentAssignee:MERCK&COINC-WO2006/113471,2006,A2Locationinpatent:Page/Pagecolumn63

[4]Bugera,MaksymYa.;Tarasenko,KarenV.;Kondratov,IvanS.;Gerus,IgorI.;Vashchenko,BohdanV.;Ivasyshyn,ViktorE.;Grygorenko,OleksandrO.[EuropeanJournalofOrganicChemistry,2020,vol.2020,#9,p.1069-1077]

[5]Flavell,RobertR.;Liu,Jianbo;Parker,MatthewF.L.;Toste,F.Dean;Wang,Sinan;Wilson,DavidM.[Chem,2021,vol.7,#8,p.2245-2255]

2248-46-6

360-03-2

[1]Middleton,W.J.;Bingham,E.M.[JournalofOrganicChemistry,1980,vol.45,#14,p.2883-2887]

[2]Fujikawa,Kenichi;Fujioka,Yasutaka;Kobayashi,Akira;Amii,Hideki[OrganicLetters,2011,vol.13,#20,p.5560-5563]

[3]Shao,Changdong;Shi,Guangfa;Zhang,Yanghui[EuropeanJournalofOrganicChemistry,2016,vol.2016,#33,p.5529-5538]

[4]Wang,Pingyang;Du,Pengcheng;Sun,Qianqian;Zhang,Jianhua;Deng,Hongmei;Jiang,Haizhen[OrganicandBiomolecularChemistry,2021,vol.19,#9,p.2023-2029]

[5]O'Connor,ThomasJ.;Mai,BinhKhanh;Nafie,Jordan;Liu,Peng;Toste,F.Dean[JournaloftheAmericanChemicalSociety,2021,vol.143,#34,p.13759-13768]

2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-5-phenylsulfanyl-1,3dioxolan-4-yl)-ethanol

360-03-2

C37H40F2O5SSi

[1]Tony,KurisseryA.;Denton,RichardW.;Dilhas,Anna;Jimenez-Barbero,Jesus;Mootoo,DavidR.[OrganicLetters,2007,vol.9,#8,p.1441-1444]

360-03-2

68641-49-6

57260-71-6

1-(tert-Butoxycarbonyl)-4-(2,2-difluoro-2-phenylacetamido)-piperazine

[1]Patent:US5981529,1999,A

486449-00-7

360-03-2

N-{3-1-(3-DIFLUORO(PHENYL)ACETYLAMINO}PROPYL)-4-PIPERIDINYLPHENYL}-2-METHYLPROPANAMIDE

[1]CurrentPatentAssignee:H.LUNDBECKA/S-US2004/186103,2004,A1

360-03-2 | 2,2-Difluoro-2-phenylacetic acid