Title: Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia.
Journal: Journal of lipid research20121101
Title: Synthesis of highly water-soluble fibrate derivatives via BGLation.
Journal: Bioorganic & medicinal chemistry letters20121015
Title: Study design, rationale, and baseline characteristics: evaluation of fenofibric acid on carotid intima-media thickness in patients with type IIb dyslipidemia with residual risk in addition to atorvastatin therapy (FIRST) trial.
Journal: Cardiovascular drugs and therapy20120801
Title: The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): evaluation of impacts on fish liver, by histopathology, stereology, vitellogenin and CYP1A immunohistochemistry, after sub-acute exposures of the zebrafish model.
Journal: Environmental toxicology and pharmacology20120701
Title: Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.
Journal: Bioorganic & medicinal chemistry letters20120615
Title: Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions.
Journal: Journal of cellular physiology20120601
Title: Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors.
Journal: ChemMedChem20120601
Title: A review of time courses and predictors of lipid changes with fenofibric acid-statin combination.
Journal: Cardiovascular drugs and therapy20120601
Title: Development of a sensitive liquid chromatography/tandem mass spectrometry method for the determination of fenofibric acid in rat plasma.
Journal: Biomedical chromatography : BMC20120401
Title: Novel phenoxyalkylcarboxylic acid derivatives as hypolipidaemic agents.
Journal: Journal of enzyme inhibition and medicinal chemistry20120401
Title: Biomolecular chemistry of isopropyl fibrates.
Journal: Journal of pharmaceutical sciences20120401
Title: A randomized, double-blind, placebo-controlled study of the safety and tolerance of regadenoson in subjects with stage 3 or 4 chronic kidney disease.
Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology20120401
Title: One-year efficacy and safety of rosuvastatin + fenofibric acid combination therapy in patients with mixed dyslipidemia: evaluation of dose response.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20120401
Title: Fenofibric acid for hyperlipidemia.
Journal: Expert opinion on pharmacotherapy20120401
Title: LPL gene variants affect apoC-III response to combination therapy of statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia.
Journal: Journal of lipid research20120301
Title: Relationship between paraoxonase and homocysteine: crossroads of oxidative diseases.
Journal: Archives of medical science : AMS20120227
Title: In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions.
Journal: Pharmaceutical research20120201
Title: A review of the rationale for additional therapeutic interventions to attain lower LDL-C when statin therapy is not enough.
Journal: Current atherosclerosis reports20120201
Title: Severe neutropenia in a renal transplant patient suggesting an interaction between mycophenolate and fenofibrate.
Journal: Current drug safety20120201
Title: Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α.
Journal: Molecular and cellular endocrinology20120102
Title: Relaxation of rat thoracic aorta by fibrate drugs correlates with their potency to disturb intracellular calcium of VSMCs.
Journal: Vascular pharmacology20120101
Title: Rosuvastatin: a review of the pharmacology and clinical effectiveness in cardiovascular disease.
Journal: Clinical Medicine Insights. Cardiology20120101
Title: Femtosecond transient absorption, nanosecond time-resolved resonance Raman, and density functional theory study of fenofibric acid in acetonitrile and isopropyl alcohol solvents.
Journal: The journal of physical chemistry. A20111215
Title: Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia.
Journal: Atherosclerosis20111201
Title: Oxidation by-products and ecotoxicity assessment during the photodegradation of fenofibric acid in aqueous solution with UV and UV/H2O2.
Journal: Journal of hazardous materials20111030
Title: The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): assessing impacts on gonadal maturation with a histopathological and stereological study of zebrafish ovary and testis after sub-acute exposures.
Journal: Aquatic toxicology (Amsterdam, Netherlands)20111001
Title: Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism.
Journal: Bioorganic & medicinal chemistry letters20111001
Title: The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal)--experimental assessment using a zebrafish embryo test.
Journal: Environmental toxicology and pharmacology20110901
Title: Synthesis and biological evaluation of orally active hypolipidemic agents.
Journal: Journal of medicinal chemistry20110825
Title: Fenofibric acid reduces fibronectin and collagen type IV overexpression in human retinal pigment epithelial cells grown in conditions mimicking the diabetic milieu: functional implications in retinal permeability.
