Home Amines 52712-76-2
52712-76-2,MFCD00941411
Catalog No.:AA00I9CN

52712-76-2 | 1H-1,4-Diazepine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-,monohydrochloride

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5mg
95%
1 week  
$123.00   $86.00
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10mg
95%
1 week  
$156.00   $109.00
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25mg
95%
1 week  
$216.00   $152.00
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50mg
95%
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$317.00   $222.00
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100mg
95%
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$528.00   $370.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I9CN
Chemical Name:
1H-1,4-Diazepine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-,monohydrochloride
CAS Number:
52712-76-2
Molecular Formula:
C19H28ClN5O3
Molecular Weight:
409.9103
MDL Number:
MFCD00941411
SMILES:
CCCC(=O)N1CCCN(CC1)c1nc(N)c2c(n1)cc(c(c2)OC)OC.Cl
Properties
Computed Properties
 
Complexity:
494  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  

Literature

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Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

Title: Distinctive effects of carvedilol in the non-infarct zone: remodelling of the ligated rat heart linked to oxidative stress.

Journal: The Journal of international medical research 20090101

Title: Possible mechanism of intraoperative floppy iris syndrome: a clinicopathological study.

Journal: The British journal of ophthalmology 20080801

Title: Ocular pharmacokinetic/pharmacodynamic modeling for multiple anti-glaucoma drugs.

Journal: Biological & pharmaceutical bulletin 20080801

Title: Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin.

Journal: Journal of biomedical science 20080701

Title: Protective effects of carvedilol in murine model with the coxsackievirus B3-induced viral myocarditis.

Journal: Journal of cardiovascular pharmacology 20080101

Title: Effects of adrenergic and cholinergic antagonists on diameter of nasolacrimal drainage system.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20071201

Title: [Case of pigmentary glaucoma treated with medical therapy, laser treatment, and trabeculotomy].

Journal: Nippon Ganka Gakkai zasshi 20070201

Title: Incidence of intraoperative floppy iris syndrome in patients on either systemic or topical alpha(1)-adrenoceptor antagonist.

Journal: American journal of ophthalmology 20070101

Title: An alpha1-receptor blocker reduces plasma leptin levels in hypertensive patients with obesity and hyperleptinemia.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20061001

Title: Correlation between the additive effect of bunazosin and the response to latanoprost on intraocular pressure in patients with glaucoma treated with bunazosin as adjunctive therapy to latanoprost.

Journal: Japanese journal of ophthalmology 20060101

Title: Addition of or switch to topical bunazosin hydrochloride in elderly patients with normal-tension glaucoma: A one-year follow-up study.

Journal: Japanese journal of ophthalmology 20060101

Title: Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20051001

Title: Alterations of alpha-adrenergic modulations of coronary microvascular tone in dogs with heart failure.

Journal: Journal of cardiac failure 20050601

Title: Alpha1-receptor or adenosine A1-receptor dependent pathway alone is not sufficient but summation of these pathways is required to achieve an ischaemic preconditioning effect in rabbits.

Journal: Clinical and experimental pharmacology & physiology 20050401

Title: Amelioration of endothelin-1-induced optic nerve head ischemia by topical bunazosin.

Journal: Current eye research 20050201

Title: alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.

Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) 20050101

Title: Evaluation of the additive effect of bunazosin on latanoprost in primary open-angle glaucoma.

Journal: Japanese journal of ophthalmology 20050101

Title: Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage.

Journal: Cardiovascular drug reviews 20050101

Title: Comparative study on the combined effects of bunazosin and nipradilol or timolol on intraocular pressure in normotensive rabbits.

Journal: Japanese journal of ophthalmology 20050101

Title: Effects of topically instilled bunazosin, an alpha1-adrenoceptor antagonist, on constrictions induced by phenylephrine and ET-1 in rabbit retinal arteries.

Journal: Investigative ophthalmology & visual science 20041101

Title: Effects of bunazosin hydrochloride on ciliary muscle constriction and matrix metalloproteinase activities.

Journal: Journal of glaucoma 20040801

Title: Ocular pharmacokinetic/ pharmacodynamic modeling for bunazosin after instillation into rabbits.

Journal: Pharmaceutical research 20040501

Title: Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures.

Journal: Brain research 20040402

Title: Efficacy of bunazosin hydrochloride 0.01% as adjunctive therapy of latanoprost or timolol.

Journal: Journal of glaucoma 20040201

Title: Binding affinity of bunazosin, dorzolamide, and timolol to synthetic melanin.

Journal: Japanese journal of ophthalmology 20040101

Title: Effects of topically instilled bunazosin hydrochloride and other ocular hypotensive drugs on endothelin-1-induced constriction in rabbit retinal arteries.

Journal: Japanese journal of ophthalmology 20040101

Title: [Effects of ocular hypotensive agents on the circadian rhythm in intraocular pressure in rabbits as measured by telemetry].

Journal: Nippon Ganka Gakkai zasshi 20030901

Title: Amelioration by topical bunazosin hydrochloride of the impairment in ocular blood flow caused by nitric oxide synthase inhibition in rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030201

Title: Additive effect of bunazosin on intraocular pressure when topically added to treatment with latanoprost in patients with glaucoma.

Journal: Japanese journal of ophthalmology 20030101

Title: Neuroprotective effects of nipradilol on purified cultured retinal ganglion cells.

Journal: Journal of glaucoma 20020601

Title: The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction.

Journal: The Journal of clinical investigation 20020315

Title: Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats.

Journal: Circulation 20020226

Title: The renin-angiotensin and adrenergic nervous system in cardiac hypertrophy in fructose-fed rats.

Journal: American journal of hypertension 20020101

Title: Purinergic modulation of vascular sympathetic neurotransmission.

Journal: Japanese journal of pharmacology 20020101

Title: Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors.

Journal: European journal of pharmacology 20011207

Title: Neuroprotective effect and intraocular penetration of nipradilol, a beta-blocker with nitric oxide donative action.

Journal: Investigative ophthalmology & visual science 20010301

Title: Orthostatic hypotension: how to avoid it during antihypertensive therapy.

Journal: American journal of hypertension 19961101

Title: [Comparison of selective alpha-1 blockades for alpha-receptors in human hypertrophied prostatic adenomas].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 19920301

Title: Effects of regression of left ventricular hypertrophy following atenolol or bunazosin therapy on ischemic cardiac function and myocardial metabolism in spontaneously hypertensive rats.

Journal: Japanese circulation journal 19911201

Title: Mechanism of myocardial injury in dogs with hypokalaemia.

Journal: Cardiovascular research 19880401

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SDS
Tags:52712-76-2 Molecular Formula|52712-76-2 MDL|52712-76-2 SMILES|52712-76-2 1H-1,4-Diazepine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-,monohydrochloride