Journal: Investigative ophthalmology & visual science20110801
Title: Fenofibric acid prevents retinal pigment epithelium disruption induced by interleukin-1β by suppressing AMP-activated protein kinase (AMPK) activation.
Journal: Diabetologia20110601
Title: Single-dose bioequivalence of 105-mg fenofibric acid tablets versus 145-mg fenofibrate tablets under fasting and fed conditions: a report of two phase I, open-label, single-dose, randomized, crossover clinical trials.
Journal: Clinical therapeutics20110601
Title: Evaluating optimal lipid levels in patients with mixed dyslipidemia following short- and long-term treatment with fenofibric acid and statin combination therapy: a post hoc analysis.
Journal: Current medical research and opinion20110501
Title: Synthesis and pharmacological evaluation of novel benzoylazole-based PPAR α/γ activators.
Journal: Bioorganic & medicinal chemistry letters20110401
Title: Efficacy of fenofibric acid plus statins on multiple lipid parameters and its safety in women with mixed dyslipidemia.
Journal: The American journal of cardiology20110315
Title: Effect of gemfibrozil and fenofibrate on the pharmacokinetics of atorvastatin.
Journal: Journal of clinical pharmacology20110301
Title: Achievement of lipid targets with the combination of rosuvastatin and fenofibric Acid in patients with type 2 diabetes mellitus.
Journal: Cardiovascular drugs and therapy20110201
Title: Long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients with persistent elevated triglycerides.
Journal: Cardiovascular drugs and therapy20110201
Title: Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets.
Journal: Journal of atherosclerosis and thrombosis20110101
Title: Considering statins for cholesterol-reduction in children if lifestyle and diet changes do not improve their health: a review of the risks and benefits.
Journal: Vascular health and risk management20110101
Title: Food protein-stabilized nanoemulsions as potential delivery systems for poorly water-soluble drugs: preparation, in vitro characterization, and pharmacokinetics in rats.
Journal: International journal of nanomedicine20110101
Title: A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.
Journal: BMC systems biology20110101
Title: Tissue factor, blood coagulation, and beyond: an overview.
Journal: International journal of inflammation20110101
Title: Effects of combination therapy with rosuvastatin and fenofibric acid in patients with mixed dyslipidemia and high-sensitivity C-reactive protein (≥ 2 mg/L). [email protected].
Journal: Journal of clinical lipidology20110101
Title: In situ formation of nanocrystals from a self-microemulsifying drug delivery system to enhance oral bioavailability of fenofibrate.
Journal: International journal of nanomedicine20110101
Title: Atorvastatin and fenofibric acid differentially affect the release of adipokines in the visceral and subcutaneous cultures of adipocytes that were obtained from patients with and without mixed dyslipidemia.
Journal: Pharmacological reports : PR20110101
Title: Efficacy and safety of rosuvastatin 5 mg in combination with fenofibric acid 135 mg in patients with mixed dyslipidemia - a phase 3 study.
Journal: Cardiovascular drugs and therapy20101201
Title: Effects of statins on the epicardial fat thickness in patients with coronary artery stenosis underwent percutaneous coronary intervention: comparison of atorvastatin with simvastatin/ezetimibe.
Journal: Journal of cardiovascular ultrasound20101201
Title: Catalytic ozonation of fenofibric acid over alumina-supported manganese oxide.
Journal: Journal of hazardous materials20101115
Title: Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes.
Journal: Molecular and cellular biochemistry20101101
Title: Human health risk assessment of pharmaceuticals in water: issues and challenges ahead.
Journal: International journal of environmental research and public health20101101
Title: Spatiotemporal distribution of pharmaceuticals in the Douro River estuary (Portugal).
Journal: The Science of the total environment20101015
Title: Unmetabolized fenofibrate, but not fenofibric acid, activates AMPK and inhibits the expression of phosphoenolpyruvate carboxykinase in hepatocytes.
Journal: Life sciences20101009
Title: Efficacy and safety of fenofibric acid in combination with atorvastatin and ezetimibe in patients with mixed dyslipidemia.
Journal: American heart journal20101001
Title: Combination rosuvastatin plus fenofibric acid in a cohort of patients 65 years or older with mixed dyslipidemia: subanalysis of two randomized, controlled studies.
Journal: Clinical cardiology20101001
Title: The role of a new formulation of fenofibric acid in the treatment of mixed dyslipidemia in type 2 diabetes.
Journal: Drugs of today (Barcelona, Spain : 1998)20101001
Title: The effects of fenofibric acid alone and with statins on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia.
Journal: Diabetes care20100901
Title: Comparison of the gastrointestinal absorption and bioavailability of fenofibrate and fenofibric acid in humans.
Journal: Journal of clinical pharmacology20100801
Title: Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes.
Journal: Hepatology (Baltimore, Md.)20100501
Title: Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain.
Journal: Protein expression and purification20100401
Title: Fibrate therapy in the management of dyslipidemias, alone and in combination with statins: role of delayed-release fenofibric acid.
Journal: Expert opinion on pharmacotherapy20100401
Title: Ecotoxicity assessment of lipid regulators in water and biologically treated wastewater using three aquatic organisms.
Journal: Environmental science and pollution research international20100101
Title: Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation.
Journal: Water research20100101
Title: Year two assessment of fenofibric acid and moderate-dose statin combination: a phase 3, open-label, extension study.
Journal: Clinical drug investigation20100101
Title: Medicinal chemistry of drugs used in diabetic cardiomyopathy.
Journal: Current medicinal chemistry20100101
Title: Effect of fenofibrate on uric acid metabolism and urate transporter 1.
Journal: Internal medicine (Tokyo, Japan)20100101
Title: Efficacy and safety of fenofibric acid co-administered with low- or moderate-dose statin in patients with mixed dyslipidemia and type 2 diabetes mellitus: results of a pooled subgroup analysis from three randomized, controlled, double-blind trials.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20100101
Title: Cardiovascular computed tomographic assessment of the effect of combination lipoprotein therapy on coronary arterial plaque: rationale and design of the AFRICA (Atorvastatin plus Fenofibric acid in the Reduction of Intermediate Coronary Atherosclerosis) study.
Journal: Journal of cardiovascular computed tomography20100101
Title: Therapeutic options to further lower C-reactive protein for patients on statin treatment.
Journal: Current atherosclerosis reports20100101
Title: Efficacy and safety of rosuvastatin and fenofibric acid combination therapy versus simvastatin monotherapy in patients with hypercholesterolemia and hypertriglyceridemia: a randomized, double-blind study.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20100101
Title: Fenofibric acid: a new fibrate approved for use in combination with statin for the treatment of mixed dyslipidemia.
Journal: Vascular health and risk management20100101
Title: Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acid.
Journal: Vascular health and risk management20100101
Title: Role of PPARα and Its Agonist in Renal Diseases.
Journal: PPAR research20100101
Title: Pharmacokinetics and comparative bioavailability of two fenofibrate capsule formulations in healthy volunteers.
Journal: Arzneimittel-Forschung20100101
Title: Pitavastatin: evidence for its place in treatment of hypercholesterolemia.
Journal: Core evidence20100101
Title: A review on the rationale and clinical use of concomitant rosuvastatin and fenofibrate/fenofibric acid therapy.
Journal: Clinical pharmacology : advances and applications20100101
Title: Capecitabine-induced severe hypertriglyceridaemia and diabetes: a case report and review of the literature.
Journal: Diabetic medicine : a journal of the British Diabetic Association20091201
Title: In vitro glucuronidation of fenofibric acid by human UDP-glucuronosyltransferases and liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals20091101
Title: Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.
Journal: Journal of neurochemistry20091101
Title: New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
Journal: Journal of medicinal chemistry20091022
Title: Probing the fibrate binding specificity of rat liver fatty acid binding protein.
Journal: Journal of medicinal chemistry20090910
Title: Determination of fenofibric acid in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry: application to a bioequivalence study.
Journal: Biomedical chromatography : BMC20090901
Title: Myopathy with statin-fibrate combination therapy: clinical considerations.
Journal: Nature reviews. Endocrinology20090901
Title: Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.
Journal: Current neurovascular research20090801
Title: Advances in the medical treatment of diabetic retinopathy.
Journal: Diabetes care20090801
Title: IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system.
Journal: Journal of pharmaceutical sciences20090601
Title: Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein.
Journal: Molecular and cellular biochemistry20090601
Title: Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics.
Journal: Drug metabolism and disposition: the biological fate of chemicals20090601
Title: Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.
Journal: European journal of gastroenterology & hepatology20090601
Title: Fenofibric Acid (trilipix).
Journal: The Medical letter on drugs and therapeutics20090504
Title: Efficacy and safety of ABT-335 (fenofibric acid) in combination with rosuvastatin in patients with mixed dyslipidemia: a phase 3 study.
Journal: Atherosclerosis20090501
Title: Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Journal: Bioorganic & medicinal chemistry letters20090501
Title: Fenofibrate-loaded PLGA microparticles: effects on ischemic stroke.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20090411
Title: Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression.
Journal: British journal of pharmacology20090401
Title: Efficacy and safety of fenofibric acid in combination with a statin in patients with mixed dyslipidemia: Pooled analysis of three phase 3, 12-week randomized, controlled studies.
Journal: Journal of clinical lipidology20090401
Title: Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia.
Journal: The American journal of cardiology20090215
Title: ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans.
Journal: Journal of clinical pharmacology20090101
Title: Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study.
Journal: American heart journal20090101
Title: MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation.
Journal: PPAR research20090101
Title: Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.
Journal: PPAR research20090101
Title: Thinking beyond low-density lipoprotein cholesterol: strategies to further reduce cardiovascular risk.
Journal: Vascular health and risk management20090101
Title: Fenofibric acid: in combination therapy in the treatment of mixed dyslipidemia.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20090101
Title: Effect of atorvastatin and fenofibric acid on adipokine release from visceral and subcutaneous adipose tissue of patients with mixed dyslipidemia and normolipidemic subjects.
Journal: Pharmacological reports : PR20090101
Title: Long-term safety and efficacy of fenofibric acid in combination with statin therapy for the treatment of patients with mixed dyslipidemia.
Journal: Journal of clinical lipidology20081201
Title: Treatment of hyperlipidaemia with fenofibrate and related fibrates.
Journal: Expert opinion on investigational drugs20081001
Title: Update on the clinical utility of fenofibrate in mixed dyslipidemias: mechanisms of action and rational prescribing.
Journal: Vascular health and risk management20081001
Title: Nanocrystal technology, drug delivery and clinical applications.
Journal: International journal of nanomedicine20080901
Title: PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes.
Journal: Toxicology and applied pharmacology20080815
Title: Characterization of the drug binding specificity of rat liver fatty acid binding protein.
Journal: Journal of medicinal chemistry20080710
Title: An automated method for the simultaneous determination of pravastatin, 3-hydroxy isomeric metabolite, pravalactone and fenofibric acid in human plasma by sensitive liquid chromatography combined with diode array and tandem mass spectrometry detection.
Journal: Journal of chromatography. A20080502
Title: A novel PPARalpha agonist ameliorates insulin resistance in dogs fed a high-fat diet.
Journal: American journal of physiology. Endocrinology and metabolism20080501
Title: Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.
Journal: European journal of pharmacology20080428
Title: Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.
Journal: The Journal of biological chemistry20080411
Title: Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
Journal: Bioorganic & medicinal chemistry letters20080315
Title: Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
Journal: Bioorganic & medicinal chemistry20080115
Title: Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems.
Journal: PPAR research20080101
Title: Fenofibrate set to benefit from new research on its active metabolite, fenofibric acid.
Journal: Cardiovascular journal of Africa20080101
Title: Evaluation of a new formulation of fenofibric acid, ABT-335, co-administered with statins : study design and rationale of a phase III clinical programme.
Journal: Clinical drug investigation20080101
Title: Statins Activate Human PPARalpha Promoter and Increase PPARalpha mRNA Expression and Activation in HepG2 Cells.
Journal: PPAR research20080101
Title: Development and Validation of RP-HPLC Method for Simultaneous Estimation of Atorvastatin Calcium and Fenofibrate in Tablet Dosage Forms.
Journal: Indian journal of pharmaceutical sciences20080101
Title: Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid.
Journal: Drug metabolism and disposition: the biological fate of chemicals20070801
Title: Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.
Journal: Journal of lipid research20070801
Title: Effects of peroxisome proliferator-activated receptor activation on gonadotropin transcription and cell mitosis induced by bone morphogenetic proteins in mouse gonadotrope LbetaT2 cells.
Journal: The Journal of endocrinology20070701
Title: Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.
Journal: The Journal of pharmacology and experimental therapeutics20070501
Title: Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Journal: Journal of medicinal chemistry20070405
Title: Determination of fenofibric acid concentrations by HPLC after anion exchange solid-phase extraction from human serum.
Journal: Therapeutic drug monitoring20070401
Title: LC-MS analysis and environmental risk of lipid regulators.
Journal: Analytical and bioanalytical chemistry20070201
Title: Activating effect of benzbromarone, a uricosuric drug, on peroxisome proliferator-activated receptors.
Journal: PPAR research20070101
Title: Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.
Journal: Bioorganic & medicinal chemistry letters20061215
Title: Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.
Journal: Bioorganic & medicinal chemistry letters20061215
Title: Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha.
Journal: The Journal of pharmacology and experimental therapeutics20061201
Title: Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro.
Journal: Biochemical and biophysical research communications20061124
Title: The transfer of a LC-UV method for the determination of fenofibrate and fenofibric acid in Lidoses: use of total error as decision criterion.
Journal: Journal of pharmaceutical and biomedical analysis20060911
Title: Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.
Journal: Bioorganic & medicinal chemistry letters20060615
Title: Effects of fenofibrate on C-reactive protein levels in hypertriglyceridemic patients.
Journal: Journal of cardiovascular pharmacology20060601
Title: Fenofibrate: a novel formulation (Triglide) in the treatment of lipid disorders: a review.
Journal: International journal of nanomedicine20060601
Title: The PPAR-alpha activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs.
Journal: American journal of physiology. Heart and circulatory physiology20060501
Title: Evaluation of the potential for pharmacokinetic interaction between fenofibrate and ezetimibe: A phase I, open-label, multiple-dose, three-period crossover study in healthy subjects.
Journal: Clinical therapeutics20060301
Title: Absence of a food effect with a 145 mg nanoparticle fenofibrate tablet formulation.
Journal: International journal of clinical pharmacology and therapeutics20060201
Title: The effects of food on the bioavailability of fenofibrate administered orally in healthy volunteers via sustained-release capsule.
Journal: Clinical pharmacokinetics20060101
Title: Optimal lipid modification: the rationale for combination therapy.
Journal: Vascular health and risk management20051201
Title: Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study.
Journal: Journal of pharmaceutical and biomedical analysis20050915
Title: Bezafibrate increases very-long-chain acyl-CoA dehydrogenase protein and mRNA expression in deficient fibroblasts and is a potential therapy for fatty acid oxidation disorders.
Journal: Human molecular genetics20050915
Title: Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.
Journal: Biochemical and biophysical research communications20050902
Title: Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells.
Journal: Cardiovascular research20050701
Title: Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20050701
Title: Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner.
Journal: Arteriosclerosis, thrombosis, and vascular biology20050601
Title: Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.
Journal: Journal of medicinal chemistry20050407
Title: Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.
Journal: Journal of medicinal chemistry20050324
Title: Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.
Journal: Gastroenterology20050201
Title: Fenofibric acid.
Journal: Acta crystallographica. Section C, Crystal structure communications20050201
Title: 2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.
Journal: Bioorganic & medicinal chemistry letters20050103
Title: Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes.
Journal: Pharmaceutical research20050101
Title: Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.
Journal: Nuclear receptor20050101
Title: Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion.
Journal: The Journal of pharmacology and experimental therapeutics20040901
Title: Simvastatin does not have a clinically significant pharmacokinetic interaction with fenofibrate in humans.
Journal: Journal of clinical pharmacology20040901
Title: A new fenofibrate formulation: results of six single-dose, clinical studies of bioavailability under fed and fasting conditions.
Journal: Clinical therapeutics20040901
Title: Photosensitization of thymine nucleobase by benzophenone derivatives as models for photoinduced DNA damage: Paterno-Büchi vs energy and electron transfer processes.
Journal: Chemical research in toxicology20040701
Title: A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice.
Journal: The Journal of pharmacology and experimental therapeutics20040601
Title: Fenofibrate and fenofibric acid analysis by capillary electrophoresis.
Journal: Electrophoresis20040601
Title: Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages.
Journal: DNA and cell biology20040501
Title: Influence of lipid lowering fibrates on P-glycoprotein activity in vitro.
Journal: Biochemical pharmacology20040115
Title: Effect of colesevelam HCl on single-dose fenofibrate pharmacokinetics.
Journal: Clinical pharmacokinetics20040101
Title: Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.
Journal: Journal of medicinal chemistry20031120
Title: Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme.
Journal: The Journal of biological chemistry20030829
Title: Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells.
Journal: European journal of pharmacology20030815
Title: Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists.
Journal: Journal of molecular endocrinology20030601
Title: Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins.
Journal: Molecular pharmacology20030401
Title: An open-label, randomized, three-way crossover trial of the effects of coadministration of rosuvastatin and fenofibrate on the pharmacokinetic properties of rosuvastatin and fenofibric acid in healthy male volunteers.
Journal: Clinical therapeutics20030201
Title: A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
Journal: The Journal of biological chemistry20030124
Title: Fenofibrate in the treatment of dyslipidemia: a review of the data as they relate to the new suprabioavailable tablet formulation.
Journal: Clinical therapeutics20021201
Title: Induction of plasminogen activator inhibitor-1 in endothelial cells by basic fibroblast growth factor and its modulation by fibric acid.
Journal: Arteriosclerosis, thrombosis, and vascular biology20020501
Title: A laser flash photolysis study of fenofibric acid in aqueous buffered media: unexpected triplet state inversion in a derivative of 4-alkoxybenzophenone.
Journal: Photochemistry and photobiology20020301
Title: PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.
Journal: European journal of pharmacology20020125
Title: Randomised crossover studies of the bioequivalence of two fenofibrate formulations after administration of a single oral dose in healthy volunteers.
Journal: Arzneimittel-Forschung20020101
Title: Update on fenofibrate.
Journal: Cardiovascular drug reviews20020101
Title: Micronized fenofibrate in dyslipidemia: a focus on plasma high-density lipoprotein cholesterol (HDL-C) levels.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20020101
Title: Comparison of DNA damage photoinduced by ketoprofen, fenofibric acid and benzophenone via electron and energy transfer.
Journal: Photochemistry and photobiology20011101
Title: Regulation of lipid metabolism and gene expression by fenofibrate in hamsters.
Journal: Biochimica et biophysica acta20011031
Title: Effect of fenofibrate on plasma concentration and urinary excretion of purine bases and oxypurinol.
Journal: The Journal of rheumatology20011001
Title: Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresson.
Journal: The Journal of biological chemistry20010824
Title: PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells.
Journal: Biochemical and biophysical research communications20010824
Title: Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
Journal: Journal of medicinal chemistry20010621
Title: Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I.
Journal: The Journal of clinical investigation20010601
Title: Choice of lipid-regulating drugs.
Journal: The Medical letter on drugs and therapeutics20010528
Title: A potent PPARalpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscle.
Journal: American journal of physiology. Endocrinology and metabolism20010201
Title: PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages.
Journal: Circulation20010116
Title: Rapid and simple method for detection of fenofibric acid in human serum by high-performance liquid chromatography.
Journal: Die Pharmazie20010101
Title: Drug treatment of combined hyperlipidemia.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20010101
Title: A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Journal: Journal of medicinal chemistry19990923
Title: Dietz M, et al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem. 2012 Jun;7(6):1101-11.
Title: Prasad GS, et al. Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies. Inflammopharmacology. 2017 Dec 13.
Title: Neumeier M, et al. Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biophys Res Commun. 2006 Nov 24;350(3):731-5. Epub 2006 Sep 27.
Title: Miranda S, et al. Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions. J Cell Physiol. 2012 Jun;227(6):2352-62.
